Discovery of N‑(4-Fluoro-3-methoxybenzyl)-6-(2-(((2S,5R)‑5-(hydroxymethyl)-1,4-dioxan-2-yl)methyl)‑2H‑tetrazol-5-yl)-2-methylpyrimidine-4-carboxamide. A Highly Selective and Orally Bioavailable Matrix Metalloproteinase-13 Inhibitor for the Potential Treatment of Osteoarthritis
Ruminski, Peter G, Massa, Mark, Strohbach, Joseph, Hanau, Cathleen E, Schmidt, Michelle, Scholten, Jeffrey A, Fletcher, Theresa R, Hamper, Bruce C, Carroll, Jeffery N, Shieh, Huey S, Caspers, Nicole, Collins, Brandon, Grapperhaus, Margaret, Palmquist, Katherine E, Collins, Joe, Baldus, John E, Hitchcock, Jeffrey, Kleine, H. Peter, Rogers, Michael D, McDonald, Joseph, Munie, Grace E, Messing, Dean M, Portolan, Silvia, Whiteley, Laurence O, Sunyer, Teresa, Schnute, Mark E
Published in Journal of medicinal chemistry (14.01.2016)
Published in Journal of medicinal chemistry (14.01.2016)
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Phase I Study of Azacitidine following Donor Lymphocyte Infusion for Relapsed Acute Myeloid Leukemia Post Allogeneic Stem Cell Transplantation
Ghobadi, Armin, MD, Choi, Jaebok, PhD, Fiala, Mark A., BS, CCRP, Fletcher, Theresa, MS, Liu, Jingxia, PhD, Eissenberg, Linda G., PhD, Abboud, Camille, MD, Cashen, Amanda, MD, Vij, Ravi, MD, Schroeder, Mark A., MD, Pusic, Iskra, MD, Stockerl-GoldsteinMD, Keith, MD, Jacoby, Meagan, MD, PhD, Uy, Geoffrey, MD, DiPersio, John, MD, PhD, Westervelt, Peter, MD, PhD
Published in Leukemia research (01.10.2016)
Published in Leukemia research (01.10.2016)
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Targeting bone marrow lymphoid niches in acute lymphoblastic leukemia
Uy, Geoffrey L, Hsu, Yen-Michael S, Schmidt, Amy P, Stock, Wendy, Fletcher, Theresa R, Trinkaus, Kathryn M, Westervelt, Peter, DiPersio, John F, Link, Daniel C
Published in Leukemia research (01.12.2015)
Published in Leukemia research (01.12.2015)
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MMP-13 selective isonipecotamide α-sulfone hydroxamates
Kolodziej, Stephen A., Hockerman, Susan L., DeCrescenzo, Gary A., McDonald, Joseph J., Mischke, Debbie A., Munie, Grace E., Fletcher, Theresa R., Stehle, Nathan, Swearingen, Craig, Becker, Daniel P.
Published in Bioorganic & medicinal chemistry letters (15.06.2010)
Published in Bioorganic & medicinal chemistry letters (15.06.2010)
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Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis
SCHNUTE, Mark E, O'BRIEN, Patrick M, CARROLL, Jeffery N, PATT, William C, SHIEH, Huey S, COLLINS, Brandon, PAVLOVSKY, Alexander G, PALMQUIST, Katherine E, ASTON, Karl W, HITCHCOCK, Jeffrey, ROGERS, Michael D, MCDONALD, Joseph, NAHRA, Joe, JOHNSON, Adam R, MUNIE, Grace E, WITTWER, Arthur J, MAN, Chiu-Fai, SETTLE, Steven L, NEMIROVSKIY, Olga, VICKERY, Lillian E, AGAWAL, Arun, DYER, Richard D, SUNYER, Teresa, MORRIS, Mark, HOWARD ROARK, W, HANAU, Cathleen E, RUMINSKI, Peter G, SCHOLTEN, Jeffrey A, FLETCHER, Theresa R, HAMPER, Bruce C
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
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Orally bioavailable dual MMP-1/MMP-14 sparing, MMP-13 selective α-sulfone hydroxamates
Kolodziej, Stephen A., Hockerman, Susan L., Boehm, Terri L., Carroll, Jeffery N., DeCrescenzo, Gary A., McDonald, Joseph J., Mischke, Debbie A., Munie, Grace E., Fletcher, Theresa R., Rico, Joseph G., Stehle, Nathan W., Swearingen, Craig, Becker, Daniel P.
