Solubility-Driven Optimization of Phosphodiesterase‑4 Inhibitors Leading to a Clinical Candidate
Press, Neil J, Taylor, Roger J, Fullerton, Joseph D, Tranter, Pamela, McCarthy, Clive, Keller, Thomas H, Arnold, Nicola, Beer, David, Brown, Lyndon, Cheung, Robert, Christie, Julie, Denholm, Alastair, Haberthuer, Sandra, Hatto, Julia D. I, Keenan, Mark, Mercer, Mark K, Oakman, Helen, Sahri, Helene, Tuffnell, Andrew R, Tweed, Morris, Tyler, John W, Wagner, Trixie, Fozard, John R, Trifilieff, Alexandre
Published in Journal of medicinal chemistry (13.09.2012)
Published in Journal of medicinal chemistry (13.09.2012)
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Discovery of Icenticaftor (QBW251), a Cystic Fibrosis Transmembrane Conductance Regulator Potentiator with Clinical Efficacy in Cystic Fibrosis and Chronic Obstructive Pulmonary Disease
Grand, Darren Le, Gosling, Martin, Baettig, Urs, Bahra, Parmjit, Bala, Kamlesh, Brocklehurst, Cara, Budd, Emma, Butler, Rebecca, Cheung, Atwood K, Choudhury, Hedaythul, Collingwood, Stephen P, Cox, Brian, Danahay, Henry, Edwards, Lee, Everatt, Brian, Glaenzel, Ulrike, Glotin, Anne-Lise, Groot-Kormelink, Paul, Hall, Edward, Hatto, Julia, Howsham, Catherine, Hughes, Glyn, King, Anna, Koehler, Julia, Kulkarni, Swarupa, Lightfoot, Megan, Nicholls, Ian, Page, Christopher, Pergl-Wilson, Giles, Popa, Mariana Oana, Robinson, Richard, Rowlands, David, Sharp, Tom, Spendiff, Matthew, Stanley, Emily, Steward, Oliver, Taylor, Roger J, Tranter, Pamela, Wagner, Trixie, Watson, Hazel, Williams, Gareth, Wright, Penny, Young, Alice, Sandham, David A
Published in Journal of medicinal chemistry (10.06.2021)
Published in Journal of medicinal chemistry (10.06.2021)
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Discovery and Optimization of 4-(8-(3-Fluorophenyl)-1,7-naphthyridin-6-yl)transcyclohexanecarboxylic Acid, an Improved PDE4 Inhibitor for the Treatment of Chronic Obstructive Pulmonary Disease (COPD)
Press, Neil J., Taylor, Roger J., Fullerton, Joseph D., Tranter, Pamela, McCarthy, Clive, Keller, Thomas H., Arnold, Nicola, Beer, David, Brown, Lyndon, Cheung, Robert, Christie, Julie, Denholm, Alastair, Haberthuer, Sandra, Hatto, Julia D. I., Keenan, Mark, Mercer, Mark K., Oakman, Helen, Sahri, Helene, Tuffnell, Andrew R., Tweed, Morris, Trifilieff, Alexandre
Published in Journal of medicinal chemistry (10.09.2015)
Published in Journal of medicinal chemistry (10.09.2015)
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The identification of 7-[(R)-2-((1S,2S)-2-benzyloxycyclopentylamino)-1-hydroxyethyl]-4-hydroxybenzothiazolone as an inhaled long-acting β2-adrenoceptor agonist
Arnold, Nicola, Beattie, David, Bradley, Michelle, Brearley, Andrew, Brown, Lyndon, Charlton, Steven J., Fairhurst, Robin A., Farr, David, Fozard, John, Fullerton, Joe, Gosling, Martin, Hatto, Julia, Janus, Diana, Jones, Darryl, Jordan, Lynne, Lewis, Christine, Maas, Janet, McCarthy, Clive, Mercer, Mark, Oakman, Helen, Press, Neil, Profit, Rachel, Schuerch, Friedrich, Sykes, David, Taylor, Roger J., Trifilieff, Alexandre, Tuffnell, Andrew
Published in Bioorganic & medicinal chemistry letters (01.09.2014)
Published in Bioorganic & medicinal chemistry letters (01.09.2014)
