Fragment-Based Discovery of Pyrazolopyridones as JAK1 Inhibitors with Excellent Subtype Selectivity
Hansen, Bettina Borreschmidt, Jepsen, Tue Heesgaard, Larsen, Mogens, Sindet, Rikke, Vifian, Thomas, Burhardt, Mia Nørreskov, Larsen, Jens, Seitzberg, Jimmi Gerner, Carnerup, Martin A, Jerre, Anders, Mølck, Christina, Lovato, Paola, Rai, Sanjay, Nasipireddy, Venkatarathnam Reddy, Ritzén, Andreas
Published in Journal of medicinal chemistry (09.07.2020)
Published in Journal of medicinal chemistry (09.07.2020)
Get full text
Journal Article
Discovery and Early Clinical Development of Isobutyl 1-[8-Methoxy-5-(1-oxo-3H-isobenzofuran-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxylate (LEO 39652), a Novel "Dual-Soft" PDE4 Inhibitor for Topical Treatment of Atopic Dermatitis
Larsen, Jens, Lambert, Maja, Pettersson, Henrik, Vifian, Thomas, Larsen, Mogens, Ollerstam, Anna, Hegardt, Pontus, Eskilsson, Cecilia, Laursen, Steen, Soehoel, Anders, Skak-Nielsen, Tine, Hansen, Lene M., Knudsen, Nina O., Eirefelt, Stefan, Sorensen, Morten D., Stilou, Tatiana G., Nielsen, Simon F.
Published in Journal of medicinal chemistry (10.12.2020)
Published in Journal of medicinal chemistry (10.12.2020)
Get full text
Journal Article
Discovery and Early Clinical Development of Isobutyl 1‑[8-Methoxy-5-(1-oxo‑3H‑isobenzofuran-5-yl)-[1,2,4]triazolo[1,5‑a]pyridin-2-yl]cyclopropanecarboxylate (LEO 39652), a Novel “Dual-Soft” PDE4 Inhibitor for Topical Treatment of Atopic Dermatitis
Larsen, Jens, Lambert, Maja, Pettersson, Henrik, Vifian, Thomas, Larsen, Mogens, Ollerstam, Anna, Hegardt, Pontus, Eskilsson, Cecilia, Laursen, Steen, Soehoel, Anders, Skak-Nielsen, Tine, Hansen, Lene M, Knudsen, Nina Ø, Eirefelt, Stefan, Sørensen, Morten D, Stilou, Tatiana G, Nielsen, Simon F
Published in Journal of medicinal chemistry (10.12.2020)
Published in Journal of medicinal chemistry (10.12.2020)
Get full text
Journal Article
INGENOL-3-ACYLATES III AND INGENOL-3-CARBAMATES
LIANG XIFU, PER VEDSOE, THOMAS VIFIAN, THOMAS HOEGBERG, KRISTOFFER MAANSSON, GUNNAR GRUE-SOERENSEN
Year of Publication 03.03.2016
Get full text
Year of Publication 03.03.2016
Patent
composto, uso de um composto, métodos de prevenção, tratamento, melhora ou profilaxia de distúrbios fisiológicos ou doenças, e de tratamento ou melhora de indicações cosméticas, e, composição farmacêutica
THOMAS HÖGBERG, THOMAS VIFIAN, GUNNAR GRUE-S\ORENSEN, PER VEDS\O, XIFU LIANG, KRISTOFFER M\AANSSON
Year of Publication 05.06.2018
Get full text
Year of Publication 05.06.2018
Patent
INGENOL-3-ACYLATES III AND INGENOL-3-CARBAMATES
GRUE-SØRENSEN, Gunnar, VIFIAN, Thomas, LIANG, Xifu, VEDSØ, Per, HÖGBERG, Thomas, MÅNSSON, Kristoffer
Year of Publication 20.12.2017
Get full text
Year of Publication 20.12.2017
Patent
INGENOL-3-ACYLATES III AND INGENOL-3-CARBAMATES
VIFIAN Thomas, MÅNSSON Kristoffer, GRUE-SØRENSEN Gunnar, HÖGBERG Thomas, LIANG Xifu, VEDSØ Per
Year of Publication 03.08.2017
