Property-Driven Design and Development of Lipids for Efficient Delivery of siRNA
Rajappan, Kumar, Tanis, Steven P, Mukthavaram, Rajesh, Roberts, Scott, Nguyen, Michelle, Tachikawa, Kiyoshi, Sagi, Amit, Sablad, Marciano, Limphong, Pattraranee, Leu, Angel, Yu, Hailong, Chivukula, Padmanabh, Payne, Joseph E, Karmali, Priya
Published in Journal of medicinal chemistry (12.11.2020)
Published in Journal of medicinal chemistry (12.11.2020)
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Journal Article
Synthesis and bioactivity of readily hydrolysable novel cationic lipids for potential lung delivery application of mRNAs
Pei, Yihua, Bao, Yanjie, Sacchetti, Cristiano, Brady, Juthamart, Gillard, Kyra, Yu, Hailong, Roberts, Scott, Rajappan, Kumar, Tanis, Steven P., Perez-Garcia, Carlos G., Chivukula, Padmanabh, Karmali, Priya P.
Published in Chemistry and physics of lipids (01.03.2022)
Published in Chemistry and physics of lipids (01.03.2022)
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Journal Article
Development of a Safe and Scalable Process for the Production of a High-Purity Thiocarbamate-Based Ionizable Lipid as an Excipient in mRNA-Encapsulating Lipid Nanoparticles
Rajappan, Kumar, Tanis, Steven P, Roberts, Scott, Karmali, Priya, Chivukula, Padmanabh, Zhuang, Jin, Xin, Mingxing, Zheng, Manman, Edmonds, Ian
Published in Organic process research & development (18.06.2021)
Published in Organic process research & development (18.06.2021)
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Journal Article
PPARγ-sparing thiazolidinediones as insulin sensitizers. Design, synthesis and selection of compounds for clinical development
Tanis, Steven P., Colca, Jerry R., Parker, Timothy T., Artman, Gerald D., Larsen, Scott D., McDonald, William G., Gadwood, Robert C., Kletzien, Rolf F., Zeller, James B., Lee, Pil H., Adams, Wade J.
Published in Bioorganic & medicinal chemistry (01.12.2018)
Published in Bioorganic & medicinal chemistry (01.12.2018)
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Journal Article
Azaindole Hydroxamic Acids are Potent HIV-1 Integrase Inhibitors
Plewe, Michael B, Butler, Scott L, R. Dress, Klaus, Hu, Qiyue, Johnson, Ted W, Kuehler, Jon E, Kuki, Atsuo, Lam, Hieu, Liu, Wen, Nowlin, Dawn, Peng, Qinghai, Rahavendran, Sadayappan V, Tanis, Steven P, Tran, Khanh T, Wang, Hai, Yang, Anle, Zhang, Junhu
Published in Journal of medicinal chemistry (26.11.2009)
Published in Journal of medicinal chemistry (26.11.2009)
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Journal Article
Design and Synthesis of Novel N-Hydroxy-Dihydronaphthyridinones as Potent and Orally Bioavailable HIV-1 Integrase Inhibitors
Johnson, Ted W, Tanis, Steven P, Butler, Scott L, Dalvie, Deepak, DeLisle, Dorothy M, Dress, Klaus R, Flahive, Erik J, Hu, Qiyue, Kuehler, Jon E, Kuki, Atsuo, Liu, Wen, McClellan, Guy A, Peng, Qinghai, Plewe, Michael B, Richardson, Paul F, Smith, Graham L, Solowiej, Jim, Tran, Khanh T, Wang, Hai, Yu, Xiaoming, Zhang, Junhu, Zhu, Huichun
Published in Journal of medicinal chemistry (12.05.2011)
Published in Journal of medicinal chemistry (12.05.2011)
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Journal Article
Discovery of Novel, Potent, and Selective Inhibitors of 3-Phosphoinositide-Dependent Kinase (PDK1)
Murphy, Sean T, Alton, Gordon, Bailey, Simon, Baxi, Sangita M, Burke, Benjamin J, Chappie, Thomas A, Ermolieff, Jacques, Ferre, RoseAnn, Greasley, Samantha, Hickey, Michael, Humphrey, John, Kablaoui, Natasha, Kath, John, Kazmirski, Steven, Kraus, Michelle, Kupchinsky, Stan, Li, John, Lingardo, Laura, Marx, Matthew A, Richter, Dan, Tanis, Steven P, Tran, Khanh, Vernier, William, Xie, Zhi, Yin, Min-Jean, Yu, Xiao-Hong
Published in Journal of medicinal chemistry (22.12.2011)
Published in Journal of medicinal chemistry (22.12.2011)
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Journal Article
Azaindole N-methyl hydroxamic acids as HIV-1 integrase inhibitors-II. The impact of physicochemical properties on ADME and PK
Tanis, Steven P., Plewe, Michael B., Johnson, Ted W., Butler, Scott L., Dalvie, Deepak, DeLisle, Dorothy, Dress, Klaus R., Hu, Qiyue, Huang, Buwen, Kuehler, Jon E., Kuki, Atsuo, Liu, Wen, Peng, Qinghai, Smith, Graham L., Solowiej, Jim, Tran, Khanh T., Wang, Hai, Yang, Anle, Yin, Chunfeng, Yu, Xiaoming, Zhang, Junhu, Zhu, Huichun
Published in Bioorganic & medicinal chemistry letters (15.12.2010)
Published in Bioorganic & medicinal chemistry letters (15.12.2010)
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Journal Article
2-Aryl-2-hydroxyethylamine substituted 4-oxo-4,7-dihydrothieno[2,3- b]pyridines as broad-spectrum inhibitors of human herpesvirus polymerases
Schnute, Mark E., Anderson, David J., Brideau, Roger J., Ciske, Fred L., Collier, Sarah A., Cudahy, Michele M., Eggen, MariJean, Genin, Michael J., Hopkins, Todd A., Judge, Thomas M., Kim, Euibong J., Knechtel, Mary L., Nair, Sajiv K., Nieman, James A., Oien, Nancee L., Scott, Allen, Tanis, Steven P., Vaillancourt, Valerie A., Wathen, Michael W., Wieber, Janet L.
