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Published in European journal of medicinal chemistry (29.11.2016)
Published in European journal of medicinal chemistry (29.11.2016)
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Tetrahydroquinoline sulfonamides as γ-secretase inhibitors
Asberom, Theodros, Bara, Thomas A., Clader, John W., Greenlee, William J., Guzik, Henry S., Josien, Hubert B., Li, Wei, Parker, Eric M., Pissarnitski, Dmitri A., Song, Lixin, Zhang, Lili, Zhao, Zhiqiang
Published in Bioorganic & medicinal chemistry letters (2007)
Published in Bioorganic & medicinal chemistry letters (2007)
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Published in Bioorganic & medicinal chemistry (15.11.2007)
Published in Bioorganic & medicinal chemistry (15.11.2007)
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2,6-Disubstituted N-arylsulfonyl piperidines as γ-secretase inhibitors
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Published in Bioorganic & medicinal chemistry letters (2007)
Published in Bioorganic & medicinal chemistry letters (2007)
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Discovery of γ-secretase inhibitors efficacious in a transgenic animal model of Alzheimer’s disease
Asberom, Theodros, Zhao, Zhiqiang, Bara, Thomas A., Clader, John W., Greenlee, William J., Hyde, Lynn A., Josien, Hubert B., Li, Wei, McPhail, Andrew T., Nomeir, Amin A., Parker, Eric M., Rajagopalan, Murali, Song, Lixin, Wong, Gwendolyn T., Zhang, Lili, Zhang, Qi, Pissarnitski, Dmitri A.
Published in Bioorganic & medicinal chemistry letters (15.01.2007)
Published in Bioorganic & medicinal chemistry letters (15.01.2007)
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Chronic Treatment with the γ-Secretase Inhibitor LY-411,575 Inhibits β-Amyloid Peptide Production and Alters Lymphopoiesis and Intestinal Cell Differentiation
Wong, Gwendolyn T., Manfra, Denise, Poulet, Frederique M., Zhang, Qi, Josien, Hubert, Bara, Thomas, Engstrom, Laura, Pinzon-Ortiz, Maria, Fine, Jay S., Lee, Hu-Jung J., Zhang, Lili, Higgins, Guy A., Parker, Eric M.
Published in The Journal of biological chemistry (26.03.2004)
Published in The Journal of biological chemistry (26.03.2004)
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Sun, Zhong-Yue, Asberom, Theodros, Bara, Thomas, Bennett, Chad, Burnett, Duane, Chu, Inhou, Clader, John, Cohen-Williams, Mary, Cole, David, Czarniecki, Michael, Durkin, James, Gallo, Gioconda, Greenlee, William, Josien, Hubert, Huang, Xianhai, Hyde, Lynn, Jones, Nicholas, Kazakevich, Irina, Li, Hongmei, Liu, Xiaoxiang, Lee, Julie, MacCoss, Malcolm, Mandal, Mihir B, McCracken, Troy, Nomeir, Amin, Mazzola, Robert, Palani, Anandan, Parker, Eric M, Pissarnitski, Dmitri A, Qin, Jun, Song, Lixin, Terracina, Giuseppe, Vicarel, Monica, Voigt, Johannes, Xu, Ruo, Zhang, Lili, Zhang, Qi, Zhao, Zhiqiang, Zhu, Xiaohong, Zhu, Zhaoning
Published in Journal of medicinal chemistry (12.01.2012)
Published in Journal of medicinal chemistry (12.01.2012)
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Identification of Presenilin 1-Selective γ-Secretase Inhibitors with Reconstituted γ-Secretase Complexes
Lee, Julie, Song, Lixin, Terracina, Giuseppe, Bara, Thomas, Josien, Hubert, Asberom, Theodros, Sasikumar, Thavalakulamgar K, Burnett, Duane A, Clader, John, Parker, Eric M, Zhang, Lili
Published in Biochemistry (Easton) (07.06.2011)
