Design, synthesis, structure–activity relationship, and in vivo activity of azabicyclic aryl amides as α7 nicotinic acetylcholine receptor agonists
Walker, Daniel P., Wishka, Donn G., Piotrowski, David W., Jia, Shaojuan, Reitz, Steven C., Yates, Karen M., Myers, Jason K., Vetman, Tatiana N., Margolis, Brandon J., Jacobsen, E. Jon, Acker, Brad A., Groppi, Vincent E., Wolfe, Mark L., Thornburgh, Bruce A., Tinholt, Paula M., Cortes-Burgos, Luz A., Walters, Rodney R., Hester, Matthew R., Seest, Eric P., Dolak, Lester A., Han, Fusen, Olson, Barbara A., Fitzgerald, Laura, Staton, Brian A., Raub, Thomas J., Hajos, Mihaly, Hoffmann, William E., Li, Kai S., Higdon, Nicole R., Wall, Theron M., Hurst, Raymond S., Wong, Erik H.F., Rogers, Bruce N.
Published in Bioorganic & medicinal chemistry (01.12.2006)
Published in Bioorganic & medicinal chemistry (01.12.2006)
Get full text
Journal Article
Discovery of N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an Agonist of the α7 Nicotinic Acetylcholine Receptor, for the Potential Treatment of Cognitive Deficits in Schizophrenia: Synthesis and Structure−Activity Relationship
Wishka, Donn G, Walker, Daniel P, Yates, Karen M, Reitz, Steven C, Jia, Shaojuan, Myers, Jason K, Olson, Kirk L, Jacobsen, E. Jon, Wolfe, Mark L, Groppi, Vincent E, Hanchar, Alexander J, Thornburgh, Bruce A, Cortes-Burgos, Luz A, Wong, Erik H. F, Staton, Brian A, Raub, Thomas J, Higdon, Nicole R, Wall, Theron M, Hurst, Raymond S, Walters, Rodney R, Hoffmann, William E, Hajos, Mihaly, Franklin, Stanley, Carey, Galen, Gold, Lisa H, Cook, Karen K, Sands, Steven B, Zhao, Sabrina X, Soglia, John R, Kalgutkar, Amit S, Arneric, Stephen P, Rogers, Bruce N
Published in Journal of medicinal chemistry (13.07.2006)
Published in Journal of medicinal chemistry (13.07.2006)
Get full text
Journal Article
Discovery of N-[(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl]furo[2,3- c]pyridine-5-carboxamide as an agonist of the alpha 7 nicotinic acetylcholine receptor: In vitro and in vivo activity
Acker, Brad A, Jacobsen, EJon, Rogers, Bruce N, Wishka, Donn G, Reitz, Steven C, Piotrowski, David W, Myers, Jason K, Wolfe, Mark L, Groppi, Vincent E, Thornburgh, Bruce A, Tinholt, Paula M, Walters, Rodney R, Olson, Barbara A, Fitzgerald, Laura, Staton, Brian A, Raub, Thomas J, Krause, Michael, Li, Kai S, Hoffmann, William E, Hajos, Mihaly, Hurst, Raymond S, Walker, Daniel P
Published in Bioorganic & medicinal chemistry (15.06.2008)
Published in Bioorganic & medicinal chemistry (15.06.2008)
Get full text
Journal Article
Design, synthesis, structure-activity relationship, and in vivo activity of azabicyclic aryl amides as alpha 7 nicotinic acetylcholine receptor agonists
Walker, Daniel P, Wishka, Donn G, Piotrowski, David W, Jia, Shaojuan, Reitz, Steven C, Yates, Karen M, Myers, Jason K, Vetman, Tatiana N, Margolis, Brandon J, Jacobsen, EJon, Acker, Brad A, Groppi, Vincent E, Wolfe, Mark L, Thornburgh, Bruce A, Tinholt, Paula M, Cortes-Burgos, Luz A, Walters, Rodney R, Hester, Matthew R, Seest, Eric P, Dolak, Lester A, Han, Fusen, Olson, Barbara A, Fitzgerald, Laura, Staton, Brian A, Raub, Thomas J, Hajos, Mihaly, Hoffmann, William E, Li, Kai S, Higdon, Nicole R, Wall, Theron M, Hurst, Raymond S, Wong, Erik HF, Rogers, Bruce N
Published in Bioorganic & medicinal chemistry (15.12.2006)
Published in Bioorganic & medicinal chemistry (15.12.2006)
Get full text
Journal Article
Discovery of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an agonist of the alpha 7 nicotinic acetylcholine receptor, for the potential treatment of cognitive deficits in schizophrenia: Synthesis and structure-activity relationship
Wishka, Donn G., Walker, Daniel P., Yates, Karen M., Reitz, Steven C., Jia, Shaojuan, Myers, Jason K., Olson, Kirk L., Jacobsen, E. Jon, Wolfe, Mark L., Groppi, Vincent E., Hanchar, Alexander J., Thornburgh, Bruce A., Cortes-Burgos, Luz A., Wong, Erik H. F., Staton, Brian A., Raub, Thomas J., Higdon, Nicole R., Wall, Theron M., Hurst, Raymond S., Walters, Rodney R., Hoffmann, William E., Hajos, Mihaly, Franklin, Stanley, Carey, Galen, Gold, Lisa H., Cook, Karen K., Sands, Steven B., Zhao, Sabrina X., Soglia, John R., Kalgutkar, Amit S., Arneric, Stephen P., Rogers, Bruce N.
