A miniaturized mode-of-action profiling platform enables high throughput characterization of the molecular and cellular dynamics of EZH2 inhibition
Falkenstern, Lilia, Georgi, Victoria, Bunse, Stefanie, Badock, Volker, Husemann, Manfred, Roehn, Ulrike, Stellfeld, Timo, Fitzgerald, Mark, Ferrara, Steven, Stöckigt, Detlef, Stresemann, Carlo, Hartung, Ingo V, Fernández-Montalván, Amaury
Published in Scientific reports (19.01.2024)
Published in Scientific reports (19.01.2024)
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Coordination of stress signals by the lysine methyltransferase SMYD2 promotes pancreatic cancer
Reynoird, Nicolas, Mazur, Pawel K, Stellfeld, Timo, Flores, Natasha M, Lofgren, Shane M, Carlson, Scott M, Brambilla, Elisabeth, Hainaut, Pierre, Kaznowska, Ewa B, Arrowsmith, Cheryl H, Khatri, Purvesh, Stresemann, Carlo, Gozani, Or, Sage, Julien
Published in Genes & development (01.04.2016)
Published in Genes & development (01.04.2016)
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Discovery and Characterization of a Highly Potent and Selective Aminopyrazoline-Based in Vivo Probe (BAY-598) for the Protein Lysine Methyltransferase SMYD2
Eggert, Erik, Hillig, Roman C, Koehr, Silke, Stöckigt, Detlef, Weiske, Jörg, Barak, Naomi, Mowat, Jeffrey, Brumby, Thomas, Christ, Clara D, ter Laak, Antonius, Lang, Tina, Fernandez-Montalvan, Amaury E, Badock, Volker, Weinmann, Hilmar, Hartung, Ingo V, Barsyte-Lovejoy, Dalia, Szewczyk, Magdalena, Kennedy, Steven, Li, Fengling, Vedadi, Masoud, Brown, Peter J, Santhakumar, Vijayaratnam, Arrowsmith, Cheryl H, Stellfeld, Timo, Stresemann, Carlo
Published in Journal of medicinal chemistry (26.05.2016)
Published in Journal of medicinal chemistry (26.05.2016)
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Potent and Selective Human Prostaglandin F (FP) Receptor Antagonist (BAY-6672) for the Treatment of Idiopathic Pulmonary Fibrosis (IPF)
Beck, Hartmut, Thaler, Tobias, Meibom, Daniel, Meininghaus, Mark, Jörißen, Hannah, Dietz, Lisa, Terjung, Carsten, Bairlein, Michaela, von Bühler, Clemens-Jeremias, Anlauf, Sonja, Fürstner, Chantal, Stellfeld, Timo, Schneider, Dirk, Gericke, Kersten M, Buyck, Thomas, Lovis, Kai, Münster, Uwe, Anlahr, Johanna, Kersten, Elisabeth, Levilain, Guillaume, Marossek, Virginia, Kast, Raimund
Published in Journal of medicinal chemistry (22.10.2020)
Published in Journal of medicinal chemistry (22.10.2020)
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18F-Radiolabeling of Aromatic Compounds Using Triarylsulfonium Salts
Mu, Linjing, Fischer, Cindy R., Holland, Jason P., Becaud, Jessica, Schubiger, P. August, Schibli, Roger, Ametamey, Simon M., Graham, Keith, Stellfeld, Timo, Dinkelborg, Ludger M., Lehmann, Lutz
Published in European Journal of Organic Chemistry (01.02.2012)
Published in European Journal of Organic Chemistry (01.02.2012)
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Book Review
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Gene expression levels of matrix metalloproteinases in human atherosclerotic plaques and evaluation of radiolabeled inhibitors as imaging agents for plaque vulnerability
Müller, Adrienne, Krämer, Stefanie D, Meletta, Romana, Beck, Katharina, Selivanova, Svetlana V, Rancic, Zoran, Kaufmann, Philipp A, Vos, Bernhard, Meding, Jörg, Stellfeld, Timo, Heinrich, Tobias K, Bauser, Marcus, Hütter, Joachim, Dinkelborg, Ludger M, Schibli, Roger, Ametamey, Simon M
Published in Nuclear medicine and biology (01.08.2014)
