Repurposing atovaquone: targeting mitochondrial complex III and OXPHOS to eradicate cancer stem cells
Fiorillo, Marco, Lamb, Rebecca, Tanowitz, Herbert B, Mutti, Luciano, Krstic-Demonacos, Marija, Cappello, Anna Rita, Martinez-Outschoorn, Ubaldo E, Sotgia, Federica, Lisanti, Michael P
Published in Oncotarget (07.06.2016)
Published in Oncotarget (07.06.2016)
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Journal Article
The role of microsporidian polar tube protein 4 (PTP4) in host cell infection
Han, Bing, Polonais, Valérie, Sugi, Tatsuki, Yakubu, Rama, Takvorian, Peter M, Cali, Ann, Maier, Keith, Long, Mengxian, Levy, Matthew, Tanowitz, Herbert B, Pan, Guoqing, Delbac, Frédéric, Zhou, Zeyang, Weiss, Louis M
Published in PLoS pathogens (01.04.2017)
Published in PLoS pathogens (01.04.2017)
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Journal Article
Bedaquiline, an FDA-approved antibiotic, inhibits mitochondrial function and potently blocks the proliferative expansion of stem-like cancer cells (CSCs)
Fiorillo, Marco, Lamb, Rebecca, Tanowitz, Herbert B, Cappello, Anna Rita, Martinez-Outschoorn, Ubaldo E, Sotgia, Federica, Lisanti, Michael P
Published in Aging (Albany, NY.) (01.08.2016)
Published in Aging (Albany, NY.) (01.08.2016)
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Journal Article
NADH autofluorescence, a new metabolic biomarker for cancer stem cells: Identification of Vitamin C and CAPE as natural products targeting "stemness"
Bonuccelli, Gloria, De Francesco, Ernestina Marianna, de Boer, Rianne, Tanowitz, Herbert B, Lisanti, Michael P
Published in Oncotarget (28.03.2017)
Published in Oncotarget (28.03.2017)
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Journal Article
Connexin 43 Mediates White Adipose Tissue Beiging by Facilitating the Propagation of Sympathetic Neuronal Signals
Zhu, Yi, Gao, Yong, Tao, Caroline, Shao, Mengle, Zhao, Shangang, Huang, Wei, Yao, Ting, Johnson, Joshua A., Liu, Tiemin, Cypess, Aaron M., Gupta, Olga, Holland, William L., Gupta, Rana K., Spray, David C., Tanowitz, Herbert B., Cao, Lei, Lynes, Matthew D., Tseng, Yu-Hua, Elmquist, Joel K., Williams, Kevin W., Lin, Hua V., Scherer, Philipp E.
Published in Cell metabolism (13.09.2016)
Published in Cell metabolism (13.09.2016)
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Journal Article
Energy transfer in "parasitic" cancer metabolism: Mitochondria are the powerhouse and Achilles' heel of tumor cells
Martinez-Outschoorn, Ubaldo E., Pestell, Richard G., Howell, Anthony, Tykocinski, Mark L., Nagajyothi, Fnu, Machado, Fabiana S., Tanowitz, Herbert B., Sotgia, Federica, Lisanti, Michael P.
Published in Cell cycle (Georgetown, Tex.) (15.12.2011)
Published in Cell cycle (Georgetown, Tex.) (15.12.2011)
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Journal Article
Current understanding of immunity to Trypanosoma cruzi infection and pathogenesis of Chagas disease
Machado, Fabiana S., Dutra, Walderez O., Esper, Lisia, Gollob, Kenneth J., Teixeira, Mauro M., Factor, Stephen M., Weiss, Louis M., Nagajyothi, Fnu, Tanowitz, Herbert B., Garg, Nisha J.
Published in Seminars in immunopathology (01.11.2012)
Published in Seminars in immunopathology (01.11.2012)
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Journal Article
HIF1-alpha functions as a tumor promoter in cancer-associated fibroblasts, and as a tumor suppressor in breast cancer cells: Autophagy drives compartment-specific oncogenesis
Chiavarina, Barbara, Whitaker-Menezes, Diana, Migneco, Gemma, Martinez-Outschoorn, Ubaldo E., Pavlides, Stephanos, Howell, Anthony, Tanowitz, Herbert B., Casimiro, Mathew C., Wang, Chenguang, Pestell, Richard G., Grieshaber, Philip, Caro, Jaime, Sotgia, Federica, Lisanti, Michael P.
Published in Cell cycle (Georgetown, Tex.) (01.09.2010)
Published in Cell cycle (Georgetown, Tex.) (01.09.2010)
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Journal Article
Two-compartment tumor metabolism: Autophagy in the tumor microenvironment and oxidative mitochondrial metabolism (OXPHOS) in cancer cells
Salem, Ahmed F., Whitaker-Menezes, Diana, Lin, Zhao, Martinez-Outschoorn, Ubaldo E., Tanowitz, Herbert B., Al-Zoubi, Mazhar Salim, Howell, Anthony, Pestell, Richard G., Sotgia, Federica, Lisanti, Michael P.
