Structure of the eukaryotic translation initiation factor eIF4E in complex with 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G
Papadopoulos, Evangelos, Jenni, Simon, Kabha, Eihab, Takrouri, Khuloud J, Yi, Tingfang, Salvi, Nicola, Luna, Rafael E, Gavathiotis, Evripidis, Mahalingam, Poornachandran, Arthanari, Haribabu, Rodriguez-Mias, Ricard, Yefidoff-Freedman, Revital, Aktas, Bertal H, Chorev, Michael, Halperin, Jose A, Wagner, Gerhard
Published in Proceedings of the National Academy of Sciences - PNAS (05.08.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (05.08.2014)
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Journal Article
Explorations of Substituted Urea Functionality for the Discovery of New Activators of the Heme-Regulated Inhibitor Kinase
Chen, Ting, Takrouri, Khuloud, Hee-Hwang, Sung, Rana, Sandeep, Yefidoff-Freedman, Revital, Halperin, Jose, Natarajan, Amarnath, Morisseau, Christophe, Hammock, Bruce, Chorev, Michael, Aktas, Bertal H
Published in Journal of medicinal chemistry (12.12.2013)
Published in Journal of medicinal chemistry (12.12.2013)
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Journal Article
Structure–activity relationship study of 4EGI-1, small molecule eIF4E/eIF4G protein–protein interaction inhibitors
Takrouri, Khuloud, Chen, Ting, Papadopoulos, Evangelos, Sahoo, Rupam, Kabha, Eihab, Chen, Han, Cantel, Sonia, Wagner, Gerhard, Halperin, Jose A., Aktas, Bertal H., Chorev, Michael
Published in European journal of medicinal chemistry (22.04.2014)
Published in European journal of medicinal chemistry (22.04.2014)
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Journal Article
Semiautomated synthesis of a novel [ 18F] amine fluorocyanoborane for PET imaging studies. Radiosynthesis and in vivo characterization in rats
Shalom, Eli, Takrouri, Khuloud, Metsuyanim, Nir, Grufi, Arik, Katzhendler, Jehoshua, Srebnik, Morris
Published in Applied radiation and isotopes (01.02.2007)
Published in Applied radiation and isotopes (01.02.2007)
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Journal Article
ORM-6151: A First-in-Class, Anti-CD33 Antibody-Enabled GSPT1 Degrader for AML
Palacino, James, Lee, Pedro, Jeong, Hangyeol, Kim, Yeonjoon, Song, Yoojin, Permpoon, Uttapol, Wong, Wesley, Bai, Chen, Fishkin, Nathan, Takrouri, Khuloud, Yu, Eunjin, Yi, Yong, Skaletskaya, Anna, Chang, Ki-Hwan, Kim, Min-Soo, Kim, Da-Yeong, Choi, Dong-Ki, Park, Peter U
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
Synthesis of Rigidified eIF4E/eIF4G Inhibitor‑1 (4EGI-1) Mimetic and Their in Vitro Characterization as Inhibitors of Protein–Protein Interaction
Mahalingam, Poornachandran, Takrouri, Khuloud, Chen, Ting, Sahoo, Rupam, Papadopoulos, Evangelos, Chen, Limo, Wagner, Gerhard, Aktas, Bertal H, Halperin, Jose A, Chorev, Michael
Published in Journal of medicinal chemistry (26.06.2014)
Published in Journal of medicinal chemistry (26.06.2014)
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Journal Article
Compound design guidelines for evading the efflux and permeation barriers of Escherichia coli with the oxazolidinone class of antibacterials: Test case for a general approach to improving whole cell Gram-negative activity
Spaulding, Andrew, Takrouri, Khuloud, Mahalingam, Pornachandran, Cleary, Dillon C., Cooper, Harold D., Zucchi, Paola, Tear, Westley, Koleva, Bilyana, Beuning, Penny J., Hirsch, Elizabeth B., Aggen, James B.
Published in Bioorganic & medicinal chemistry letters (01.12.2017)
Published in Bioorganic & medicinal chemistry letters (01.12.2017)
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Journal Article
Abstract 4436: A novel antibody-enabled dual precision targeted protein stabilization (TPS2) that augments anti-tumor immune response by targeting CBL-B inhibitor to exhausted T cells while blocking checkpoint molecule, PD-1
Lim, Joanne, Skaletskaya, Anna, Permpoon, Uttapol, Kim, Yeonjoon, Saini, Shikha, Takrouri, Khuloud, Ribkovskaia, Zinaida, Bhar, Palash, Fishkin, Nathan, Choi, Dong-Ki, Park, Ji Hyun, Palacino, James, Park, Peter U.