Published in Nuclear medicine and biology (01.08.2014)
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18F-labeled bombesin analog for specific and effective targeting of prostate tumors expressing gastrin-releasing peptide receptors
Honer, Michael, Mu, Linjing, Stellfeld, Timo, Graham, Keith, Martic, Miljen, Fischer, Cindy R, Lehmann, Lutz, Schubiger, Pius A, Ametamey, Simon M, Dinkelborg, Ludger, Srinivasan, Ananth, Borkowski, Sandra
Published in The Journal of nuclear medicine (1978) (01.02.2011)
Published in The Journal of nuclear medicine (1978) (01.02.2011)
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Silicon-Based Building Blocks for One-Step ¹⁸F-Radiolabeling of Peptides for PET Imaging
Mu, Linjing, Höhne, Aileen, Schubiger, P. August, Ametamey, Simon M, Graham, Keith, Cyr, John E, Dinkelborg, Ludger, Stellfeld, Timo, Srinivasan, Ananth, Voigtmann, Ulrike, Klar, Ulrich
Published in Angewandte Chemie (International ed.) (2008)
Published in Angewandte Chemie (International ed.) (2008)
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Discovery and Structure-Based Design of Potent Covalent PPARγ Inverse-Agonists BAY-4931 and BAY-0069
Orsi, Douglas L., Pook, Elisabeth, Bräuer, Nico, Friberg, Anders, Lienau, Philip, Lemke, Christopher T., Stellfeld, Timo, Brüggemeier, Ulf, Pütter, Vera, Meyer, Hanna, Baco, Maria, Tang, Stephanie, Cherniack, Andrew D., Westlake, Lindsay, Bender, Samantha A., Kocak, Mustafa, Strathdee, Craig A., Meyerson, Matthew, Eis, Knut, Goldstein, Jonathan T.
Published in Journal of medicinal chemistry (10.11.2022)
Published in Journal of medicinal chemistry (10.11.2022)
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Discovery and characterization of orally bioavailable 4-chloro-6-fluoroi-sophthalamides as covalent PPARG inverse-agonists
Orsi, Douglas L., Ferrara, Steven J., Siegel, Stephan, Friberg, Anders, Bouche, Lea, Pook, Elisabeth, Lienau, Philip, Bluck, Joseph P., Lemke, Christopher T., Akcay, Gizem, Stellfeld, Timo, Meyer, Hanna, Puetter, Vera, Holton, Simon J., Korr, Daniel, Jerchel-Furau, Isabel, Pantelidou, Constantia, Strathdee, Craig A., Meyerson, Matthew, Eis, Knut, Goldstein, Jonathan T.
Published in Bioorganic & medicinal chemistry (15.01.2023)
Published in Bioorganic & medicinal chemistry (15.01.2023)
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Journal Article
Correction to “Discovery and Structure-Based Design of Potent Covalent PPARγ Inverse-Agonists BAY-4931 and BAY-0069”
Orsi, Douglas L., Pook, Elisabeth, Bräuer, Nico, Friberg, Anders, Lienau, Philip, Lemke, Christopher T., Stellfeld, Timo, Brüggemeier, Ulf, Pütter, Vera, Meyer, Hanna, Baco, Maria, Tang, Stephanie, Cherniack, Andrew D., Westlake, Lindsay, Bender, Samantha A., Kocak, Mustafa, Strathdee, Craig A., Meyerson, Matthew, Eis, Knut, Goldstein, Jonathan T.
Published in Journal of medicinal chemistry (12.01.2023)
Published in Journal of medicinal chemistry (12.01.2023)
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Journal Article
Discovery and characterization of orally bioavailable 4-chloro-6-fluoroisophthalamides as covalent PPARG inverse-agonists
Orsi, Douglas L., Ferrara, Steven J., Siegel, Stephan, Friberg, Anders, Bouché, Léa, Pook, Elisabeth, Lienau, Philip, Bluck, Joseph P., Lemke, Christopher T., Akcay, Gizem, Stellfeld, Timo, Meyer, Hanna, Pütter, Vera, Holton, Simon J., Korr, Daniel, Jerchel-Furau, Isabel, Pantelidou, Constantia, Strathdee, Craig A., Meyerson, Matthew, Eis, Knut, Goldstein, Jonathan T.
