Predicting where small molecules bind at protein-protein interfaces
Walter, Peter, Metzger, Jennifer, Thiel, Christoph, Helms, Volkhard
Published in PloS one (07.03.2013)
Published in PloS one (07.03.2013)
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Journal Article
A Physiology-Based Model of Human Bile Acid Metabolism for Predicting Bile Acid Tissue Levels After Drug Administration in Healthy Subjects and BRIC Type 2 Patients
Baier, Vanessa, Cordes, Henrik, Thiel, Christoph, Castell, José V., Neumann, Ulf P., Blank, Lars M., Kuepfer, Lars
Published in Frontiers in physiology (27.09.2019)
Published in Frontiers in physiology (27.09.2019)
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Journal Article
A Comparative Analysis of Drug-Induced Hepatotoxicity in Clinically Relevant Situations
Thiel, Christoph, Cordes, Henrik, Fabbri, Lorenzo, Aschmann, Hélène Eloise, Baier, Vanessa, Smit, Ines, Atkinson, Francis, Blank, Lars Mathias, Kuepfer, Lars
Published in PLoS computational biology (01.02.2017)
Published in PLoS computational biology (01.02.2017)
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Journal Article
A Systematic Evaluation of the Use of Physiologically Based Pharmacokinetic Modeling for Cross-Species Extrapolation
Thiel, Christoph, Schneckener, Sebastian, Krauss, Markus, Ghallab, Ahmed, Hofmann, Ute, Kanacher, Tobias, Zellmer, Sebastian, Gebhardt, Rolf, Hengstler, Jan G., Kuepfer, Lars
Published in Journal of pharmaceutical sciences (01.01.2015)
Published in Journal of pharmaceutical sciences (01.01.2015)
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Journal Article
MO053INHIBITION OF SODIUM PHOSPHATE TRANSPORTER NPT2A IMPROVES EXPERIMENTAL VASCULAR CALCIFICATION AND PHOSPHATE HOMEOSTASIS IN RATS
Klar, Juergen, Anja, Giese, Ehrmann, Alexander, Thiel, Christoph, Riedl, Bernd, Eitner, Frank
Published in Nephrology, dialysis, transplantation (01.06.2020)
Published in Nephrology, dialysis, transplantation (01.06.2020)
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Journal Article
Relationship of criminality to endogeneity and anxiety in patients with unipolar depression
Modestin, Jiri, Thiel, Christoph, Erni, Thomas
Published in Psychiatry and clinical neurosciences (01.04.2002)
Published in Psychiatry and clinical neurosciences (01.04.2002)
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Journal Article
A Physiologically Based Pharmacokinetic Model of Isoniazid and Its Application in Individualizing Tuberculosis Chemotherapy
Cordes, Henrik, Thiel, Christoph, Aschmann, Hélène E, Baier, Vanessa, Blank, Lars M, Kuepfer, Lars
Published in Antimicrobial agents and chemotherapy (01.10.2016)
Published in Antimicrobial agents and chemotherapy (01.10.2016)
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Journal Article
A Model‐Based Workflow to Benchmark the Clinical Cholestasis Risk of Drugs
Baier, Vanessa, Clayton, Olivia, Nudischer, Ramona, Cordes, Henrik, Schneider, Annika R. P., Thiel, Christoph, Wittenberger, Timo, Moritz, Wolfgang, Blank, Lars M., Neumann, Ulf P., Trautwein, Christian, Kelm, Jens, Schrooders, Yannick, Caiment, Florian, Gmuender, Hans, Roth, Adrian, Castell, José V., Kleinjans, Jos, Kuepfer, Lars
Published in Clinical pharmacology and therapeutics (01.11.2021)
Published in Clinical pharmacology and therapeutics (01.11.2021)
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Journal Article
Integration of genome-scale metabolic networks into whole-body PBPK models shows phenotype-specific cases of drug-induced metabolic perturbation
Cordes, Henrik, Thiel, Christoph, Baier, Vanessa, Blank, Lars M., Kuepfer, Lars
