Synthesis of Novel Farnesoid X Receptor Agonists and Validation of Their Efficacy in Activating Differentiation of Mouse Bone Marrow-Derived Mesenchymal Stem Cells into Osteoblasts
Fujimori, Ko, Iguchi, Yusuke, Yamashita, Yukiko, Gohda, Keigo, Teno, Naoki
Published in Molecules (Basel, Switzerland) (16.11.2019)
Published in Molecules (Basel, Switzerland) (16.11.2019)
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Journal Article
FXR Antagonist FLG249 Lowers Hepatic Triacylglycerol and Serum Cholesterol Level in High-Fat Diet-Induced Obese Mice
Iguchi, Yusuke, Yamashita, Yukiko, Gohda, Keigo, Oda, Keisuke, Fujimori, Ko, Sera, Yukihiro, Imanaka, Tsuneo, Yamaguchi, Masafumi, Une, Mizuho, Teno, Naoki
Published in Biological & pharmaceutical bulletin (13.08.2024)
Published in Biological & pharmaceutical bulletin (13.08.2024)
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Design and identification of a new farnesoid X receptor (FXR) partial agonist by computational structure–activity relationship analysis: Ligand-induced H8 helix fluctuation in the ligand-binding domain of FXR may lead to partial agonism
Gohda, Keigo, Iguchi, Yusuke, Masuda, Arisa, Fujimori, Ko, Yamashita, Yukiko, Teno, Naoki
Published in Bioorganic & medicinal chemistry letters (01.06.2021)
Published in Bioorganic & medicinal chemistry letters (01.06.2021)
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Journal Article
Active site-directed plasmin inhibitors: Extension on the P2 residue
Hidaka, Koushi, Gohda, Keigo, Teno, Naoki, Wanaka, Keiko, Tsuda, Yuko
Published in Bioorganic & medicinal chemistry (15.02.2016)
Published in Bioorganic & medicinal chemistry (15.02.2016)
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Journal Article
Identification of potent farnesoid X receptor (FXR) antagonist showing favorable PK profile and distribution toward target tissues: Comprehensive understanding of structure-activity relationship of FXR antagonists
Teno, Naoki, Yamashita, Yukiko, Masuda, Arisa, Iguchi, Yusuke, Oda, Keisuke, Fujimori, Ko, Hiramoto, Takie, Nishimaki-Mogami, Tomoko, Une, Mizuho, Gohda, Keigo
Published in Bioorganic & medicinal chemistry (01.06.2019)
Published in Bioorganic & medicinal chemistry (01.06.2019)
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Journal Article
Discovery and optimization of benzimidazole derivatives as a novel chemotype of farnesoid X receptor (FXR) antagonists
Teno, Naoki, Iguchi, Yusuke, Yamashita, Yukiko, Mori, Nobuhiro, Une, Mizuho, Nishimaki-Mogami, Tomoko, Gohda, Keigo
Published in Bioorganic & medicinal chemistry (15.03.2017)
Published in Bioorganic & medicinal chemistry (15.03.2017)
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Journal Article
Nonacidic Chemotype Possessing N‑Acylated Piperidine Moiety as Potent Farnesoid X Receptor (FXR) Antagonists
Teno, Naoki, Yamashita, Yukiko, Iguchi, Yusuke, Fujimori, Ko, Une, Mizuho, Nishimaki-Mogami, Tomoko, Hiramoto, Takie, Gohda, Keigo
Published in ACS medicinal chemistry letters (08.02.2018)
Published in ACS medicinal chemistry letters (08.02.2018)
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Journal Article
Identification of novel plasmin inhibitors possessing nitrile moiety as warhead
Teno, Naoki, Gohda, Keigo, Wanaka, Keiko, Sueda, Takuya, Tsuda, Yuko
Published in Bioorganic & medicinal chemistry letters (01.11.2011)
Published in Bioorganic & medicinal chemistry letters (01.11.2011)