Published in Cell cycle (Georgetown, Tex.) (01.07.2012)
Published in Cell cycle (Georgetown, Tex.) (01.07.2012)
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Journal Article
Chagas disease has now gone global
Tanowitz, Herbert B, Weiss, Louis M, Montgomery, Susan P
Published in PLoS neglected tropical diseases (01.04.2011)
Published in PLoS neglected tropical diseases (01.04.2011)
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Journal Article
Metabolic reprogramming and two-compartment tumor metabolism: Opposing role(s) of HIF1α and HIF2α in tumor-associated fibroblasts and human breast cancer cells
Chiavarina, Barbara, Martinez-Outschoorn, Ubaldo E., Whitaker-Menezes, Diana, Howell, Anthony, Tanowitz, Herbert B., Pestell, Richard G., Sotgia, Federica, Lisanti, Michael P.
Published in Cell cycle (Georgetown, Tex.) (01.09.2012)
Published in Cell cycle (Georgetown, Tex.) (01.09.2012)
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Journal Article
Disruption of calcium homeostasis in cardiomyocytes underlies cardiac structural and functional changes in severe sepsis
Celes, Mara R N, Malvestio, Lygia M, Suadicani, Sylvia O, Prado, Cibele M, Figueiredo, Maria J, Campos, Erica C, Freitas, Ana C S, Spray, David C, Tanowitz, Herbert B, da Silva, João S, Rossi, Marcos A
Published in PloS one (23.07.2013)
Published in PloS one (23.07.2013)
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Journal Article
The Aryl Hydrocarbon Receptor Modulates Production of Cytokines and Reactive Oxygen Species and Development of Myocarditis during Trypanosoma cruzi Infection
Barroso, Andréia, Gualdrón-López, Melisa, Esper, Lísia, Brant, Fátima, Araújo, Ronan R S, Carneiro, Matheus B H, Ávila, Thiago V, Souza, Danielle G, Vieira, Leda Q, Rachid, Milene A, Tanowitz, Herbert B, Teixeira, Mauro M, Machado, Fabiana S
Published in Infection and immunity (01.10.2016)
Published in Infection and immunity (01.10.2016)
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Journal Article
High fat diet modulates Trypanosoma cruzi infection associated myocarditis
Nagajyothi, Fnu, Weiss, Louis M, Zhao, Dazhi, Koba, Wade, Jelicks, Linda A, Cui, Min-Hui, Factor, Stephen M, Scherer, Philipp E, Tanowitz, Herbert B
Published in PLoS neglected tropical diseases (01.10.2014)
Published in PLoS neglected tropical diseases (01.10.2014)
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Journal Article
Activation of Both the Calpain and Ubiquitin-Proteasome Systems Contributes to Septic Cardiomyopathy through Dystrophin Loss/Disruption and mTOR Inhibition
Freitas, Ana Caroline Silva, Figueiredo, Maria Jose, Campos, Erica Carolina, Soave, Danilo Figueiredo, Ramos, Simone Gusmao, Tanowitz, Herbert B, Celes, Mara Rúbia N
Published in PloS one (23.11.2016)
Published in PloS one (23.11.2016)
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Journal Article
Editorial commentary: Targeting Chagas disease
Tanowitz, Herbert B., MD, Garg, Nisha Jain, PhD
Published in Trends in cardiovascular medicine (01.02.2017)
Published in Trends in cardiovascular medicine (01.02.2017)
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Journal Article
Development of a rapid serological assay for the diagnosis of strongyloidiasis using a novel diffraction-based biosensor technology
Pak, Brian J, Vasquez-Camargo, Fabio, Kalinichenko, Evgeniya, Chiodini, Peter L, Nutman, Thomas B, Tanowitz, Herbert B, McAuliffe, Isabel, Wilkins, Patricia, Smith, Paul T, Ward, Brian J, Libman, Michael D, Ndao, Momar
Published in PLoS neglected tropical diseases (01.08.2014)
Published in PLoS neglected tropical diseases (01.08.2014)
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Journal Article
Pathogenesis of chagas cardiomyopathy: role of inflammation and oxidative stress
Machado, Fabiana S, Tanowitz, Herbert B, Ribeiro, Antonio L
Published in Journal of the American Heart Association (23.10.2013)
Published in Journal of the American Heart Association (23.10.2013)
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Journal Article
Coronary microvascular disease in chronic Chagas cardiomyopathy including an overview on history, pathology, and other proposed pathogenic mechanisms
Rossi, Marcos A, Tanowitz, Herbert B, Malvestio, Lygia M, Celes, Mara R, Campos, Erica C, Blefari, Valdecir, Prado, Cibele M
Published in PLoS neglected tropical diseases (31.08.2010)
Published in PLoS neglected tropical diseases (31.08.2010)
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Journal Article