Identification of a Benzoisoxazoloazepine Inhibitor (CPI-0610) of the Bromodomain and Extra-Terminal (BET) Family as a Candidate for Human Clinical Trials
Albrecht, Brian K, Gehling, Victor S, Hewitt, Michael C, Vaswani, Rishi G, Côté, Alexandre, Leblanc, Yves, Nasveschuk, Christopher G, Bellon, Steve, Bergeron, Louise, Campbell, Robert, Cantone, Nico, Cooper, Michael R, Cummings, Richard T, Jayaram, Hariharan, Joshi, Shivangi, Mertz, Jennifer A, Neiss, Adrianne, Normant, Emmanuel, O’Meara, Michael, Pardo, Eneida, Poy, Florence, Sandy, Peter, Supko, Jeffrey, Sims, Robert J, Harmange, Jean-Christophe, Taylor, Alexander M, Audia, James E
Published in Journal of medicinal chemistry (25.02.2016)
Published in Journal of medicinal chemistry (25.02.2016)
Get full text
Journal Article
Classic ataxia-telangiectasia: the phenotype of long-term survivors
van Os, Nienke J. H., van Deuren, Marcel, Weemaes, Corry M. R., van Gaalen, Judith, Hijdra, Helma, Taylor, Alexander M. R., van de Warrenburg, Bart P. C., Willemsen, Michèl A. A. P.
Published in Journal of neurology (01.03.2020)
Published in Journal of neurology (01.03.2020)
Get full text
Journal Article
Inhibition of bromodomain-containing protein 9 for the prevention of epigenetically-defined drug resistance
Crawford, Terry D., Vartanian, Steffan, Côté, Alexandre, Bellon, Steve, Duplessis, Martin, Flynn, E. Megan, Hewitt, Michael, Huang, Hon-Ren, Kiefer, James R., Murray, Jeremy, Nasveschuk, Christopher G., Pardo, Eneida, Romero, F. Anthony, Sandy, Peter, Tang, Yong, Taylor, Alexander M., Tsui, Vickie, Wang, Jian, Wang, Shumei, Zawadzke, Laura, Albrecht, Brian K., Magnuson, Steven R., Cochran, Andrea G., Stokoe, David
Published in Bioorganic & medicinal chemistry letters (01.08.2017)
Published in Bioorganic & medicinal chemistry letters (01.08.2017)
Get full text
Journal Article
Discovery, Design, and Optimization of Isoxazole Azepine BET Inhibitors
Gehling, Victor S, Hewitt, Michael C, Vaswani, Rishi G, Leblanc, Yves, Côté, Alexandre, Nasveschuk, Christopher G, Taylor, Alexander M, Harmange, Jean-Christophe, Audia, James E, Pardo, Eneida, Joshi, Shivangi, Sandy, Peter, Mertz, Jennifer A, Sims, Robert J, Bergeron, Louise, Bryant, Barbara M, Bellon, Steve, Poy, Florence, Jayaram, Hariharan, Sankaranarayanan, Ravichandran, Yellapantula, Sreegouri, Bangalore Srinivasamurthy, Nandana, Birudukota, Swarnakumari, Albrecht, Brian K
Published in ACS medicinal chemistry letters (12.09.2013)
Published in ACS medicinal chemistry letters (12.09.2013)
Get full text
Journal Article
Discovery of Benzotriazolo[4,3‑d][1,4]diazepines as Orally Active Inhibitors of BET Bromodomains
Taylor, Alexander M, Vaswani, Rishi G, Gehling, Victor S, Hewitt, Michael C, Leblanc, Yves, Audia, James E, Bellon, Steve, Cummings, Richard T, Côté, Alexandre, Harmange, Jean-Christophe, Jayaram, Hari, Joshi, Shivangi, Lora, Jose M, Mertz, Jennifer A, Neiss, Adrianne, Pardo, Eneida, Nasveschuk, Christopher G, Poy, Florence, Sandy, Peter, Setser, Jeremy W, Sims, Robert J, Tang, Yong, Albrecht, Brian K
Published in ACS medicinal chemistry letters (11.02.2016)
Published in ACS medicinal chemistry letters (11.02.2016)
Get full text
Journal Article
Influence of Pore Fluid on Grain‐Scale Interactions and Mobility of Granular Flows of Differing Volume
Taylor‐Noonan, Alexander M., Bowman, Elisabeth T., McArdell, Brian W., Kaitna, Roland, McElwaine, Jim N., Take, W. Andy
Published in Journal of geophysical research. Earth surface (01.12.2022)
Published in Journal of geophysical research. Earth surface (01.12.2022)
Get full text
Journal Article
Ataxia telangiectasia mutated–deficient B-cell chronic lymphocytic leukemia occurs in pregerminal center cells and results in defective damage response and unrepaired chromosome damage
Stankovic, Tatjana, Stewart, Grant S., Fegan, Christopher, Biggs, Paul, Last, James, Byrd, Philip J., Keenan, Russell D., Moss, Paul A.H., Taylor, Alexander M.R.
