Structure-activity relationships of 2-arylquinazolin-4-ones as highly selective and potent inhibitors of the tankyrases
Nathubhai, Amit, Haikarainen, Teemu, Hayward, Penelope C., Muñoz-Descalzo, Silvia, Thompson, Andrew S., Lloyd, Matthew D., Lehtiö, Lari, Threadgill, Michael D.
Published in European journal of medicinal chemistry (08.08.2016)
Published in European journal of medicinal chemistry (08.08.2016)
Get full text
Journal Article
Structure-based design, synthesis and preliminary evaluation of selective inhibitors of dihydrofolate reductase from Mycobacterium tuberculosis
El-Hamamsy, Mervat H.R.I., Smith, Anthony W., Thompson, Andrew S., Threadgill, Michael D.
Published in Bioorganic & medicinal chemistry (01.07.2007)
Published in Bioorganic & medicinal chemistry (01.07.2007)
Get full text
Journal Article
Practical Asymmetric Synthesis of Efavirenz (DMP 266), an HIV-1 Reverse Transcriptase Inhibitor
Pierce, Michael E, Parsons, Rodney L, Radesca, Lilian A, Lo, Young S, Silverman, Stuart, Moore, James R, Islam, Qamrul, Choudhury, Anusuya, Fortunak, Joseph M. D, Nguyen, Dieu, Luo, Chi, Morgan, Susan J, Davis, Wayne P, Confalone, Pat N, Chen, Cheng-yi, Tillyer, Richard D, Frey, Lisa, Tan, Lushi, Xu, Feng, Zhao, Dalian, Thompson, Andrew S, Corley, Edward G, Grabowski, Edward J. J, Reamer, Robert, Reider, Paul J
Published in Journal of organic chemistry (13.11.1998)
Published in Journal of organic chemistry (13.11.1998)
Get full text
Journal Article
Structure-based design, synthesis and evaluation in vitro of arylnaphthyridinones, arylpyridopyrimidinones and their tetrahydro derivatives as inhibitors of the tankyrases
Kumpan, Katerina, Nathubhai, Amit, Zhang, Chenlu, Wood, Pauline J., Lloyd, Matthew D., Thompson, Andrew S., Haikarainen, Teemu, Lehtiö, Lari, Threadgill, Michael D.
Published in Bioorganic & medicinal chemistry (01.07.2015)
Published in Bioorganic & medicinal chemistry (01.07.2015)
Get full text
Journal Article
Effects of 5‐aminoisoquinolinone, a water‐soluble, potent inhibitor of the activity of poly (ADP‐ribose) polymerase on the organ injury and dysfunction caused by haemorrhagic shock
McDonald, Michelle C, Mota‐Filipe, Helder, Wright, James A, Abdelrahman, Maha, Threadgill, Michael D, Thompson, Andrew S, Thiemermann, Christoph
Published in British journal of pharmacology (01.06.2000)
Published in British journal of pharmacology (01.06.2000)
Get full text
Journal Article
The Pyrrolobenzodiazepine Dimer SJG-136 Forms Sequence-Dependent Intrastrand DNA Cross-Links and Monoalkylated Adducts in Addition to Interstrand Cross-Links
Rahman, Khondaker M, Thompson, Andrew S, James, Colin H, Narayanaswamy, Mathangi, Thurston, David E
Published in Journal of the American Chemical Society (30.09.2009)
Published in Journal of the American Chemical Society (30.09.2009)
Get full text
Journal Article
Manufacture of the PI3K β‑Sparing Inhibitor Taselisib. Part 1: Early-Stage Development Routes to the Bromobenzoxazepine Core
Remarchuk, Travis, Angelaud, Rémy, Askin, David, Kumar, Archana, Thompson, Andrew S, Cheng, Hua, Reichwein, John F, Chen, Yanping, St-Jean, Frédéric
Published in Organic process research & development (17.05.2019)
Published in Organic process research & development (17.05.2019)
Get full text
Journal Article
Direct conversion of activated alcohols to azides using diphenyl phosphorazidate. A practical alternative to Mitsunobu conditions
Thompson, Andrew S, Humphrey, Guy R, DeMarco, Anthony M, Mathre, David J, Grabowski, Edward J. J
Published in Journal of organic chemistry (01.10.1993)
Published in Journal of organic chemistry (01.10.1993)
Get full text
Journal Article
Exploration of the nicotinamide-binding site of the tankyrases, identifying 3-arylisoquinolin-1-ones as potent and selective inhibitors in vitro
Paine, Helen A., Nathubhai, Amit, Woon, Esther C.Y., Sunderland, Peter T., Wood, Pauline J., Mahon, Mary F., Lloyd, Matthew D., Thompson, Andrew S., Haikarainen, Teemu, Narwal, Mohit, Lehtiö, Lari, Threadgill, Michael D.
Published in Bioorganic & medicinal chemistry (01.09.2015)
Published in Bioorganic & medicinal chemistry (01.09.2015)
Get full text
Journal Article
Synthesis of Sequence-Selective C8-Linked Pyrrolo[2,1-c][1,4]benzodiazepine DNA Interstrand Cross-Linking Agents
Thurston, David E, Bose, D. Subhas, Thompson, Andrew S, Howard, Philip W, Leoni, Alberto, Croker, Stephen J, Jenkins, Terrence C, Neidle, Stephen, Hartley, John A, Hurley, Laurence H
Published in Journal of organic chemistry (15.11.1996)
Published in Journal of organic chemistry (15.11.1996)
Get full text
Journal Article
A practical process for the preparation of tetrahydro-1-methyl-3,3-diphenyl-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaborole-borane. A highly enantioselective stoichiometric and catalytic reducing agent
Mathre, David J, Thompson, Andrew S, Douglas, Alan W, Hoogsteen, Karst, Carroll, James D, Corley, Edward G, Grabowski, Edward J. J
Published in Journal of organic chemistry (01.05.1993)
Published in Journal of organic chemistry (01.05.1993)
Get full text
Journal Article
Chiral inversion of 2-arylpropionyl-CoA esters by human alpha-methylacyl-CoA racemase 1A (P504S)-a potential mechanism for the anti-cancer effects of ibuprofen
Woodman, Timothy J., Wood, Pauline J., Thompson, Andrew S., Hutchings, Thomas J., Steel, Georgina R., Jiao, Ping, Threadgill, Michael D., Lloyd, Matthew D.
Published in Chemical communications (Cambridge, England) (14.07.2011)
Published in Chemical communications (Cambridge, England) (14.07.2011)
Get full text
Journal Article