Published in Bioorganic & medicinal chemistry letters (15.06.2010)
Published in Bioorganic & medicinal chemistry letters (15.06.2010)
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Structure-based parallel medicinal chemistry approach to improve metabolic stability of benzopyran COX-2 inhibitors
Xing, Li, Hamper, Bruce C., Fletcher, Theresa R., Wendling, Jay M., Carter, Jeffery, Gierse, James K., Liao, Subo
Published in Bioorganic & medicinal chemistry letters (01.02.2011)
Published in Bioorganic & medicinal chemistry letters (01.02.2011)
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A novel class of apical sodium co-dependent bile acid transporter inhibitors: The 1,2-benzothiazepines
TOLLEFSON, Michael B, KOLODZIEJ, Stephen A, FLETCHER, Theresa R, VERNIER, William F, BEAUDRY, Judith A, KELLER, Bradley T, REITZ, David B
Published in Bioorganic & medicinal chemistry letters (03.11.2003)
Published in Bioorganic & medicinal chemistry letters (03.11.2003)
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Phase II Study of Propylene Glycol-Free Melphalan (Evomela) Combined with Carmustine, Etoposide, and Cytarabine (BEAM) for Myeloablative Conditioning in Lymphoma Patients Undergoing Autologous Stem Cell Transplantation (ASCT)
Cashen, Amanda, MD, Gosch, Kendall, BA, Fletcher, Theresa, MS, Ceriotti, Connie, RN BSN, Ghobadi, Armin, MD, Vij, Ravi, MD, Stockerl-Goldstein, Keith, MD, DiPersio, John F., MD, PhD, Abboud, Camille, MD
Published in Biology of blood and marrow transplantation (01.03.2016)
Published in Biology of blood and marrow transplantation (01.03.2016)
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Phase I Study of Brentuximab Vedotin for the Prevention of Acute GvHD after Unrelated Allogeneic Stem Cell Transplantation
Schroeder, Mark A., MD, Rettig, Michael P., PhD, Willey, Sarah, Fletcher, Theresa, MS, Meier, Stephanie, Wang, Tzu-Fei, MD, Trinkaus, Kathryn, Ph.D, Romee, Rizwan, MD, Ghobadi, Armin, MD, Pusic, Iskra, MD, Abboud, Camille, MD, Stockerl-Goldstein, Keith, MD, Uy, Geoffrey L., MD, Vij, Ravi, MD, Westervelt, Peter, MD, PhD, DiPersio, John F., MD, PhD
Published in Biology of blood and marrow transplantation (01.03.2016)
Published in Biology of blood and marrow transplantation (01.03.2016)
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A Study of Tbo-Filgrastim (Granix) to Disrupt the Bone Marrow Microenvironment in Patients with Multiple Myeloma Undergoing Autologous Stem Cell Transplantation
Jacoby, Meagan, Bera, Reetom, Fletcher, Theresa, Fiala, Mark A., Trinkaus, Kathryn, DiPersio, John F., Stockerl-Goldstein, Keith E., Schroeder, Mark A., Link, Daniel C., Vij, Ravi
Published in Blood (29.11.2018)
Published in Blood (29.11.2018)
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A phase I trial evaluating the effects of plerixafor, G-CSF, and azacitidine for the treatment of myelodysplastic syndromes
Huselton, Eric, Rettig, Michael P., Fletcher, Theresa, Ritchey, Julie, Gehrs, Leah, McFarland, Kyle, Christ, Stephanie, Eades, William C., Trinkaus, Kathryn, Romee, Rizwan, Kulkarni, Shashikant, Ghobadi, Armin, Abboud, Camille, Cashen, Amanda F., Stockerl-Goldstein, Keith, Uy, Geoffrey L., Vij, Ravi, Westervelt, Peter, DiPersio, John F., Schroeder, Mark A.
