4-Phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione Inhibitors of the Checkpoint Kinase Wee1. Structure−Activity Relationships for Chromophore Modification and Phenyl Ring Substitution
Palmer, Brian D, Thompson, Andrew M, Booth, R. John, Dobrusin, Ellen M, Kraker, Alan J, Lee, Ho H, Lunney, Elizabeth A, Mitchell, Lorna H, Ortwine, Daniel F, Smaill, Jeff B, Swan, Leesa M, Denny, William A
Published in Journal of medicinal chemistry (10.08.2006)
Published in Journal of medicinal chemistry (10.08.2006)
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Journal Article
Tuberculosis Drug Discovery: Challenges and New Horizons
Fernandes, Guilherme F. S., Thompson, Andrew M., Castagnolo, Daniele, Denny, William A., Dos Santos, Jean L.
Published in Journal of medicinal chemistry (09.06.2022)
Published in Journal of medicinal chemistry (09.06.2022)
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Journal Article
Synthesis and Structure−Activity Relationships of Soluble 7-Substituted 3-(3,5-Dimethoxyphenyl)-1,6-naphthyridin-2-amines and Related Ureas as Dual Inhibitors of the Fibroblast Growth Factor Receptor-1 and Vascular Endothelial Growth Factor Receptor-2 Tyrosine Kinases
Thompson, Andrew M, Delaney, Amy M, Hamby, James M, Schroeder, Mel C, Spoon, Teresa A, Crean, Sheila M, Showalter, H. D. Hollis, Denny, William A
Published in Journal of medicinal chemistry (14.07.2005)
Published in Journal of medicinal chemistry (14.07.2005)
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Journal Article
Synthesis and structure–activity relationships of soluble 8-substituted 4-(2-chlorophenyl)-9-hydroxypyrrolo[3,4- c]carbazole-1,3(2 H,6 H)-diones as inhibitors of the Wee1 and Chk1 checkpoint kinases
Smaill, Jeff B., Lee, Ho H., Palmer, Brian D., Thompson, Andrew M., Squire, Christopher J., Baker, Edward N., Booth, R. John, Kraker, Alan, Hook, Ken, Denny, William A.
Published in Bioorganic & medicinal chemistry (01.02.2008)
Published in Bioorganic & medicinal chemistry (01.02.2008)
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Journal Article
7‑Substituted 2‑Nitro-5,6-dihydroimidazo[2,1‑b][1,3]oxazines: Novel Antitubercular Agents Lead to a New Preclinical Candidate for Visceral Leishmaniasis
Thompson, Andrew M, O’Connor, Patrick D, Marshall, Andrew J, Yardley, Vanessa, Maes, Louis, Gupta, Suman, Launay, Delphine, Braillard, Stephanie, Chatelain, Eric, Franzblau, Scott G, Wan, Baojie, Wang, Yuehong, Ma, Zhenkun, Cooper, Christopher B, Denny, William A
Published in Journal of medicinal chemistry (25.05.2017)
Published in Journal of medicinal chemistry (25.05.2017)
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Journal Article
Π-Π interactions stabilize PeptoMicelle-based formulations of Pretomanid derivatives leading to promising therapy against tuberculosis in zebrafish and mouse models
Dal, Nils-Jørgen K., Schäfer, Gabriela, Thompson, Andrew M., Schmitt, Sascha, Redinger, Natalja, Alonso-Rodriguez, Noelia, Johann, Kerstin, Ojong, Jessica, Wohlmann, Jens, Best, Andreas, Koynov, Kaloian, Zentel, Rudolf, Schaible, Ulrich E., Griffiths, Gareth, Barz, Matthias, Fenaroli, Federico
Published in Journal of controlled release (01.02.2023)
Published in Journal of controlled release (01.02.2023)
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Journal Article
Development of (6 R)-2-Nitro-6-[4-(trifluoromethoxy)phenoxy]-6,7-dihydro-5 H-imidazo[2,1- b][1,3]oxazine (DNDI-8219): A New Lead for Visceral Leishmaniasis
Thompson, Andrew M, O'Connor, Patrick D, Marshall, Andrew J, Blaser, Adrian, Yardley, Vanessa, Maes, Louis, Gupta, Suman, Launay, Delphine, Braillard, Stephanie, Chatelain, Eric, Wan, Baojie, Franzblau, Scott G, Ma, Zhenkun, Cooper, Christopher B, Denny, William A
Published in Journal of medicinal chemistry (22.03.2018)
Published in Journal of medicinal chemistry (22.03.2018)
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Journal Article
