Structural basis for RNA replication by the hepatitis C virus polymerase
Appleby, Todd C., Perry, Jason K., Murakami, Eisuke, Barauskas, Ona, Feng, Joy, Cho, Aesop, Fox, David, Wetmore, Diana R., McGrath, Mary E., Ray, Adrian S., Sofia, Michael J., Swaminathan, S., Edwards, Thomas E.
Published in Science (American Association for the Advancement of Science) (13.02.2015)
Published in Science (American Association for the Advancement of Science) (13.02.2015)
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Clinical targeting of HIV capsid protein with a long-acting small molecule
Link, John O, Rhee, Martin S, Tse, Winston C, Zheng, Jim, Somoza, John R, Rowe, William, Begley, Rebecca, Chiu, Anna, Mulato, Andrew, Hansen, Derek, Singer, Eric, Tsai, Luong K, Bam, Rujuta A, Chou, Chien-Hung, Canales, Eda, Brizgys, Gediminas, Zhang, Jennifer R, Li, Jiayao, Graupe, Michael, Morganelli, Philip, Liu, Qi, Wu, Qiaoyin, Halcomb, Randall L, Saito, Roland D, Schroeder, Scott D, Lazerwith, Scott E, Bondy, Steven, Jin, Debi, Hung, Magdeleine, Novikov, Nikolai, Liu, Xiaohong, Villaseñor, Armando G, Cannizzaro, Carina E, Hu, Eric Y, Anderson, Robert L, Appleby, Todd C, Lu, Bing, Mwangi, Judy, Liclican, Albert, Niedziela-Majka, Anita, Papalia, Giuseppe A, Wong, Melanie H, Leavitt, Stephanie A, Xu, Yili, Koditek, David, Stepan, George J, Yu, Helen, Pagratis, Nikos, Clancy, Sheila, Ahmadyar, Shekeba, Cai, Terrence Z, Sellers, Scott, Wolckenhauer, Scott A, Ling, John, Callebaut, Christian, Margot, Nicolas, Ram, Renee R, Liu, Ya-Pei, Hyland, Rob, Sinclair, Gary I, Ruane, Peter J, Crofoot, Gordon E, McDonald, Cheryl K, Brainard, Diana M, Lad, Latesh, Swaminathan, Swami, Sundquist, Wesley I, Sakowicz, Roman, Chester, Anne E, Lee, William E, Daar, Eric S, Yant, Stephen R, Cihlar, Tomas
Published in Nature (London) (27.08.2020)
Published in Nature (London) (27.08.2020)
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Journal Article
An atomistic model of the coronavirus replication-transcription complex as a hexamer assembled around nsp15
Perry, Jason K., Appleby, Todd C., Bilello, John P., Feng, Joy Y., Schmitz, Uli, Campbell, Elizabeth A.
Published in The Journal of biological chemistry (01.10.2021)
Published in The Journal of biological chemistry (01.10.2021)
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Structural basis for substrate selection by the SARS-CoV-2 replicase
Malone, Brandon F, Perry, Jason K, Olinares, Paul Dominic B, Lee, Hery W, Chen, James, Appleby, Todd C, Feng, Joy Y, Bilello, John P, Ng, Honkit, Sotiris, Johanna, Ebrahim, Mark, Chua, Eugene Y D, Mendez, Joshua H, Eng, Ed T, Landick, Robert, Götte, Matthias, Chait, Brian T, Campbell, Elizabeth A, Darst, Seth A
Published in Nature (London) (23.02.2023)
Published in Nature (London) (23.02.2023)
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Biochemical characterization and structure determination of a potent, selective antibody inhibitor of human MMP9
Appleby, Todd C., Greenstein, Andrew E., Hung, Magdeleine, Liclican, Albert, Velasquez, Maile, Villaseñor, Armando G., Wang, Ruth, Wong, Melanie H., Liu, Xiaohong, Papalia, Giuseppe A., Schultz, Brian E., Sakowicz, Roman, Smith, Victoria, Kwon, Hyock Joo
Published in The Journal of biological chemistry (21.04.2017)
