CAR T Cells Targeting B7-H3, a Pan-Cancer Antigen, Demonstrate Potent Preclinical Activity Against Pediatric Solid Tumors and Brain Tumors
Majzner, Robbie G, Theruvath, Johanna L, Nellan, Anandani, Heitzeneder, Sabine, Cui, Yongzhi, Mount, Christopher W, Rietberg, Skyler P, Linde, Miles H, Xu, Peng, Rota, Christopher, Sotillo, Elena, Labanieh, Louai, Lee, Daniel W, Orentas, Rimas J, Dimitrov, Dimiter S, Zhu, Zhongyu, Croix, Brad St, Delaidelli, Alberto, Sekunova, Alla, Bonvini, Ezio, Mitra, Siddhartha S, Quezado, Martha M, Majeti, Ravindra, Monje, Michelle, Sorensen, Poul H B, Maris, John M, Mackall, Crystal L
Published in Clinical cancer research (15.04.2019)
Published in Clinical cancer research (15.04.2019)
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Locoregionally administered B7-H3-targeted CAR T cells for treatment of atypical teratoid/rhabdoid tumors
Theruvath, Johanna, Sotillo, Elena, Mount, Christopher W., Graef, Claus Moritz, Delaidelli, Alberto, Heitzeneder, Sabine, Labanieh, Louai, Dhingra, Shaurya, Leruste, Amaury, Majzner, Robbie G., Xu, Peng, Mueller, Sabine, Yecies, Derek W., Finetti, Martina A., Williamson, Daniel, Johann, Pascal D., Kool, Marcel, Pfister, Stefan, Hasselblatt, Martin, Frühwald, Michael C., Delattre, Olivier, Surdez, Didier, Bourdeaut, Franck, Puget, Stephanie, Zaidi, Sakina, Mitra, Siddhartha S., Cheshier, Samuel, Sorensen, Poul H., Monje, Michelle, Mackall, Crystal L.
Published in Nature medicine (01.05.2020)
Published in Nature medicine (01.05.2020)
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Anti-GD2 synergizes with CD47 blockade to mediate tumor eradication
Theruvath, Johanna, Menard, Marie, Smith, Benjamin A. H., Linde, Miles H., Coles, Garry L., Dalton, Guillermo Nicolas, Wu, Wei, Kiru, Louise, Delaidelli, Alberto, Sotillo, Elena, Silberstein, John L., Geraghty, Anna C., Banuelos, Allison, Radosevich, Molly Thomas, Dhingra, Shaurya, Heitzeneder, Sabine, Tousley, Aidan, Lattin, John, Xu, Peng, Huang, Jing, Nasholm, Nicole, He, Andy, Kuo, Tracy C., Sangalang, Emma R. B., Pons, Jaume, Barkal, Amira, Brewer, Rachel E., Marjon, Kristopher D., Vilches-Moure, Jose G., Marshall, Payton L., Fernandes, Ricardo, Monje, Michelle, Cochran, Jennifer R., Sorensen, Poul H., Daldrup-Link, Heike E., Weissman, Irving L., Sage, Julien, Majeti, Ravindra, Bertozzi, Carolyn R., Weiss, William A., Mackall, Crystal L., Majzner, Robbie G.
Published in Nature medicine (01.02.2022)
Published in Nature medicine (01.02.2022)
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Developmental phosphoproteomics identifies the kinase CK2 as a driver of Hedgehog signaling and a therapeutic target in medulloblastoma
Purzner, Teresa, Purzner, James, Buckstaff, Taylor, Cozza, Giorgio, Gholamin, Sharareh, Rusert, Jessica M, Hartl, Tom A, Sanders, John, Conley, Nicholas, Ge, Xuecai, Langan, Marc, Ramaswamy, Vijay, Ellis, Lauren, Litzenburger, Ulrike, Bolin, Sara, Theruvath, Johanna, Nitta, Ryan, Qi, Lin, Li, Xiao-Nan, Li, Gordon, Taylor, Michael D, Wechsler-Reya, Robert J, Pinna, Lorenzo A, Cho, Yoon-Jae, Fuller, Margaret T, Elias, Joshua E, Scott, Matthew P
Published in Science signaling (11.09.2018)
Published in Science signaling (11.09.2018)
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Notch1 regulates the initiation of metastasis and self-renewal of Group 3 medulloblastoma
Kahn, Suzana A., Wang, Xin, Nitta, Ryan T., Gholamin, Sharareh, Theruvath, Johanna, Hutter, Gregor, Azad, Tej D., Wadi, Lina, Bolin, Sara, Ramaswamy, Vijay, Esparza, Rogelio, Liu, Kun-Wei, Edwards, Michael, Swartling, Fredrik J., Sahoo, Debashis, Li, Gordon, Wechsler-Reya, Robert J., Reimand, Jüri, Cho, Yoon-Jae, Taylor, Michael D., Weissman, Irving L., Mitra, Siddhartha S., Cheshier, Samuel H.
