Integration of Alzheimer’s disease genetics and myeloid genomics identifies disease risk regulatory elements and genes
Novikova, Gloriia, Kapoor, Manav, TCW, Julia, Abud, Edsel M., Efthymiou, Anastasia G., Chen, Steven X., Cheng, Haoxiang, Fullard, John F., Bendl, Jaroslav, Liu, Yiyuan, Roussos, Panos, Björkegren, Johan LM, Liu, Yunlong, Poon, Wayne W., Hao, Ke, Marcora, Edoardo, Goate, Alison M.
Published in Nature communications (12.03.2021)
Published in Nature communications (12.03.2021)
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Journal Article
APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline
Montagne, Axel, Nation, Daniel A., Sagare, Abhay P., Barisano, Giuseppe, Sweeney, Melanie D., Chakhoyan, Ararat, Pachicano, Maricarmen, Joe, Elizabeth, Nelson, Amy R., D’Orazio, Lina M., Buennagel, David P., Harrington, Michael G., Benzinger, Tammie L. S., Fagan, Anne M., Ringman, John M., Schneider, Lon S., Morris, John C., Reiman, Eric M., Caselli, Richard J., Chui, Helena C., TCW, Julia, Chen, Yining, Pa, Judy, Conti, Peter S., Law, Meng, Toga, Arthur W., Zlokovic, Berislav V.
Published in Nature (London) (01.05.2020)
Published in Nature (London) (01.05.2020)
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Journal Article
CRISPRi screens in human iPSC-derived astrocytes elucidate regulators of distinct inflammatory reactive states
Leng, Kun, Rose, Indigo V. L., Kim, Hyosung, Xia, Wenlong, Romero-Fernandez, Wilber, Rooney, Brendan, Koontz, Mark, Li, Emmy, Ao, Yan, Wang, Shinong, Krawczyk, Mitchell, TCW, Julia, Goate, Alison, Zhang, Ye, Ullian, Erik M., Sofroniew, Michael V., Fancy, Stephen P. J., Schrag, Matthew S., Lippmann, Ethan S., Kampmann, Martin
Published in Nature neuroscience (01.11.2022)
Published in Nature neuroscience (01.11.2022)
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Journal Article
Cholesterol and matrisome pathways dysregulated in astrocytes and microglia
Tcw, Julia, Qian, Lu, Pipalia, Nina H, Chao, Michael J, Liang, Shuang A, Shi, Yang, Jain, Bharat R, Bertelsen, Sarah E, Kapoor, Manav, Marcora, Edoardo, Sikora, Elizabeth, Andrews, Elizabeth J, Martini, Alessandra C, Karch, Celeste M, Head, Elizabeth, Holtzman, David M, Zhang, Bin, Wang, Minghui, Maxfield, Frederick R, Poon, Wayne W, Goate, Alison M
Published in Cell (23.06.2022)
Published in Cell (23.06.2022)
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Journal Article
Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen
Xu, Miao, Lee, Emily M, Wen, Zhexing, Cheng, Yichen, Huang, Wei-Kai, Qian, Xuyu, TCW, Julia, Kouznetsova, Jennifer, Ogden, Sarah C, Hammack, Christy, Jacob, Fadi, Nguyen, Ha Nam, Itkin, Misha, Hanna, Catherine, Shinn, Paul, Allen, Chase, Michael, Samuel G, Simeonov, Anton, Huang, Wenwei, Christian, Kimberly M, Goate, Alison, Brennand, Kristen J, Huang, Ruili, Xia, Menghang, Ming, Guo-li, Zheng, Wei, Song, Hongjun, Tang, Hengli
Published in Nature medicine (01.10.2016)
Published in Nature medicine (01.10.2016)
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Journal Article
MicroRNA-195 rescues ApoE4-induced cognitive deficits and lysosomal defects in Alzheimer’s disease pathogenesis
Cao, Jiqing, Huang, Min, Guo, Lei, Zhu, Li, Hou, Jianwei, Zhang, Larry, Pero, Adriana, Ng, Sabrina, El Gaamouch, Farida, Elder, Gregory, Sano, Mary, Goate, Alison, TCW, Julia, Haroutunian, Vahram, Zhang, Bin, Cai, Dongming
Published in Molecular psychiatry (01.09.2021)
Published in Molecular psychiatry (01.09.2021)
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Journal Article
An Efficient Platform for Astrocyte Differentiation from Human Induced Pluripotent Stem Cells
TCW, Julia, Wang, Minghui, Pimenova, Anna A., Bowles, Kathryn R., Hartley, Brigham J., Lacin, Emre, Machlovi, Saima I., Abdelaal, Rawan, Karch, Celeste M., Phatnani, Hemali, Slesinger, Paul A., Zhang, Bin, Goate, Alison M., Brennand, Kristen J.
