Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiac hypertrophy
Myers, Robert W., Guan, Hong-Ping, Ehrhart, Juliann, Petrov, Aleksandr, Prahalada, Srinivasa, Tozzo, Effie, Yang, Xiaodong, Kurtz, Marc M., Trujillo, Maria, Trotter, Dinko Gonzalez, Feng, Danqing, Xu, Shiyao, Eiermann, George, Holahan, Marie A., Rubins, Daniel, Conarello, Stacey, Niu, Xiaoda, Souza, Sandra C., Miller, Corin, Liu, Jinqi, Lu, Ku, Feng, Wen, Li, Ying, Painter, Ronald E., Milligan, James A., He, Huaibing, Liu, Franklin, Ogawa, Aimie, Wisniewski, Douglas, Rohm, Rory J., Wang, Liyang, Bunzel, Michelle, Qian, Ying, Zhu, Wei, Wang, Hongwu, Bennet, Bindu, Scheuch, Lisa LaFranco, Fernandez, Guillermo E., Li, Cai, Klimas, Michael, Zhou, Gaochao, van Heek, Margaret, Biftu, Tesfaye, Weber, Ann, Kelley, David E., Thornberry, Nancy, Erion, Mark D., Kemp, Daniel M., Sebhat, Iyassu K.
Published in Science (American Association for the Advancement of Science) (04.08.2017)
Published in Science (American Association for the Advancement of Science) (04.08.2017)
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Omarigliptin (MK-3102): A Novel Long-Acting DPP‑4 Inhibitor for Once-Weekly Treatment of Type 2 Diabetes
Biftu, Tesfaye, Sinha-Roy, Ranabir, Chen, Ping, Qian, Xiaoxia, Feng, Dennis, Kuethe, Jeffrey T, Scapin, Giovanna, Gao, Ying Duo, Yan, Youwei, Krueger, Davida, Bak, Annette, Eiermann, George, He, Jiafang, Cox, Jason, Hicks, Jacqueline, Lyons, Kathy, He, Huaibing, Salituro, Gino, Tong, Sharon, Patel, Sangita, Doss, George, Petrov, Aleksandr, Wu, Joseph, Xu, Shiyao Sherrie, Sewall, Charles, Zhang, Xiaoping, Zhang, Bei, Thornberry, Nancy A, Weber, Ann E
Published in Journal of medicinal chemistry (24.04.2014)
Published in Journal of medicinal chemistry (24.04.2014)
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Discovery of MK-8722: A Systemic, Direct Pan-Activator of AMP-Activated Protein Kinase
Feng, Danqing, Biftu, Tesfaye, Romero, F. Anthony, Kekec, Ahmet, Dropinski, James, Kassick, Andrew, Xu, Shiyao, Kurtz, Marc M, Gollapudi, Anantha, Shao, Qing, Yang, Xiaodong, Lu, Ku, Zhou, Gaochao, Kemp, Daniel, Myers, Robert W, Guan, Hong-Ping, Trujillo, Maria E, Li, Cai, Weber, Ann, Sebhat, Iyassu K
Published in ACS medicinal chemistry letters (11.01.2018)
Published in ACS medicinal chemistry letters (11.01.2018)
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Novel tetrahydropyran analogs as dipeptidyl peptidase IV inhibitors: Profile of clinical candidate (2R,3S,5R)-2-(2,5-difluorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]tetrahydro-2H-pyran-3-amine (23)
Biftu, Tesfaye, Qian, Xiaoxia, Chen, Ping, Feng, Dennis, Scapin, Giovanna, Gao, Ying-Duo, Cox, Jason, Sinha Roy, Ranabir, Eiermann, George, He, Huabing, Lyons, Kathy, Salituro, Gino, Patel, Sangita, Petrov, Alexander, Xu, Feng, Xu, Shiyao Sherrie, Zhang, Bei, Caldwell, Charles, Wu, Joseph K., Weber, Ann E.
