Diastereoselective, large-scale synthesis of beta-amino acids via asymmetric aza-Michael addition as alpha 2 delta ligands for the treatment of generalized anxiety disorder and insomnia
Magano, Javier, Bowles, Daniel, Conway, Brian, Nanninga, Thomas N., Winkle, Derick D.
Published in Tetrahedron letters (18.11.2009)
Published in Tetrahedron letters (18.11.2009)
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Diastereoselective, large scale synthesis of beta-amino acids via asymmetric enamide hydrogenation as alpha 2 delta ligands for the treatment of generalized anxiety disorder and insomnia
Magano, Javier, Conway, Brian, Bowles, Daniel, Nelson, Jade, Nanninga, Thomas N., Winkle, Derick D., Wu, Haifeng, Chen, Michael H.
Published in Tetrahedron letters (18.11.2009)
Published in Tetrahedron letters (18.11.2009)
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Development of a Scalable Process for CI-1034, an Endothelin Antagonist
Jacks, Thomas E, Belmont, Daniel T, Briggs, Christopher A, Horne, Nicole M, Kanter, Gerald D, Karrick, Greg L, Krikke, James J, McCabe, Richard J, Mustakis, Jason G, Nanninga, Thomas N, Risedorph, Guy S, Seamans, Ronald E, Skeean, Richard, Winkle, Derick D, Zennie, Thomas M
Published in Organic process research & development (01.03.2004)
Published in Organic process research & development (01.03.2004)
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Journal Article
Diastereoselective, large-scale synthesis of β-amino acids via asymmetric aza-Michael addition as α2δ ligands for the treatment of generalized anxiety disorder and insomnia
Magano, Javier, Bowles, Daniel, Conway, Brian, Nanninga, Thomas N., Winkle, Derick D.
Published in Tetrahedron letters (18.11.2009)
Published in Tetrahedron letters (18.11.2009)
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Expeditious, large scale preparation of ethyl ( R)-5-methyl-3-oxo octanoate via a cross Claisen reaction between N-acyl oxazolidinone derivatives and the magnesium enolate of potassium ethyl malonate
Magano, Javier, Nanninga, Thomas N., Winkle, Derick D.
Published in Tetrahedron letters (28.04.2008)
Published in Tetrahedron letters (28.04.2008)
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Journal Article
Diastereoselective, large scale synthesis of β-amino acids via asymmetric enamide hydrogenation as α2δ ligands for the treatment of generalized anxiety disorder and insomnia
Magano, Javier, Conway, Brian, Bowles, Daniel, Nelson, Jade, Nanninga, Thomas N., Winkle, Derick D., Wu, Haifeng, Chen, Michael H.
Published in Tetrahedron letters (18.11.2009)
Published in Tetrahedron letters (18.11.2009)
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THE SYNTHESIS OF (4R-CIS)-1,1-DIMETHYLETHYL 6-CYANOMETHYL-2,2-DIMETHYL-1,3-DIOXANE-4-ACETATE, A KEY INTERMEDIATE FOR THE PREPARATION OF CI-981, A HIGHLY POTENT, TISSUE SELECTIVE INHIBITOR OF HMG-COA REDUCTASE
BROWER, PL, BUTLER, DE, DEERING, CF, LE, TV, MILLAR, A, NANNINGA, TN, ROTH, BD
Published in Tetrahedron letters (01.04.1992)
Published in Tetrahedron letters (01.04.1992)
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Chemoselectivity in palladium-mediated cycloadditions of substituted trimethylenemethanes
Trost, Barry M, Nanninga, Thomas N, Satoh, Tsuyoshi
Published in Journal of the American Chemical Society (01.02.1985)
Published in Journal of the American Chemical Society (01.02.1985)
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Chemical Development of an α2δ Ligand, (3S,5R)-3-(Aminomethyl)-5-methyloctanoic Acid
Murtagh, Lorraine, Dunne, Catherine, Gabellone, Gino, Panesar, Niamh J., Field, Stuart, Reeder, Lisa M., Saenz, James, Smith, George P., Kissick, Kyle, Martinez, Carlos, Van Alsten, John G., Evans, Margaret C., Franklin, Lloyd C., Nanninga, Thomas, Wong, John
Published in Organic process research & development (18.11.2011)
Published in Organic process research & development (18.11.2011)
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Journal Article
Chemical Development of an alpha 2 delta Ligand, (3S,5R)-3-(Aminomethyl)-5-methyloctanoic Acid
Murtagh, Lorraine, Dunne, Catherine, Gabellone, Gino, Panesar, Niamh J., Field, Stuart, Reeder, Lisa M., Saenz, James, Smith, George P., Kissick, Kyle, Carlos, Martinez, Van Alsten, John G., Evans, Margaret C., Franklin, Lloyd C., Nanninga, Thomas
Published in Organic process research & development (01.11.2011)
Published in Organic process research & development (01.11.2011)
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Carboxylative trimethylenemethane cycloadditions catalyzed by palladium
Trost, Barry M, Mignani, Serge M, Nanninga, Thomas N
Published in Journal of the American Chemical Society (01.09.1986)
Published in Journal of the American Chemical Society (01.09.1986)
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