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Journal Article
Effect of Cathepsin K Inhibitors on Bone Resorption
Teno, Naoki, Masuya, Keiichi, Ehara, Takeru, Kosaka, Takatoshi, Miyake, Takahiro, Irie, Osamu, Hitomi, Yuko, Matsuura, Naoko, Umemura, Ichiro, Iwasaki, Genji, Fukaya, Hiroaki, Toriyama, Kazuhiro, Uchiyama, Noriko, Nonomura, Kazuhiko, Sugiyama, Ikuo, Kometani, Motohiko
Published in Journal of medicinal chemistry (11.09.2008)
Published in Journal of medicinal chemistry (11.09.2008)
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Journal Article
Species Differences Between Human and Rat in the Substrate Specificity of Cathepsin K
Tada, Sachiyo, Tsutsumi, Kae, Ishihara, Hideki, Suzuki, Kenji, Gohda, Keigo, Teno, Naoki
Published in Journal of biochemistry (Tokyo) (01.10.2008)
Published in Journal of biochemistry (Tokyo) (01.10.2008)
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Journal Article
Discovery of FXR/PPAR? dual partial agonist
Yamashita, Yukiko, Gohda, Keigo, Iguchi, Yusuke, Fujimori, Ko, Oda, Keisuke, Masuda, Arisa, Une, Mizuho, Teno, Naoki
Published in Bioorganic & medicinal chemistry (01.05.2023)
Published in Bioorganic & medicinal chemistry (01.05.2023)
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Journal Article
Discovery of FXR/PPARγ dual partial agonist
Yamashita, Yukiko, Gohda, Keigo, Iguchi, Yusuke, Fujimori, Ko, Oda, Keisuke, Masuda, Arisa, Une, Mizuho, Teno, Naoki
Published in Bioorganic & medicinal chemistry (01.05.2023)
Published in Bioorganic & medicinal chemistry (01.05.2023)
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Journal Article
N-1-Substituted benzimidazole scaffold for farnesoid X receptor (FXR) agonists accompanying prominent selectivity against vitamin D receptor (VDR)
Masuda, Arisa, Gohda, Keigo, Iguchi, Yusuke, Fujimori, Ko, Yamashita, Yukiko, Oda, Keisuke, Une, Mizuho, Teno, Naoki
Published in Bioorganic & medicinal chemistry (15.07.2020)
Published in Bioorganic & medicinal chemistry (15.07.2020)
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Journal Article
N1-Substituted benzimidazole scaffold for farnesoid X receptor (FXR) agonists accompanying prominent selectivity against vitamin D receptor (VDR)
Masuda, Arisa, Gohda, Keigo, Iguchi, Yusuke, Fujimori, Ko, Yamashita, Yukiko, Oda, Keisuke, Une, Mizuho, Teno, Naoki
Published in Bioorganic & medicinal chemistry (15.07.2020)
Published in Bioorganic & medicinal chemistry (15.07.2020)
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Journal Article
Discovery of Orally Active and Nonsteroidal Farnesoid X Receptor (FXR) Antagonist with Propensity for Accumulation and Responsiveness in Ileum
Teno, Naoki, Iguchi, Yusuke, Oda, Keisuke, Yamashita, Yukiko, Masuda, Arisa, Fujimori, Ko, Une, Mizuho, Gohda, Keigo
Published in ACS medicinal chemistry letters (11.03.2021)
Published in ACS medicinal chemistry letters (11.03.2021)
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Journal Article
Plasmin inhibitors with hydrophobic amino acid-based linker between hydantoin moiety and benzimidazole scaffold enhance inhibitory activity
Teno, Naoki, Gohda, Keigo, Yamashita, Yukiko, Otsubo, Tadamune, Yamaguchi, Masafumi, Wanaka, Keiko, Tsuda, Yuko
Published in Bioorganic & medicinal chemistry letters (01.05.2016)
Published in Bioorganic & medicinal chemistry letters (01.05.2016)
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