structural overview of the PDI family of proteins
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Published in The FEBS journal (01.10.2010)
Published in The FEBS journal (01.10.2010)
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ERdj5 Is Required as a Disulfide Reductase for Degradation of Misfolded Proteins in the ER
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Published in Science (American Association for the Advancement of Science) (25.07.2008)
Published in Science (American Association for the Advancement of Science) (25.07.2008)
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Macrocycle-stabilization of its interaction with 14-3-3 increases plasma membrane localization and activity of CFTR
Stevers, Loes M, Wolter, Madita, Carlile, Graeme W, Macdonald, Dwight, Richard, Luc, Gielkens, Frank, Hanrahan, John W, Thomas, David Y, Chakka, Sai Kumar, Peterson, Mark L, Thomas, Helmut, Brunsveld, Luc, Ottmann, Christian
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Published in Nature communications (23.06.2022)
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Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR
Stevers, Loes M., Lam, Chan V., Leysen, Seppe F. R., Meijer, Femke A., van Scheppingen, Daphne S., de Vries, Rens M. J. M., Carlile, Graeme W., Milroy, Lech G., Thomas, David Y., Brunsveld, Luc, Ottmann, Christian
Published in Proceedings of the National Academy of Sciences - PNAS (01.03.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (01.03.2016)
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Low free drug concentration prevents inhibition of F508del CFTR functional expression by the potentiator VX‐770 (ivacaftor)
Matthes, Elizabeth, Goepp, Julie, Carlile, Graeme W, Luo, Yishan, Dejgaard, Kurt, Billet, Arnaud, Robert, Renaud, Thomas, David Y, Hanrahan, John W
Published in British journal of pharmacology (01.02.2016)
Published in British journal of pharmacology (01.02.2016)
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Tankyrase-1 regulates RBP-mediated mRNA turnover to promote muscle fiber formation
Mubaid, Souad, Sanchez, Brenda Janice, Algehani, Rinad A, Skopenkova, Viktoriia, Adjibade, Pauline, Hall, Derek T, Busque, Sandrine, Lian, Xian Jin, Ashour, Kholoud, Tremblay, Anne-Marie K, Carlile, Graeme, Gagné, Jean-Philippe, Diaz-Gaxiola, Andrea, Khattak, Shahryar, Di Marco, Sergio, Thomas, David Y, Poirier, Guy G, Gallouzi, Imed-Eddine
Published in Nucleic acids research (24.04.2024)
Published in Nucleic acids research (24.04.2024)
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Phosphodiesterase 8A Regulates CFTR Activity in Airway Epithelial Cells
Turner, Mark J, Sato, Yukiko, Thomas, David Y, Abbott-Banner, Kathy, Hanrahan, John W
Published in Cellular physiology and biochemistry (23.12.2021)
Published in Cellular physiology and biochemistry (23.12.2021)
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The NSAID glafenine rescues class 2 CFTR mutants via cyclooxygenase 2 inhibition of the arachidonic acid pathway
Carlile, Graeme W, Yang, Qi, Matthes, Elizabeth, Liao, Jie, Birault, Véronique, Sneddon, Helen F, Poole, Darren L, Hall, Callum J, Hanrahan, John W, Thomas, David Y
Published in Scientific reports (17.03.2022)
Published in Scientific reports (17.03.2022)
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An Interaction Map of Endoplasmic Reticulum Chaperones and Foldases
Jansen, Gregor, Määttänen, Pekka, Denisov, Alexey Y., Scarffe, Leslie, Schade, Babette, Balghi, Haouaria, Dejgaard, Kurt, Chen, Leanna Y., Muller, William J., Gehring, Kalle, Thomas, David Y.