Published in NPJ systems biology and applications (26.02.2018)
Published in NPJ systems biology and applications (26.02.2018)
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Journal Article
신규 항-A2AP 항체 및 그의 용도
WILMEN ANDREAS, SCHULENBURG CINDY, GLUNZ JULIA, JOERISSEN HANNAH, THIEL CHRISTOPH, FISCHER MELANIE, HEITMEIER STEFAN, WEBER ERNST
Year of Publication 18.05.2023
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Year of Publication 18.05.2023
Patent
A model-based assay design to reproduce in vivo patterns of acute drug-induced toxicity
Kuepfer, Lars, Clayton, Olivia, Thiel, Christoph, Cordes, Henrik, Nudischer, Ramona, Blank, Lars M., Baier, Vanessa, Heymans, Stephane, Caiment, Florian, Roth, Adrian, Fluri, David A., Kelm, Jens M., Castell, José, Selevsek, Nathalie, Schlapbach, Ralph, Keun, Hector, Hynes, James, Sarkans, Ugis, Gmuender, Hans, Herwig, Ralf, Niederer, Steven, Schuchhardt, Johannes, Segall, Matthew, Kleinjans, Jos
Published in Archives of toxicology (01.01.2018)
Published in Archives of toxicology (01.01.2018)
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Journal Article
A 3D Heterotypic Multicellular Tumor Spheroid Assay Platform to Discriminate Drug Effects on Stroma versus Cancer Cells
Weydert, Zoe, Lal-Nag, Madhu, Mathews-Greiner, Lesley, Thiel, Christoph, Cordes, Henrik, Küpfer, Lars, Guye, Patrick, Kelm, Jens M., Ferrer, Marc
Published in SLAS discovery (01.03.2020)
Published in SLAS discovery (01.03.2020)
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Journal Article
Using quantitative systems pharmacology to evaluate the drug efficacy of COX-2 and 5-LOX inhibitors in therapeutic situations
Thiel, Christoph, Smit, Ines, Baier, Vanessa, Cordes, Henrik, Fabry, Brigida, Blank, Lars Mathias, Kuepfer, Lars
Published in NPJ systems biology and applications (03.08.2018)
Published in NPJ systems biology and applications (03.08.2018)
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Journal Article
Network integration and modelling of dynamic drug responses at multi-omics levels
Selevsek, Nathalie, Caiment, Florian, Nudischer, Ramona, Gmuender, Hans, Agarkova, Irina, Atkinson, Francis L., Bachmann, Ivo, Baier, Vanessa, Barel, Gal, Bauer, Chris, Boerno, Stefan, Bosc, Nicolas, Clayton, Olivia, Cordes, Henrik, Deeb, Sally, Gotta, Stefano, Guye, Patrick, Hersey, Anne, Hunter, Fiona M. I., Kunz, Laura, Lewalle, Alex, Lienhard, Matthias, Merken, Jort, Minguet, Jasmine, Oliveira, Bernardo, Pluess, Carla, Sarkans, Ugis, Schrooders, Yannick, Schuchhardt, Johannes, Smit, Ines, Thiel, Christoph, Timmermann, Bernd, Verheijen, Marcha, Wittenberger, Timo, Wolski, Witold, Zerck, Alexandra, Heymans, Stephane, Kuepfer, Lars, Roth, Adrian, Schlapbach, Ralph, Niederer, Steven, Herwig, Ralf, Kleinjans, Jos
Published in Communications biology (15.10.2020)
Published in Communications biology (15.10.2020)
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Journal Article
Multi-omics HeCaToS dataset of repeated dose toxicity for cardiotoxic & hepatotoxic compounds
Verheijen, Marcha, Sarkans, Ugis, Wolski, Witold, Jennen, Danyel, Caiment, Florian, Kleinjans, Jos
Published in Scientific data (14.11.2022)
Published in Scientific data (14.11.2022)
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Journal Article
Towards knowledge-driven cross-species extrapolation
Thiel, Christoph, Hofmann, Ute, Ghallab, Ahmed, Gebhardt, Rolf, Hengstler, Jan G., Kuepfer, Lars
Published in Drug discovery today. Disease models (2016)
Published in Drug discovery today. Disease models (2016)
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Journal Article