Published in Blood (01.01.2002)
Published in Blood (01.01.2002)
Get full text
Journal Article
RLY-4008, the First Highly Selective FGFR2 Inhibitor with Activity across FGFR2 Alterations and Resistance Mutations
Subbiah, Vivek, Sahai, Vaibhav, Maglic, Dejan, Bruderek, Kamil, Touré, B Barry, Zhao, Songping, Valverde, Roberto, O'Hearn, Patrick J, Moustakas, Demetri T, Schönherr, Heike, Gerami-Moayed, Nastaran, Taylor, Alexander M, Hudson, Brandi M, Houde, Damian J, Pal, Debjani, Foster, Lindsey, Gunaydin, Hakan, Ayaz, Pelin, Sharon, Dina A, Goyal, Lipika, Schram, Alison M, Kamath, Suneel, Sherwin, Cori Ann, Schmidt-Kittler, Oleg, Jen, Kai Yu, Ricard, Fabien, Wolf, Beni B, Shaw, David E, Bergstrom, Donald A, Watters, James, Casaletto, Jessica B
Published in Cancer discovery (06.09.2023)
Published in Cancer discovery (06.09.2023)
Get full text
Journal Article
GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP)
Romero, F. Anthony, Murray, Jeremy, Lai, Kwong Wah, Tsui, Vickie, Albrecht, Brian K, An, Le, Beresini, Maureen H, de Leon Boenig, Gladys, Bronner, Sarah M, Chan, Emily W, Chen, Kevin X, Chen, Zhongguo, Choo, Edna F, Clagg, Kyle, Clark, Kevin, Crawford, Terry D, Cyr, Patrick, de Almeida Nagata, Denise, Gascoigne, Karen E, Grogan, Jane L, Hatzivassiliou, Georgia, Huang, Wei, Hunsaker, Thomas L, Kaufman, Susan, Koenig, Stefan G, Li, Ruina, Li, Yingjie, Liang, Xiaorong, Liao, Jiangpeng, Liu, Wenfeng, Ly, Justin, Maher, Jonathan, Masui, Colin, Merchant, Mark, Ran, Yingqing, Taylor, Alexander M, Wai, John, Wang, Fei, Wei, Xiaocang, Yu, Dong, Zhu, Bing-Yan, Zhu, Xiaoyu, Magnuson, Steven
Published in Journal of medicinal chemistry (22.11.2017)
Published in Journal of medicinal chemistry (22.11.2017)
Get full text
Journal Article
Identification of GDC-1971 (RLY-1971), a SHP2 Inhibitor Designed for the Treatment of Solid Tumors
Taylor, Alexander M., Williams, Bret R., Giordanetto, Fabrizio, Kelley, Elizabeth H., Lescarbeau, André, Shortsleeves, Kelley, Tang, Yong, Walters, W. Patrick, Arrazate, Alfonso, Bowman, Christine, Brophy, Erin, Chan, Emily W., Deshmukh, Gauri, Greisman, Jack B., Hunsaker, Thomas L., Kipp, D. Randal, Saenz Lopez-Larrocha, Pablo, Maddalo, Danilo, Martin, Iain J., Maragakis, Paul, Merchant, Mark, Murcko, Mark, Nisonoff, Hunter, Nguyen, Vi, Nguyen, Vy, Orozco, Olivia, Owen, Christopher, Pierce, Levi, Schmidt, Molly, Shaw, David E., Smith, Sherri, Therrien, Eric, Tran, John C., Watters, Jim, Waters, Nigel J., Wilbur, Jeremy, Willmore, Lindsay
Published in Journal of medicinal chemistry (12.10.2023)
Published in Journal of medicinal chemistry (12.10.2023)
