Rings in Clinical Trials and Drugs: Present and Future
Shearer, Jonathan, Castro, Jose L., Lawson, Alastair D. G., MacCoss, Malcolm, Taylor, Richard D.
Published in Journal of medicinal chemistry (14.07.2022)
Published in Journal of medicinal chemistry (14.07.2022)
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Journal Article
Improved protein-ligand docking using GOLD
Verdonk, Marcel L., Cole, Jason C., Hartshorn, Michael J., Murray, Christopher W., Taylor, Richard D.
Published in Proteins, structure, function, and bioinformatics (01.09.2003)
Published in Proteins, structure, function, and bioinformatics (01.09.2003)
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Journal Article
Comparing protein-ligand docking programs is difficult
Cole, Jason C., Murray, Christopher W., Nissink, J. Willem M., Taylor, Richard D., Taylor, Robin
Published in Proteins, structure, function, and bioinformatics (15.08.2005)
Published in Proteins, structure, function, and bioinformatics (15.08.2005)
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Journal Article
Insight into small molecule binding to the neonatal Fc receptor by X-ray crystallography and 100 kHz magic-angle-spinning NMR
Stöppler, Daniel, Macpherson, Alex, Smith-Penzel, Susanne, Basse, Nicolas, Lecomte, Fabien, Deboves, Hervé, Taylor, Richard D, Norman, Tim, Porter, John, Waters, Lorna C, Westwood, Marta, Cossins, Ben, Cain, Katharine, White, James, Griffin, Robert, Prosser, Christine, Kelm, Sebastian, Sullivan, Amy H, Fox, 3rd, David, Carr, Mark D, Henry, Alistair, Taylor, Richard, Meier, Beat H, Oschkinat, Hartmut, Lawson, Alastair D
Published in PLoS biology (21.05.2018)
Published in PLoS biology (21.05.2018)
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Journal Article
Computational design of an epitope-specific Keap1 binding antibody using hotspot residues grafting and CDR loop swapping
Liu, Xiaofeng, Taylor, Richard D, Griffin, Laura, Coker, Shu-Fen, Adams, Ralph, Ceska, Tom, Shi, Jiye, Lawson, Alastair D G, Baker, Terry
Published in Scientific reports (27.01.2017)
Published in Scientific reports (27.01.2017)
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Journal Article
Rings in drugs
Taylor, Richard D, MacCoss, Malcolm, Lawson, Alastair D G
Published in Journal of medicinal chemistry (24.07.2014)
Published in Journal of medicinal chemistry (24.07.2014)
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Journal Article
Virtual Screening Using Protein−Ligand Docking: Avoiding Artificial Enrichment
Verdonk, Marcel L, Berdini, Valerio, Hartshorn, Michael J, Mooij, Wijnand T. M, Murray, Christopher W, Taylor, Richard D, Watson, Paul
Published in Journal of Chemical Information and Computer Sciences (01.05.2004)
Published in Journal of Chemical Information and Computer Sciences (01.05.2004)
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Journal Article
Combining Molecular Scaffolds from FDA Approved Drugs: Application to Drug Discovery
Taylor, Richard D, MacCoss, Malcolm, Lawson, Alastair D G
Published in Journal of medicinal chemistry (09.03.2017)
Published in Journal of medicinal chemistry (09.03.2017)
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Journal Article
Open Binding Pose Metadynamics: An Effective Approach for the Ranking of Protein–Ligand Binding Poses
Lukauskis, Dominykas, Samways, Marley L., Aureli, Simone, Cossins, Benjamin P., Taylor, Richard D., Gervasio, Francesco Luigi
Published in Journal of chemical information and modeling (12.12.2022)
Published in Journal of chemical information and modeling (12.12.2022)
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Journal Article
Discovery and Characterization of Potent, Efficacious, Orally Available Antimalarial Plasmepsin X Inhibitors and Preclinical Safety Assessment of UCB7362
Lowe, Martin A., Cardenas, Alvaro, Valentin, Jean-Pierre, Zhu, Zhaoning, Abendroth, Jan, Castro, Jose L., Class, Reiner, Delaunois, Annie, Fleurance, Renaud, Gerets, Helga, Gryshkova, Vitalina, King, Lloyd, Lorimer, Donald D., MacCoss, Malcolm, Rowley, Julian H., Rosseels, Marie-Luce, Royer, Leandro, Taylor, Richard D., Wong, Melanie, Zaccheo, Oliver, Chavan, Vishal P., Ghule, Gokul A., Tapkir, Bapusaheb K., Burrows, Jeremy N., Duffey, Maëlle, Rottmann, Matthias, Wittlin, Sergio, Angulo-Barturen, Iñigo, Jiménez-Díaz, María Belén, Striepen, Josefine, Fairhurst, Kate J., Yeo, Tomas, Fidock, David A., Cowman, Alan F., Favuzza, Paola, Crespo-Fernandez, Benigno, Gamo, Francisco Javier, Goldberg, Daniel E., Soldati-Favre, Dominique, Laleu, Benoît, de Haro, Teresa
Published in Journal of medicinal chemistry (27.10.2022)
Published in Journal of medicinal chemistry (27.10.2022)
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Journal Article
Discovery of a junctional epitope antibody that stabilizes IL-6 and gp80 protein:protein interaction and modulates its downstream signaling
Adams, Ralph, Burnley, Rebecca J, Valenzano, Chiara R, Qureshi, Omar, Doyle, Carl, Lumb, Simon, Del Carmen Lopez, Maria, Griffin, Robert, McMillan, David, Taylor, Richard D, Meier, Chris, Mori, Prashant, Griffin, Laura M, Wernery, Ulrich, Kinne, Jörg, Rapecki, Stephen, Baker, Terry S, Lawson, Alastair D G, Wright, Michael, Ettorre, Anna
Published in Scientific reports (30.01.2017)
Published in Scientific reports (30.01.2017)
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Journal Article
Design of Novel Series of Antimalarial PMX Inhibitors with Increased Half-Life via Molecular Property Optimization
Sakata, Komei, Lowe, Martin A., Xuan, Mengyang, Bruffaerts, Jeffrey, Stasi, Luigi P., Lallemand, Benedicte, Cardenas, Alvaro, Taylor, Richard D., Vidler, Lewis R., King, Lloyd, Valentin, Jean-Pierre, Laleu, Benoit, de Haro, Teresa
Published in ACS medicinal chemistry letters (09.11.2023)
Published in ACS medicinal chemistry letters (09.11.2023)
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