Synthesis and SAR study of tricyclic sulfones as γ-secretase inhibitors: C-6 and C-8 positions
Su, Jing, Tang, Haiqun, McKittrick, Brian A., Xu, Ruo, Clader, John W., Greenlee, William J., Hyde, Lynn, Zhang, Lili
Published in Bioorganic & medicinal chemistry letters (01.06.2011)
Published in Bioorganic & medicinal chemistry letters (01.06.2011)
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SAR studies of C2 ethers of 2H-pyrano[2,3-d]pyrimidine-2,4,7(1H,3H)-triones as nicotinic acid receptor (NAR) agonist
Huang, Xianhai, Su, Jing, Rao, Ashwin U., Tang, Haiqun, Zhou, Wei, Zhu, Xiaohong, Chen, Xiao, Liu, Zhidan, Huang, Ying, Degrado, Sylvia, Xiao, Dong, Qin, Jun, Aslanian, Robert, McKittrick, Brian A., Greenfeder, Scott, Heek, Margaret van, Chintala, Madhu, Palani, Anandan
Published in Bioorganic & medicinal chemistry letters (15.01.2012)
Published in Bioorganic & medicinal chemistry letters (15.01.2012)
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Modification of the clozapine structure by parallel synthesis
Su, Jing, Tang, Haiqun, McKittrick, Brian A., Burnett, Duane A., Zhang, Hongtao, Smith-Torhan, April, Fawzi, Ahmad, Lachowicz, Jean
Published in Bioorganic & medicinal chemistry letters (01.09.2006)
Published in Bioorganic & medicinal chemistry letters (01.09.2006)
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Discovery of SCH 900271, a Potent Nicotinic Acid Receptor Agonist for the Treatment of Dyslipidemia
Palani, Anandan, Rao, Ashwin U, Chen, Xiao, Huang, Xianhai, Su, Jing, Tang, Haiqun, Huang, Ying, Qin, Jun, Xiao, Dong, Degrado, Sylvia, Sofolarides, Michael, Zhu, Xiaohong, Liu, Zhidan, McKittrick, Brian, Zhou, Wei, Aslanian, Robert, Greenlee, William J, Senior, Mary, Cheewatrakoolpong, Boonlert, Zhang, Hongtao, Farley, Constance, Cook, John, Kurowski, Stan, Li, Qiu, van Heek, Margaret, Wang, Gangfeng, Hsieh, Yunsheng, Li, Fangbiao, Greenfeder, Scott, Chintala, Madhu
Published in ACS medicinal chemistry letters (12.01.2012)
Published in ACS medicinal chemistry letters (12.01.2012)
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Journal Article
SAR of tricyclic sulfones as γ-secretase inhibitors
Xu, Ruo, Cole, David, Asberom, Ted, Bara, Tom, Bennett, Chad, Burnett, Duane A., Clader, John, Domalski, Martin, Greenlee, William J., Hyde, Lynn, Josien, Hubert, Li, HongMei, McBriar, Mark, McKittrick, Brian, Pissarnitski, Dmitri, Qiang, Li, Rajagopalan, Murali, Sasikumar, Thavalakulamgara, Su, Jing, Tang, HaiQun, Wu, Wen-Lian, Zhang, LiLi, Zhao, ZhiQiang
Published in Science China. Chemistry (01.11.2011)
Published in Science China. Chemistry (01.11.2011)
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Discovery of melanin-concentrating hormone receptor R1 antagonists using high-throughput synthesis
Su, Jing, McKittrick, Brian A., Tang, Haiqun, Czarniecki, Michael, Greenlee, William J., Hawes, Brian E., O’Neill, Kim
Published in Bioorganic & medicinal chemistry (01.03.2005)
Published in Bioorganic & medicinal chemistry (01.03.2005)
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Synthesis of novel bicyclo[4.1.0]heptane and bicyclo[3.1.0]hexane derivatives as melanin-concentrating hormone receptor R1 antagonists
Su, Jing, Tang, Haiqun, McKittrick, Brian A., Gu, Huizhong, Guo, Tao, Qian, Gang, Burnett, Duane A., Clader, John W., Greenlee, William J., Hawes, Brian E., O’Neill, Kim, Spar, Brian, Weig, Blair, Kowalski, Timothy, Sorota, Steve
Published in Bioorganic & medicinal chemistry letters (01.09.2007)
Published in Bioorganic & medicinal chemistry letters (01.09.2007)
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Chemoselective Peptide Modification via Photocatalytic Tryptophan β‑Position Conjugation
Yu, Younong, Zhang, Li-Kang, Buevich, Alexei V, Li, Guoqing, Tang, Haiqun, Vachal, Petr, Colletti, Steven L, Shi, Zhi-Cai
Published in Journal of the American Chemical Society (06.06.2018)
