Pharmacologic inhibition of ketohexokinase prevents fructose-induced metabolic dysfunction
Gutierrez, Jemy A., Liu, Wei, Perez, Sylvie, Xing, Gang, Sonnenberg, Gabriele, Kou, Kou, Blatnik, Matt, Allen, Richard, Weng, Yan, Vera, Nicholas B., Chidsey, Kristin, Bergman, Arthur, Somayaji, Veena, Crowley, Collin, Clasquin, Michelle F., Nigam, Anu, Fulham, Melissa A., Erion, Derek M., Ross, Trenton T., Esler, William P., Magee, Thomas V., Pfefferkorn, Jeffrey A., Bence, Kendra K., Birnbaum, Morris J., Tesz, Gregory J.
Published in Molecular metabolism (Germany) (01.06.2021)
Published in Molecular metabolism (Germany) (01.06.2021)
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Application of emerging biomarkers of acute kidney injury in development of kidney-sparing polypeptide-based antibiotics
Burt, Deborah, Crowell, Sarah J., Ackley, David C., Magee, Thomas V., Aubrecht, Jiri
Published in Drug and chemical toxicology (New York, N.Y. 1978) (01.04.2014)
Published in Drug and chemical toxicology (New York, N.Y. 1978) (01.04.2014)
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Discovery of PF-06835919: A Potent Inhibitor of Ketohexokinase (KHK) for the Treatment of Metabolic Disorders Driven by the Overconsumption of Fructose
Futatsugi, Kentaro, Smith, Aaron C, Tu, Meihua, Raymer, Brian, Ahn, Kay, Coffey, Steven B, Dowling, Matthew S, Fernando, Dilinie P, Gutierrez, Jemy A, Huard, Kim, Jasti, Jayasankar, Kalgutkar, Amit S, Knafels, John D, Pandit, Jayvardhan, Parris, Kevin D, Perez, Sylvie, Pfefferkorn, Jeffrey A, Price, David A, Ryder, Tim, Shavnya, Andre, Stock, Ingrid A, Tsai, Andy S, Tesz, Gregory J, Thuma, Benjamin A, Weng, Yan, Wisniewska, Hanna M, Xing, Gang, Zhou, Jun, Magee, Thomas V
Published in Journal of medicinal chemistry (25.11.2020)
Published in Journal of medicinal chemistry (25.11.2020)
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Discovery and characterization of novel inhibitors of the sodium-coupled citrate transporter (NaCT or SLC13A5)
Huard, Kim, Brown, Janice, Jones, Jessica C., Cabral, Shawn, Futatsugi, Kentaro, Gorgoglione, Matthew, Lanba, Adhiraj, Vera, Nicholas B., Zhu, Yimin, Yan, Qingyun, Zhou, Yingjiang, Vernochet, Cecile, Riccardi, Keith, Wolford, Angela, Pirman, David, Niosi, Mark, Aspnes, Gary, Herr, Michael, Genung, Nathan E., Magee, Thomas V., Uccello, Daniel P., Loria, Paula, Di, Li, Gosset, James R., Hepworth, David, Rolph, Timothy, Pfefferkorn, Jeffrey A., Erion, Derek M.
