Nelotanserin, a Novel Selective Human 5-Hydroxytryptamine2A Inverse Agonist for the Treatment of Insomnia
Al-Shamma, Hussien A, Anderson, Christen, Chuang, Emil, Luthringer, Remy, Grottick, Andrew J, Hauser, Erin, Morgan, Michael, Shanahan, William, Teegarden, Bradley R, Thomsen, William J, Behan, Dominic
Published in The Journal of pharmacology and experimental therapeutics (01.01.2010)
Published in The Journal of pharmacology and experimental therapeutics (01.01.2010)
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APD791, 3-Methoxy-N-(3-(1-methyl-1H-pyrazol-5-yl)-4-(2-morpholinoethoxy)phenyl)benzamide, a Novel 5-Hydroxytryptamine 2A Receptor Antagonist: Pharmacological Profile, Pharmacokinetics, Platelet Activity and Vascular Biology
Adams, John W, Ramirez, Juan, Shi, Yunqing, Thomsen, William, Frazer, John, Morgan, Michael, Edwards, Jeffrey E, Chen, Weichao, Teegarden, Bradley R, Xiong, Yifeng, Al-Shamma, Hussien, Behan, Dominic P, Connolly, Daniel T
Published in The Journal of pharmacology and experimental therapeutics (01.10.2009)
Published in The Journal of pharmacology and experimental therapeutics (01.10.2009)
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Synthesis and in Vivo Evaluation of Phenethylpiperazine Amides: Selective 5-Hydroxytryptamine(2A) Receptor Antagonists for the Treatment of Insomnia
Xiong, Yifeng, Ullman, Brett, Choi, Jin-Sun Karoline, Cherrier, Martin, Strah-Pleynet, Sonja, Decaire, Marc, Dosa, Peter I., Feichtinger, Konrad, Teegarden, Bradley R., Frazer, John M., Yoon, Woo H., Shan, Yun, Whelan, Kevin, Hauser, Erin K., Grottick, Andrew J., Semple, Graeme, Al-Shamma, Hussien
Published in Journal of medicinal chemistry (12.08.2010)
Published in Journal of medicinal chemistry (12.08.2010)
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Journal Article
Discovery and Structure−Activity Relationship of 3-Methoxy-N-(3-(1-methyl-1H-pyrazol-5-yl)-4-(2-morpholinoethoxy)phenyl)benzamide (APD791): A Highly Selective 5-Hydroxytryptamine2A Receptor Inverse Agonist for the Treatment of Arterial Thrombosis
Xiong, Yifeng, Teegarden, Bradley R, Choi, Jin-Sun Karoline, Strah-Pleynet, Sonja, Decaire, Marc, Jayakumar, Honnappa, Dosa, Peter I, Casper, Martin D, Pham, Lan, Feichtinger, Konrad, Ullman, Brett, Adams, John, Yuskin, Diane, Frazer, John, Morgan, Michael, Sadeque, Abu, Chen, Weichao, Webb, Robert R, Connolly, Daniel T, Semple, Graeme, Al-Shamma, Hussien
Published in Journal of medicinal chemistry (10.06.2010)
Published in Journal of medicinal chemistry (10.06.2010)
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Anti-thrombotic and vascular effects of AR246686, a novel 5-HT2A receptor antagonist
ADAMS, John W, RAMIREZ, Juan, BEHAN, Dominic P, CONNOLLY, Daniel T, ORTUNO, Danny, YUNQING SHI, THOMSEN, William, RICHMAN, Jeremy G, MORGAN, Michael, DOSA, Peter, TEEGARDEN, Bradley R, AL-SHAMMA, Hussien
Published in European journal of pharmacology (31.05.2008)
Published in European journal of pharmacology (31.05.2008)
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Journal Article
Synthesis and in Vivo Evaluation of Phenethylpiperazine Amides: Selective 5-Hydroxytryptamine2A Receptor Antagonists for the Treatment of Insomnia