Published in The Journal of biological chemistry (21.04.2017)
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Journal Article
Protein Footprinting and X‑ray Crystallography Reveal the Interaction of PD-L1 and a Macrocyclic Peptide
Niu, Ben, Appleby, Todd C, Wang, Ruth, Morar, Mariya, Voight, Johannes, Villaseñor, Armando G, Clancy, Sheila, Wise, Sarah, Belzile, Jean-Philippe, Papalia, Giuseppe, Wong, Melanie, Brendza, Katherine M, Lad, Latesh, Gross, Michael L
Published in Biochemistry (Easton) (04.02.2020)
Published in Biochemistry (Easton) (04.02.2020)
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Journal Article
Discovery of the pan-genotypic hepatitis C virus NS3/4A protease inhibitor voxilaprevir (GS-9857): A component of Vosevi
Taylor, James G., Zipfel, Sheila, Ramey, Kyla, Vivian, Randy, Schrier, Adam, Karki, Kapil K., Katana, Ashley, Kato, Darryl, Kobayashi, Tetsuya, Martinez, Ruben, Sangi, Michael, Siegel, Dustin, Tran, Chinh V., Yang, Zheng-Yu, Zablocki, Jeff, Yang, Cheng Y., Wang, Yujin, Wang, Kelly, Chan, Katie, Barauskas, Ona, Cheng, Guofeng, Jin, Debi, Schultz, Brian E., Appleby, Todd, Villaseñor, Armando G., Link, John O.
Published in Bioorganic & medicinal chemistry letters (15.08.2019)
Published in Bioorganic & medicinal chemistry letters (15.08.2019)
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Journal Article
Characterization of a KDM5 small molecule inhibitor with antiviral activity against hepatitis B virus
Gilmore, Sarah A, Tam, Danny, Cheung, Tara L, Snyder, Chelsea, Farand, Julie, Dick, Ryan, Matles, Mike, Feng, Joy Y, Ramirez, Ricardo, Li, Li, Yu, Helen, Xu, Yili, Barnes, Dwight, Czerwieniec, Gregg, Brendza, Katherine M, Appleby, Todd C, Birkus, Gabriel, Willkom, Madeleine, Kobayashi, Tetsuya, Paoli, Eric, Labelle, Marc, Boesen, Thomas, Tay, Chin H, Delaney, 4th, William E, Notte, Gregory T, Schmitz, Uli, Feierbach, Becket
Published in PloS one (07.12.2022)
Published in PloS one (07.12.2022)
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Journal Article
Visualizing ATP-Dependent RNA Translocation by the NS3 Helicase from HCV
Appleby, Todd C., Anderson, Robert, Fedorova, Olga, Pyle, Anna M., Wang, Ruth, Liu, Xiaohong, Brendza, Katherine M., Somoza, John R.
Published in Journal of molecular biology (04.02.2011)
Published in Journal of molecular biology (04.02.2011)
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Journal Article
Discovery of Potent Cyclophilin Inhibitors Based on the Structural Simplification of Sanglifehrin A
Steadman, Victoria A, Pettit, Simon B, Poullennec, Karine G, Lazarides, Linos, Keats, Andrew J, Dean, David K, Stanway, Steven J, Austin, Carol A, Sanvoisin, Jonathan A, Watt, Gregory M, Fliri, Hans G, Liclican, Albert C, Jin, Debi, Wong, Melanie H, Leavitt, Stephanie A, Lee, Yu-Jen, Tian, Yang, Frey, Christian R, Appleby, Todd C, Schmitz, Uli, Jansa, Petr, Mackman, Richard L, Schultz, Brian E
Published in Journal of medicinal chemistry (09.02.2017)
Published in Journal of medicinal chemistry (09.02.2017)
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Journal Article
Identification and structure–activity relationships of substituted pyridones as inhibitors of Pim-1 kinase
Cheney, I. Wayne, Yan, Shunqi, Appleby, Todd, Walker, Heli, Vo, Todd, Yao, Nanhua, Hamatake, Robert, Hong, Zhi, Wu, Jim Z.