Published in Journal of the American Chemical Society (06.06.2018)
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Discovery of sulfone containing metallo-β-lactamase inhibitors with reduced bacterial cell efflux and histamine release issues
Bennett, Frank, Huang, Yuhua, Dong, Shuzhi, Jiang, Jinlong, Hunter, David, Zhao, Zhiqiang, Gu, Xin, Scott, Jack D., Tang, Haiqun, Yang, Dexi, Xiao, Li, Scapin, Giovanna, Fischmann, Thierry, Mirza, Asra, Dayananth, Priya, Painter, Ronald E., Villafania, Artjohn, Garlisi, Charles G., Zhang, Rumin, Mayhood, Todd W., Si, Qian, Li, Nianyu, Amin, Rupesh P., Chen, Feifei, Bhatt, Bhavana, Regan, Christopher P., Regan, Hilary, Lin, Xinjie, Wu, Jin, Leithead, Andrew, Young, Katherine, Pasternak, Alexander
Published in Bioorganic & medicinal chemistry letters (01.12.2024)
Published in Bioorganic & medicinal chemistry letters (01.12.2024)
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Rapid Evolution of a Fragment-like Molecule to Pan-Metallo-Beta-Lactamase Inhibitors: Initial Leads toward Clinical Candidates
Mandal, Mihirbaran, Xiao, Li, Pan, Weidong, Scapin, Giovanna, Li, Guoqing, Tang, Haiqun, Yang, Shu-Wei, Pan, Jianping, Root, Yuriko, de Jesus, Reynalda Keh, Yang, Christine, Prosise, Winnie, Dayananth, Priya, Mirza, Asra, Therien, Alex G., Young, Katherine, Flattery, Amy, Garlisi, Charles, Zhang, Rumin, Chu, Donald, Sheth, Payal, Chu, Inhou, Wu, Jin, Markgraf, Carrie, Kim, Hai-Young, Painter, Ronald, Mayhood, Todd W., DiNunzio, Edward, Wyss, Daniel F., Buevich, Alexei V., Fischmann, Thierry, Pasternak, Alexander, Dong, Shuzhi, Hicks, Jacqueline D., Villafania, Artjohn, Liang, Lianzhu, Murgolo, Nicholas, Black, Todd, Hagmann, William K., Tata, Jim, Parmee, Emma R., Weber, Ann E., Su, Jing, Tang, Haifeng
Published in Journal of medicinal chemistry (22.12.2022)
Published in Journal of medicinal chemistry (22.12.2022)
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Structure Guided Discovery of Novel Pan Metallo-β-Lactamase Inhibitors with Improved Gram-Negative Bacterial Cell Penetration
Dong, Shuzhi, Zhao, Zhiqiang, Tang, Haiqun, Li, Guoqing, Pan, Jianping, Gu, Xin, Jiang, Jinlong, Xiao, Li, Scapin, Giovanna, Hunter, David N., Yang, Dexi, Huang, Yuhua, Bennett, Frank, Yang, Shu-Wei, Mandal, Mihirbaran, Tang, Haifeng, Su, Jing, Tudge, Clare, deJesus, Reynalda Keh, Ding, Fa-Xiang, Lombardo, Matthew, Hicks, Jacqueline D., Fischmann, Thierry, Mirza, Asra, Dayananth, Priya, Painter, Ronald E., Villafania, Artjohn, Garlisi, Charles G., Zhang, Rumin, Mayhood, Todd W., Si, Qian, Li, Nianyu, Amin, Rupesh P., Bhatt, Bhavana, Chen, Feifei, Regan, Christopher P., Regan, Hillary, Lin, Xinjie, Wu, Jin, Leithead, Andrew, Pollack, Scott R., Scott, Jack D., Nargund, Ravi P., Therien, Alex G., Black, Todd, Young, Katherine, Pasternak, Alexander
Published in Journal of medicinal chemistry (14.03.2024)
Published in Journal of medicinal chemistry (14.03.2024)
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1723. MK-3866, a metallo-β-lactamase inhibitor, is not subject to efflux in Pseudomonas aeruginosa
Young, Katherine, Mirza, Asra, Balibar, Carl, Dong, Shuzhi, Bennett, Frank, Jiang, Jinlong, Tang, Haiqun, Tudge, Claire, Scott, Jack, Yang, Dexi, Pasternak, Alexander
Published in Open forum infectious diseases (15.12.2022)
Published in Open forum infectious diseases (15.12.2022)
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MK-8325: A silyl proline-containing NS5A inhibitor with pan-genotype activity for treatment of HCV
Nair, Anilkumar G., Zeng, Qingbei, Selyutin, Oleg, Rosenblum, Stuart B., Jiang, Yueheng, Yang, De-Yi, Keertikar, Kerry, Zhou, Guowei, Dwyer, Michael, Kim, Seong Heon, Shankar, Bandarpalle, Yu, Wensheng, Tong, Ling, Chen, Lei, Mazzola, Robert, Caldwell, John, Tang, Haiqun, Agrawal, Sony, Liu, Rong, Kong, Rong, Ingravallo, Paul, Xia, Ellen, Zhai, Ying, Nomeir, Amin, Asante-Appiah, Ernest, Kozlowski, Joseph A.