Xiong, Yifeng, Ullman, Brett, Choi, Jin-Sun Karoline, Cherrier, Martin, Strah-Pleynet, Sonja, Decaire, Marc, Dosa, Peter I, Feichtinger, Konrad, Teegarden, Bradley R, Frazer, John M, Yoon, Woo H, Shan, Yun, Whelan, Kevin, Hauser, Erin K, Grottick, Andrew J, Semple, Graeme, Al-Shamma, Hussien
Published in Journal of medicinal chemistry (12.08.2010)
Published in Journal of medicinal chemistry (12.08.2010)
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Solubilized phenyl-pyrazole ureas as potent, selective 5-HT2A inverse-agonists and their application as antiplatelet agents
DOSA, Peter I, STRAH-PLEYNET, Sonja, WEBB, Robert R, ADAMS, John W, RAMIREZ, Juan, RICHMAN, Jeremy G, THOMSEN, William, SEMPLE, Graeme, TEEGARDEN, Bradley R, JAYAKUMAR, Honnappa, CASPER, Martin, DECAIRE, Marc, YIFENG XIONG, LEHMANN, Juerg, CHOI, Karoline, ELWELL, Katie, WONG, Amy
Published in Bioorganic & medicinal chemistry letters (15.09.2009)
Published in Bioorganic & medicinal chemistry letters (15.09.2009)
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Synthesis and SAR of N-benzoyl-L-biphenylalanine derivatives: Discovery of TR-14035, a dual α4β7/α4β1 integrin antagonist
SIRCAR, Ila, GUDMUNDSSON, Kristjan S, CONNELL, Samuel, GRIFFITH, Ronald C, LAZARIDES, Elias, MARTIN, Richard, LIANG, Jimmy, NOMURA, Sumihiro, JAYAKUMAR, Honnappa, TEEGARDEN, Bradley R, NOWLIN, Dawn M, CARDARELLI, Pina M, MAH, Jason R
Published in Bioorganic & medicinal chemistry (2002)
Published in Bioorganic & medicinal chemistry (2002)
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Vancomycin and ristocetin models: synthesis via the Ullmann macrocyclization reaction
Boger, Dale L, Nomoto, Yuji, Teegarden, Bradley R
Published in Journal of organic chemistry (01.03.1993)
Published in Journal of organic chemistry (01.03.1993)
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S-Adenosyl-l-homocysteine Hydrolase Inhibitor Mediates Immunosuppressive Effects in Vivo: Suppression of Delayed Type Hypersensitivity Ear Swelling and Peptidoglycan Polysaccharide-Induced Arthritis
Saso, Y, Conner, E M, Teegarden, B R, Yuan, C S
Published in The Journal of pharmacology and experimental therapeutics (01.01.2001)
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Published in The Journal of pharmacology and experimental therapeutics (01.01.2001)
Journal Article
p-Quinonemethide Analog of the CC-1065 and Duocarmycin Alkylation Subunits
Boger, Dale L, Nishi, Takahide, Teegarden, Bradley R
Published in Journal of organic chemistry (01.08.1994)
Published in Journal of organic chemistry (01.08.1994)
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Journal Article
Discovery of 1-[3-(4-Bromo-2-methyl-2 H -pyrazol-3-yl)-4-methoxyphenyl]-3-(2,4-difluorophenyl)urea (Nelotanserin) and Related 5-Hydroxytryptamine 2A Inverse Agonists for the Treatment of Insomnia
Teegarden, Bradley R., Li, Hongmei, Jayakumar, Honnappa, Strah-Pleynet, Sonja, Dosa, Peter I., Selaya, Susan D., Kato, Naomi, Elwell, Katie H., Davidson, Jarrod, Cheng, Karen, Saldana, Hazel, Frazer, John M., Whelan, Kevin, Foster, Jonathan, Espitia, Stephan, Webb, Robert R., Beeley, Nigel R. A., Thomsen, William, Morairty, Stephen R., Kilduff, Thomas S., Al-Shamma, Hussien A.
