The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part 2: The second clinical candidate having a shorter and favorable human half-life
Wang, Jane L., Limburg, David, Graneto, Matthew J., Springer, John, Hamper, Joseph Rogier Bruce, Liao, Subo, Pawlitz, Jennifer L., Kurumbail, Ravi G., Maziasz, Timothy, Talley, John J., Kiefer, James R., Carter, Jeffery
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Published in Bioorganic & medicinal chemistry letters (01.12.2010)
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Identification and Small Molecule Inhibition of an Activating Transcription Factor 4 (ATF4)-dependent Pathway to Age-related Skeletal Muscle Weakness and Atrophy
Ebert, Scott M., Dyle, Michael C., Bullard, Steven A., Dierdorff, Jason M., Murry, Daryl J., Fox, Daniel K., Bongers, Kale S., Lira, Vitor A., Meyerholz, David K., Talley, John J., Adams, Christopher M.
Published in The Journal of biological chemistry (16.10.2015)
Published in The Journal of biological chemistry (16.10.2015)
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Biology of Activating Transcription Factor 4 (ATF4) and Its Role in Skeletal Muscle Atrophy
Ebert, Scott M, Rasmussen, Blake B, Judge, Andrew R, Judge, Sarah M, Larsson, Lars, Wek, Ronald C, Anthony, Tracy G, Marcotte, George R, Miller, Matthew J, Yorek, Mark A, Vella, Adrian, Volpi, Elena, Stern, Jennifer I, Strub, Matthew D, Ryan, Zachary, Talley, John J, Adams, Christopher M
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Published in The Journal of nutrition (01.04.2022)
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Ursolic Acid Induces Beneficial Changes in Skeletal Muscle mRNA Expression and Increases Exercise Participation and Performance in Dogs with Age-Related Muscle Atrophy
Ebert, Scott M, Nicolas, Celine S, Schreiber, Paul, Lopez, Jaime G, Taylor, Alan T, Judge, Andrew R, Judge, Sarah M, Rasmussen, Blake B, Talley, John J, Rème, Christophe A, Adams, Christopher M
Published in Animals (Basel) (01.01.2024)
Published in Animals (Basel) (01.01.2024)
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The novel benzopyran class of selective cyclooxygenase-2 inhibitors-part I: The first clinical candidate
Wang, Jane L., Carter, Jeffery, Kiefer, James R., Kurumbail, Ravi G., Pawlitz, Jennifer L., Brown, David, Hartmann, Susan J., Graneto, Matthew J., Seibert, Karen, Talley, John J.
Published in Bioorganic & medicinal chemistry letters (01.12.2010)
Published in Bioorganic & medicinal chemistry letters (01.12.2010)
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Pentafluorosulfanyl-Substituted Benzopyran Analogues As New Cyclooxygenase‑2 Inhibitors with Excellent Pharmacokinetics and Efficacy in Blocking Inflammation
Zhang, Yanmei, Wang, Yican, He, Chuang, Liu, Xiaorong, Lu, Yongzhi, Chen, Tingting, Pan, Qiong, Xiong, Jingfang, She, Miaoqin, Tu, Zhengchao, Qin, Xiaochu, Li, Minke, Tortorella, Micky D, Talley, John J
Published in Journal of medicinal chemistry (25.05.2017)
Published in Journal of medicinal chemistry (25.05.2017)
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Synthesis and Evaluation of Novel Erlotinib–NSAID Conjugates as More Comprehensive Anticancer Agents
Zhang, Yanmei, Tortorella, Micky D, Liao, Jinxi, Qin, Xiaochu, Chen, Tingting, Luo, Jinfeng, Guan, Jiantong, Talley, John J, Tu, Zhengchao
Published in ACS medicinal chemistry letters (08.10.2015)
Published in ACS medicinal chemistry letters (08.10.2015)
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N-[[(5-Methyl-3-phenylisoxazol-4-yl)- phenyl]sulfonyl]propanamide, Sodium Salt, Parecoxib Sodium: A Potent and Selective Inhibitor of COX-2 for Parenteral Administration
Talley, John J, Bertenshaw, Stephen R, Brown, David L, Carter, Jeffery S, Graneto, Matthew J, Kellogg, Michael S, Koboldt, Carol M, Yuan, Jinhua, Zhang, Yan Y, Seibert, Karen
Published in Journal of medicinal chemistry (04.05.2000)
Published in Journal of medicinal chemistry (04.05.2000)