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Neelamkavil, Santhosh F, Agrawal, Sony, Bara, Thomas, Bennett, Chad, Bhat, Sathesh, Biswas, Dipshikha, Brockunier, Linda, Buist, Nicole, Burnette, Duane, Cartwright, Mark, Chackalamannil, Samuel, Chase, Robert, Chelliah, Mariappan, Chen, Austin, Clasby, Martin, Colandrea, Vincent J, Davies, Ian W, Eagen, Keith, Guo, Zhuyan, Han, Yongxin, Howe, John, Jayne, Charles, Josien, Hubert, Kargman, Stacia, Marcantonio, Karen, Miao, Shouwu, Miller, Randy, Nolting, Andrew, Pinto, Patrick, Rajagopalan, Murali, Ruck, Rebecca T, Shah, Unmesh, Soriano, Aileen, Sperbeck, Donald, Velazquez, Francisco, Wu, Jin, Xia, Yan, Venkatraman, Srikanth
Published in ACS medicinal chemistry letters (14.01.2016)
Published in ACS medicinal chemistry letters (14.01.2016)
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discovery of fused oxadiazepines as gamma secretase modulators for treatment of Alzheimer’s disease
Li, Hongmei, Qin, Jun, Dhondi, Pawan, Zhou, Wei, Vicarel, Monica, Bara, Thomas, Cole, David, Josien, Hubert, Pissarnitski, Dmitri, Zhu, Zhaoning, Palani, Anandan, Aslanian, Robert, Clader, John, Czarniecki, Michael, Greenlee, William, Cohen-Williams, Mary, Hyde, Lynn, Song, Lixin, Zhang, Lili, Chu, Inhou, Huang, Xianhai
Published in Bioorganic & medicinal chemistry letters (15.01.2013)
Published in Bioorganic & medicinal chemistry letters (15.01.2013)
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Studies to Investigate the in Vivo Therapeutic Window of the γ-Secretase Inhibitor N 2 -[(2 S )-2-(3,5-Difluorophenyl)-2-hydroxyethanoyl]- N 1 -[(7 S )-5-methyl-6-oxo-6,7-dihydro-5 H -dibenzo[ b , d ]azepin-7-yl]-l-alaninamide (LY411,575) in the CRND8 Mouse
Hyde, Lynn A., McHugh, Nansie A., Chen, Joseph, Zhang, Qi, Manfra, Denise, Nomeir, Amin A., Josien, Hubert, Bara, Thomas, Clader, John W., Zhang, Lili, Parker, Eric M., Higgins, Guy A.
Published in The Journal of pharmacology and experimental therapeutics (01.12.2006)
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Iminopyrimidinones: A novel pharmacophore for the development of orally active renin inhibitors
McKittrick, Brian A., Caldwell, John P., Bara, Thomas, Boykow, George, Chintala, Madhu, Clader, John, Czarniecki, Michael, Courneya, Brandy, Duffy, Ruth, Fleming, Linda, Giessert, Rachel, Greenlee, William J., Heap, Charles, Hong, Liwu, Huang, Ying, Iserloh, Ulrich, Josien, Hubert, Khan, Tanweer, Korfmacher, Walter, Liang, Xian, Mazzola, Robert, Mitra, Soumya, Moore, Kristina, Orth, Peter, Rajagopalan, Murali, Roy, Sudipta, Sakwa, Samuel, Strickland, Corey, Vaccaro, Henry, Voigt, Johannes, Wang, Hongwu, Wong, Jesse, Zhang, Rumin, Zych, Andrew
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Published in Bioorganic & medicinal chemistry letters (01.04.2015)
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Structure activity relationship studies of tricyclic bispyran sulfone γ-secretase inhibitors
Wu, Wen-Lian, Asberom, Theodros, Bara, Thomas, Bennett, Chad, Burnett, Duane A., Clader, John, Domalski, Martin, Greenlee, William J., Josien, Hubert, McBriar, Mark, Rajagopalan, Murali, Vicarel, Monica, Xu, Ruo, Hyde, Lynn A., Del Vecchio, Robert A., Cohen-Williams, Mary E., Song, Lixin, Lee, Julie, Terracina, Giuseppe, Zhang, Qi, Nomeir, Amin, Parker, Eric M., Zhang, Lili
Published in Bioorganic & medicinal chemistry letters (01.02.2013)
Published in Bioorganic & medicinal chemistry letters (01.02.2013)
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Iminoheterocycles as γ-secretase modulators
Caldwell, John P., Bennett, Chad E., McCracken, Troy M., Mazzola, Robert D., Bara, Thomas, Buevich, Alexei, Burnett, Duane A., Chu, Inhou, Cohen-Williams, Mary, Josein, Hubert, Hyde, Lynn, Lee, Julie, McKittrick, Brian, Song, Lixin, Terracina, Giuseppe, Voigt, Johannes, Zhang, Lili, Zhu, Zhaoning
