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The contribution of Na V 1.6 to the efficacy of voltage-gated sodium channel inhibitors in wild type and Na V 1.6 gain-of-function (GOF) mouse seizure control
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Published in British journal of pharmacology (01.10.2024)
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NBI-921352, a first-in-class, NaV1.6 selective, sodium channel inhibitor that prevents seizures in Scn8a gain-of-function mice, and wild-type mice and rats
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Published in Journal of medicinal chemistry (14.06.2018)
Published in Journal of medicinal chemistry (14.06.2018)
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Design of Conformationally Constrained Acyl Sulfonamide Isosteres: Identification of N-([1,2,4]Triazolo[4,3- a]pyridin-3-yl)methane-sulfonamides as Potent and Selective hNa V 1.7 Inhibitors for the Treatment of Pain
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Published in Journal of medicinal chemistry (14.06.2018)
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Design of Conformationally Constrained Acyl Sulfonamide Isosteres: Identification of N -([1,2,4]Triazolo[4,3- a ]pyridin-3-yl)methane-sulfonamides as Potent and Selective h Na V 1.7 Inhibitors for the Treatment of Pain
Focken, Thilo, Chowdhury, Sultan, Zenova, Alla, Grimwood, Michael E., Chabot, Christine, Sheng, Tao, Hemeon, Ivan, Decker, Shannon M., Wilson, Michael, Bichler, Paul, Jia, Qi, Sun, Shaoyi, Young, Clint, Lin, Sophia, Goodchild, Samuel J., Shuart, Noah G., Chang, Elaine, Xie, Zhiwei, Li, Bowen, Khakh, Kuldip, Bankar, Girish, Waldbrook, Matthew, Kwan, Rainbow, Nelkenbrecher, Karen, Karimi Tari, Parisa, Chahal, Navjot, Sojo, Luis, Robinette, C. Lee, White, Andrew D., Chen, Chien-An, Zhang, Yi, Pang, Jodie, Chang, Jae H., Hackos, David H., Johnson, J. P., Cohen, Charles J., Ortwine, Daniel F., Sutherlin, Daniel P., Dehnhardt, Christoph M., Safina, Brian S.
Published in Journal of medicinal chemistry (14.06.2018)
Published in Journal of medicinal chemistry (14.06.2018)
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Design of Conformationally Constrained Acyl Sulfonamide Isosteres: Identification of N‑([1,2,4]Triazolo[4,3‑a]pyridin-3-yl)methane-sulfonamides as Potent and Selective hNaV1.7 Inhibitors for the Treatment of Pain
Focken, Thilo, Chowdhury, Sultan, Zenova, Alla, Grimwood, Michael E, Chabot, Christine, Sheng, Tao, Hemeon, Ivan, Decker, Shannon M, Wilson, Michael, Bichler, Paul, Jia, Qi, Sun, Shaoyi, Young, Clint, Lin, Sophia, Goodchild, Samuel J, Shuart, Noah G, Chang, Elaine, Xie, Zhiwei, Li, Bowen, Khakh, Kuldip, Bankar, Girish, Waldbrook, Matthew, Kwan, Rainbow, Nelkenbrecher, Karen, Karimi Tari, Parisa, Chahal, Navjot, Sojo, Luis, Robinette, C. Lee, White, Andrew D, Chen, Chien-An, Zhang, Yi, Pang, Jodie, Chang, Jae H, Hackos, David H, Johnson, J. P, Cohen, Charles J, Ortwine, Daniel F, Sutherlin, Daniel P, Dehnhardt, Christoph M, Safina, Brian S
Published in Journal of medicinal chemistry (14.06.2018)
Published in Journal of medicinal chemistry (14.06.2018)
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NBI-921352, a first-in-class, Na V 1.6 selective, sodium channel inhibitor that prevents seizures in Scn8a gain-of-function mice, and wild-type mice and rats
Johnson, J P, Focken, Thilo, Khakh, Kuldip, Tari, Parisa Karimi, Dube, Celine, Goodchild, Samuel J, Andrez, Jean-Christophe, Bankar, Girish, Bogucki, David, Burford, Kristen, Chang, Elaine, Chowdhury, Sultan, Dean, Richard, de Boer, Gina, Decker, Shannon, Dehnhardt, Christoph, Feng, Mandy, Gong, Wei, Grimwood, Michael, Hasan, Abid, Hussainkhel, Angela, Jia, Qi, Lee, Stephanie, Li, Jenny, Lin, Sophia, Lindgren, Andrea, Lofstrand, Verner, Mezeyova, Janette, Namdari, Rostam, Nelkenbrecher, Karen, Shuart, Noah Gregory, Sojo, Luis, Sun, Shaoyi, Taron, Matthew, Waldbrook, Matthew, Weeratunge, Diana, Wesolowski, Steven, Williams, Aaron, Wilson, Michael, Xie, Zhiwei, Yoo, Rhena, Young, Clint, Zenova, Alla, Zhang, Wei, Cutts, Alison J, Sherrington, Robin P, Pimstone, Simon N, Winquist, Raymond, Cohen, Charles J, Empfield, James R
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Published in eLife (02.03.2022)
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METHOD FOR TREATING EPILEPSY
BECHARD, Jeffrey Paul, SHERRINGTON, Robin Paul, TARI, Parisa Karimi, CADIEUX, Jean-Jacques Alexandre
Year of Publication 03.07.2024
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Year of Publication 03.07.2024
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METHOD FOR TREATING EPILEPSY
BECHARD, Jeffrey Paul, SHERRINGTON, Robin Paul, TARI, Parisa Karimi, CADIEUX, Jean-Jacques Alexandre
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MÉTHODES DE TRAITEMENT DE L'ÉPILEPSIE
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Year of Publication 02.03.2022
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METHOD FOR TREATING EPILEPSY
BECHARD, Jeffrey Paul, SHERRINGTON, Robin Paul, TARI, Parisa Karimi, CADIEUX, Jean-Jacques Alexandre
Year of Publication 11.10.2021
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Year of Publication 11.10.2021
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