The DOT1L inhibitor pinometostat reduces H3K79 methylation and has modest clinical activity in adult acute leukemia
Stein, Eytan M., Garcia-Manero, Guillermo, Rizzieri, David A., Tibes, Raoul, Berdeja, Jesus G., Savona, Michael R., Jongen-Lavrenic, Mojca, Altman, Jessica K., Thomson, Blythe, Blakemore, Stephen J., Daigle, Scott R., Waters, Nigel J., Suttle, A. Benjamin, Clawson, Alicia, Pollock, Roy, Krivtsov, Andrei, Armstrong, Scott A., DiMartino, Jorge, Hedrick, Eric, Löwenberg, Bob, Tallman, Martin S.
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Published in Blood (14.06.2018)
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Sorafenib treatment following hematopoietic stem cell transplant in pediatric FLT3/ITD acute myeloid leukemia
Tarlock, Katherine, Chang, Bill, Cooper, Todd, Gross, Thomas, Gupta, Sumit, Neudorf, Steven, Adlard, Kathleen, Ho, Phoenix A., McGoldrick, Suzanne, Watt, Tanya, Templeman, Tina, Sisler, India, Garee, Amy, Thomson, Blythe, Woolfrey, Ann, Estey, Elihu, Meshinchi, Soheil, Pollard, Jessica A.
Published in Pediatric blood & cancer (01.06.2015)
Published in Pediatric blood & cancer (01.06.2015)
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Analysis of engraftment, graft-versus-host disease, and immune recovery following unrelated donor cord blood transplantation
Thomson, Blythe G., Robertson, Kent A., Gowan, Darla, Heilman, Doug, Broxmeyer, Hal E., Emanuel, David, Kotylo, Patricia, Brahmi, Zacharie, Smith, Franklin O.
Published in Blood (15.10.2000)
Published in Blood (15.10.2000)
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Asparaginase Pharmacokinetics After Intensive Polyethylene Glycol-Conjugated L-Asparaginase Therapy for Children with Relapsed Acute Lymphoblastic Leukemia
HAWKINS, Douglas S, PARK, Julie R, THOMSON, Blythe G, FELGENHAUER, Judy L, HOLCENBERG, John S, PANOSYAN, Eduard H, AVRAMIS, Vassilios I
Published in Clinical cancer research (15.08.2004)
Published in Clinical cancer research (15.08.2004)
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Tazemetostat, an EZH2 inhibitor, in relapsed or refractory B-cell non-Hodgkin lymphoma and advanced solid tumours: a first-in-human, open-label, phase 1 study
Italiano, Antoine, Soria, Jean-Charles, Toulmonde, Maud, Michot, Jean-Marie, Lucchesi, Carlo, Varga, Andrea, Coindre, Jean-Michel, Blakemore, Stephen J, Clawson, Alicia, Suttle, Benjamin, McDonald, Alice A, Woodruff, Mark, Ribich, Scott, Hedrick, Eric, Keilhack, Heike, Thomson, Blythe, Owa, Takashi, Copeland, Robert A, Ho, Peter T C, Ribrag, Vincent
Published in The lancet oncology (01.05.2018)
Published in The lancet oncology (01.05.2018)
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SCIDOT-42. FT-2102 – A POTENT AND SELECTIVE BRAIN PENETRANT INHIBITOR OF MUTANT ISOCITRATE DEHYDROGENASE
Ribadeneira, Maria, Guichard, Sylvie, Yao, Lili, Toms, Angela, Forsyth, Sanjeev, Thomson, Blythe, Ehrlich, Paul
Published in Neuro-oncology (Charlottesville, Va.) (11.11.2019)
Published in Neuro-oncology (Charlottesville, Va.) (11.11.2019)
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Phase 2 trial of clofarabine in combination with etoposide and cyclophosphamide in pediatric patients with refractory or relapsed acute lymphoblastic leukemia
Hijiya, Nobuko, Thomson, Blythe, Isakoff, Michael S., Silverman, Lewis B., Steinherz, Peter G., Borowitz, Michael J., Kadota, Richard, Cooper, Todd, Shen, Violet, Dahl, Gary, Thottassery, Jaideep V., Jeha, Sima, Maloney, Kelly, Paul, Jo-Anne, Barry, Elly, Carroll, William L., Gaynon, Paul S.