Published in Nature communications (08.10.2018)
Published in Nature communications (08.10.2018)
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Tacedinaline (CI-994), a class I HDAC inhibitor, targets intrinsic tumor growth and leptomeningeal dissemination in MYC-driven medulloblastoma while making them susceptible to anti-CD47-induced macrophage phagocytosis via NF-kB-TGM2 driven tumor inflammation
Marquardt, Viktoria, Theruvath, Johanna, Pauck, David, Picard, Daniel, Qin, Nan, Blümel, Lena, Maue, Mara, Bartl, Jasmin, Ahmadov, Ulvi, Langini, Maike, Meyer, Frauke-Dorothee, Cole, Allison, Cruz-Cruz, Joselyn, Graef, Claus M, Wölfl, Matthias, Milde, Till, Witt, Olaf, Erdreich-Epstein, Anat, Leprivier, Gabriel, Kahlert, Ulf, Stefanski, Anja, Stühler, Kai, Keir, Stephen T, Bigner, Darell D, Hauer, Julia, Beez, Thomas, Knobbe-Thomsen, Christiane B, Fischer, Ute, Felsberg, Jörg, Hansen, Finn K, Vibhakar, Rajeev, Venkatraman, Sujatha, Cheshier, Samuel H, Reifenberger, Guido, Borkhardt, Arndt, Kurz, Thomas, Remke, Marc, Mitra, Siddhartha
Published in Journal for immunotherapy of cancer (01.01.2023)
Published in Journal for immunotherapy of cancer (01.01.2023)
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Nanoparticle enhanced MRI can monitor macrophage response to CD47 mAb immunotherapy in osteosarcoma
Mohanty, Suchismita, Yerneni, Ketan, Theruvath, Johanna Lena, Graef, Claus Moritz, Nejadnik, Hossein, Lenkov, Olga, Pisani, Laura, Rosenberg, Jarrett, Mitra, Siddhartha, Cordero, Alejandro Sweet, Cheshier, Samuel, Daldrup-Link, Heike E.
Published in Cell death & disease (15.01.2019)
Published in Cell death & disease (15.01.2019)
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Improving the efficacy of osteosarcoma therapy: combining drugs that turn cancer cell ‘don't eat me’ signals off and ‘eat me’ signals on
Mohanty, Suchismita, Aghighi, Maryam, Yerneni, Ketan, Theruvath, Johanna Lena, Daldrup‐Link, Heike E.
Published in Molecular oncology (01.10.2019)
Published in Molecular oncology (01.10.2019)
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Publisher Correction: Notch1 regulates the initiation of metastasis and self-renewal of Group 3 medulloblastoma
Kahn, Suzana A., Wang, Xin, Nitta, Ryan T., Gholamin, Sharareh, Theruvath, Johanna, Hutter, Gregor, Azad, Tej D., Wadi, Lina, Bolin, Sara, Ramaswamy, Vijay, Esparza, Rogelio, Liu, Kun-Wei, Edwards, Michael, Swartling, Fredrik J., Sahoo, Debashis, Li, Gordon, Wechsler-Reya, Robert J., Reimand, Jüri, Cho, Yoon-Jae, Taylor, Michael D., Weissman, Irving L., Mitra, Siddhartha S., Cheshier, Samuel H.
