SLC46A3 as a Potential Predictive Biomarker for Antibody-Drug Conjugates Bearing Noncleavable Linked Maytansinoid and Pyrrolobenzodiazepine Warheads
Kinneer, Krista, Meekin, John, Tiberghien, Arnaud C, Tai, Yu-Tzu, Phipps, Sandrina, Kiefer, Christine Mione, Rebelatto, Marlon C, Dimasi, Nazzareno, Moriarty, Alyssa, Papadopoulos, Kyriakos P, Sridhar, Sriram, Gregson, Stephen J, Wick, Michael J, Masterson, Luke, Anderson, Kenneth C, Herbst, Ronald, Howard, Philip W, Tice, David A
Published in Clinical cancer research (15.12.2018)
Published in Clinical cancer research (15.12.2018)
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Design and Synthesis of Tesirine, a Clinical Antibody–Drug Conjugate Pyrrolobenzodiazepine Dimer Payload
Tiberghien, Arnaud C, Levy, Jean-Noel, Masterson, Luke A, Patel, Neki V, Adams, Lauren R, Corbett, Simon, Williams, David G, Hartley, John A, Howard, Philip W
Published in ACS medicinal chemistry letters (10.11.2016)
Published in ACS medicinal chemistry letters (10.11.2016)
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Structure−Activity Relationships of Monomeric C2-Aryl Pyrrolo[2,1-c][1,4]benzodiazepine (PBD) Antitumor Agents
Antonow, Dyeison, Kaliszczak, Maciej, Kang, Gyoung-Dong, Coffils, Marissa, Tiberghien, Arnaud C, Cooper, Nectaroula, Barata, Teresa, Heidelberger, Sibylle, James, Colin H, Zloh, Mire, Jenkins, Terence C, Reszka, Anthony P, Neidle, Stephen, Guichard, Sylvie M, Jodrell, Duncan I, Hartley, John A, Howard, Philip W, Thurston, David E
Published in Journal of medicinal chemistry (08.04.2010)
Published in Journal of medicinal chemistry (08.04.2010)
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Pyrrolobenzodiazepine Antibody-Drug Conjugates Designed for Stable Thiol Conjugation
Christie, R., Tiberghien, Arnaud, Du, Qun, Bezabeh, Binyam, Fleming, Ryan, Shannon, Amanda, Mao, Shenlan, Breen, Shannon, Zhang, Jing, Zhong, Haihong, Harper, Jay, Wu, Herren, Howard, Philip, Gao, Changshou
Published in Antibodies (Basel) (28.11.2017)
Published in Antibodies (Basel) (28.11.2017)
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A Potent Anti-CD70 Antibody–Drug Conjugate Combining a Dimeric Pyrrolobenzodiazepine Drug with Site-Specific Conjugation Technology
Jeffrey, Scott C, Burke, Patrick J, Lyon, Robert P, Meyer, David W, Sussman, Django, Anderson, Martha, Hunter, Joshua H, Leiske, Chris I, Miyamoto, Jamie B, Nicholas, Nicole D, Okeley, Nicole M, Sanderson, Russell J, Stone, Ivan J, Zeng, Weiping, Gregson, Stephen J, Masterson, Luke, Tiberghien, Arnaud C, Howard, Philip W, Thurston, David E, Law, Che-Leung, Senter, Peter D
Published in Bioconjugate chemistry (17.07.2013)
Published in Bioconjugate chemistry (17.07.2013)
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Journal Article
An Isomerization Approach to Tesirine and Pyrrolobenzodiazepines
Campbell, Andrew D, Tomasi, Simone, Tiberghien, Arnaud C, Parker, Jeremy S
Published in Organic process research & development (15.11.2019)
Published in Organic process research & development (15.11.2019)
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Comparison of Pyrrolobenzodiazepine Dimer Bis-imine versus Mono-imine: DNA Interstrand Cross-linking, Cytotoxicity, Antibody-Drug Conjugate Efficacy and Toxicity
Tiberghien, Arnaud C, Vijayakrishnan, Balakumar, Esfandiari, Arman, Ahmed, Mahammad, Pardo, Raul, Bingham, John, Adams, Lauren, Santos, Kathleen, Kang, Gyoung-Dong, Pugh, Kathryn M, Afif-Rider, Shameen, Vashisht, Kapil, Haque, Kemal, Tammali, Ravinder, Rosfjord, Edward, Savoca, Adriana, Hartley, John A, Howard, Philip W
Published in Molecular cancer therapeutics (01.02.2023)
Published in Molecular cancer therapeutics (01.02.2023)
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Journal Article
Scale-up Synthesis of Tesirine
Tiberghien, Arnaud C, von Bulow, Christina, Barry, Conor, Ge, Huajun, Noti, Christian, Collet Leiris, Florence, McCormick, Marc, Howard, Philip W, Parker, Jeremy S
Published in Organic process research & development (21.09.2018)
Published in Organic process research & development (21.09.2018)
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Preclinical characterization of an antibody-drug conjugate targeting CS-1 and the identification of uncharacterized populations of CS-1-positive cells
Chen, Ruoyan, Rajan, Saravanan, Overstreet, Michael G, Hurt, Elaine M, Thomas, Suneetha B, Muniz-Medina, Vanessa, Ward, Christopher, Sadowska, Agnieszka, Fleming, Ryan, Karanth, Subramanya, Breen, Shannon, Zheng, Bo, Wu, Yuling, Iverson, William O, Novick, Steven, O'Day, Terrence, Shah, Dipesha P, Dimasi, Nazzareno, Tiberghien, Arnaud C, Osbourn, Jane, Walker, Jill
Published in Molecular cancer therapeutics (01.08.2020)
Published in Molecular cancer therapeutics (01.08.2020)
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Journal Article
Synthesis and in vitro evaluation of SG3227, a pyrrolobenzodiazepine dimer antibody-drug conjugate payload based on sibiromycin
Kemp, Gary C., Tiberghien, Arnaud C., Patel, Neki V., D'Hooge, Francois, Nilapwar, Sanjay M., Adams, Lauren R., Corbett, Simon, Williams, David G., Hartley, John A., Howard, Philip W.