Published in Blood (01.12.2011)
Published in Blood (01.12.2011)
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Escalating intravenous methotrexate improves event-free survival in children with standard-risk acute lymphoblastic leukemia: a report from the Children's Oncology Group
Matloub, Yousif, Bostrom, Bruce C., Hunger, Stephen P., Stork, Linda C., Angiolillo, Anne, Sather, Harland, La, Mei, Gastier-Foster, Julie M., Heerema, Nyla A., Sailer, Scott, Buckley, Patrick J., Thomson, Blythe, Cole, Catherine, Nachman, James B., Reaman, Gregory, Winick, Naomi, Carroll, William L., Devidas, Meenakshi, Gaynon, Paul S.
Published in Blood (14.07.2011)
Published in Blood (14.07.2011)
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A phase Ib/II study of olutasidenib in patients with relapsed/refractory IDH1 mutant gliomas: Safety and efficacy as single agent and in combination with azacitidine
De La Fuente, Macarena Ines, Colman, Howard, Rosenthal, Mark, Van Tine, Brian Andrew, Levaci, Danijela, Walbert, Tobias, Gan, Hui Kong, Vieito, Maria, Milhem, Mohammed M., Lipford, Kate, Forsyth, Sanjeev, Guichard, Sylvie Mireille, Mikhailov, Yelena, Sedkov, Alexander, Thomson, Blythe, Kelly, Patrick Francis, Monga, Varun
Published in Journal of clinical oncology (20.05.2020)
Published in Journal of clinical oncology (20.05.2020)
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A phase Ib/II study of olutasidenib in patients with relapsed/refractory IDH1 mutant solid tumors: Safety and efficacy as single agent
Jones, Robin Lewis, Macarulla, Teresa, Charlson, John A., Van Tine, Brian Andrew, Goyal, Lipika, Italiano, Antoine, Massard, Christophe, Rosenthal, Mark, De La Fuente, Macarena Ines, Roxburgh, Patricia, Kundranda, Madappa N., Blay, Jean-Yves, Yoo, Changhoon, Lipford, Kate, Forsyth, Sanjeev, Guichard, Sylvie Mireille, Mikhailov, Yelena, Thomson, Blythe, Kelly, Patrick Francis, Duffaud, Florence
Published in Journal of clinical oncology (20.05.2020)
Published in Journal of clinical oncology (20.05.2020)
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ACTR-52. PHASE 1 STUDY OF FT-2102, AN INHIBITOR OF MUTANT IDH1, IN PATIENTS WITH RELAPSED/REFRACTORY IDH1 MUTANT GLIOMAS: PRELIMINARY SAFETY AND CLINICAL ACTIVITY
De la Fuente, Macarena I, Colman, Howard, Rosenthal, Mark, Van Tine, Brian A, Fonkem, Ekokobe, Walbert, Tobias, Milhem, Mohammed, Lipford, Kate, Forsyth, Sanjeev, Guichard, Sylvie, Brevard, Julie, Mikhailov, Yelena, Thomson, Blythe, Monga, Varun
Published in Neuro-oncology (Charlottesville, Va.) (11.11.2019)
Published in Neuro-oncology (Charlottesville, Va.) (11.11.2019)
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A phase I study of panobinostat in children with relapsed and refractory hematologic malignancies
Goldberg, John, Sulis, Maria Luisa, Bender, Julia, Jeha, Sima, Gardner, Rebecca, Pollard, Jessica, Aquino, Victor, Laetsch, Theodore, Winick, Naomi, Fu, Cecilia, Marcus, Leigh, Sun, Weili, Verma, Anupam, Burke, Michael, Ho, Phoenix, Manley, Thomas, Mody, Rajen, Tcheng, Wendy, Thomson, Blythe, Park, Julie, Sposto, Richard, Messinger, Yoav, Hijiya, Nobuko, Gaynon, Paul, Barredo, Julio