Published in Nature communications (02.11.2018)
Published in Nature communications (02.11.2018)
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Journal Article
Microglia are effector cells of CD47-SIRPα antiphagocytic axis disruption against glioblastoma
Hutter, Gregor, Theruvath, Johanna, Graef, Claus Moritz, Zhang, Michael, Schoen, Matthew Kenneth, Manz, Eva Maria, Bennett, Mariko L., Olson, Andrew, Azad, Tej D., Sinha, Rahul, Chan, Carmel, Kahn, Suzana Assad, Gholamin, Sharareh, Wilson, Christy, Grant, Gerald, He, Joy, Weissman, Irving L., Mitra, Siddhartha S., Cheshier, Samuel H.
Published in Proceedings of the National Academy of Sciences - PNAS (15.01.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (15.01.2019)
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Tuning the Antigen Density Requirement for CAR T-cell Activity
Majzner, Robbie G, Rietberg, Skyler P, Sotillo, Elena, Dong, Rui, Vachharajani, Vipul T, Labanieh, Louai, Myklebust, June H, Kadapakkam, Meena, Weber, Evan W, Tousley, Aidan M, Richards, Rebecca M, Heitzeneder, Sabine, Nguyen, Sang M, Wiebking, Volker, Theruvath, Johanna, Lynn, Rachel C, Xu, Peng, Dunn, Alexander R, Vale, Ronald D, Mackall, Crystal L
Published in Cancer discovery (01.05.2020)
Published in Cancer discovery (01.05.2020)
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Enhanced safety and efficacy of protease-regulated CAR-T cell receptors
Labanieh, Louai, Majzner, Robbie G., Klysz, Dorota, Sotillo, Elena, Fisher, Chris J., Vilches-Moure, José G., Pacheco, Kaithlen Zen B., Malipatlolla, Meena, Xu, Peng, Hui, Jessica H., Murty, Tara, Theruvath, Johanna, Mehta, Nishant, Yamada-Hunter, Sean A., Weber, Evan W., Heitzeneder, Sabine, Parker, Kevin R., Satpathy, Ansuman T., Chang, Howard Y., Lin, Michael Z., Cochran, Jennifer R., Mackall, Crystal L.
Published in Cell (12.05.2022)
Published in Cell (12.05.2022)
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IMMU-07. TACEDINALINE (CI994), A CLASS I HDAC INHIBITOR, TARGETS INTRINSIC TUMOR GROWTH AND LEPTOMENINGEAL DISSEMINATION IN MYC-DRIVEN MEDULLOBLASTOMA WHILE MAKING THEM SUSCEPTIBLE TO ANTI-CD47 INDUCED MACROPHAGE PHAGOCYTOSIS VIA NF-KB-TGM2 DRIVEN TUMOR INFLAMMATION
Marquardt, Viktoria, Theruvath, Johanna, Qin, Nan, Picard, Daniel, Vibhakar, Rajeev, Venkararaman, Sujatha, Remke, Marc, Mitra, Siddhartha
Published in Neuro-oncology (Charlottesville, Va.) (12.06.2023)
Published in Neuro-oncology (Charlottesville, Va.) (12.06.2023)
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IMMU-55. GD2 IS A MACROPHAGE CHECKPOINT MOLECULE AND COMBINED GD2/CD47 BLOCKADE RESULTS IN SYNERGISTIC EFFECTS AGAINST GD2 POSITIVE MALIGNANCIES
Theruvath, Johanna, Mount, Christopher, Monje, Michelle, Mackall, Crystal, Majzner, Robbie
Published in Neuro-oncology (Charlottesville, Va.) (09.11.2020)
Published in Neuro-oncology (Charlottesville, Va.) (09.11.2020)
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Abstract PR04: Locoregionally administered B7H3-targeting CAR T cells mediate potent antitumor effects in atypical teratoid/rhabdoid tumor
Theruvath, Johanna, Sotillo, Elena, Graef, Claus Moritz, Heitzeneder, Sabine, Labanieh, Louai, Majzner, Robbie, Mackall, Crystal
Published in Cancer research (Chicago, Ill.) (15.07.2020)
Published in Cancer research (Chicago, Ill.) (15.07.2020)
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Journal Article
GPC2-CAR T cells tuned for low antigen density mediate potent activity against neuroblastoma without toxicity
Heitzeneder, Sabine, Bosse, Kristopher R., Zhu, Zhongyu, Zhelev, Doncho, Majzner, Robbie G., Radosevich, Molly T., Dhingra, Shaurya, Sotillo, Elena, Buongervino, Samantha, Pascual-Pasto, Guillem, Garrigan, Emily, Xu, Peng, Huang, Jing, Salzer, Benjamin, Delaidelli, Alberto, Raman, Swetha, Cui, Hong, Martinez, Benjamin, Bornheimer, Scott J., Sahaf, Bita, Alag, Anya, Fetahu, Irfete S., Hasselblatt, Martin, Parker, Kevin R., Anbunathan, Hima, Hwang, Jennifer, Huang, Min, Sakamoto, Kathleen, Lacayo, Norman J., Klysz, Dorota D., Theruvath, Johanna, Vilches-Moure, José G., Satpathy, Ansuman T., Chang, Howard Y., Lehner, Manfred, Taschner-Mandl, Sabine, Julien, Jean-Phillipe, Sorensen, Poul H., Dimitrov, Dimiter S., Maris, John M., Mackall, Crystal L.
