Discovery of novel forkhead box O1 inhibitors for treating type 2 diabetes: improvement of fasting glycemia in diabetic db/db mice
Nagashima, Takeyuki, Shigematsu, Nobuharu, Maruki, Riyo, Urano, Yasuharu, Tanaka, Hirotsugu, Shimaya, Akiyoshi, Shimokawa, Teruhiko, Shibasaki, Masayuki
Published in Molecular pharmacology (01.11.2010)
Published in Molecular pharmacology (01.11.2010)
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A novel anti-NGF PEGylated Fab' provides analgesia with lower risk of adverse effects
Koya, Yukari, Tanaka, Hirotsugu, Yoshimi, Eiji, Takeshita, Nobuaki, Morita, Shuji, Morio, Hiroki, Mori, Kanako, Fushiki, Hiroshi, Kamohara, Masazumi
Published in mAbs (01.01.2023)
Published in mAbs (01.01.2023)
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Hexanucleotide motifs mediate recruitment of the RNA elimination machinery to silent meiotic genes
Yamashita, Akira, Shichino, Yuichi, Tanaka, Hirotsugu, Hiriart, Edwige, Touat-Todeschini, Leila, Vavasseur, Aurélia, Ding, Da-Qiao, Hiraoka, Yasushi, Verdel, André, Yamamoto, Masayuki
Published in Open biology (01.03.2012)
Published in Open biology (01.03.2012)
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Novel GPR40 agonist AS2575959 exhibits glucose metabolism improvement and synergistic effect with sitagliptin on insulin and incretin secretion
Tanaka, Hirotsugu, Yoshida, Shigeru, Minoura, Hideaki, Negoro, Kenji, Shimaya, Akiyoshi, Shimokawa, Teruhiko, Shibasaki, Masayuki
Published in Life sciences (1973) (17.01.2014)
Published in Life sciences (1973) (17.01.2014)
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Selective elimination of messenger RNA prevents an incidence of untimely meiosis
Harigaya, Y, Tanaka, H, Yamanaka, S, Tanaka, K, Watanabe, Y, Tsutsumi, C, Chikashige, Y, Hiraoka, Y, Yamashita, A, Yamamoto, M
Published in Nature (06.07.2006)
Published in Nature (06.07.2006)
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AS1907417, a novel GPR119 agonist, as an insulinotropic and β-cell preservative agent for the treatment of type 2 diabetes
Yoshida, Shigeru, Tanaka, Hirotsugu, Oshima, Hiroyuki, Yamazaki, Takao, Yonetoku, Yasuhiro, Ohishi, Takahide, Matsui, Tetsuo, Shibasaki, Masayuki
Published in Biochemical and biophysical research communications (01.10.2010)
Published in Biochemical and biophysical research communications (01.10.2010)
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Chronic treatment with novel GPR40 agonists improve whole-body glucose metabolism based on the glucose-dependent insulin secretion
Tanaka, Hirotsugu, Yoshida, Shigeru, Oshima, Hiroyuki, Minoura, Hideaki, Negoro, Kenji, Yamazaki, Takao, Sakuda, Shuichi, Iwasaki, Fumiyoshi, Matsui, Tetsuo, Shibasaki, Masayuki
Published in The Journal of pharmacology and experimental therapeutics (01.09.2013)
Published in The Journal of pharmacology and experimental therapeutics (01.09.2013)
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Enhanced insulin secretion and sensitization in diabetic mice on chronic treatment with a transient receptor potential vanilloid 1 antagonist
Tanaka, Hirotsugu, Shimaya, Akiyoshi, Kiso, Tetsuo, Kuramochi, Takahiro, Shimokawa, Teruhiko, Shibasaki, Masayuki
Published in Life sciences (1973) (14.03.2011)
Published in Life sciences (1973) (14.03.2011)
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Novel GPR119 agonist AS1535907 contributes to first-phase insulin secretion in rat perfused pancreas and diabetic db/db mice
Yoshida, Shigeru, Ohishi, Takahide, Matsui, Tetsuo, Tanaka, Hirotsugu, Oshima, Hiroyuki, Yonetoku, Yasuhiro, Shibasaki, Masayuki
Published in Biochemical and biophysical research communications (12.11.2010)
Published in Biochemical and biophysical research communications (12.11.2010)
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Novel GPR119 agonist AS1669058 potentiates insulin secretion from rat islets and has potent anti-diabetic effects in ICR and diabetic db/db mice
Oshima, Hiroyuki, Yoshida, Shigeru, Ohishi, Takahide, Matsui, Tetsuo, Tanaka, Hirotsugu, Yonetoku, Yasuhiro, Shibasaki, Masayuki, Uchiyama, Yasuo
Published in Life sciences (1973) (07.02.2013)
Published in Life sciences (1973) (07.02.2013)
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Effects of the novel Foxo1 inhibitor AS1708727 on plasma glucose and triglyceride levels in diabetic db/db mice
Tanaka, Hirotsugu, Nagashima, Takeyuki, Shimaya, Akiyoshi, Urano, Yasuharu, Shimokawa, Teruhiko, Shibasaki, Masayuki
Published in European journal of pharmacology (25.10.2010)
Published in European journal of pharmacology (25.10.2010)
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