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A physical properties based approach for the exploration of a 4-hydroxybenzothiazolone series of β2-adrenoceptor agonists as inhaled long-acting bronchodilators
BEATTIE, David, BRADLEY, Michelle, LEWIS, Christine, MCCARTHY, Clive, OAKMAN, Helen, STRINGER, Rowan, TAYLOR, Roger J, TUFFNELL, Andrew, BREARLEY, Andrew, CHARLTON, Steven J, CUENOUD, Bernard M, FAIRHURST, Robin A, GEDECK, Peter, GOSLING, Martin, JANUS, Diana, JONES, Darryl
Published in Bioorganic & medicinal chemistry letters (01.09.2010)
Published in Bioorganic & medicinal chemistry letters (01.09.2010)
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Synthesis and evaluation of two series of 4'-aza-carbocyclic nucleosides as adenosine A2A receptor agonists
BEATTIE, David, BREARLEY, Andrew, NANSON, Lana, NEEF, James, OAKMAN, Helen, SPOONER, Gillian, TAYLOR, Roger J, TURNER, Robert J, WEST, Ryan, WOODWARD, Hannah, BROWN, Zarin, CHARLTON, Steven J, COX, Brian, FAIRHURST, Robin A, FOZARD, John R, GEDECK, Peter, KIRKHAM, Paul, MEJA, Koremu
Published in Bioorganic & medicinal chemistry letters (01.02.2010)
Published in Bioorganic & medicinal chemistry letters (01.02.2010)
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A new orally bioavailable dual adenosine A2B/A3 receptor antagonist with therapeutic potential
PRESS, Neil J, TAYLOR, Roger J, HATTO, Julia D. I, KEENAN, Mark, MERCER, Mark K, PRESS, Nicola E, SAHRI, Helene, TUFFNELL, Andrew R, TWEED, Morris, FOZARD, John R, FULLERTON, Joseph D, TRANTER, Pamela, MCCARTHY, Clive, KELLER, Thomas H, BROWN, Lyndon, CHEUNG, Robert, CHRISTIE, Julie, HABERTHUER, Sandra
Published in Bioorganic & medicinal chemistry letters (15.06.2005)
Published in Bioorganic & medicinal chemistry letters (15.06.2005)
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A convergent synthesis of the renin inhibitor CGP60536B
Sandham, David A, Taylor, Roger J, Carey, John S, Fässler, Alexander
Published in Tetrahedron letters (16.12.2000)
Published in Tetrahedron letters (16.12.2000)
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Journal Article
Discovery and Optimization of 4‑(8-(3-Fluorophenyl)-1,7-naphthyridin-6-yl)transcyclohexanecarboxylic Acid, an Improved PDE4 Inhibitor for the Treatment of Chronic Obstructive Pulmonary Disease (COPD)
Press, Neil J., Taylor, Roger J., Fullerton, Joseph D., Tranter, Pamela, McCarthy, Clive, Keller, Thomas H., Arnold, Nicola, Beer, David, Brown, Lyndon, Cheung, Robert, Christie, Julie, Denholm, Alastair, Haberthuer, Sandra, Hatto, Julia D. I., Keenan, Mark, Mercer, Mark K., Oakman, Helen, Sahri, Helene, Tuffnell, Andrew R., Tweed, Morris, Trifilieff, Alexandre
Published in Journal of medicinal chemistry (10.09.2015)
Published in Journal of medicinal chemistry (10.09.2015)
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Journal Article
The identification of 7-[(R)-2-((1S,2S)-2-benzyloxycyclopentylamino)-1-hydroxyethyl]-4-hydroxybenzothiazolone as an inhaled long-acting beta(2)-adrenoceptor agonist
Arnold, Nicola, Beattie, David, Bradley, Michelle, Brearley, Andrew, Brown, Lyndon, Charlton, Steven J., Fairhurst, Robin A., Farr, David, Fozard, John, Fullerton, Joe, Gosling, Martin, Hatto, Julia, Janus, Diana, Jones, Darryl, Jordan, Lynne, Lewis, Christine, Maas, Janet, McCarthy, Clive, Mercer, Mark, Oakman, Helen, Press, Neil, Profit, Rachel, Schuerch, Friedrich, Sykes, David, Taylor, Roger J., Trifilieff, Alexandre, Tuffnell, Andrew