Published in Cancer cell (10.01.2022)
Published in Cancer cell (10.01.2022)
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IMMU-19. HDAC INHIBITORS SENSITIZE MYC-AMPLIFIED MEDULLOBLASTOMA TO IMMUNOTHERAPY BY ACTIVATING THE NF-kB PATHWAYS
Marquardt, Viktoria, Theruvath, Johanna, Pauck, David, Picard, Daniel, Reifenberger, Guido, Borkhardt, Arndt, Cheshier, Samuel, Kurz, Thomas, Remke, Marc, Mitra, Siddhartha
Published in Neuro-oncology (Charlottesville, Va.) (04.12.2020)
Published in Neuro-oncology (Charlottesville, Va.) (04.12.2020)
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Prospective analysis of long-term renal function in survivors of childhood Wilms tumor
Neu, Marie A., Russo, Alexandra, Wingerter, Arthur, Alt, Francesca, Theruvath, Johanna, El Malki, Khalifa, Kron, Bettina, Dittrich, Matthias, Lotz, Johannes, Stein, Raimund, Beetz, Rolf, Faber, Joerg
Published in Pediatric nephrology (Berlin, West) (01.10.2017)
Published in Pediatric nephrology (Berlin, West) (01.10.2017)
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Journal Article
Engineered CD47 protects T cells for enhanced antitumour immunity
Yamada-Hunter, Sean A., Theruvath, Johanna, McIntosh, Brianna J., Freitas, Katherine A., Lin, Frank, Radosevich, Molly T., Leruste, Amaury, Dhingra, Shaurya, Martinez-Velez, Naiara, Xu, Peng, Huang, Jing, Delaidelli, Alberto, Desai, Moksha H., Good, Zinaida, Polak, Roel, May, Audre, Labanieh, Louai, Bjelajac, Jeremy, Murty, Tara, Ehlinger, Zach, Mount, Christopher W., Chen, Yiyun, Heitzeneder, Sabine, Marjon, Kristopher D., Banuelos, Allison, Khan, Omair, Wasserman, Savannah L., Spiegel, Jay Y., Fernandez-Pol, Sebastian, Kuo, Calvin J., Sorensen, Poul H., Monje, Michelle, Majzner, Robbie G., Weissman, Irving L., Sahaf, Bita, Sotillo, Elena, Cochran, Jennifer R., Mackall, Crystal L.
Published in Nature (London) (01.06.2024)
Published in Nature (London) (01.06.2024)
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IMMU-09. LOCALLY ADMINISTERED CAR T CELLS DEMONSTRATE MOST FAVORABLE ROUTE OF ADMINISTRATION IN A MODEL OF ATRT
Theruvath, Johanna, Graef, Claus Moritz, Heitzeneder, Sabine, Majzner, Robbie, Labanieh, Louai, Mackall, Crystal
Published in Neuro-oncology (Charlottesville, Va.) (23.04.2019)
Published in Neuro-oncology (Charlottesville, Va.) (23.04.2019)
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