The histamine H3 receptor: from gene cloning to H3 receptor drugs
Leurs, Rob, Bakker, Remko A, Timmerman, Henk, de Esch, Iwan J P
Published in Nature reviews. Drug discovery (01.02.2005)
Published in Nature reviews. Drug discovery (01.02.2005)
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Journal Article
Pharmacogenomic and structural analysis of constitutive g protein-coupled receptor activity
Smit, Martine J, Vischer, Henry F, Bakker, Remko A, Jongejan, Aldo, Timmerman, Henk, Pardo, Leonardo, Leurs, Rob
Published in Annual review of pharmacology and toxicology (01.01.2007)
Published in Annual review of pharmacology and toxicology (01.01.2007)
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Journal Article
Identification of Rat H3 Receptor Isoforms with Different Brain Expression and Signaling Properties
Drutel, G, Peitsaro, N, Karlstedt, K, Wieland, K, Smit, M J, Timmerman, H, Panula, P, Leurs, R
Published in Molecular pharmacology (01.01.2001)
Published in Molecular pharmacology (01.01.2001)
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Journal Article
The histamine H3 receptor antagonist clobenpropit enhances GABA release to protect against NMDA-induced excitotoxicity through the cAMP/protein kinase A pathway in cultured cortical neurons
HAIBIN DAI, QIULI FU, YAO SHEN, WEIWEI HU, ZHONGMIAO ZHANG, TIMMERMAN, Henk, LEURS, Rob, ZHONG CHEN
Published in European journal of pharmacology (01.06.2007)
Published in European journal of pharmacology (01.06.2007)
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Journal Article
SYNOPSIS: SYNthesize and OPtimize System in Silico
Vinkers, H. Maarten, de Jonge, Marc R, Daeyaert, Frederik F. D, Heeres, Jan, Koymans, Lucien M. H, van Lenthe, Joop H, Lewi, Paul J, Timmerman, Henk, Van Aken, Koen, Janssen, Paul A. J
Published in Journal of medicinal chemistry (19.06.2003)
Published in Journal of medicinal chemistry (19.06.2003)
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Journal Article
Constitutive Activity of Histamine H3 Receptors Stably Expressed in SK-N-MC Cells: Display of Agonism and Inverse Agonism by H3 Antagonists
Kerstin Wieland, Gerold Bongers, Yumiko Yamamoto, Takeshi Hashimoto, Atsushi Yamatodani, Wiro M. B. P. Menge, Henk Timmerman, Timothy W. Lovenberg, Rob Leurs
Published in The Journal of pharmacology and experimental therapeutics (01.12.2001)
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Published in The Journal of pharmacology and experimental therapeutics (01.12.2001)
Journal Article
Kaposi's Sarcoma-Associated Herpesvirus-Encoded G Protein-Coupled Receptor ORF74 Constitutively Activates p44/p42 MAPK and Akt via Gi and Phospholipase C-Dependent Signaling Pathways
Smit, Martine J., Verzijl, Dennis, Casarosa, Paola, Navis, Marjon, Timmerman, Henk, Leurs, Rob
Published in Journal of Virology (15.02.2002)
Published in Journal of Virology (15.02.2002)
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Journal Article
Constitutive activity of the histamine H1 receptor reveals inverse agonism of histamine H1 receptor antagonists
BAKKER, R. A, WIELAND, K, TIMMERMAN, H, LEURS, R
Published in European journal of pharmacology (01.11.2000)
Published in European journal of pharmacology (01.11.2000)
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Journal Article
CC and CX3C Chemokines Differentially Interact with the N Terminus of the Human Cytomegalovirus-encoded US28 Receptor
Casarosa, Paola, Waldhoer, Maria, LiWang, Patricia J., Vischer, Henry F., Kledal, Thomas, Timmerman, Henk, Schwartz, Thue W., Smit, Martine J., Leurs, Rob
Published in The Journal of biological chemistry (04.02.2005)
Published in The Journal of biological chemistry (04.02.2005)
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Journal Article
Mutational Analysis of the Antagonist-binding Site of the Histamine H1 Receptor
Wieland, Kerstin, Laak, Anton M. Ter, Smit, Martine J., Kühne, Ronald, Timmerman, Henk, Leurs, Rob
Published in The Journal of biological chemistry (15.10.1999)
Published in The Journal of biological chemistry (15.10.1999)
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Journal Article
Constitutively Active Mutants of the Histamine H1 Receptor Suggest a Conserved Hydrophobic Asparagine-Cage That Constrains the Activation of Class A G Protein-Coupled Receptors
Bakker, Remko A, Jongejan, Aldo, Sansuk, Kamonchanok, Hacksell, Uli, Timmerman, Henk, Brann, Mark R, Weiner, Dave M, Pardo, Leonardo, Leurs, Rob
Published in Molecular pharmacology (01.01.2008)
Published in Molecular pharmacology (01.01.2008)
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Journal Article
Identification of the First Nonpeptidergic Inverse Agonist for a Constitutively Active Viral-encoded G Protein-coupled Receptor
Casarosa, Paola, Menge, Wiro M, Minisini, Rosalba, Otto, Claas, van Heteren, Jane, Jongejan, Aldo, Timmerman, Henk, Moepps, Barbara, Kirchhoff, Frank, Mertens, Thomas, Smit, Martine J, Leurs, Rob
Published in The Journal of biological chemistry (14.02.2003)
Published in The Journal of biological chemistry (14.02.2003)
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Journal Article
Helix 8 of the Viral Chemokine Receptor ORF74 Directs Chemokine Binding
Verzijl, Dennis, Pardo, Leonardo, van Dijk, Marie, Gruijthuijsen, Yvonne K., Jongejan, Aldo, Timmerman, Henk, Nicholas, John, Schwarz, Mario, Murphy, Philip M., Leurs, Rob, Smit, Martine J.
Published in The Journal of biological chemistry (17.11.2006)
Published in The Journal of biological chemistry (17.11.2006)
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Journal Article
Effect of the histamine H3-antagonist clobenpropit on spatial memory deficits induced by MK-801 as evaluated by radial maze in Sprague-Dawley rats
HUANG, Yu-Wen, HU, Wei-Wei, ZHONG CHEN, ZHANG, Li-San, SHEN, Hai-Qing, TIMMERMAN, Henk, LEURS, Rob, YANAI, Kazuhiko
Published in Behavioural brain research (05.05.2004)
Published in Behavioural brain research (05.05.2004)
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Journal Article
Cardiotoxic potential and CNS effects of first-generation antihistamines
Taglialatela, M, Timmerman, H, Annunziato, L
Published in Trends in pharmacological sciences (Regular ed.) (01.02.2000)
Published in Trends in pharmacological sciences (Regular ed.) (01.02.2000)
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Journal Article
Histamine receptors are finally ‘coming out’
Leurs, Rob, Watanabe, Takehiko, Timmerman, Henk
Published in Trends in pharmacological sciences (Regular ed.) (01.07.2001)
Published in Trends in pharmacological sciences (Regular ed.) (01.07.2001)
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