Published in Bioorganic & medicinal chemistry letters (01.06.2018)
Published in Bioorganic & medicinal chemistry letters (01.06.2018)
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Optimization of brain-penetrant picolinamide derived leucine-rich repeat kinase 2 (LRRK2) inhibitors
Gulati, Anmol, Yeung, Charles S, Lapointe, Blair, Kattar, Solomon D, Gunaydin, Hakan, Scott, Jack D, Childers, Kaleen K, Methot, Joey L, Simov, Vladimir, Kurukulasuriya, Ravi, Pio, Barbara, Morriello, Greg J, Liu, Ping, Tang, Haiqun, Neelamkavil, Santhosh, Wood, Harold B, Rada, Vanessa L, Ardolino, Michael J, Yan, Xin Cindy, Palte, Rachel, Otte, Karin, Faltus, Robert, Woodhouse, Janice, Hegde, Laxminarayan G, Ciaccio, Paul, Minnihan, Ellen C, DiMauro, Erin F, Fell, Matthew J, Fuller, Peter H, Ellis, J. Michael
Published in MedChemComm (21.07.2021)
Published in MedChemComm (21.07.2021)
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Discovery of silyl proline containing HCV NS5A inhibitors with pan-genotype activity: SAR development
Nair, Anilkumar G., Zeng, Qingbei, Selyutin, Oleg, Rosenblum, Stuart B., Jiang, Yueheng, Yang, De-Yi, Keertikar, Kerry, Zhou, Guowei, Dwyer, Michael P., Kim, Seong Heon, Shankar, Bandarpalle, Yu, Wensheng, Tong, Ling, Chen, Lei, Mazzola, Robert, Caldwell, John, Tang, Haiqun, Allard, Melissa L., Buckle, Ronald N., Gauuan, Polivina Jolicia F., Holst, Christian L., Martin, Gregory S., Naicker, Kannan P., Vellekoop, Samuel, Agrawal, Sony, Liu, Rong, Kong, Rong, Ingravallo, Paul, Xia, Ellen, Zhai, Ying, Nomeir, Amin, Kozlowski, Joseph A.
Published in Bioorganic & medicinal chemistry letters (01.03.2016)
Published in Bioorganic & medicinal chemistry letters (01.03.2016)
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혈장 칼리크레인 억제제
OGAWA ANTHONY KEN, MERCHANT ROHAN, SHARP PHILLIP PATRICK, BAO JIANMING, JABRI SALMAN, XIAO DONG, CERNAKA NATALIJA, OSLER SKYLAR K, SINZ CHRISTOPHER J, CHENG ALAN C, TANG HAIQUN, GAO YING DUO, LOPEZ JOVAN ALEXANDER, TIAN MAOQUN, YANG SONG
Year of Publication 24.07.2023
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Year of Publication 24.07.2023
Patent
Quality by design (QbD) of amide isosteres: 5,5-Disubstituted isoxazolines as potent CRTh2 antagonists with favorable pharmacokinetic and drug-like properties
Xiao, Dong, Zhu, Xiaohong, Yu, Younong, Shao, Ning, Wu, Jie, McCormick, Kevin D., Dhondi, Pawan, Qin, Jun, Mazzola, Robert, Tang, Haiqun, Rao, Ashwin, Siliphaivanh, Phieng, Qiu, Hongchen, Yang, Xiaoxin, Rivelli, Maria, Garlisi, Charles G., Eckel, Steve, Mukhopadhyay, Gitali, Correll, Craig, Rindgen, Diane, Aslanian, Robert, Palani, Anandan
Published in Bioorganic & medicinal chemistry letters (15.03.2014)
Published in Bioorganic & medicinal chemistry letters (15.03.2014)
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Journal Article
Quality by design (QbD) of amide isosteres: 5,5-Disubstituted isoxazolines as potent CRTh sub(2) antagonists with favorable pharmacokinetic and drug-like properties
Xiao, Dong, Zhu, Xiaohong, Yu, Younong, Shao, Ning, Wu, Jie, McCormick, Kevin D, Dhondi, Pawan, Qin, Jun, Mazzola, Robert, Tang, Haiqun, Rao, Ashwin, Siliphaivanh, Phieng, Qiu, Hongchen, Yang, Xiaoxin, Rivelli, Maria, Garlisi, Charles G, Eckel, Steve, Mukhopadhyay, Gitali, Correll, Craig, Rindgen, Diane, Aslanian, Robert, Palani, Anandan
Published in Bioorganic & medicinal chemistry letters (01.03.2014)
Published in Bioorganic & medicinal chemistry letters (01.03.2014)
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