Published in Bioorganic & medicinal chemistry letters (01.09.2014)
Published in Bioorganic & medicinal chemistry letters (01.09.2014)
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Journal Article
Synthesis and evaluation of two series of 4'-aza-carbocyclic nucleosides as adenosine A sub(2A) receptor agonists
Beattie, David, Brearley, Andrew, Brown, Zarin, Charlton, Steven J, Cox, Brian, Fairhurst, Robin A, Fozard, John R, Gedeck, Peter, Kirkham, Paul, Meja, Koremu, Nanson, Lana, Neef, James, Oakman, Helen, Spooner, Gillian, Taylor, Roger J, Turner, Robert J, West, Ryan, Woodward, Hannah
Published in Bioorganic & medicinal chemistry letters (01.02.2010)
Published in Bioorganic & medicinal chemistry letters (01.02.2010)
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Journal Article
Synthesis and evaluation of two series of 4′-aza-carbocyclic nucleosides as adenosine A 2A receptor agonists
Beattie, David, Brearley, Andrew, Brown, Zarin, Charlton, Steven J., Cox, Brian, Fairhurst, Robin A., Fozard, John R., Gedeck, Peter, Kirkham, Paul, Meja, Koremu, Nanson, Lana, Neef, James, Oakman, Helen, Spooner, Gillian, Taylor, Roger J., Turner, Robert J., West, Ryan, Woodward, Hannah
Published in Bioorganic & medicinal chemistry letters (2010)
Published in Bioorganic & medicinal chemistry letters (2010)
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Journal Article
A physical properties based approach for the exploration of a 4-hydroxybenzothiazolone series of β 2-adrenoceptor agonists as inhaled long-acting bronchodilators
Beattie, David, Bradley, Michelle, Brearley, Andrew, Charlton, Steven J., Cuenoud, Bernard M., Fairhurst, Robin A., Gedeck, Peter, Gosling, Martin, Janus, Diana, Jones, Darryl, Lewis, Christine, McCarthy, Clive, Oakman, Helen, Stringer, Rowan, Taylor, Roger J., Tuffnell, Andrew
Published in Bioorganic & medicinal chemistry letters (2010)
Published in Bioorganic & medicinal chemistry letters (2010)
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Journal Article
A physical properties based approach for the exploration of a 4-hydroxybenzothiazolone series of beta2-adrenoceptor agonists as inhaled long-acting bronchodilators
Beattie, David, Bradley, Michelle, Brearley, Andrew, Charlton, Steven J, Cuenoud, Bernard M, Fairhurst, Robin A, Gedeck, Peter, Gosling, Martin, Janus, Diana, Jones, Darryl, Lewis, Christine, McCarthy, Clive, Oakman, Helen, Stringer, Rowan, Taylor, Roger J, Tuffnell, Andrew
Published in Bioorganic & medicinal chemistry letters (01.09.2010)
Published in Bioorganic & medicinal chemistry letters (01.09.2010)
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Journal Article
A new orally bioavailable dual adenosine A 2B/A 3 receptor antagonist with therapeutic potential
Press, Neil J., Taylor, Roger J., Fullerton, Joseph D., Tranter, Pamela, McCarthy, Clive, Keller, Thomas H., Brown, Lyndon, Cheung, Robert, Christie, Julie, Haberthuer, Sandra, Hatto, Julia D.I., Keenan, Mark, Mercer, Mark K., Press, Nicola E., Sahri, Helene, Tuffnell, Andrew R., Tweed, Morris, Fozard, John R.
Published in Bioorganic & medicinal chemistry letters (2005)
Published in Bioorganic & medicinal chemistry letters (2005)
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