Published in Molecular & cellular proteomics (01.09.2012)
Published in Molecular & cellular proteomics (01.09.2012)
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The dual phosphodiesterase 3 and 4 inhibitor RPL554 stimulates CFTR and ciliary beating in primary cultures of bronchial epithelia
Turner, Mark J, Matthes, Elizabeth, Billet, Arnaud, Ferguson, Amy J, Thomas, David Y, Randell, Scott H, Ostrowski, Lawrence E, Abbott-Banner, Kathy, Hanrahan, John W
Published in American journal of physiology. Lung cellular and molecular physiology (01.01.2016)
Published in American journal of physiology. Lung cellular and molecular physiology (01.01.2016)
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Structural Basis of Cyclophilin B Binding by the Calnexin/Calreticulin P-domain
Kozlov, Guennadi, Bastos-Aristizabal, Sara, Määttänen, Pekka, Rosenauer, Angelika, Zheng, Fenglin, Killikelly, April, Trempe, Jean-François, Thomas, David Y., Gehring, Kalle
Published in The Journal of biological chemistry (12.11.2010)
Published in The Journal of biological chemistry (12.11.2010)
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Solution structure of the bb' domains of human protein disulfide isomerase
Denisov, Alexey Y, Määttänen, Pekka, Dabrowski, Christian, Kozlov, Guennadi, Thomas, David Y, Gehring, Kalle
Published in The FEBS journal (01.03.2009)
Published in The FEBS journal (01.03.2009)
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Structural Analog of Sildenafil Identified as a Novel Corrector of the F508del-CFTR Trafficking Defect
Robert, Renaud, Carlile, Graeme W, Pavel, Catalin, Liu, Na, Anjos, Suzana M, Liao, Jie, Luo, Yishan, Zhang, Donglei, Thomas, David Y, Hanrahan, John W
Published in Molecular pharmacology (01.02.2008)
Published in Molecular pharmacology (01.02.2008)
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Intracellular eukaryotic parasites have a distinct unfolded protein response
Gosline, Sara J C, Nascimento, Mirna, McCall, Laura-Isobel, Zilberstein, Dan, Thomas, David Y, Matlashewski, Greg, Hallett, Michael
Published in PloS one (29.04.2011)
Published in PloS one (29.04.2011)
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Crystal Structure of the bb′ Domains of the Protein Disulfide Isomerase ERp57
Kozlov, Guennadi, Maattanen, Pekka, Schrag, Joseph D., Pollock, Stephanie, Cygler, Miroslaw, Nagar, Bhushan, Thomas, David Y., Gehring, Kalle
Published in Structure (London) (01.08.2006)
Published in Structure (London) (01.08.2006)
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Rescue of Mutant CFTR Trafficking Defect by the Investigational Compound MCG1516A
Lopes-Pacheco, Miquéias, Bacalhau, Mafalda, Ramalho, Sofia S, Silva, Iris A L, Ferreira, Filipa C, Carlile, Graeme W, Thomas, David Y, Farinha, Carlos M, Hanrahan, John W, Amaral, Margarida D
Published in Cells (Basel, Switzerland) (01.01.2022)
Published in Cells (Basel, Switzerland) (01.01.2022)
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Unravelling druggable signalling networks that control F508del-CFTR proteostasis
Hegde, Ramanath Narayana, Parashuraman, Seetharaman, Iorio, Francesco, Ciciriello, Fabiana, Capuani, Fabrizio, Carissimo, Annamaria, Carrella, Diego, Belcastro, Vincenzo, Subramanian, Advait, Bounti, Laura, Persico, Maria, Carlile, Graeme, Galietta, Luis, Thomas, David Y, Di Bernardo, Diego, Luini, Alberto
Published in eLife (23.12.2015)
Published in eLife (23.12.2015)
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Combination of Selective PARP3 and PARP16 Inhibitory Analogues of Latonduine A Corrects F508del-CFTR Trafficking
Centko, Ryan M, Carlile, Graeme W, Barne, Isabel, Patrick, Brian O, Blagojevic, Polina, Thomas, David Y, Andersen, Raymond J
Published in ACS omega (13.10.2020)
Published in ACS omega (13.10.2020)
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