Published in Bioorganic & medicinal chemistry letters (01.10.2013)
Published in Bioorganic & medicinal chemistry letters (01.10.2013)
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Structure–activity-relationship of amide and sulfonamide analogs of omarigliptin
Chen, Ping, Feng, Dennis, Qian, Xiaoxia, Apgar, James, Wilkening, Robert, Kuethe, Jeffrey T., Gao, Ying-Duo, Scapin, Giovanna, Cox, Jason, Doss, George, Eiermann, George, He, Huaibing, Li, Xiaohua, Lyons, Kathryn A., Metzger, Joseph, Petrov, Aleksandr, Wu, Joseph K., Xu, Shiyao, Weber, Ann E., Yan, Youwei, Roy, Ranabir Sinha, Biftu, Tesfaye
Published in Bioorganic & medicinal chemistry letters (15.12.2015)
Published in Bioorganic & medicinal chemistry letters (15.12.2015)
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Heterocyclic core analogs of a direct thrombin inhibitor
Blizzard, Timothy A., Singh, Sanjay, Patil, Basanagoud, Chidurala, Naresh, Komanduri, Venukrishnan, Debnath, Samarpita, Belyakov, Sergei, Crespo, Alejandro, Struck, Alice, Kurtz, Marc, Wiltsie, Judyann, Shen, Xun, Sonatore, Lisa, Arocho, Marta, Lewis, Dale, Ogletree, Martin, Biftu, Tesfaye
Published in Bioorganic & medicinal chemistry letters (15.02.2014)
Published in Bioorganic & medicinal chemistry letters (15.02.2014)
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Rational design of a novel, potent, and orally bioavailable cyclohexylamine DPP-4 inhibitor by application of molecular modeling and X-ray crystallography of sitagliptin
Biftu, Tesfaye, Scapin, Giovanna, Singh, Suresh, Feng, Dennis, Becker, Joe W., Eiermann, George, He, Huaibing, Lyons, Kathy, Patel, Sangita, Petrov, Aleksandr, Sinha-Roy, Ranabir, Zhang, Bei, Wu, Joseph, Zhang, Xiaoping, Doss, George A., Thornberry, Nancy A., Weber, Ann E.
Published in Bioorganic & medicinal chemistry letters (15.06.2007)
Published in Bioorganic & medicinal chemistry letters (15.06.2007)
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Dipeptidyl Peptidase IV Inhibition for the Treatment of Type 2 Diabetes
Lankas, George R., Leiting, Barbara, Roy, Ranabir Sinha, Eiermann, George J., Beconi, Maria G., Biftu, Tesfaye, Chan, Chi-Chung, Edmondson, Scott, Feeney, William P., He, Huaibing, Ippolito, Dawn E., Kim, Dooseop, Lyons, Kathryn A., Ok, Hyun O., Patel, Reshma A., Petrov, Aleksandr N., Pryor, Kelly Ann, Qian, Xiaoxia, Reigle, Leah, Woods, Andrea, Wu, Joseph K., Zaller, Dennis, Zhang, Xiaoping, Zhu, Lan, Weber, Ann E., Thornberry, Nancy A.
Published in Diabetes (New York, N.Y.) (01.10.2005)
Published in Diabetes (New York, N.Y.) (01.10.2005)
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Lead Optimization to Advance Protease-Activated Receptor‑1 Antagonists in Early Discovery
Mandal, Mihirbaran, Madeira, Maria, Amin, Rupesh P, Buevich, Alexei V, Cheng, Alan, Labroli, Marc, Liu, Xiaoxiang, Acton, John, Pio, Barbara, Basso, Andrea, Chobanian, Harry, Dong, Grace, Dropinski, Jamie, Guo, Yan, Guo, Zhuyan, Kurowski, Stan, Korfmacher, Walter, Lee, Sandra, Meng, Dongfang, Ondeyka, Debra, Yang, Zhiqiang, Zhang, Rumin, Wei, Huijun, Wu, Zhicai, Zhang, Fengqi, Wollenberg, Gordon, Biftu, Tesfaye, Greenlee, William J, Chintala, Madhu, Maletic, Milana, Zhu, Zhaoning
Published in Journal of medicinal chemistry (14.04.2022)
Published in Journal of medicinal chemistry (14.04.2022)
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Purification and Molecular Characterization of cGMP-dependent Protein Kinase from Apicomplexan Parasites
Gurnett, Anne M., Liberator, Paul A., Dulski, Paula M., Salowe, Scott P., Donald, Robert G.K., Anderson, Jennifer W., Wiltsie, Judyann, Diaz, Carmen A., Harris, Georgiana, Chang, Ben, Darkin-Rattray, Sandra J., Nare, Bakela, Crumley, Tami, Blum, Penny Sue, Misura, Andrew S., Tamas, Tamas, Sardana, Mohinder K., Yuan, Jeffrey, Biftu, Tesfaye, Schmatz, Dennis M.