Published in Bioorganic & medicinal chemistry (15.01.2023)
Published in Bioorganic & medicinal chemistry (15.01.2023)
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Studies toward the Development of New Silicon-Containing Building Blocks for the Direct F-18-Labeling of Peptides
Dialer, Lukas O., Selivanova, Svetlana V., Mueller, Carmen J., Mueller, Adrienne, Stellfeld, Timo, Graham, Keith, Dinkelborg, Ludger M., Kraemer, Stefanie D., Schibli, Roger, Reiher, Markus, Ametamey, Simon M.
Published in Journal of medicinal chemistry (10.10.2013)
Published in Journal of medicinal chemistry (10.10.2013)
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Rational Design and Synthesis of Selective PRMT4 Inhibitors: A New Chemotype for Development of Cancer Therapeutics
Sutherland, Mathew, Li, Alice, Kaghad, Anissa, Panagopoulos, Dimitrios, Li, Fengling, Szewczyk, Magdalena, Smil, David, Scholten, Cora, Bouché, Léa, Stellfeld, Timo, Arrowsmith, Cheryl H., Barsyte, Dalia, Vedadi, Masoud, Hartung, Ingo V., Steuber, Holger, Britton, Robert, Santhakumar, Vijayaratnam
Published in ChemMedChem (08.04.2021)
Published in ChemMedChem (08.04.2021)
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Abstract 2: Discovery of BAY 2402234 by phenotypic screening: A human Dihydroorotate Dehydrogenase (DHODH) inhibitor in clinical trials for the treatment of myeloid malignancies
Gradl, Stefan N., Mueller, Thomas, Ferrara, Steven, Sheikh, Sherif El, Janzer, Andreas, Zhou, Han-Jie, Friberg, Anders, Guenther, Judith, Schaefer, Martina, Stellfeld, Timo, Eis, Knut, Kroeber, Michael, Nguyen, Duy, Merz, Claudia, Niehues, Michael, Stoeckigt, Detlef, Christian, Sven, Zimmermann, Katja, Lejeune, Pascal, Bruening, Michael, Meyer, Hanna, Puetter, Vera, Scadden, David T., Sykes, David B., Seidel, Henrik, Eheim, Ashley, Michels, Martin, Haegebarth, Andrea, Bauser, Marcus
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Abstract DDT02-04: BAY 2402234: A novel, selective dihydroorotate dehydrogenase (DHODH) inhibitor for the treatment of myeloid malignancies
Janzer, Andreas, Gradl, Stefan, Christian, Sven, Zimmermann, Katja, Merz, Claudia, Meyer, Hanna, Stellfeld, Timo, Guenther, Judith, Stoeckigt, Detlef, Seidel, Henrik, Lejeune, Pascale, Bruening, Michael, Eheim, Ashley, Mueller, Thomas, Lesche, Ralf, Michels, Martin, Haegebarth, Andrea, Bauser, Marcus, Sheikh, Sherif El, Ferrara, Steven, Sykes, David, Scadden, David
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Abstract A44: Coordination of stress signals by the lysine methyltransferase SMYD2 promotes pancreatic cancer
Mazur, Pawel K., Reynoird, Nicolas, Stellfeld, Timo, Flores, Natasha M., Lofgren, Shane M., Carlson, Scott M., Brambilla, Elisabeth, Hainaut, Pierre, Kaznowska, Ewa B., Arrowsmith, Cheryl H., Khatri, Purvesh, Stresemann, Carlo, Gozani, Or, Sage, Julien
Published in Cancer research (Chicago, Ill.) (15.12.2016)
Published in Cancer research (Chicago, Ill.) (15.12.2016)
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Journal Article
Studies toward the development of new silicon-containing building blocks for the direct (18)F-labeling of peptides
Dialer, Lukas O, Selivanova, Svetlana V, Müller, Carmen J, Müller, Adrienne, Stellfeld, Timo, Graham, Keith, Dinkelborg, Ludger M, Krämer, Stefanie D, Schibli, Roger, Reiher, Markus, Ametamey, Simon M
Published in Journal of medicinal chemistry (10.10.2013)
Published in Journal of medicinal chemistry (10.10.2013)
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