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Journal Article
Abstract 2118: Development of RNAscope multiplex-based assay for exploratory pharmacodynamic biomarkers assessment in breast cancer patients from Phase I clinical trial of ORM-5029, a potent GSPT1 degrader
Saini, Shikha, Kim, Yeonjoon, Wong, Wesley, Karunaratne, Tina, Christensen, Olaf, Dutta, Sujoy, Bhar, Palash, Takrouri, Khuloud, Fishkin, Nathan, Choi, Dong-Ki, Kim, Min-Soo, Lim, Joanne, Skaletskaya, Anna, Palacino, James, Park, Peter
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Journal Article
Abstract 3933: ORM-5029: A first-in-class targeted protein degradation therapy using antibody neodegrader conjugate (AnDC) for HER2-expressing breast cancer
Palacino, James, Bai, Chen, Yi, Yong, Skaletskaya, Anna, Takrouri, Khuloud, Wong, Wesley, Kim, Min-Soo, Choi, Dong-Ki, Kim, Da-Young, Yang, Yeonhee, Kook, Jiae, Lee, Pedro, Jeong, Hangyeol, Jee, Sang-Mi, Park, Jiyun, Chang, Ki-Hwan, Fishkin, Nathan, Park, Peter U.
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Journal Article
Structure of the eukaryotic translation initiation factor eIF4E in complex with 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G
Papadopoulos, Evangelos, Jenni, Simon, Kabha, Eihab, Takrouri, Khuloud J., Yi, Tingfang, Salvi, Nicola, Luna, Rafael E., Gavathiotis, Evripidis, Mahalingam, Poornachandran, Arthanari, Haribabu, Rodriguez-Mias, Ricard, Yefidoff-Freedman, Revital, Aktas, Bertal H., Chorev, Michael, Halperin, Jose A., Wagner, Gerhard
Published in Proceedings of the National Academy of Sciences - PNAS (05.08.2014)
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Published in Proceedings of the National Academy of Sciences - PNAS (05.08.2014)
Journal Article
Structureeactivity relationship study of 4EGI-1, small molecule eIF4E/eIF4G proteineprotein interaction inhibitors
Takrouri, Khuloud, Chen, Ting, Papadopoulos, Evangelos, Sahoo, Rupam, Kabha, Eihab, Chen, Han, Cantel, Sonia, Wagner, Gerhard, Halperin, Jose A, Aktas, Bertal H., Chorev, Michael
Published in European journal of medicinal chemistry (14.04.2014)
Published in European journal of medicinal chemistry (14.04.2014)
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Journal Article
Progress against Escherichia coli with the Oxazolidinone Class of Antibacterials: Test Case for a General Approach To Improving Whole-Cell Gram-Negative Activity
Takrouri, Khuloud, Cooper, Harold D, Spaulding, Andrew, Zucchi, Paola, Koleva, Bilyana, Cleary, Dillon C, Tear, Westley, Beuning, Penny J, Hirsch, Elizabeth B, Aggen, James B
Published in ACS infectious diseases (10.06.2016)
Published in ACS infectious diseases (10.06.2016)
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Journal Article
Synthesis and Antifungal Activity of a Novel Series of Alkyldimethylamine Cyanoboranes and Their Derivatives
Takrouri, Khuloud, Oren, Gal, Polacheck, Itzhack, Sionov, Edward, Shalom, Eli, Katzhendler, Jehoshua, Srebnik, Morris
Published in Journal of medicinal chemistry (10.08.2006)
Published in Journal of medicinal chemistry (10.08.2006)
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Journal Article
Pharmacologically active boranes
Jabbour, Adel, Smoum, Reem, Takrouri, Khuloud, Shalom, Eli, Zaks, Batia, Steinberg, Doron, Rubinstein, Abraham, Goldberg, Israel, Katzhendler, Jehoshua, Srebnik, Morris
Published in Pure and applied chemistry (01.07.2006)
Published in Pure and applied chemistry (01.07.2006)
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