Get full text
Journal Article
Discovery of lirafugratinib (RLY-4008), a highly selective irreversible small-molecule inhibitor of FGFR2
Schönherr, Heike, Ayaz, Pelin, Taylor, Alexander M, Casaletto, Jessica B, Touré, B Barry, Moustakas, Demetri T, Hudson, Brandi M, Valverde, Roberto, Zhao, Songping, O'Hearn, Patrick J, Foster, Lindsey, Sharon, Dina A, Garfinkle, Sam, Giordanetto, Fabrizio, Lescarbeau, André, Kurukulasuriya, Ravi, Gerami-Moayed, Nastaran, Maglic, Dejan, Bruderek, Kamil, Naik, Gaauri, Gunaydin, Hakan, Mader, Mary M, Boezio, Alessandro A, McLean, Thomas H, Chen, Rongfeng, Wang, Yanxia, Shaw, David E, Watters, James, Bergstrom, Donald A
Published in Proceedings of the National Academy of Sciences - PNAS (06.02.2024)
Published in Proceedings of the National Academy of Sciences - PNAS (06.02.2024)
Get full text
Journal Article
Diving into the Water: Inducible Binding Conformations for BRD4, TAF1(2), BRD9, and CECR2 Bromodomains
Crawford, Terry D, Tsui, Vickie, Flynn, E. Megan, Wang, Shumei, Taylor, Alexander M, Côté, Alexandre, Audia, James E, Beresini, Maureen H, Burdick, Daniel J, Cummings, Richard, Dakin, Les A, Duplessis, Martin, Good, Andrew C, Hewitt, Michael C, Huang, Hon-Ren, Jayaram, Hariharan, Kiefer, James R, Jiang, Ying, Murray, Jeremy, Nasveschuk, Christopher G, Pardo, Eneida, Poy, Florence, Romero, F. Anthony, Tang, Yong, Wang, Jian, Xu, Zhaowu, Zawadzke, Laura E, Zhu, Xiaoyu, Albrecht, Brian K, Magnuson, Steven R, Bellon, Steve, Cochran, Andrea G
Published in Journal of medicinal chemistry (09.06.2016)
Published in Journal of medicinal chemistry (09.06.2016)
Get full text
Journal Article
Pathogenic variants in SLF2 and SMC5 cause segmented chromosomes and mosaic variegated hyperploidy
Grange, Laura J., Reynolds, John J., Ullah, Farid, Isidor, Bertrand, Shearer, Robert F., Latypova, Xenia, Baxley, Ryan M., Oliver, Antony W., Ganesh, Anil, Cooke, Sophie L., Jhujh, Satpal S., McNee, Gavin S., Hollingworth, Robert, Higgs, Martin R., Natsume, Toyoaki, Khan, Tahir, Martos-Moreno, Gabriel Á., Chupp, Sharon, Mathew, Christopher G., Parry, David, Simpson, Michael A., Nahavandi, Nahid, Yüksel, Zafer, Drasdo, Mojgan, Kron, Anja, Vogt, Petra, Jonasson, Annemarie, Seth, Saad Ahmed, Gonzaga-Jauregui, Claudia, Brigatti, Karlla W., Stegmann, Alexander P. A., Kanemaki, Masato, Josifova, Dragana, Uchiyama, Yuri, Oh, Yukiko, Morimoto, Akira, Osaka, Hitoshi, Ammous, Zineb, Argente, Jesús, Matsumoto, Naomichi, Stumpel, Constance T.R.M., Taylor, Alexander M. R., Jackson, Andrew P., Bielinsky, Anja-Katrin, Mailand, Niels, Le Caignec, Cedric, Davis, Erica E., Stewart, Grant S.