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Synthesis of Deuterated Benzopyran Derivatives as Selective COX‑2 Inhibitors with Improved Pharmacokinetic Properties
Zhang, Yanmei, Tortorella, Micky D, Wang, Yican, Liu, Jianqi, Tu, Zhengchao, Liu, Xiaorong, Bai, Yang, Wen, Dingsheng, Lu, Xin, Lu, Yongzhi, Talley, John J
Published in ACS medicinal chemistry letters (09.10.2014)
Published in ACS medicinal chemistry letters (09.10.2014)
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4-[5-Methyl-3-phenylisoxazol-4-yl]- benzenesulfonamide, Valdecoxib: A Potent and Selective Inhibitor of COX-2
Talley, John J, Brown, David L, Carter, Jeffery S, Graneto, Matthew J, Koboldt, Carol M, Masferrer, Jaime L, Perkins, William E, Rogers, Roland S, Shaffer, Alexander F, Zhang, Yan Y, Zweifel, Ben S, Seibert, Karen
Published in Journal of medicinal chemistry (09.03.2000)
Published in Journal of medicinal chemistry (09.03.2000)
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Pharmacological Analysis of Cyclooxygenase-1 in Inflammation
Smith, Christopher J., Zhang, Yan, Koboldt, Carol M., Muhammad, Jerry, Zweifel, Ben S., Shaffer, Alex, Talley, John J., Masferrer, Jaime L., Seibert, Karen, Isakson, Peter C.
Published in Proceedings of the National Academy of Sciences - PNAS (27.10.1998)
Published in Proceedings of the National Academy of Sciences - PNAS (27.10.1998)
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Discovery of a novel class of potent HIV-1 protease inhibitors containing the (R)-(hydroxyethyl)urea isostere
Getman, Daniel P, DeCrescenzo, Gary A, Heintz, Robert M, Reed, Kathryn L, Talley, John J, Bryant, Martin L, Clare, Michael, Houseman, Kathryn A, Marr, J. Joseph
Published in Journal of medicinal chemistry (1993)
Published in Journal of medicinal chemistry (1993)
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Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors: Identification of 4-[5-(4-Methylphenyl)-3- (trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (SC-58635, Celecoxib)
Penning, Thomas D, Talley, John J, Bertenshaw, Stephen R, Carter, Jeffery S, Collins, Paul W, Docter, Stephen, Graneto, Matthew J, Lee, Len F, Malecha, James W, Miyashiro, Julie M, Rogers, Roland S, Rogier, D. J, Yu, Stella S, Anderson, Gary D, Burton, Earl G, Cogburn, J. Nita, Gregory, Susan A, Koboldt, Carol M, Perkins, William E, Seibert, Karen, Veenhuizen, Amy W, Zhang, Yan Y, Isakson, Peter C
Published in Journal of medicinal chemistry (25.04.1997)
Published in Journal of medicinal chemistry (25.04.1997)
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Synthesis of 4-(5-[ 18F]fluoromethyl-3-phenylisoxazol-4-yl)benzenesulfonamide, a new [ 18F]fluorinated analogue of valdecoxib, as a potential radiotracer for imaging cyclooxygenase-2 with positron emission tomography
Toyokuni, Tatsushi, Dileep Kumar, J.S., Walsh, Joseph C., Shapiro, Alan, Talley, John J., Phelps, Michael E., Herschman, Harvey R., Barrio, Jorge R., Satyamurthy, Nagichettiar
Published in Bioorganic & medicinal chemistry letters (01.11.2005)
Published in Bioorganic & medicinal chemistry letters (01.11.2005)
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Cyclooxygenase 2 (COX-2) as a target for therapy and noninvasive imaging
Herschman, Harvey R, Talley, John J, DuBois, Raymond
Published in Molecular imaging and biology (01.09.2003)
Published in Molecular imaging and biology (01.09.2003)
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Synthesis and activity of sulfonamide-substituted 4,5-diaryl thiazoles as selective cyclooxygenase-2 inhibitors
Carter, Jeffery S., Kramer, Steven, Talley, John J., Penning, Thomas, Collins, Paul, Graneto, Matthew J., Seibert, Karen, Koboldt, Carol M., Masferrer, Jaime, Zweifel, Ben
Published in Bioorganic & medicinal chemistry letters (19.04.1999)
Published in Bioorganic & medicinal chemistry letters (19.04.1999)
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