Published in Bioorganic & medicinal chemistry letters (15.09.2010)
Published in Bioorganic & medicinal chemistry letters (15.09.2010)
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Structure activity relationship studies of tricyclic bispyran sulfone [gamma]-secretase inhibitors
Wu, Wen-Lian, Asberom, Theodros, Bara, Thomas, Bennett, Chad, Burnett, Duane A, Clader, John, Domalski, Martin, Greenlee, William J, Josien, Hubert, McBriar, Mark, Rajagopalan, Murali, Vicarel, Monica, Xu, Ruo, Hyde, Lynn A, Del Vecchio, Robert A, Cohen-Williams, Mary E, Song, Lixin, Lee, Julie, Terracina, Giuseppe, Zhang, Qi, Nomeir, Amin, Parker, Eric M, Zhang, Lili
Published in Bioorganic & medicinal chemistry letters (01.02.2013)
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Published in Bioorganic & medicinal chemistry letters (01.02.2013)
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Novel orally active morpholine N-arylsulfonamides γ-secretase inhibitors with low CYP 3A4 liability
Josien, Hubert, Bara, Thomas, Rajagopalan, Murali, Clader, John W., Greenlee, William J., Favreau, Leonard, Hyde, Lynn A., Nomeir, Amin A., Parker, Eric M., Song, Lixin, Zhang, Lili, Zhang, Qi
Published in Bioorganic & medicinal chemistry letters (01.11.2009)
Published in Bioorganic & medicinal chemistry letters (01.11.2009)
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Discovery of SCH 900229, a Potent Presenilin 1 Selective γ-Secretase Inhibitor for the Treatment of Alzheimer’s Disease
Wu, Wen-Lian, Domalski, Martin, Burnett, Duane A, Josien, Hubert, Bara, Thomas, Rajagopalan, Murali, Xu, Ruo, Clader, John, Greenlee, William J, Brunskill, Andrew, Hyde, Lynn A, Del Vecchio, Robert A, Cohen-Williams, Mary E, Song, Lixin, Lee, Julie, Terracina, Giuseppe, Zhang, Qi, Nomeir, Amin, Parker, Eric M, Zhang, Lili
Published in ACS medicinal chemistry letters (08.11.2012)
Published in ACS medicinal chemistry letters (08.11.2012)
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Synthesis, SAR, and Biological Evaluation of Oximino-Piperidino-Piperidine Amides. 1. Orally Bioavailable CCR5 Receptor Antagonists with Potent Anti-HIV Activity
Palani, Anandan, Shapiro, Sherry, Josien, Hubert, Bara, Thomas, Clader, John W, Greenlee, William J, Cox, Kathleen, Strizki, Julie M, Baroudy, Bahige M
Published in Journal of medicinal chemistry (04.07.2002)
Published in Journal of medicinal chemistry (04.07.2002)
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Small conformationally restricted piperidine N-arylsulfonamides as orally active γ-secretase inhibitors
Josien, Hubert, Bara, Thomas, Rajagopalan, Murali, Asberom, Theodros, Clader, John W., Favreau, Leonard, Greenlee, William J., Hyde, Lynn A., Nomeir, Amin A., Parker, Eric M., Pissarnitski, Dmitri A., Song, Lixin, Wong, Gwendolyn T., Zhang, Lili, Zhang, Qi, Zhao, Zhiqiang
Published in Bioorganic & medicinal chemistry letters (01.10.2007)
Published in Bioorganic & medicinal chemistry letters (01.10.2007)
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Iminoheterocycles as g-secretase modulators
Caldwell, John P, Bennett, Chad E, McCracken, Troy M, Mazzola, Robert D, Bara, Thomas, Buevich, Alexei, Burnett, Duane A, Chu, Inhou, Cohen-Williams, Mary, Josein, Hubert, Hyde, Lynn, Lee, Julie, McKittrick, Brian, Song, Lixin, Terracina, Giuseppe, Voigt, Johannes, Zhang, Lili, Zhu, Zhaoning
Published in Bioorganic & medicinal chemistry letters (15.09.2010)
Published in Bioorganic & medicinal chemistry letters (15.09.2010)
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