Phosphorylation of Histone H2AX and Activation of Mre11, Rad50, and Nbs1 in Response to Replication-dependent DNA Double-strand Breaks Induced by Mammalian DNA Topoisomerase I Cleavage Complexes
Furuta, Takahisa, Takemura, Haruyuki, Liao, Zhi-Yong, Aune, Gregory J., Redon, Christophe, Sedelnikova, Olga A., Pilch, Duane R., Rogakou, Emmy P., Celeste, Arkady, Chen, Hua Tang, Nussenzweig, Andre, Aladjem, Mirit I., Bonner, William M., Pommier, Yves
Published in The Journal of biological chemistry (30.05.2003)
Published in The Journal of biological chemistry (30.05.2003)
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Defective Mre11-dependent Activation of Chk2 by Ataxia Telangiectasia Mutated in Colorectal Carcinoma Cells in Response to Replication-dependent DNA Double Strand Breaks
Takemura, Haruyuki, Rao, V. Ashutosh, Sordet, Olivier, Furuta, Takahisa, Miao, Ze-Hong, Meng, LingHua, Zhang, Hongliang, Pommier, Yves
Published in The Journal of biological chemistry (13.10.2006)
Published in The Journal of biological chemistry (13.10.2006)
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Fludarabine-mediated circumvention of cytarabine resistance is associated with fludarabine triphosphate accumulation in cytarabine-resistant leukemic cells
YAMAMOTO, Shuji, YAMAUCHI, Takahiro, KAWAI, Yasukazu, TAKEMURA, Haruyuki, KISHI, Shinji, YOSHIDA, Akira, URASAKI, Yoshimasa, IWASAKI, Hiromichi, UEDA, Takanori
Published in International journal of hematology (01.02.2007)
Published in International journal of hematology (01.02.2007)
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Combined Low-dose Cytarabine, Melphalan and Mitoxantone for Older Patients with Acute Myeloid Leukemia or High-risk Myelodysplastic Syndrome
YAMAUCHI, Takahiro, NEGORO, Eiju, UEDA, Takanori, ARAI, Hajime, IKEGAYA, Satoshi, TAKAGI, Kazutaka, TAKEMURA, Haruyuki, INAI, Kunihiro, YOSHIDA, Akira, URASAKI, Yoshimasa, IWASAKI, Hiromichi
Published in Anticancer research (01.07.2007)
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Published in Anticancer research (01.07.2007)
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Dexamethasone‐resistant Human Pre‐B Leukemia 697 Cell Line Evolving Elevation of Intracellular Glutathione Level: An Additional Resistance Mechanism
Inoue, Hitoshi, Takemura, Haruyuki, Kawai, Yasukazu, Yoshida, Akira, Ueda, Takanori, Miyashita, Toshiyuki
Published in Cancer science (01.05.2002)
Published in Cancer science (01.05.2002)
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Inhibition of glutathione synthesis overcomes Bcl-2-mediated topoisomerase inhibitor resistance and induces nonapoptotic cell death via mitochondrial-independent pathway
Yoshida, Akira, Takemura, Haruyuki, Inoue, Hitoshi, Miyashita, Toshiyuki, Ueda, Takanori
Published in Cancer research (Chicago, Ill.) (01.06.2006)
Published in Cancer research (Chicago, Ill.) (01.06.2006)
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Journal Article
Repair of and checkpoint response to topoisomerase I-mediated DNA damage
Pommier, Yves, Redon, Christophe, Rao, V Ashutosh, Seiler, Jennifer A, Sordet, Olivier, Takemura, Haruyuki, Antony, Smitha, Meng, LingHua, Liao, ZhiYong, Kohlhagen, Glenda, Zhang, HongLiang, Kohn, Kurt W
Published in Mutation research (27.11.2003)
Published in Mutation research (27.11.2003)
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UCN-01 inhibits p53 up-regulation and abrogates γ-radiation-induced G2-M checkpoint independently of p53 by targeting both of the checkpoint kinases, Chk2 and Chk1
QIANG YU, JIHYUN LA ROSE, HONGLIANG ZHANG, TAKEMURA, Haruyuki, KOHN, Kurt W, POMMIER, Yves
Published in Cancer research (Chicago, Ill.) (15.10.2002)
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Published in Cancer research (Chicago, Ill.) (15.10.2002)
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UCN-01 inhibits p53 up-regulation and abrogates gamma-radiation-induced G(2)-M checkpoint independently of p53 by targeting both of the checkpoint kinases, Chk2 and Chk1
Yu, Qiang, La Rose, JiHyun, Zhang, Hongliang, Takemura, Haruyuki, Kohn, Kurt W, Pommier, Yves
Published in Cancer research (Chicago, Ill.) (15.10.2002)
