Discovery of N‑(6-Fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3R)‑3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide (LSN 3213128), a Potent and Selective Nonclassical Antifolate Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase (AICARFT) Inhibitor Effective at Tumor Suppression in a Cancer Xenograft Model
Fales, Kevin R., Njoroge, F. George, Brooks, Harold B., Thibodeaux, Stefan, Torrado, Alicia, Si, Chong, Toth, James L., Mc Cowan, Jefferson R., Roth, Kenneth D., Thrasher, Kenneth J., Frimpong, Kwame, Lee, Matthew R., Dally, Robert D., Shepherd, Timothy A., Durham, Timothy B., Margolis, Brandon J., Wu, Zhipei, Wang, Yong, Atwell, Shane, Wang, Jing, Hui, Yu-Hua, Meier, Timothy I., Konicek, Susan A., Geeganage, Sandaruwan
Published in Journal of medicinal chemistry (14.12.2017)
Published in Journal of medicinal chemistry (14.12.2017)
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Characterization of a novel AICARFT inhibitor which potently elevates ZMP and has anti-tumor activity in murine models
Brooks, Harold B., Meier, Timothy I., Geeganage, Sandaruwan, Fales, Kevin R., Thrasher, Kenneth J., Konicek, Susan A., Spencer, Charles D., Thibodeaux, Stefan, Foreman, Robert T., Hui, Yu-Hua, Roth, Kenneth D., Qian, Yue-Wei, Wang, Tao, Luo, Shuang, Torrado, Alicia, Si, Chong, Toth, James L., Mc Cowan, Jefferson R., Frimpong, Kwame, Lee, Matthew R., Dally, Robert D., Shepherd, Timothy A., Durham, Timothy B., Wang, Yong, Wu, Zhipei, Iversen, Philip W., Njoroge, F. George
Published in Scientific reports (18.10.2018)
Published in Scientific reports (18.10.2018)
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Structure activity studies of the serine-AIB dipeptide domain in 2,3-dihydroisothiazole based growth hormone secretagogues
Evers, Britta, Ruehter, Gerd, Berg, Martina, Dodge, Jeffrey A., Hankotius, Dirk, Hary, Ulrike, Jungheim, Louis N., Mest, Hans-Juergen, de la Nava, Eva-Maria Martin, Mohr, Michael, Muehl, Brian S., Petersen, Soenke, Sommer, Birgit, Riedel-Herold, Grit, Tebbe, Mark J., Thrasher, Kenneth J., Voelkers, Silke
Published in Bioorganic & medicinal chemistry (15.12.2005)
Published in Bioorganic & medicinal chemistry (15.12.2005)
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PROCESS FOR 2-SUBSTITUTED BENZO[B]THIOPHENE COMPOUNDS AND INTERMEDIATES THEREOF
HAUSER,KENNETH L, THRASHER,KENNETH J, PALKOWITZ,ALAN D, SALL,DANIEL J
Year of Publication 28.09.1999
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Year of Publication 28.09.1999
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Selective beta3 adrenergic agonists
EVRARD DEBORAH A, THORPE ANDREW J, JONES CHARLES D, MUEHL BRIAN S, THRASHER KENNETH J, SHUKER ANTHONY J, CROWELL THOMAS A, RITO CHRISTOPHER J
Year of Publication 03.02.2004
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Year of Publication 03.02.2004
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Selective 3 adrenergic agonists
Crowell, Thomas A, Evrard, Deborah A, Jones, Charles D, Muehl, Brian S, Rito, Christopher J, Shuker, Anthony J, Thorpe, Andrew J, Thrasher, Kenneth J
Year of Publication 03.02.2004
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Year of Publication 03.02.2004
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Process for 2-substituted benzo{b}thiophene compounds and intermediates thereof
ALAN D. PALKOWITZ, KENNETH J. THRASHER, DANIEL J. SALL, KENNETH L. HAUSER
Year of Publication 03.12.1998
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Year of Publication 03.12.1998
Patent
Process for preparing 2-substituted benzo [B] Thiophene compounds and intermediates thereof
PALKOWITZ; ALAN D, SALL; DANIEL J, THRASHER; KENNETH J, HAUSER; KENNETH L
Year of Publication 27.01.1998
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Year of Publication 27.01.1998
Patent
Process for preparing 2-substituted benzo[B]thiophene compounds and intermediates thereof
PALKOWITZ; ALAN D, SALL; DANIEL J, THRASHER; KENNETH J, HAUSER; KENNETH L
Year of Publication 20.01.1998
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Year of Publication 20.01.1998
Patent