Dioxotriazine derivatives as a new class of P2X3 receptor antagonists: Identification of a lead and initial SAR studies
Kai, Hiroyuki, Horiguchi, Tohru, Kameyama, Takayuki, Asahi, Kentaro, Endoh, Takeshi, Jikihara, Sae, Hasegawa, Tsuyoshi, Tanaka, Satoru, Nozu, Azusa, Takeyama, Chie, Tomari, Maki, Takahashi, Fumiyo, Tamura, Naomi, Yagi, Shigenori, Itoh, Tetsuji, Isou, Yasuyoshi
Published in Bioorganic & medicinal chemistry letters (01.04.2021)
Published in Bioorganic & medicinal chemistry letters (01.04.2021)
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BACE1 inhibition reduces endogenous Abeta and alters APP processing in wild‐type mice2
Nishitomi, Kouhei, Sakaguchi, Gaku, Horikoshi, Yuko, Gray, Audrey J., Maeda, Masahiro, Hirata‐Fukae, Chiho, Becker, Amanda G., Hosono, Motoko, Sakaguchi, Isako, Minami, S. Sakura, Nakajima, Yoshihiro, Li, Hui‐Fang, Takeyama, Chie, Kihara, Tsuyoshi, Ota, Akinobu, Wong, Philip C., Aisen, Paul S., Kato, Akira, Kinoshita, Noriaki, Matsuoka, Yasuji
Published in Journal of neurochemistry (01.12.2006)
Published in Journal of neurochemistry (01.12.2006)
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Dioxotriazine derivatives as a new class of P2X(3) receptor antagonists: Identification of a lead and initial SAR studies
Kai, Hiroyuki, Horiguchi, Tohru, Kameyama, Takayuki, Asahi, Kentaro, Endoh, Takeshi, Jikihara, Sae, Hasegawa, Tsuyoshi, Tanaka, Satoru, Nozu, Azusa, Takeyama, Chie, Tomari, Maki, Takahashi, Fumiyo, Tamura, Naomi, Yagi, Shigenori, Itoh, Tetsuji, Isou, Yasuyoshi
Published in Bioorganic & medicinal chemistry letters (01.04.2021)
Published in Bioorganic & medicinal chemistry letters (01.04.2021)
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Pyrrolinone derivatives as a new class of P2X3 receptor antagonists. Part 3: Structure-activity relationships of pyrropyrazolone derivatives
Tobinaga, Hiroyuki, Kameyama, Takayuki, Asahi, Kentarou, Horiguchi, Tohru, Oohara, Miho, Taoda, Yoshiyuki, Hata, Kayoko, Hasegawa, Tsuyoshi, Tada, Yukio, Kurihara, Naoko, Kanda, Yasuhiko, Yagi, Shigenori, Tomari, Maki, Tanaka, Yoshikazu, Takahashi, Fumiyo, Taniguchi, Emiko, Takahara, Yukio, Shimada, Shinji, Takeyama, Chie, Yamamoto, Shoichi, Shinohara, Shunji, Kai, Hiroyuki
Published in Bioorganic & medicinal chemistry letters (15.12.2020)
Published in Bioorganic & medicinal chemistry letters (15.12.2020)
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Pyrrolinone derivatives as a new class of P2X3 receptor antagonists Part 2: Discovery of orally bioavailable compounds
Tobinaga, Hiroyuki, Kameyama, Takayuki, Asahi, Kentarou, Horiguchi, Tohru, Oohara, Miho, Tada, Yukio, Fuchino, Kouki, Jikihara, Sae, Endoh, Takeshi, Kurihara, Naoko, Kanda, Yasuhiko, Ogawa, Masayoshi, Tamura, Naomi, Yagi, Shigenori, Taniguchi, Emiko, Takahara, Yukio, Shimada, Shinji, Takeyama, Chie, Yamamoto, Shoichi, Shinohara, Shunji, Kai, Hiroyuki
Published in Bioorganic & medicinal chemistry letters (01.03.2019)
Published in Bioorganic & medicinal chemistry letters (01.03.2019)
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Journal Article
BACE1 inhibition reduces endogenous Abeta and alters APP processing in wild-type mice
NISHITOMI, Kouhei, SAKAGUCHI, Gaku, NAKAJIMA, Yoshihiro, LI, Hui-Fang, TAKEYAMA, Chie, KIHARA, Tsuyoshi, OTA, Akinobu, WONG, Philip C, AISEN, Paul S, KATO, Akira, KINOSHITA, Noriaki, MATSUOKA, Yasuji, HORIKOSHI, Yuko, GRAY, Audrey J, MAEDA, Masahiro, HIRATA-FUKAE, Chiho, BECKER, Amanda G, HOSONO, Motoko, SAKAGUCHI, Isako, SAKURA MINAMI, S
Published in Journal of neurochemistry (01.12.2006)
Published in Journal of neurochemistry (01.12.2006)
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Journal Article
Dioxotriazine derivatives as a new class of P2X 3 receptor antagonists: Identification of a lead and initial SAR studies
Kai, Hiroyuki, Horiguchi, Tohru, Kameyama, Takayuki, Asahi, Kentaro, Endoh, Takeshi, Jikihara, Sae, Hasegawa, Tsuyoshi, Tanaka, Satoru, Nozu, Azusa, Takeyama, Chie, Tomari, Maki, Takahashi, Fumiyo, Tamura, Naomi, Yagi, Shigenori, Itoh, Tetsuji, Isou, Yasuyoshi
Published in Bioorganic & medicinal chemistry letters (01.04.2021)
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Published in Bioorganic & medicinal chemistry letters (01.04.2021)
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P1-057: Presenilin-1 I213T knock-in mutation accelerates Alzheimer’s phenotype in Tg2576 mice
Nishitomi, Kouhei, Sakaguchi, Gaku, Nakajima, Yoshihiro, Hosono, Motoko, Takeyama, Chie, Kudo, Takashi, Takeda, Masatoshi, Kato, Akira
Published in Alzheimer's & dementia (01.07.2006)
Published in Alzheimer's & dementia (01.07.2006)
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Journal Article
BACE1 inhibition reduces endogenous Abeta and alters APP processing in wild‐type mice 2
Nishitomi, Kouhei, Sakaguchi, Gaku, Horikoshi, Yuko, Gray, Audrey J., Maeda, Masahiro, Hirata‐Fukae, Chiho, Becker, Amanda G., Hosono, Motoko, Sakaguchi, Isako, Minami, S. Sakura, Nakajima, Yoshihiro, Li, Hui‐Fang, Takeyama, Chie, Kihara, Tsuyoshi, Ota, Akinobu, Wong, Philip C., Aisen, Paul S., Kato, Akira, Kinoshita, Noriaki, Matsuoka, Yasuji
Published in Journal of neurochemistry (01.12.2006)
Published in Journal of neurochemistry (01.12.2006)
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Acute intracerebroventricular administration of either carboxyl-terminal or amino-terminal fragments of agouti-related peptide produces a long-term decrease in energy expenditure in rats
Goto, Kyoko, Inui, Akio, Takimoto, Yoshiyuki, Yuzuriha, Hideki, Asakawa, Akihiro, Kawamura, Yoshihiro, Tsuji, Hiroki, Takahara, Yukio, Takeyama, Chie, Katsuura, Goro, Kasuga, Masato
Published in International journal of molecular medicine (01.09.2003)
Published in International journal of molecular medicine (01.09.2003)
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