A preoperative nomogram for the prediction of ipsilateral central compartment lymph node metastases in papillary thyroid cancer
Thompson, Andrew M, Turner, Robin M, Hayen, Andrew, Aniss, Ahmad, Jalaty, Salvatore, Learoyd, Diana L, Sidhu, Stan, Delbridge, Leigh, Yeh, Michael W, Clifton-Bligh, Roderick, Sywak, Mark
Published in Thyroid (New York, N.Y.) (01.04.2014)
Published in Thyroid (New York, N.Y.) (01.04.2014)
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Journal Article
Heteroaryl ether analogues of an antileishmanial 7-substituted 2-nitroimidazooxazine lead afford attenuated hERG risk: In vitro and in vivo appraisal
Thompson, Andrew M., O’Connor, Patrick D., Marshall, Andrew J., Yardley, Vanessa, Maes, Louis, Gupta, Suman, Launay, Delphine, Braillard, Stephanie, Chatelain, Eric, Wan, Baojie, Franzblau, Scott G., Ma, Zhenkun, Cooper, Christopher B., Denny, William A.
Published in European journal of medicinal chemistry (01.01.2021)
Published in European journal of medicinal chemistry (01.01.2021)
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Journal Article
Repositioning Antitubercular 6‑Nitro-2,3-dihydroimidazo[2,1‑b][1,3]oxazoles for Neglected Tropical Diseases: Structure–Activity Studies on a Preclinical Candidate for Visceral Leishmaniasis
Thompson, Andrew M, O’Connor, Patrick D, Blaser, Adrian, Yardley, Vanessa, Maes, Louis, Gupta, Suman, Launay, Delphine, Martin, Denis, Franzblau, Scott G, Wan, Baojie, Wang, Yuehong, Ma, Zhenkun, Denny, William A
Published in Journal of medicinal chemistry (24.03.2016)
Published in Journal of medicinal chemistry (24.03.2016)
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Journal Article
Tyrosine Kinase Inhibitors. 20. Optimization of Substituted Quinazoline and Pyrido[3,4‑d]pyrimidine Derivatives as Orally Active, Irreversible Inhibitors of the Epidermal Growth Factor Receptor Family
Smaill, Jeff B, Gonzales, Andrea J, Spicer, Julie A, Lee, Helen, Reed, Jessica E, Sexton, Karen, Althaus, Irene W, Zhu, Tong, Black, Shannon L, Blaser, Adrian, Denny, William A, Ellis, Paul A, Fakhoury, Stephen, Harvey, Patricia J, Hook, Ken, McCarthy, Florence O. J, Palmer, Brian D, Rivault, Freddy, Schlosser, Kevin, Ellis, Teresa, Thompson, Andrew M, Trachet, Erin, Winters, R. Thomas, Tecle, Haile, Bridges, Alexander
Published in Journal of medicinal chemistry (08.09.2016)
Published in Journal of medicinal chemistry (08.09.2016)
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Journal Article
Synthesis and Structure−Activity Studies of Biphenyl Analogues of the Tuberculosis Drug (6S)-2-Nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824)
Palmer, Brian D, Thompson, Andrew M, Sutherland, Hamish S, Blaser, Adrian, Kmentova, Iveta, Franzblau, Scott G, Wan, Baojie, Wang, Yuehong, Ma, Zhenkun, Denny, William A
Published in Journal of medicinal chemistry (14.01.2010)
Published in Journal of medicinal chemistry (14.01.2010)
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Journal Article
Antitubercular Nitroimidazoles Revisited: Synthesis and Activity of the Authentic 3‑Nitro Isomer of Pretomanid
Thompson, Andrew M, Bonnet, Muriel, Lee, Ho H, Franzblau, Scott G, Wan, Baojie, Wong, George S, Cooper, Christopher B, Denny, William A
Published in ACS medicinal chemistry letters (14.12.2017)
Published in ACS medicinal chemistry letters (14.12.2017)
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Journal Article
Re-evaluating pretomanid analogues for Chagas disease: Hit-to-lead studies reveal both in vitro and in vivo trypanocidal efficacy
Thompson, Andrew M., O’Connor, Patrick D., Marshall, Andrew J., Francisco, Amanda F., Kelly, John M., Riley, Jennifer, Read, Kevin D., Perez, Catherine J., Cornwall, Scott, Thompson, R.C. Andrew, Keenan, Martine, White, Karen L., Charman, Susan A., Zulfiqar, Bilal, Sykes, Melissa L., Avery, Vicky M., Chatelain, Eric, Denny, William A.
