4-Substituted cyclohexyl sulfones as potent, orally active γ-secretase inhibitors
Churcher, Ian, Beher, Dirk, Best, Jonathan D., Castro, José L., Clarke, Earl E., Gentry, Amy, Harrison, Timothy, Hitzel, Laure, Kay, Euan, Kerrad, Sonia, Lewis, Huw D., Morentin-Gutierrez, Pablo, Mortishire-Smith, Russell, Oakley, Paul J., Reilly, Michael, Shaw, Duncan E., Shearman, Mark S., Teall, Martin R., Williams, Susie, Wrigley, Jonathan D.J.
Published in Bioorganic & medicinal chemistry letters (15.01.2006)
Published in Bioorganic & medicinal chemistry letters (15.01.2006)
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A new series of potent benzodiazepine γ-secretase inhibitors
Churcher, Ian, Ashton, Kate, Butcher, John W., Clarke, Earl E., Harrison, Timothy, Lewis, Huw D., Owens, Andrew P., Teall, Martin R., Williams, Susie, Wrigley, Jonathan D.J.
Published in Bioorganic & medicinal chemistry letters (20.01.2003)
Published in Bioorganic & medicinal chemistry letters (20.01.2003)
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Discovery and Characterization of Novel CNS-Penetrant GPR55 Agonists
Hewer, Richard C., Christie, Louisa A., Doyle, Kevin J., Xu, Xiao, Roberts, Maxine J., Dickson, Louise, Cheung, Toni, Cadwalladr, David H., Pickford, Philip, Teall, Martin, Powell, Justin A. C., Sheardown, Steven, Narayana, Lakshminarayana, Brice, Nicola L., Dawson, Lee A., Carlton, Mark, Bürli, Roland W.
Published in Journal of medicinal chemistry (28.09.2023)
Published in Journal of medicinal chemistry (28.09.2023)
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Discovery of CVN417, a Novel Brain-Penetrant α6-Containing Nicotinic Receptor Antagonist for the Modulation of Motor Dysfunction
Christie, Louisa A., Brice, Nicola L., Rowland, Anna, Dickson, Louise, Anand, Rishi, Teall, Martin, Doyle, Kevin J., Narayana, Lakshminarayana, Mitchell, Christine, Harvey, Jenna R. M., Mulligan, Victoria, Dawson, Lee A., Cragg, Stephanie J., Carlton, Mark, Bürli, Roland W.
Published in Journal of medicinal chemistry (14.09.2023)
Published in Journal of medicinal chemistry (14.09.2023)
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Characterisation of C101248: A novel selective THIK-1 channel inhibitor for the modulation of microglial NLRP3-inflammasome
Ossola, Bernardino, Rifat, Ali, Rowland, Anna, Hunter, Helen, Drinkall, Samuel, Bender, Clare, Hamlischer, Mayida, Teall, Martin, Burley, Russell, Barker, Daneil F., Cadwalladr, David, Dickson, Louise, Lawrence, Jason M.K., Harvey, Jenna R.M., Lizio, Marina, Xu, Xiao, Kavanagh, Edel, Cheung, Toni, Sheardown, Steve, Lawrence, Catherine B., Harte, Michael, Brough, David, Madry, Christian, Matthews, Kim, Doyle, Kevin, Page, Keith, Powell, Justin, Brice, Nicola L., Bürli, Roland W., Carlton, Mark B., Dawson, Lee A.
Published in Neuropharmacology (15.02.2023)
Published in Neuropharmacology (15.02.2023)
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Synthesis and SAR of novel GPR39 agonists and positive allosteric modulators
Burley, Russell, Hewer, Richard C., Teall, Martin, Dickson, Louise, Ossola, Bernardino, Russell, Sam, Bender, Clare, Cheung, Toni, Powell, Justin A.C., Xu, Xiao, Brice, Nicola L., Otter, Lucy, Arimont, Marta, Kidd, Sarah L., Vidal, David, Dale, James W., Mervin, Lewis, Sore, Hannah F., Mateu, Natalia, Lakshminarayana, Narayana, Dawson, Lee A., Carlton, Mark, Bürli, Roland W.
Published in Bioorganic & medicinal chemistry letters (01.04.2022)
Published in Bioorganic & medicinal chemistry letters (01.04.2022)
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Discovery of CVN293, a Brain Permeable KCNK13 (THIK-1) Inhibitor Suitable for Clinical Assessment
Bürli, Roland W., Doyle, Kevin J., Dickson, Louise, Rowland, Anna, Matthews, Kim, Stott, Andrew J., Teall, Martin, Ossola, Bernardino, Russell, Samuel G., Harvey, Jenna R. M., Wu, Yiming, Narayana, Lakshminarayana, Brice, Nicola L., Carlton, Mark, Dawson, Lee A.
Published in ACS medicinal chemistry letters (09.05.2024)
Published in ACS medicinal chemistry letters (09.05.2024)
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Discovery of CVN636: A Highly Potent, Selective, and CNS Penetrant mGluR7 Allosteric Agonist
Dickson, Louise, Teall, Martin, Chevalier, Elodie, Cheung, Toni, Liwicki, Gemma M., Mack, Stephen, Stephenson, Anne, White, Kathryn, Fosbeary, Richard, Harrison, David C., Brice, Nicola L., Doyle, Kevin, Ciccocioppo, Roberto, Wu, Chaobo, Almond, Sarah, Patel, Toshal R., Mitchell, Philip, Barnes, Matt, Ayscough, Andrew P., Dawson, Lee A., Carlton, Mark, Bürli, Roland W.
Published in ACS medicinal chemistry letters (13.04.2023)
Published in ACS medicinal chemistry letters (13.04.2023)
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Novel TRPM8 antagonist attenuates cold hypersensitivity after peripheral nerve injury in rats
Patel, Ryan, Gonçalves, Leonor, Newman, Robert, Jiang, Feng Li, Goldby, Anne, Reeve, Jennifer, Hendrick, Alan, Teall, Martin, Hannah, Duncan, Almond, Sarah, Brice, Nicola, Dickenson, Anthony H
Published in The Journal of pharmacology and experimental therapeutics (01.04.2014)
Published in The Journal of pharmacology and experimental therapeutics (01.04.2014)
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Discovery of CVN636 : A Highly Potent, Selective, and CNS Penetrant mGluR 7 Allosteric Agonist
Dickson, Louise, Teall, Martin, Chevalier, Elodie, Cheung, Toni, Liwicki, Gemma M, Mack, Stephen, Stephenson, Anne, White, Kathryn, Fosbeary, Richard, Harrison, David C, Brice, Nicola L, Doyle, Kevin, Ciccocioppo, Roberto, Wu, Chaobo, Almond, Sarah, Patel, Toshal R, Mitchell, Philip, Barnes, Matt, Ayscough, Andrew P, Dawson, Lee A, Carlton, Mark, Bürli, Roland W
Published in ACS medicinal chemistry letters (13.04.2023)
Published in ACS medicinal chemistry letters (13.04.2023)
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Aryl sulfones: a new class of γ-secretase inhibitors
Teall, Martin, Oakley, Paul, Harrison, Timothy, Shaw, Duncan, Kay, Euan, Elliott, Jason, Gerhard, Ute, Castro, José L., Shearman, Mark, Ball, Richard G., Tsou, Nancy N.
Published in Bioorganic & medicinal chemistry letters (16.05.2005)
Published in Bioorganic & medicinal chemistry letters (16.05.2005)
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