Published in Journal of medicinal chemistry (13.07.2006)
Published in Journal of medicinal chemistry (13.07.2006)
Get full text
Journal Article
Discovery of N-[(3 R,5 R)-1-azabicyclo[3.2.1]oct-3-yl]furo[2,3- c]pyridine-5-carboxamide as an agonist of the α7 nicotinic acetylcholine receptor: In vitro and in vivo activity
Acker, Brad A., Jacobsen, E. Jon, Rogers, Bruce N., Wishka, Donn G., Reitz, Steven C., Piotrowski, David W., Myers, Jason K., Wolfe, Mark L., Groppi, Vincent E., Thornburgh, Bruce A., Tinholt, Paula M., Walters, Rodney R., Olson, Barbara A., Fitzgerald, Laura, Staton, Brian A., Raub, Thomas J., Krause, Michael, Li, Kai S., Hoffmann, William E., Hajos, Mihaly, Hurst, Raymond S., Walker, Daniel P.
Published in Bioorganic & medicinal chemistry letters (15.06.2008)
Published in Bioorganic & medicinal chemistry letters (15.06.2008)
Get full text
Journal Article
Drug-induced hepatic microgranulomatosis in cynomolgus monkeys
Mesfin, G M, Higgins, M J, Thornburgh, B A, Jones, B W, Vande Giessen, T L, Sinha, A J
Published in Toxicologic pathology (1992)
Published in Toxicologic pathology (1992)
Get more information
Journal Article
Discovery of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an agonist of the alpha7 nicotinic acetylcholine receptor, for the potential treatment of cognitive deficits in schizophrenia: synthesis and structure--activity relationship
Wishka, Donn G, Walker, Daniel P, Yates, Karen M, Reitz, Steven C, Jia, Shaojuan, Myers, Jason K, Olson, Kirk L, Jacobsen, E Jon, Wolfe, Mark L, Groppi, Vincent E, Hanchar, Alexander J, Thornburgh, Bruce A, Cortes-Burgos, Luz A, Wong, Erik H F, Staton, Brian A, Raub, Thomas J, Higdon, Nicole R, Wall, Theron M, Hurst, Raymond S, Walters, Rodney R, Hoffmann, William E, Hajos, Mihaly, Franklin, Stanley, Carey, Galen, Gold, Lisa H, Cook, Karen K, Sands, Steven B, Zhao, Sabrina X, Soglia, John R, Kalgutkar, Amit S, Arneric, Stephen P, Rogers, Bruce N
Published in Journal of medicinal chemistry (13.07.2006)
Get full text
Published in Journal of medicinal chemistry (13.07.2006)
Journal Article
Design, synthesis, structure-activity relationship, and in vivo activity of azabicyclic aryl amides as alpha7 nicotinic acetylcholine receptor agonists
Walker, Daniel P, Wishka, Donn G, Piotrowski, David W, Jia, Shaojuan, Reitz, Steven C, Yates, Karen M, Myers, Jason K, Vetman, Tatiana N, Margolis, Brandon J, Jacobsen, E Jon, Acker, Brad A, Groppi, Vincent E, Wolfe, Mark L, Thornburgh, Bruce A, Tinholt, Paula M, Cortes-Burgos, Luz A, Walters, Rodney R, Hester, Matthew R, Seest, Eric P, Dolak, Lester A, Han, Fusen, Olson, Barbara A, Fitzgerald, Laura, Staton, Brian A, Raub, Thomas J, Hajos, Mihaly, Hoffmann, William E, Li, Kai S, Higdon, Nicole R, Wall, Theron M, Hurst, Raymond S, Wong, Erik H F, Rogers, Bruce N
Published in Bioorganic & medicinal chemistry (15.12.2006)
Get full text
Published in Bioorganic & medicinal chemistry (15.12.2006)
Journal Article
Discovery of N-[(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide as an agonist of the alpha7 nicotinic acetylcholine receptor: in vitro and in vivo activity
Acker, Brad A, Jacobsen, E Jon, Rogers, Bruce N, Wishka, Donn G, Reitz, Steven C, Piotrowski, David W, Myers, Jason K, Wolfe, Mark L, Groppi, Vincent E, Thornburgh, Bruce A, Tinholt, Paula M, Walters, Rodney R, Olson, Barbara A, Fitzgerald, Laura, Staton, Brian A, Raub, Thomas J, Krause, Michael, Li, Kai S, Hoffmann, William E, Hajos, Mihaly, Hurst, Raymond S, Walker, Daniel P
Published in Bioorganic & medicinal chemistry letters (15.06.2008)
Published in Bioorganic & medicinal chemistry letters (15.06.2008)
Get full text
Journal Article