Published in European journal of medicinal chemistry (01.12.2020)
Published in European journal of medicinal chemistry (01.12.2020)
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Journal Article
Assessment of a pretomanid analogue library for African trypanosomiasis: Hit-to-lead studies on 6-substituted 2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazine 8-oxides
Thompson, Andrew M., Marshall, Andrew J., Maes, Louis, Yarlett, Nigel, Bacchi, Cyrus J., Gaukel, Eric, Wring, Stephen A., Launay, Delphine, Braillard, Stephanie, Chatelain, Eric, Mowbray, Charles E., Denny, William A.
Published in Bioorganic & medicinal chemistry letters (15.01.2018)
Published in Bioorganic & medicinal chemistry letters (15.01.2018)
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Journal Article
6-Nitro-2,3-dihydroimidazo[2,1-b][1,3]thiazoles: Facile synthesis and comparative appraisal against tuberculosis and neglected tropical diseases
Thompson, Andrew M., Blaser, Adrian, Palmer, Brian D., Anderson, Robert F., Shinde, Sujata S., Launay, Delphine, Chatelain, Eric, Maes, Louis, Franzblau, Scott G., Wan, Baojie, Wang, Yuehong, Ma, Zhenkun, Denny, William A.
Published in Bioorganic & medicinal chemistry letters (01.06.2017)
Published in Bioorganic & medicinal chemistry letters (01.06.2017)
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Journal Article
Synthesis and Anti‐Mycobacterium tuberculosis Activity of Imidazo[2,1‐b][1,3]oxazine Derivatives against Multidrug‐Resistant Strains
Fernandes, Guilherme F. S., Manieri, Karyn F., Bonjorno, Andressa F., Campos, Debora L., Ribeiro, Camila M., Demarqui, Fernanda M., Ruiz, Daniel A. G., Nascimento‐Junior, Nailton M., Denny, William A., Thompson, Andrew M., Pavan, Fernando R., Dos Santos, Jean L.
Published in ChemMedChem (15.06.2023)
Published in ChemMedChem (15.06.2023)
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Synthesis and Structure−Activity Relationships of Aza- and Diazabiphenyl Analogues of the Antitubercular Drug (6S)-2-Nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824)
Kmentova, Iveta, Sutherland, Hamish S, Palmer, Brian D, Blaser, Adrian, Franzblau, Scott G, Wan, Baojie, Wang, Yuehong, Ma, Zhenkun, Denny, William A, Thompson, Andrew M
Published in Journal of medicinal chemistry (09.12.2010)
Published in Journal of medicinal chemistry (09.12.2010)
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Journal Article
Synthesis and Structure–Activity Relationships of Varied Ether Linker Analogues of the Antitubercular Drug (6S)-2-Nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824)
Thompson, Andrew M, Sutherland, Hamish S, Palmer, Brian D, Kmentova, Iveta, Blaser, Adrian, Franzblau, Scott G, Wan, Baojie, Wang, Yuehong, Ma, Zhenkun, Denny, William A
Published in Journal of medicinal chemistry (13.10.2011)
Published in Journal of medicinal chemistry (13.10.2011)
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