Discovery and Development of Potent LFA-1/ICAM-1 Antagonist SAR 1118 as an Ophthalmic Solution for Treating Dry Eye
Zhong, Min, Gadek, Thomas R, Bui, Minna, Shen, Wang, Burnier, John, Barr, Kenneth J, Hanan, Emily J, Oslob, Johan D, Yu, Chul H, Zhu, Jiang, Arkin, Michelle R, Evanchik, Marc J, Flanagan, W. Mike, Hoch, Ute, Hyde, Jennifer, Prabhu, Saileta, Silverman, Jeffrey A, Wright, Jasmin
Published in ACS medicinal chemistry letters (08.03.2012)
Published in ACS medicinal chemistry letters (08.03.2012)
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Safety and pharmacokinetics of a novel lymphocyte function-associated antigen-1 antagonist ophthalmic solution (SAR 1118) in healthy adults
Semba, Charles P, Swearingen, Dennis, Smith, Valerie L, Newman, Mary S, O'Neill, Charles A, Burnier, John P, Haughey, David B, Gadek, Thomas R
Published in Journal of ocular pharmacology and therapeutics (01.02.2011)
Published in Journal of ocular pharmacology and therapeutics (01.02.2011)
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Competition between intercellular adhesion molecule‐1 and a small‐molecule antagonist for a common binding site on the αl subunit of lymphocyte function‐associated antigen‐1
Keating, Susan M., Clark, Kevin R., Stefanich, Lisa D., Arellano, Fred, Edwards, Caroline P., Bodary, Sarah C., Spencer, Steven A., Gadek, Thomas R., Marsters, James C., Beresini, Maureen H.
Published in Protein science (01.02.2006)
Published in Protein science (01.02.2006)
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Structure–activity relationships by mass spectrometry: identification of novel MMP-3 inhibitors
Ockey, Denise A, Dotson, Jenna L, Struble, Martin E, Stults, John T, Bourell, James H, Clark, Kevin R, Gadek, Thomas R
Published in Bioorganic & medicinal chemistry (02.01.2004)
Published in Bioorganic & medicinal chemistry (02.01.2004)
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Discovery of small molecule leads in a biotechnology datastream
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Book Review
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N-Benzoyl amino acids as ICAM/LFA-1 inhibitors. Part 2: Structure-activity relationship of the benzoyl moiety
BURDICK, Daniel J, MARSTERS, James C, ALIAGAS-MARTIN, Ignacio, STANLEY, Mark, BERESINI, Maureen, CLARK, Kevin, MCDOWELL, Robert S, GADEK, Thomas R
Published in Bioorganic & medicinal chemistry letters (03.05.2004)
Published in Bioorganic & medicinal chemistry letters (03.05.2004)
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N-Benzoyl amino acids as LFA-1/ICAM inhibitors 1: amino acid structure–activity relationship
Burdick, Daniel J., Paris, Ken, Weese, Kenneth, Stanley, Mark, Beresini, Maureen, Clark, Kevin, McDowell, Robert S., Marsters, James C., Gadek, Thomas R.
Published in Bioorganic & medicinal chemistry letters (24.03.2003)
Published in Bioorganic & medicinal chemistry letters (24.03.2003)
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Effect of selective or combined inhibition of integrins αIIbβ3 and αvβ3 on thrombosis and neointima after oversized porcine coronary angioplasty
CHICO, Timothy J. A, CHAMBERLAIN, Janet, LIPARI, Michael T, QUAN, Clifford, KNOLLE, Jochen, STILZ, Hans Ulrich, PEYMAN, Anusch, CROSSMAN, David C, GUNN, Julian, ARNOLD, Nadine, BULLENS, Sherron L, GADEK, Thomas R, FRANCIS, Sheila E, BUNTING, Stuart, HORTON, Michael, SHEPHERD, Lynda
Published in Circulation (New York, N.Y.) (27.02.2001)
Published in Circulation (New York, N.Y.) (27.02.2001)
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Structural studies of potent constrained RGD peptides
McDowell, Robert S, Gadek, Thomas R
Published in Journal of the American Chemical Society (01.11.1992)
Published in Journal of the American Chemical Society (01.11.1992)
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αvβ3 antagonists based on a central thiophene scaffold
PEYMAN, Anusch, SCHEUNEMANN, Karl-Heinz, AUBERVAL, Marielle, DOUCET, Bernard, BARON, Roland, GAILLARD, Martine, GADEK, Thomas R, BODARY, Sarah, WILL, David W, KNOLLE, Jochen, WEHNER, Volkmar, BREIPOHL, Gerhard, STILZ, Hans Ulrich, CARNIATO, Denis, RUXER, Jean-Marie, GOURVEST, Jean-Francois
Published in Bioorganic & medicinal chemistry letters (06.08.2001)
Published in Bioorganic & medicinal chemistry letters (06.08.2001)
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Vitronectin Receptor Antagonists: Purine-Based Peptidomimetics
Peyman, Anusch, Gourvest, Jean-François, Gadek, Thomas R., Knolle, Jochen
Published in Angewandte Chemie International Edition (18.08.2000)
Published in Angewandte Chemie International Edition (18.08.2000)
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From Peptide to Non-Peptide. 1. The Elucidation of a Bioactive Conformation of the Arginine-Glycine-Aspartic Acid Recognition Sequence
McDowell, Robert S, Gadek, Thomas R, Barker, Peter L, Burdick, Daniel J, Chan, Kathyrn S, Quan, Clifford L, Skelton, Nicholas, Struble, Martin, Thorsett, Eugene D
Published in Journal of the American Chemical Society (01.06.1994)
Published in Journal of the American Chemical Society (01.06.1994)
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From Peptide to Non-Peptide. 2. The de Novo Design of Potent, Non-peptidal Inhibitors of Platelet Aggregation Based on a Benzodiazepinedione Scaffold
McDowell, Robert S, Blackburn, Brent K, Gadek, Thomas R, McGee, Lawrence R, Rawson, Thomas, Reynolds, Mark E, Robarge, Kirk D, Somers, Todd C, Thorsett, Eugene D
Published in Journal of the American Chemical Society (01.06.1994)
Published in Journal of the American Chemical Society (01.06.1994)
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Cyclic RGD peptide analogs as antiplatelet antithrombotics
Barker, Peter L, Bullens, Sherron, Bunting, Stuart, Burdick, Daniel J, Chan, Kathryn S, Deisher, Tracy, Eigenbrot, Charles, Gadek, Thomas R, Gantzos, Robin
Published in Journal of medicinal chemistry (01.05.1992)
Published in Journal of medicinal chemistry (01.05.1992)
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