Published in Stem cell reports (08.08.2017)
Published in Stem cell reports (08.08.2017)
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Journal Article
Human iPSC-derived astrocytes transplanted into the mouse brain undergo morphological changes in response to amyloid-β plaques
Preman, Pranav, Tcw, Julia, Calafate, Sara, Snellinx, An, Alfonso-Triguero, Maria, Corthout, Nikky, Munck, Sebastian, Thal, Dietmar Rudolf, Goate, Alison M, De Strooper, Bart, Arranz, Amaia M
Published in Molecular neurodegeneration (25.09.2021)
Published in Molecular neurodegeneration (25.09.2021)
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Journal Article
MicroRNA-195 rescues AD-associated lysosomal defects
Cao, Jiqing, Huang, Min, Guo, Lei, Zhu, Li, Hou, Jianwei, Zhang, Larry, Pero, Adriana, Ng, Sabrina, Gaamouch, Farida El, Elder, Gregory, Sano, Mary, Goate, Alison, TCW, Julia, Haroutunian, Vahram, Zhang, Bin, Cai, Dongming
Published in Molecular psychiatry (01.09.2021)
Published in Molecular psychiatry (01.09.2021)
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Journal Article
Notch inhibition allows oncogene-independent generation of iPS cells
Ichida, Justin K, TCW, Julia, Williams, Luis A, Carter, Ava C, Shi, Yingxiao, Moura, Marcelo T, Ziller, Michael, Singh, Sean, Amabile, Giovanni, Bock, Christoph, Umezawa, Akihiro, Rubin, Lee L, Bradner, James E, Akutsu, Hidenori, Meissner, Alexander, Eggan, Kevin
Published in Nature chemical biology (01.08.2014)
Published in Nature chemical biology (01.08.2014)
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Journal Article
APOE3 AND APOE4 HIPSC-DERIVED ASTROCYTES DIFFERENTIALLY CONTRIBUTE TO ALZHEIMER’S PATHOLOGY IN CHIMERIC MICE
Cruz-Sesé, Joan, Alfonso-Triguero, María, Olano-Bringas, Jon, Ruiz, Leire, Galbis, Nuria, Preman, Pranav, Snellinx, An, Tcw, Julia, Alberdi, Elena, Goate, Alison, De Strooper, Bart, Arranz, Amaia Mendiguren
Published in IBRO neuroscience reports (01.10.2023)
Published in IBRO neuroscience reports (01.10.2023)
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Journal Article
Divergent Levels of Marker Chromosomes in an hiPSC-Based Model of Psychosis
TCW, Julia, Carvalho, Claudia M.B., Yuan, Bo, Gu, Shen, Altheimer, Alyssa N., McCarthy, Shane, Malhotra, Dheeraj, Sebat, Jonathan, Siegel, Arthur J., Rudolph, Uwe, Lupski, James R., Levy, Deborah L., Brennand, Kristen J.
Published in Stem cell reports (14.03.2017)
Published in Stem cell reports (14.03.2017)
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