Published in Bioorganic & medicinal chemistry letters (15.03.2007)
Published in Bioorganic & medicinal chemistry letters (15.03.2007)
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Journal Article
Preclinical Characterization of GS-9669, a Thumb Site II Inhibitor of the Hepatitis C Virus NS5B Polymerase
FENAUX, Martijn, ENG, Stacey, LAZERWITH, Scott E, LEW, Willard, QI LIU, MERTZMAN, Michael, MORGANELLI, Philip, LIANHONG XU, HONG YE, JENNIFER ZHANG, MATLES, Mike, MURRAY, Bernard P, LEAVITT, Stephanie A, MWANGI, Judy, JINGYU ZHANG, HASHASH, Ahmad, KRAWCZYK, Steve H, BIDGOOD, Alison M, APPLEBY, Todd C, WATKINS, William J, LEE, Yu-Jen, MABERY, Eric M, YANG TIAN, BYUN, Daniel, CANALES, Eda, CLARKE, Michael O, DOERFFLER, Edward
Published in Antimicrobial Agents and Chemotherapy (01.02.2013)
Published in Antimicrobial Agents and Chemotherapy (01.02.2013)
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Journal Article
Structural and regulatory elements of HCV NS5B polymerase--β-loop and C-terminal tail--are required for activity of allosteric thumb site II inhibitors
Boyce, Sarah E, Tirunagari, Neeraj, Niedziela-Majka, Anita, Perry, Jason, Wong, Melanie, Kan, Elaine, Lagpacan, Leanna, Barauskas, Ona, Hung, Magdeleine, Fenaux, Martijn, Appleby, Todd, Watkins, William J, Schmitz, Uli, Sakowicz, Roman
Published in PloS one (2014)
Published in PloS one (2014)
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Journal Article
Discovery of a 2′-fluoro-2′-C-methyl C-nucleotide HCV polymerase inhibitor and a phosphoramidate prodrug with favorable properties
Kirschberg, Thorsten A., Metobo, Sammy, Clarke, Michael O., Aktoudianakis, Vangelis, Babusis, Darius, Barauskas, Ona, Birkus, Gabriel, Butler, Thomas, Byun, Daniel, Chin, Gregory, Doerffler, Edward, Edwards, Thomas E., Fenaux, Martijn, Lee, Rick, Lew, Willard, Mish, Michael R., Murakami, Eisuke, Park, Yeojin, Squires, Neil H., Tirunagari, Neeraj, Wang, Ting, Whitcomb, Mark, Xu, Jie, Yang, Huiling, Ye, Hong, Zhang, Lijun, Appleby, Todd C., Feng, Joy Y., Ray, Adrian S., Cho, Aesop, Kim, Choung U.
Published in Bioorganic & medicinal chemistry letters (15.04.2017)
Published in Bioorganic & medicinal chemistry letters (15.04.2017)
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Journal Article
Characterization of a KDM5 small molecule inhibitor with antiviral activity against hepatitis B virus
Sarah A Gilmore, Danny Tam, Tara L Cheung, Chelsea Snyder, Julie Farand, Ryan Dick, Mike Matles, Joy Y Feng, Ricardo Ramirez, Li Li, Helen Yu, Yili Xu, Dwight Barnes, Gregg Czerwieniec, Katherine M Brendza, Todd C Appleby, Gabriel Birkus, Madeleine Willkom, Tetsuya Kobayashi, Eric Paoli, Marc Labelle, Thomas Boesen, Chin H Tay, William E Delaney, Gregory T Notte, Uli Schmitz, Becket Feierbach
Published in PloS one (07.12.2022)
Published in PloS one (07.12.2022)
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Journal Article
An adaptive mutation in NS2 is essential for efficient production of infectious 1b/2a chimeric hepatitis C virus in cell culture
Chan, Katie, Cheng, Guofeng, Beran, Rudolf K.F, Yang, Huiling, Appleby, Todd C, Pokrovskii, Maria V, Mo, Hongmei, Zhong, Weidong, Delaney, William E
Published in Virology (New York, N.Y.) (20.01.2012)
Published in Virology (New York, N.Y.) (20.01.2012)
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Journal Article
Isothiazoles as active-site inhibitors of HCV NS5B polymerase
Yan, Shunqi, Appleby, Todd, Gunic, Esmir, Shim, Jae Hoon, Tasu, Tania, Kim, Hongwoo, Rong, Frank, Chen, Huaming, Hamatake, Robert, Wu, Jim Z., Hong, Zhi, Yao, Nanhua
Published in Bioorganic & medicinal chemistry letters (2007)
Published in Bioorganic & medicinal chemistry letters (2007)
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