Published in Scientific reports (01.12.2015)
Published in Scientific reports (01.12.2015)
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Journal Article
Optimization of a Dicarboxylic Series for in Vivo Inhibition of Citrate Transport by the Solute Carrier 13 (SLC13) Family
Huard, Kim, Gosset, James R, Montgomery, Justin I, Gilbert, Adam, Hayward, Matthew M, Magee, Thomas V, Cabral, Shawn, Uccello, Daniel P, Bahnck, Kevin, Brown, Janice, Purkal, Julie, Gorgoglione, Matthew, Lanba, Adhiraj, Futatsugi, Kentaro, Herr, Michael, Genung, Nathan E, Aspnes, Gary, Polivkova, Jana, Garcia-Irizarry, Carmen N, Li, Qifang, Canterbury, Daniel, Niosi, Mark, Vera, Nicholas B, Li, Zhenhong, Khunte, Bhagyashree, Siderewicz, Jaclyn, Rolph, Timothy, Erion, Derek M
Published in Journal of medicinal chemistry (11.02.2016)
Published in Journal of medicinal chemistry (11.02.2016)
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Journal Article
Discovery of Fragment-Derived Small Molecules for in Vivo Inhibition of Ketohexokinase (KHK)
Huard, Kim, Ahn, Kay, Amor, Paul, Beebe, David A, Borzilleri, Kris A, Chrunyk, Boris A, Coffey, Steven B, Cong, Yang, Conn, Edward L, Culp, Jeffrey S, Dowling, Matthew S, Gorgoglione, Matthew F, Gutierrez, Jemy A, Knafels, John D, Lachapelle, Erik A, Pandit, Jayvardhan, Parris, Kevin D, Perez, Sylvie, Pfefferkorn, Jeffrey A, Price, David A, Raymer, Brian, Ross, Trenton T, Shavnya, Andre, Smith, Aaron C, Subashi, Timothy A, Tesz, Gregory J, Thuma, Benjamin A, Tu, Meihua, Weaver, John D, Weng, Yan, Withka, Jane M, Xing, Gang, Magee, Thomas V
Published in Journal of medicinal chemistry (28.09.2017)
Published in Journal of medicinal chemistry (28.09.2017)
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Discovery of Dap‑3 Polymyxin Analogues for the Treatment of Multidrug-Resistant Gram-Negative Nosocomial Infections
Magee, Thomas V, Brown, Matthew F, Starr, Jeremy T, Ackley, David C, Abramite, Joseph A, Aubrecht, Jiri, Butler, Andrew, Crandon, Jared L, Dib-Hajj, Fadia, Flanagan, Mark E, Granskog, Karl, Hardink, Joel R, Huband, Michael D, Irvine, Rebecca, Kuhn, Michael, Leach, Karen L, Li, Bryan, Lin, Jian, Luke, David R, MacVane, Shawn H, Miller, Alita A, McCurdy, Sandra, McKim, James M, Nicolau, David P, Nguyen, Thuy-Trinh, Noe, Mark C, O’Donnell, John P, Seibel, Scott B, Shen, Yue, Stepan, Antonia F, Tomaras, Andrew P, Wilga, Paul C, Zhang, Li, Xu, Jinfeng, Chen, Jinshan Michael
Published in Journal of medicinal chemistry (27.06.2013)
Published in Journal of medicinal chemistry (27.06.2013)
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Journal Article
Discovery of Selective Small Molecule Inhibitors of Monoacylglycerol Acyltransferase 3
Huard, Kim, Londregan, Allyn T, Tesz, Gregory, Bahnck, Kevin B, Magee, Thomas V, Hepworth, David, Polivkova, Jana, Coffey, Steven B, Pabst, Brandon A, Gosset, James R, Nigam, Anu, Kou, Kou, Sun, Hao, Lee, Kyuha, Herr, Michael, Boehm, Markus, Carpino, Philip A, Goodwin, Bryan, Perreault, Christian, Li, Qifang, Jorgensen, Csilla C, Tkalcevic, George T, Subashi, Timothy A, Ahn, Kay
Published in Journal of medicinal chemistry (24.09.2015)
Published in Journal of medicinal chemistry (24.09.2015)
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Discovery of a Selective Covalent Inhibitor of Lysophospholipase-like 1 (LYPLAL1) as a Tool to Evaluate the Role of this Serine Hydrolase in Metabolism
Ahn, Kay, Boehm, Markus, Brown, Matthew F, Calloway, Jessica, Che, Ye, Chen, Jinshan, Fennell, Kimberly F, Geoghegan, Kieran F, Gilbert, Adam M, Gutierrez, Jemy A, Kalgutkar, Amit S, Lanba, Adhiraj, Limberakis, Chris, Magee, Thomas V, O’Doherty, Inish, Oliver, Robert, Pabst, Brandon, Pandit, Jayvardhan, Parris, Kevin, Pfefferkorn, Jeffrey A, Rolph, Timothy P, Patel, Rushi, Schuff, Brandon, Shanmugasundaram, Veerabahu, Starr, Jeremy T, Varghese, Alison H, Vera, Nicholas B, Vernochet, Cecile, Yan, Jiangli
Published in ACS chemical biology (16.09.2016)
Published in ACS chemical biology (16.09.2016)
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Novel 3-O-carbamoyl erythromycin A derivatives (carbamolides) with activity against resistant staphylococcal and streptococcal isolates
Magee, Thomas V., Han, Seungil, McCurdy, Sandra P., Nguyen, Thuy-Trinh, Granskog, Karl, Marr, Eric S., Maguire, Bruce A., Huband, Michael D., Chen, Jinshan Michael, Subashi, Timothy A., Shanmugasundaram, Veerabahu
Published in Bioorganic & medicinal chemistry letters (15.03.2013)
Published in Bioorganic & medicinal chemistry letters (15.03.2013)
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Journal Article
Design of a multi-purpose fragment screening library using molecular complexity and orthogonal diversity metrics
Lau, Wan F., Withka, Jane M., Hepworth, David, Magee, Thomas V., Du, Yuhua J., Bakken, Gregory A., Miller, Michael D., Hendsch, Zachary S., Thanabal, Venkataraman, Kolodziej, Steve A., Xing, Li, Hu, Qiyue, Narasimhan, Lakshmi S., Love, Robert, Charlton, Maura E., Hughes, Samantha, van Hoorn, Willem P., Mills, James E.