Published in Pediatric hematology and oncology (17.08.2020)
Published in Pediatric hematology and oncology (17.08.2020)
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Anti–interleukin-5 (mepolizumab) therapy for hypereosinophilic syndromes
Garrett, Jennifer K, Jameson, Sean C, Thomson, Blythe, Collins, Margaret H, Wagoner, Lynne E, Freese, Debbie K, Beck, Lisa A, Boyce, Joshua A, Filipovich, Alexandra H, Villanueva, Joyce M, Sutton, Steven A, Assa'ad, Amal H, Rothenberg, Marc E
Published in Journal of allergy and clinical immunology (2004)
Published in Journal of allergy and clinical immunology (2004)
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Abstract A135: Physiologically-based pharmacokinetic modeling to support clinical investigation of the EZH2 inhibitor, tazemetostat (EPZ-6438) in INI1-deficient pediatric tumors
Rioux, Nathalie, Keilhack, Heike, Thomson, Blythe, Chesworth, Richard, Copeland, Robert A., Hedrick, Eric, Ho, Peter, Waters, Nigel J.
Published in Molecular cancer therapeutics (01.12.2015)
Published in Molecular cancer therapeutics (01.12.2015)
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Final Report of Phase 1 Study of the DOT1L Inhibitor, Pinometostat (EPZ-5676), in Children with Relapsed or Refractory MLL-r Acute Leukemia
Shukla, Neerav, Wetmore, Cynthia, O'Brien, Maureen M, Silverman, Lewis B., Brown, Patrick, Cooper, Todd M, Thomson, Blythe, Blakemore, Stephen J., Daigle, Scott, Suttle, Ben, Waters, Nigel J., Krivstov, Andrei V, Armstrong, Scott A., Ho, Peter T, Gore, Lia
Published in Blood (02.12.2016)
Published in Blood (02.12.2016)
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Abstract CT031: The effect of food on the pharmacokinetics (pk) of tazemetostat in patients with cancer
Suttle, Benjamin, Smith, Sherri A., Waters, Nigel L., Ribrag, Vincent, Italiano, Antoine, Michot, Jean-Marie, Postel-Vinay, Sophie, Toulmonde, Maud, Cousin, Sophie, Roche, Maria, Pimentel, Patricia, Thomson, Blythe, Ho, Peter
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Pediatric Dose Determinations for the Phase I Study of the DOT1L Inhibitor, EPZ-5676, in MLL-r Acute Leukemia: Leveraging Early Clinical Data in Adults through Physiologically-Based Pharmacokinetic Modeling
Waters, Nigel J, Thomson, Blythe, Gardner, Iain, Johnson, Trevor N, Olhava, Edward J, Pollock, Roy M, Legler, Michelle, Copeland, Robert A, Hedrick, Eric E
Published in Blood (06.12.2014)
Published in Blood (06.12.2014)
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Phase 1 Study of Tazemetostat (EPZ-6438), an Inhibitor of Enhancer of Zeste-Homolog 2 (EZH2): Preliminary Safety and Activity in Relapsed or Refractory Non-Hodgkin Lymphoma (NHL) Patients
Ribrag, Vincent, Soria, Jean-Charles, Michot, Jean-Marie, Schmitt, Anna, Postel-Vinay, Sophie, Bijou, Fontanet, Thomson, Blythe, Keilhack, Heike, Blakemore, Stephen J., Reyderman, Larisa, Kumar, Pavan, Fine, Greg, McDonald, Alice, Ho, Peter T, Italiano, Antoine
Published in Blood (03.12.2015)
Published in Blood (03.12.2015)
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