Published in Bioorganic & medicinal chemistry letters (01.03.2017)
Published in Bioorganic & medicinal chemistry letters (01.03.2017)
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Journal Article
SG2285, a Novel C2-Aryl-Substituted Pyrrolobenzodiazepine Dimer Prodrug That Cross-links DNA and Exerts Highly Potent Antitumor Activity
HARTLEY, John A, HAMAGUCHI, Anzu, PEPPER, Christopher, THET THET LIN, FEGAN, Christopher, THURSTON, David E, HOWARD, Philip W, COFFILS, Marissa, MARTIN, Christopher R. H, SUGGITT, Marie, ZHIZHI CHEN, GREGSON, Stephen J, MASTERSON, Luke A, TIBERGHIEN, Arnaud C, HARTLEY, Janet M
Published in Cancer research (Chicago, Ill.) (01.09.2010)
Published in Cancer research (Chicago, Ill.) (01.09.2010)
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Synthesis of a novel C2/C2′-aryl-substituted pyrrolo[2,1- c][1,4]benzodiazepine dimer prodrug with improved water solubility and reduced DNA reaction rate
Howard, Philip W., Chen, Zhizhi, Gregson, Stephen J., Masterson, Luke A., Tiberghien, Arnaud C., Cooper, Nectaroula, Fang, Min, Coffils, Marissa J., Klee, Sarah, Hartley, John A., Thurston, David E.
Published in Bioorganic & medicinal chemistry letters (15.11.2009)
Published in Bioorganic & medicinal chemistry letters (15.11.2009)
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An asymmetric C8/C8′-tripyrrole-linked sequence-selective pyrrolo[2,1- c][1,4]benzodiazepine (PBD) dimer DNA interstrand cross-linking agent spanning 11 DNA base pairs
Tiberghien, Arnaud C., Evans, David A., Kiakos, Konstantinos, Martin, Christopher R.H., Hartley, John A., Thurston, David E., Howard, Philip W.
Published in Bioorganic & medicinal chemistry letters (15.03.2008)
Published in Bioorganic & medicinal chemistry letters (15.03.2008)
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Journal Article
Application of the Stille coupling reaction to the synthesis of C2-substituted endo-exo unsaturated pyrrolo[2,1-c][1,4]benzodiazepines (PBDs)
TIBERGHIEN, Arnaud C, HAGAN, David, HOWARD, Philip W, THURSTON, David E
Published in Bioorganic & medicinal chemistry letters (18.10.2004)
Published in Bioorganic & medicinal chemistry letters (18.10.2004)
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Journal Article
An optimised synthesis of SG3376, a non-cleavable antibody-drug conjugate pyrrolobenzodiazepine drug-linker
Tiberghien, Arnaud C., Gregson, Stephen J., Masterson, Luke A., Levy, Jean-Noel, Kemp, Gary C., Adams, Lauren R., Patel, Neki V., Howard, Philip W.
Published in Tetrahedron letters (15.11.2017)
Published in Tetrahedron letters (15.11.2017)
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Journal Article
Comparison of pyrrolobenzodiazepine dimer bis-imine versus mono-imine: DNA interstrand cross-linking, cytotoxicity, and antibody-drug conjugate efficacy and toxicity
Tiberghien, Arnaud C, Vijayakrishnan, Balakumar, Esfandiari, Arman, Ahmed, Mahammad, Pardo, Raul, Bingham, John, Adams, Lauren, Santos, Kathleen, Kang, Gyoung-Dong, Pugh, Kathryn M, Afif-Rider, Shameen, Vashisht, Kapil, Haque, Kemal, Tammali, Ravinder, Rosfjord, Edward, Savoca, Adriana, Hartley, John A, Howard, Philip W
Published in Molecular cancer therapeutics (02.12.2022)
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Published in Molecular cancer therapeutics (02.12.2022)
Journal Article
SG2285, a novel C2-aryl-substituted pyrrolobenzodiazepine dimer pro-drug that cross-links DNA and exerts highly potent antitumor activity
Hartley, John A., Hamaguchi, Anzu, Coffils, Marissa, Martin, Christopher R.H., Suggitt, Marie, Chen, Zhizhi, Gregson, Stephen J., Masterson, Luke A., Tiberghien, Arnaud C., Hartley, Janet M., Pepper, Christopher, Lin, Thet Thet, Fegan, Christopher, Thurston, David E., Howard, Philip W.
Published in Cancer research (Chicago, Ill.) (26.07.2010)
Published in Cancer research (Chicago, Ill.) (26.07.2010)
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