Published in Journal of computer-aided molecular design (01.07.2011)
Published in Journal of computer-aided molecular design (01.07.2011)
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Synthesis of 12-membered macrocyclic templates and library analogs for PPI
Chen, Jinshan, Rong, Frank, Shan, Bo, Chen, Yuanwei, Li, Yingfu, Yu, Hua, Chen, Li, Kuang, Tongtao, Li, Shai, Chen, Youpei, Du, Jing, Ai, Chaowu, Li, Jian, Li, Xiaoyong, Shi, Changqing, Jiang, Zhilong, Long, Yuanqiang, Gao, Qiu, Wang, Zhibo, Xu, Kexin, Ran, Xin, Yi, Hua, Zhao, Dapeng, Qiao, Hongyun, Shen, Junwei, Liu, Bo, Liu, Chonggang, Wu, Kai, Geng, Xi, Tan, Jieyang, McLeod, Dale, Frost, Heather, Bai, Guoyun, Goetz, Gilles, Federico, James, Whitney-Pickett, Carrie, Troutman, Matthew, Noe, Mark C., Guimaraes, Cristiano, Piotrowski, David W., Magee, Thomas V.
Published in Tetrahedron letters (19.06.2013)
Published in Tetrahedron letters (19.06.2013)
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Journal Article
Total Synthesis of Baccatin III and Taxol
Danishefsky, Samuel J, Masters, John J, Young, Wendy B, Link, J. T, Snyder, Lawrence B, Magee, Thomas V, Jung, David K, Isaacs, Richard C. A, Bornmann, William G, Alaimo, Cheryl A, Coburn, Craig A, Di Grandi, Martin J
Published in Journal of the American Chemical Society (27.03.1996)
Published in Journal of the American Chemical Society (27.03.1996)
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Process Development of a Novel Azetidinyl Ketolide Antibiotic
Li, Bryan, Magee, Thomas V, Buzon, Richard A, Widlicka, Daniel W, Bill, Dave R, Brandt, Thomas, Cao, Xiaoping, Coutant, Michael, Dou, Haijian, Granskog, Karl, Flanagan, Mark E, Hayward, Cheryl M, Li, Bin, Liu, Fengwei, Liu, Wei, Nguyen, Thuy-Trinh, Raggon, Jeffrey W, Rose, Peter, Rainville, Joseph, Reilly, Usa Datta, Shen, Yue, Sun, Jianmin, Wilcox, Glenn E
Published in Organic process research & development (18.05.2012)
Published in Organic process research & development (18.05.2012)
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Syntheses of Dap-3 Polymyxin Analogues via a Tris-Boc-Protected Polymyxin B Heptapeptide
Li, Bryan, Akin, Anne, Magee, Thomas V., Martinez, Carlos, Szeliga, Jan, Duc Vicki Vuong
Published in Synthesis (Stuttgart) (17.07.2015)
Published in Synthesis (Stuttgart) (17.07.2015)
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