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Published in Cancer research (Chicago, Ill.) (15.10.2002)
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Inhibition of glutathione synthesis overcomes bcl-2-mediated topoisomerase inhibitor resistance and induces nonapoptotic cell death via mitochondrial-lndependent pathway
YOSHIDA, Akira, TAKEMURA, Haruyuki, INOUE, Hitoshi, MIYASHITA, Toshiyuki, UEDA, Takanori
Published in Cancer research (Chicago, Ill.) (2006)
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Published in Cancer research (Chicago, Ill.) (2006)
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Tetrandrine induces early G1 arrest in human colon carcinoma cells by down-regulating the activity and inducing the degradation of G1-S-specific cyclin-dependent kinases and by inducing p53 and p21Cip1
Meng, Ling-Hua, Zhang, Hongliang, Hayward, Larry, Takemura, Haruyuki, Shao, Rong-Guang, Pommier, Yves
Published in Cancer research (Chicago, Ill.) (15.12.2004)
Published in Cancer research (Chicago, Ill.) (15.12.2004)
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Tetrandrine Induces Early G sub(1) Arrest in Human Colon Carcinoma Cells by Down-Regulating the Activity and Inducing the Degradation of G sub(1)-S-Specific Cyclin-Dependent Kinases and by Inducing p53 and p21 super(Cip1)
Meng, Ling-Hua, Zhang, Hongliang, Hayward, Larry, Takemura, Haruyuki, Shao, Rong-Guang, Pommier, Yves
Published in Cancer research (Chicago, Ill.) (15.12.2004)
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Published in Cancer research (Chicago, Ill.) (15.12.2004)
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Combined low-dose cytarabine, melphalan and mitoxantrone for older patients with acute myeloid leukemia or high-risk myelodysplastic syndrome
Yamauchi, Takahiro, Negoro, Eiju, Arai, Hajime, Ikegaya, Satoshi, Takagi, Kazutaka, Takemura, Haruyuki, Inai, Kunihiro, Yoshida, Akira, Urasaki, Yoshimasa, Iwasaki, Hiromichi, Ueda, Takanori
Published in Anticancer research (01.07.2007)
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Published in Anticancer research (01.07.2007)
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Tetrandrine induces early G1 arrest in human colon carcinoma cells by down-regulating the activity and inducing the degradation of G1S-Specific cyclin-dependent kinases and by inducing p53 and p21Cip1
MENG, Ling-Hua, HONGLIANG ZHANG, HAYWARD, Larry, TAKEMURA, Haruyuki, SHAO, Rong-Guang, POMMIER, Yves
Published in Cancer research (Chicago, Ill.) (2004)
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Published in Cancer research (Chicago, Ill.) (2004)
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Simultaneous treatment with 1-β-D-arabinofuranosylcytosine and daunorubicin induces cross-resistance to both drugs due to a combination-specific mechanism in HL60 cells
TAKEMURA, Haruyuki, URASAKI, Yoshimasa, YOSHIDA, Akira, FUKUSHIMA, Toshihiro, UEDA, Takanori
Published in Cancer research (Chicago, Ill.) (2001)
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Published in Cancer research (Chicago, Ill.) (2001)
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Repair of and checkpoint response to topoisomerase I-mediated DNA damage: DNA replication, the cell cycle and genome stability
POMMIER, Yves, REDON, Christophe, HONGLIANG ZHANG, KOHN, Kurt W, RAO, V. Ashutosh, SEILER, Jennifer A, SORDET, Olivier, TAKEMURA, Haruyuki, ANTONY, Smitha, LINGHUA MENG, ZHIYONG LIAO, KOHLHAGEN, Glenda
Published in Mutation research. Fundamental and molecular mechanisms of mutagenesis (2003)
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Published in Mutation research. Fundamental and molecular mechanisms of mutagenesis (2003)
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Effect of PSC 833 on the cytotoxicity and pharmacodynamics of mitoxantrone in multidrug-resistant K562 cells
Fukushima, Toshihiro, Yamashita, Taro, Takemura, Haruyuki, Suto, Hidemasa, Kishi, Shinji, Urasaki, Yoshimasa, Ueda, Takanori
Published in Leukemia research (01.03.2000)
Published in Leukemia research (01.03.2000)
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