Published in Journal of medicinal chemistry (11.03.2010)
Published in Journal of medicinal chemistry (11.03.2010)
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Journal Article
Discovery and Structure-Activity Relationship of 3-Methoxy-N-(3-(1-methyl-1H-pyrazol-5-yl)-4-(2-morpholinoethoxy)phenyl)benzamide (APD791): A Highly Selective 5-Hydroxytryptamine(2A) Receptor Inverse Agonist for the Treatment of Arterial Thrombosis
Xiong, Yifeng, Teegarden, Bradley R., Choi, Jin-Sun Karoline, Strah-Pleynet, Sonja, Decaire, Marc, Jayakumar, Honnappa, Dosa, Peter I., Casper, Martin D., Pham, Lan, Feichtinger, Konrad, Ullman, Brett, Adams, John, Yuskin, Diane, Frazer, John, Morgan, Michael, Sadeque, Abu, Chen, Weichao, Webb, Robert R., Connolly, Daniel T., Semple, Graeme, Al-Shamma, Hussien
Published in Journal of medicinal chemistry (10.06.2010)
Published in Journal of medicinal chemistry (10.06.2010)
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Journal Article
Nelotanserin, a Novel Selective Human 5-Hydroxytryptamine 2A Inverse Agonist for the Treatment of Insomnia
Al-Shamma, Hussien A., Anderson, Christen, Chuang, Emil, Luthringer, Remy, Grottick, Andrew J., Hauser, Erin, Morgan, Michael, Shanahan, William, Teegarden, Bradley R., Thomsen, William J., Behan, Dominic
Published in The Journal of pharmacology and experimental therapeutics (01.01.2010)
Published in The Journal of pharmacology and experimental therapeutics (01.01.2010)
Get full text
Journal Article
Synthesis and in Vivo Evaluation of Phenethylpiperazine Amides: Selective 5-Hydroxytryptamine 2A Receptor Antagonists for the Treatment of Insomnia
Xiong, Yifeng, Ullman, Brett, Choi, Jin-Sun Karoline, Cherrier, Martin, Strah-Pleynet, Sonja, Decaire, Marc, Dosa, Peter I., Feichtinger, Konrad, Teegarden, Bradley R., Frazer, John M., Yoon, Woo H., Shan, Yun, Whelan, Kevin, Hauser, Erin K., Grottick, Andrew J., Semple, Graeme, Al-Shamma, Hussien
Published in Journal of medicinal chemistry (12.08.2010)
Published in Journal of medicinal chemistry (12.08.2010)
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Journal Article
Discovery and Structure−Activity Relationship of 3-Methoxy- N -(3-(1-methyl-1 H -pyrazol-5-yl)-4-(2-morpholinoethoxy)phenyl)benzamide (APD791): A Highly Selective 5-Hydroxytryptamine 2A Receptor Inverse Agonist for the Treatment of Arterial Thrombosis
Xiong, Yifeng, Teegarden, Bradley R., Choi, Jin-Sun Karoline, Strah-Pleynet, Sonja, Decaire, Marc, Jayakumar, Honnappa, Dosa, Peter I., Casper, Martin D., Pham, Lan, Feichtinger, Konrad, Ullman, Brett, Adams, John, Yuskin, Diane, Frazer, John, Morgan, Michael, Sadeque, Abu, Chen, Weichao, Webb, Robert R., Connolly, Daniel T., Semple, Graeme, Al-Shamma, Hussien
Published in Journal of medicinal chemistry (10.06.2010)
Published in Journal of medicinal chemistry (10.06.2010)
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Journal Article
Discovery of 1-[3-(4-Bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxyphenyl]-3-(2,4-difluorophenyl)urea (Nelotanserin) and Related 5-Hydroxytryptamine2A Inverse Agonists for the Treatment of Insomnia
Teegarden, Bradley R, Li, Hongmei, Jayakumar, Honnappa, Strah-Pleynet, Sonja, Dosa, Peter I, Selaya, Susan D, Kato, Naomi, Elwell, Katie H, Davidson, Jarrod, Cheng, Karen, Saldana, Hazel, Frazer, John M, Whelan, Kevin, Foster, Jonathan, Espitia, Stephan, Webb, Robert R, Beeley, Nigel R. A, Thomsen, William, Morairty, Stephen R, Kilduff, Thomas S, Al-Shamma, Hussien A
Published in Journal of medicinal chemistry (11.03.2010)
Published in Journal of medicinal chemistry (11.03.2010)
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Journal Article
Solubilized phenyl-pyrazole ureas as potent, selective 5-HT sub(2A) inverse-agonists and their application as antiplatelet agents
Dosa, Peter I, Strah-Pleynet, Sonja, Jayakumar, Honnappa, Casper, Martin, Decaire, Marc, Xiong, Yifeng, Lehmann, Juerg, Choi, Karoline, Elwell, Katie, Wong, Amy, Webb, Robert R, Adams, John W, Ramirez, Juan, Richman, Jeremy G, Thomsen, William, Semple, Graeme, Teegarden, Bradley R
Published in Bioorganic & medicinal chemistry letters (15.09.2009)
Published in Bioorganic & medicinal chemistry letters (15.09.2009)
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Journal Article