Published in Leukemia & lymphoma (12.05.2021)
Published in Leukemia & lymphoma (12.05.2021)
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Selinexor in Combination with Cladribine, Cytarabine and G-CSF for Relapsed or Refractory AML
Uy, Geoffrey L., Rettig, Michael P, Fletcher, Theresa, Riedell, Peter A, Stockerl-Goldstein, Keith E., Ghobadi, Armin, Jacoby, Meagan, Cashen, Amanda F., Romee, Rizwan, Pusic, Iskra, Abboud, Camille N., Schroeder, Mark A., Vij, Ravi, Westervelt, Peter, DiPersio, John F
Published in Blood (08.12.2017)
Published in Blood (08.12.2017)
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Phase II Study of Propylene Glycol-Free Melphalan (Evomela) Combined with Carmustine, Etoposide, and Cytarabine (BEAM) for Myeloablative Conditioning in Lymphoma Patients Undergoing Autologous Stem Cell Transplantation
Cashen, Amanda F., Gosch, Kendall, Fletcher, Theresa, Ceriotti, Connie, Ghobadi, Armin, Vij, Ravi, Stockerl-Goldstein, Keith, Dipersio, John F, Abboud, Camille N
Published in Blood (03.12.2015)
Published in Blood (03.12.2015)
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A phase I study of carfilzomib for relapsed or refractory acute myeloid and acute lymphoblastic leukemia
Wartman, Lukas D., Fiala, Mark A., Fletcher, Theresa, Hawkins, Emily R., Cashen, Amanda, DiPersio, John F., Jacoby, Meagan A., Stockerl-Goldstein, Keith E., Pusic, Iskra, Uy, Geoffrey L., Westervelt, Peter, Vij, Ravi
Published in Leukemia & lymphoma (03.03.2016)
Published in Leukemia & lymphoma (03.03.2016)
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A study of high-dose lenalidomide induction and low-dose lenalidomide maintenance therapy for patients with hypomethylating agent refractory myelodysplastic syndrome
Cherian, Mathew A., Tibes, Raoul, Gao, Feng, Fletcher, Theresa, Fiala, Mark, Uy, Geoffrey L., Westervelt, Peter, Jacoby, Meagan A., Cashen, Amanda F., Stockerl-Goldstein, Keith, DiPersio, John F., Vij, Ravi
Published in Leukemia & lymphoma (01.11.2016)
Published in Leukemia & lymphoma (01.11.2016)
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A Phase I Study of Carfilzomib for Relapsed or Refractory Acute Myeloid and Acute Lymphoblastic Leukemia
Wartman, Lukas D., Fiala, Mark A., Hawkins, Emily, Fletcher, Theresa, Allen, Melissa, Cashen, Amanda F., DiPersio, John F., Jacoby, Meagan, Stockerl-Goldstein, Keith E., Pusic, Iskra, Uy, Geoffrey L., Westervelt, Peter, Vij, Ravi
Published in Blood (06.12.2014)
Published in Blood (06.12.2014)
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A Study of High Dose Lenalidomide Induction and Low Dose Lenalidomide Maintenance for Patients with Hypomethylating Agent Refractory MDS
Cherian, Mathew A., Tibes, Raoul, Fletcher, Theresa, Fiala, Mark A., Uy, Geoffrey L., Westervelt, Peter, Stockerl-Goldstein, Keith E., Jacoby, Meagan, Cashen, Amanda F., DiPersio, John F., Vij, Ravi
Published in Blood (06.12.2014)
Published in Blood (06.12.2014)
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Discovery of N -(4-Fluoro-3-methoxybenzyl)-6-(2-(((2 S ,5 R )-5-(hydroxymethyl)-1,4-dioxan-2-yl)methyl)-2 H -tetrazol-5-yl)-2-methylpyrimidine-4-carboxamide. A Highly Selective and Orally Bioavailable Matrix Metalloproteinase-13 Inhibitor for the Potential Treatment of Osteoarthritis
Ruminski, Peter G., Massa, Mark, Strohbach, Joseph, Hanau, Cathleen E., Schmidt, Michelle, Scholten, Jeffrey A., Fletcher, Theresa R., Hamper, Bruce C., Carroll, Jeffery N., Shieh, Huey S., Caspers, Nicole, Collins, Brandon, Grapperhaus, Margaret, Palmquist, Katherine E., Collins, Joe, Baldus, John E., Hitchcock, Jeffrey, Kleine, H. Peter, Rogers, Michael D., McDonald, Joseph, Munie, Grace E., Messing, Dean M., Portolan, Silvia, Whiteley, Laurence O., Sunyer, Teresa, Schnute, Mark E.
Published in Journal of medicinal chemistry (14.01.2016)
Published in Journal of medicinal chemistry (14.01.2016)
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A Phase II Study Of V-BEAM (Bortezomib, Carmustine, Etoposide, Cytarabine, and Melphalan) As Conditioning Regimen Prior To Second Autologous Stem Cell Transplantation For Multiple Myeloma
Wang, Tzu-Fei, Fiala, Mark A., Wu, Ningying, Fletcher, Theresa, Abboud, Camille N., Cashen, Amanda F., Dipersio, John F., Uy, Geoffrey L., Westervelt, Peter, Stockerl-Goldstein, Keith E., Vij, Ravi
Published in Blood (15.11.2013)
Published in Blood (15.11.2013)
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