Get full text
Year of Publication 03.08.2017
Patent
Ingenol-3-acylates III and ingenol-3-carbamates
Vedsø Per, Vifian Thomas, Högberg Thomas, Grue-Sørensen Gunnar, Månsson Kristoffer, Liang Xifu
Year of Publication 18.07.2017
Get full text
Year of Publication 18.07.2017
Patent
INGENOL-3-ACYLATES III AND INGENOL-3-CARBAMATES
HÖGBERG, THOMAS, LIANG, XIFU, VEDSØ, PER, GRUE-SØRENSON, GUNNAR, MÅNSSON, KRISTOFFER, VIFIAN, THOMAS
Year of Publication 15.03.2017
Get full text
Year of Publication 15.03.2017
Patent
TRIAZOLOPYRIDINES AS PHOSPHODIESTERASE INHIBITORS FOR TREATMENT OF DERMAL DISEASES
VIFIAN, Thomas, HORNEMAN, Anne Marie, LAU, Jesper Fergemann, NIELSEN, Simon Feldbek
Year of Publication 28.11.2016
Get full text
Year of Publication 28.11.2016
Patent
INGENOL-3-ACYLATES III AND INGENOL-3-CARBAMATES
Grue-Sorensen, Gunnar, Hogberg, Thomas, Mansson, Kristoffer, Vedso, Per, Liang, Xifu, Vifian, Thomas
Year of Publication 06.10.2016
Get full text
Year of Publication 06.10.2016
Patent
TRIAZOLOPYRIDINES AS PHOSPHODIESTERASE INHIBITORS FOR TREATMENT OF DERMAL DISEASES
LAU, JESPER FÆRGEMANN, NIELSEN, SIMON FELDBÆK, HORNEMAN, ANNE MARIE, VIFIAN, THOMAS
Year of Publication 31.08.2016
Get full text
Year of Publication 31.08.2016
Patent
Ingenol-3-acylates iii and ingenol-3-carbamates
LIANG XIFU, MÅNSSON KRISTOFFER, GRUE-SØRENSEN GUNNAR, VIFIAN THOMAS, HÖGBERG THOMAS, VEDSØ PER
Year of Publication 26.08.2016
Get full text
Year of Publication 26.08.2016
Patent
TRIAZOLOPYRIDINES AS PHOSPHODIESTERASE INHIBITORS FOR TREATMENT OF DERMAL DISEASES
VIFIAN Thomas, LAU Jesper Faergemann, NIELSEN Simon Feldbaek, HORNEMAN Anne Marie
Year of Publication 30.06.2016
Get full text
Year of Publication 30.06.2016
Patent
TRIAZOLOPYRIDINES AS PHOSPHODIESTERASE INHIBITORS FOR TREATMENT OF DERMAL DISEASES
Lau, Jesper Færgemann, Nielsen, Simon Feldbæk, Horneman, Anne Marie, Vifian, Thomas
Year of Publication 17.06.2016
Get full text
Year of Publication 17.06.2016
Patent
TRIAZOLOPYRIDINER SOM PHOSPHODIESTERASEINHIBITORER TIL BEHANDLING AF HUDSYGDOMME
LAU, JESPER FAERGEMANN, HORNEMAN, ANNE MARIE, VIFIAN, THOMAS, NIELSEN, SIMON FELDBAEK
Year of Publication 17.05.2016
Get full text
Year of Publication 17.05.2016
Patent
TRIAZOLOPYRIDINES AS PHOSPHODIESTERASE INHIBITORS FOR TREATMENT OF DERMAL DISEASES
LAU, JESPER FÆRGEMANN, NIELSEN, SIMON FELDBÆK, HORNEMAN, ANNE MARIE, VIFIAN, THOMAS
Year of Publication 09.03.2016
Get full text
Year of Publication 09.03.2016
Patent
INGENOL-3-ACYLATES III AND INGENOL-3-CARBAMATES
HÖGBERG, THOMAS, LIANG, XIFU, VEDSØ, PER, GRUE-SØRENSEN, GUNNAR, MÅNSSON, KRISTOFFER, VIFIAN, THOMAS
Year of Publication 28.01.2016
Get full text
Year of Publication 28.01.2016
Patent
INGENOL-3-ACYLATES III AND INGENOL-3-CARBAMATES -3- III -3
GRUE-SRENSEN, GUNNAR, VEDS, PER, MNSSON, KRISTOFFER, LIANG, XIFU, VIFIAN, THOMAS, HGBERG, THOMAS
Year of Publication 31.12.2015
Get full text
Year of Publication 31.12.2015
Patent