Published in Nature communications (04.11.2022)
Published in Nature communications (04.11.2022)
Get full text
Journal Article
Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300
Crawford, Terry D, Romero, F. Anthony, Lai, Kwong Wah, Tsui, Vickie, Taylor, Alexander M, de Leon Boenig, Gladys, Noland, Cameron L, Murray, Jeremy, Ly, Justin, Choo, Edna F, Hunsaker, Thomas L, Chan, Emily W, Merchant, Mark, Kharbanda, Samir, Gascoigne, Karen E, Kaufman, Susan, Beresini, Maureen H, Liao, Jiangpeng, Liu, Wenfeng, Chen, Kevin X, Chen, Zhongguo, Conery, Andrew R, Côté, Alexandre, Jayaram, Hariharan, Jiang, Ying, Kiefer, James R, Kleinheinz, Tracy, Li, Yingjie, Maher, Jonathan, Pardo, Eneida, Poy, Florence, Spillane, Kerry L, Wang, Fei, Wang, Jian, Wei, Xiaocang, Xu, Zhaowu, Xu, Zhongya, Yen, Ivana, Zawadzke, Laura, Zhu, Xiaoyu, Bellon, Steven, Cummings, Richard, Cochran, Andrea G, Albrecht, Brian K, Magnuson, Steven
Published in Journal of medicinal chemistry (08.12.2016)
Published in Journal of medicinal chemistry (08.12.2016)
Get full text
Journal Article
GNE-064: A Potent, Selective, and Orally Bioavailable Chemical Probe for the Bromodomains of SMARCA2 and SMARCA4 and the Fifth Bromodomain of PBRM1
Taylor, Alexander M., Bailey, Chris, Belmont, Lisa D., Campbell, Robert, Cantone, Nico, Côté, Alexandre, Crawford, Terry D., Cummings, Richard, DeMent, Kevin, Duplessis, Martin, Flynn, Megan, Good, Andrew C., Huang, Hon-Ren, Joshi, Shivangi, Leblanc, Yves, Murray, Jeremy, Nasveschuk, Christopher G., Neiss, Adrianne, Poy, Florence, Romero, F. Anthony, Sandy, Peter, Tang, Yong, Tsui, Vickie, Zawadzke, Laura, Sims, Robert J., Audia, James E., Bellon, Steven F., Magnuson, Steven R., Albrecht, Brian K., Cochran, Andrea G.
Published in Journal of medicinal chemistry (25.08.2022)
Published in Journal of medicinal chemistry (25.08.2022)
Get full text
Journal Article
Genotype–phenotype correlations in ataxia telangiectasia patients with ATM c.3576G>A and c.8147T>C mutations
van Os, Nienke J H, Chessa, Luciana, Weemaes, Corry M R, van Deuren, Marcel, Fiévet, Alice, van Gaalen, Judith, Mahlaoui, Nizar, Roeleveld, Nel, Schrader, Christoph, Schindler, Detlev, Taylor, Alexander M R, Van de Warrenburg, Bart P C, Dörk, Thilo, Willemsen, Michèl A A P
Published in Journal of medical genetics (01.05.2019)
Published in Journal of medical genetics (01.05.2019)
Get full text
Journal Article