Published in Bioorganic & medicinal chemistry letters (15.06.2007)
Published in Bioorganic & medicinal chemistry letters (15.06.2007)
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Journal Article
The design and development of 2-aryl-2-hydroxy ethylamine substituted 1H,7H-pyrido[1,2,3-de]quinoxaline-6-carboxamides as inhibitors of human cytomegalovirus polymerase
TANIS, Steven P, STROHBACH, Joseph W, STEPHANSKI, Kevin J, WATHEN, Michael W, PARKER, Timothy T, MOON, Malcom W, THAISRIVONGS, Suvit, PERRAULT, William R, HOPKINS, Todd A, KNECHTEL, Mary L, OIEN, Nancee L, WIEBER, Janet L
Published in Bioorganic & medicinal chemistry letters (15.03.2010)
Published in Bioorganic & medicinal chemistry letters (15.03.2010)
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Journal Article
Furan-Terminated N-Acyliminium Ion Initiated Cyclizations in Alkaloid Synthesis
Tanis, Steven P, Deaton, Melissa V, Dixon, Lisa A, McMills, Mark C, Raggon, Jeffrey W, Collins, Mark A
Published in Journal of organic chemistry (02.10.1998)
Published in Journal of organic chemistry (02.10.1998)
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Journal Article
Synthesis and Biological Activity of Analogues of the Antidiabetic/Antiobesity Agent 3-Guanidinopropionic Acid: Discovery of a Novel Aminoguanidinoacetic Acid Antidiabetic Agent
Larsen, Scott D, Connell, Mark A, Cudahy, Michele M, Evans, Bruce R, May, Paul D, Meglasson, Martin D, O'Sullivan, Theresa J, Schostarez, Heinrich J, Sih, John C, Stevens, F. Craig, Tanis, Steven P, Tegley, Christopher M, Tucker, John A, Vaillancourt, Valerie A, Vidmar, Thomas J, Watt, William, Yu, Jen H
Published in Journal of medicinal chemistry (12.04.2001)
Published in Journal of medicinal chemistry (12.04.2001)
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Journal Article
Solvent and in situ catalyst preparation impacts upon Noyori reductions of aryl-chloromethyl ketones: application to syntheses of chiral 2-amino-1-aryl-ethanols
Tanis, Steven P., Evans, Bruce R., Nieman, James A., Parker, Timothy T., Taylor, Wendy D., Heasley, Steven E., Herrinton, Paul M., Perrault, William R., Hohler, Richard A., Dolak, Lester A., Hester, Matthew R., Seest, Eric P.
Published in Tetrahedron: asymmetry (28.08.2006)
Published in Tetrahedron: asymmetry (28.08.2006)
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Journal Article
Synthesis and Biological Activity of Aminoguanidine and Diaminoguanidine Analogues of the Antidiabetic/Antiobesity Agent 3-Guanidinopropionic Acid
Vaillancourt, Valerie A, Larsen, Scott D, Tanis, Steven P, Burr, Jeffery E, Connell, Mark A, Cudahy, Michele M, Evans, Bruce R, Fisher, Peter V, May, Paul D, Meglasson, Martin D, Robinson, Deborah D, Stevens, F. Craig, Tucker, John A, Vidmar, Thomas J, Yu, Jen H
Published in Journal of medicinal chemistry (12.04.2001)
Published in Journal of medicinal chemistry (12.04.2001)
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Journal Article
RNA 전달을 위한 이온화 가능한 양이온성 지질
RAJAPPAN KUMAR, SAGI AMIT, TANIS STEVEN, KARMALI PRIYA PRAKASH, CHIVUKULA PADMANABH
Year of Publication 26.08.2024
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Year of Publication 26.08.2024
Patent
Furans in synthesis. 11. Total syntheses of (.+-.)- and (-)-fastigilin C
Tanis, Steven P, Robinson, Edward D, McMills, Mark C, Watt, William
Published in Journal of the American Chemical Society (01.10.1992)
Published in Journal of the American Chemical Society (01.10.1992)
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Journal Article
치료 활성 접합체의 아시알로당단백질 수용체 매개 전달
RAJAPPAN KUMAR, TANIS STEVEN, TACHIKAWA KIYOSHI, KARMALI PRIYA, CHIVUKULA PADMANABH
Year of Publication 09.05.2022
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Year of Publication 09.05.2022
Patent
The development of improved syntheses of PPARγ-sparing, insulin sensitizing thiazolidinedione-ketones
Tanis, Steven P., Colca, Jerry R., Parker, Timothy T., Artman, Gerald D., Larsen, Scott D., Gadwood, Robert C., Zeller, James R.
Published in Tetrahedron letters (15.08.2019)
Published in Tetrahedron letters (15.08.2019)
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