Published in The Journal of biological chemistry (03.05.2002)
Published in The Journal of biological chemistry (03.05.2002)
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Pharmacological AMPK activation induces transcriptional responses congruent to exercise in skeletal and cardiac muscle, adipose tissues and liver
Muise, Eric S, Guan, Hong-Ping, Liu, Jinqi, Nawrocki, Andrea R, Yang, Xiaodong, Wang, Chuanlin, Rodríguez, Carlos G, Zhou, Dan, Gorski, Judith N, Kurtz, Marc M, Feng, Danqing, Leavitt, Kenneth J, Wei, Lan, Wilkening, Robert R, Apgar, James M, Xu, Shiyao, Lu, Ku, Feng, Wen, Li, Ying, He, Huaibing, Previs, Stephen F, Shen, Xiaolan, van Heek, Margaret, Souza, Sandra C, Rosenbach, Mark J, Biftu, Tesfaye, Erion, Mark D, Kelley, David E, Kemp, Daniel M, Myers, Robert W, Sebhat, Iyassu K
Published in PloS one (27.02.2019)
Published in PloS one (27.02.2019)
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Dipeptidyl peptidase IV inhibition for the treatment of type 2 diabetes : Potential importance of selectivity over dipeptidyl peptidases 8 and 9
LANKAS, George R, LEITING, Barbara, IPPOLITO, Dawn E, KIM, Dooseop, LYONS, Kathryn A, OK, Hyun O, PATEL, Reshma A, PETROV, Aleksandr N, PRYOR, Kelly Ann, XIAOXIA QIAN, REIGLE, Leah, WOODS, Andrea, ROY, Ranabir Sinha, WU, Joseph K, ZALLER, Dennis, XIAOPING ZHANG, LAN ZHU, WEBER, Ann E, THORNBERRY, Nancy A, EIERMANN, George J, BECONI, Maria G, BIFTU, Tesfaye, CHAN, Chi-Chung, EDMONDSON, Scott, FEENEY, William P, HUAIBING HE
Published in Diabetes (New York, N.Y.) (01.10.2005)
Published in Diabetes (New York, N.Y.) (01.10.2005)
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Assessment of Blood Donation Practice and Its Associated Factors Among Wollega University Undergraduate Students, Ethiopia
Shama, Adisu Tafari, Teka, Gemechis, Lemu, Samuel Yohannes, Tesfaye, Biftu, Ebisa, Hawi, Gebre, Dejene Seyoum, Terefa, Dufera Rikitu
Published in Journal of blood medicine (30.11.2022)
Published in Journal of blood medicine (30.11.2022)
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The discovery of novel 5,6,5- and 5,5,6-tricyclic pyrrolidines as potent and selective DPP-4 inhibitors
Cox, Jason M., Chu, Hong D., Kuethe, Jeffrey T., Gao, Ying-Duo, Scapin, Giovanna, Eiermann, George, He, Huaibing, Li, Xiaohua, Lyons, Kathryn A., Metzger, Joseph, Petrov, Aleksandr, Wu, Joseph K., Xu, Shiyao, Sinha-Roy, Ranabir, Weber, Ann E., Biftu, Tesfaye
Published in Bioorganic & medicinal chemistry letters (01.06.2016)
Published in Bioorganic & medicinal chemistry letters (01.06.2016)
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Diminishing GSH-Adduct Formation of Tricyclic Diazepine-based Mutant IDH1 Inhibitors
Huang, Chunhui, Fischer, Christian, Machacek, Michelle R, Bogen, Stephane, Biftu, Tesfaye, Huang, Xianhai, Reutershan, Michael H, Otte, Ryan, Hong, Qingmei, Wu, Zhicai, Yu, Yang, Park, Min, Chen, Lei, Biju, Purakkattle, Knemeyer, Ian, Lu, Ping, Kochansky, Christopher J, Hicks, Michael Brendan, Liu, Yong, Helmy, Roy, Fradera, Xavier, Donofrio, Anthony, Close, Josh, Maddess, Matthew L, White, Catherine, Sloman, David L, Sciammetta, Nunzio, Lu, Jun, Gibeau, Craig, Simov, Vladimir, Zhang, Hongjun, Fuller, Peter, Witter, David
Published in ACS medicinal chemistry letters (14.04.2022)
Published in ACS medicinal chemistry letters (14.04.2022)
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Synthesis and biological activity of anticoccidial agents: 5,6-Diarylimidazo[2,1- b][1,3]thiazoles
Scribner, Andrew, Meitz, Susan, Fisher, Michael, Wyvratt, Matthew, Leavitt, Penny, Liberator, Paul, Gurnett, Anne, Brown, Chris, Mathew, John, Thompson, Donald, Schmatz, Dennis, Biftu, Tesfaye
Published in Bioorganic & medicinal chemistry (01.10.2008)
Published in Bioorganic & medicinal chemistry (01.10.2008)
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NOVEL CRYSTALLINE FORM OF DIPEPTIDYL PEPTIDASE-IV INHIBITOR
ITZIA ARROYO, CHEN PING, TESFAYE BIFTU, FAYE SHEEN, DAVIDA KRUEGER, AARON MOMENT, ZHANG YANFENG
Year of Publication 26.07.2018
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Year of Publication 26.07.2018
Patent
(±)-Trans-2-(3-methoxy-5-methylsulfonyl-4-propoxyphenyl)-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran (L-659,989), a novel, potent PAF receptor antagonist
Ponpipom, Mitree M., Hwang, San-Bao, Doebber, Thomas W., Acton, John J., Alberts, Alfred W., Biftu, Tesfaye, Brooker, David R., Bugianesi, Robert L., Chabala, John C., Gamble, Nancy L., Graham, Donald W., Lam, My-Hanh, Wu, Margaret S.
Published in Biochemical and biophysical research communications (15.02.1988)
Published in Biochemical and biophysical research communications (15.02.1988)
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