Development of torsadogenic risk assessment using human induced pluripotent stem cell-derived cardiomyocytes: Japan iPS Cardiac Safety Assessment (JiCSA) update
Kanda, Yasunari, Yamazaki, Daiju, Osada, Tomoharu, Yoshinaga, Takashi, Sawada, Kohei
Published in Journal of pharmacological sciences (01.12.2018)
Published in Journal of pharmacological sciences (01.12.2018)
Get full text
Journal Article
Renal Biomarkers in the Early Detection of Acute Kidney Injury After Off-Pump Coronary Artery Bypass Grafting
Takaki, Jun, Morinaga, Jun, Sadanaga, Tatsuaki, Hirota, Takahumi, Hidaka, Hideaki, Horibe, Tatsuya, Nishigawa, Kosaku, Yoshinaga, Takashi, Fukui, Toshihiro
Published in Circulation Journal (24.05.2024)
Published in Circulation Journal (24.05.2024)
Get full text
Journal Article
Electrophysiological Characteristics of Human iPSC-Derived Cardiomyocytes for the Assessment of Drug-Induced Proarrhythmic Potential
Yamamoto, Wataru, Asakura, Keiichi, Ando, Hiroyuki, Taniguchi, Tomohiko, Ojima, Atsuko, Uda, Takaaki, Osada, Tomoharu, Hayashi, Seiji, Kasai, Chieko, Miyamoto, Norimasa, Tashibu, Hiroyuki, Yoshinaga, Takashi, Yamazaki, Daiju, Sugiyama, Atsushi, Kanda, Yasunari, Sawada, Kohei, Sekino, Yuko
Published in PloS one (06.12.2016)
Published in PloS one (06.12.2016)
Get full text
Journal Article
Risk of Out-of-Hospital Cardiac Arrest in Aged Individuals in Relation to Cold Ambient Temperature ― A Report From North Tochigi Experience
Yoshinaga, Takashi, Shiba, Nobuyuki, Kunitomo, Ryuji, Hasegawa, Nobuyuki, Suzuki, Masanori, Sekiguchi, Chuji, Shinozawa, Yotaro, Tsuge, Shunsuke, Kitajima, Toshimitsu, Miyahara, Yasuyuki, Misawa, Yoshio
Published in Circulation Journal (25.12.2019)
Published in Circulation Journal (25.12.2019)
Get full text
Journal Article
Acute heart failure due to coronary subclavian steal syndrome after coronary artery bypass grafting
Nakata, Kosuke, Nishigawa, Kosaku, Yoshinaga, Takashi, Fukui, Toshihiro
Published in Clinical case reports (01.05.2023)
Published in Clinical case reports (01.05.2023)
Get full text
Journal Article
Arrhythmic hazard map for a 3D whole‐ventricle model under multiple ion channel block
Okada, Jun‐ichi, Yoshinaga, Takashi, Kurokawa, Junko, Washio, Takumi, Furukawa, Tetsushi, Sawada, Kohei, Sugiura, Seiryo, Hisada, Toshiaki
Published in British journal of pharmacology (01.09.2018)
Published in British journal of pharmacology (01.09.2018)
Get full text
Journal Article
Macrophage-Derived Angiopoietin-Like Protein 2 Accelerates Development of Abdominal Aortic Aneurysm
Tazume, Hirokazu, Miyata, Keishi, Tian, Zhe, Endo, Motoyoshi, Horiguchi, Haruki, Takahashi, Otowa, Horio, Eiji, Tsukano, Hiroto, Kadomatsu, Tsuyoshi, Nakashima, Yukiko, Kunitomo, Ryuji, Kaneko, Yasushi, Moriyama, Shuji, Sakaguchi, Hisashi, Okamoto, Ken, Hara, Masahiko, Yoshinaga, Takashi, Yoshimura, Koichi, Aoki, Hiroki, Araki, Kimi, Hao, Hiroyuki, Kawasuji, Michio, Oike, Yuichi
Published in Arteriosclerosis, thrombosis, and vascular biology (01.06.2012)
Published in Arteriosclerosis, thrombosis, and vascular biology (01.06.2012)
Get full text
Journal Article
Comparative sensitivity of laboratory animals used for preclinical convulsion risk assessment to drug-induced convulsion
Shiotani, Motohiro, Seki, Yuki, Takano, Misato, Ishihara, Hiroki, Mikamoto, Masaki, Nozaki, Yoshitane, Maeda, Sanae, Taniguchi, Tomohiko, Miyamoto, Norimasa, Yoshinaga, Takashi, Asakura, Shoji
Published in Journal of toxicological sciences (2024)
Published in Journal of toxicological sciences (2024)
Get full text
Journal Article
Concentration-Response Modeling of ECG Data From Early-Phase Clinical Studies as an Alternative Clinical and Regulatory Approach to Assessing QT Risk - Experience From the Development Program of Lemborexant
Murphy, Patricia J, Yasuda, Sanae, Nakai, Kenya, Yoshinaga, Takashi, Hall, Nancy, Zhou, Meijian, Aluri, Jagadeesh, Rege, Bhaskar, Moline, Margaret, Ferry, Jim, Darpo, Borje
Published in Journal of clinical pharmacology (01.01.2017)
Published in Journal of clinical pharmacology (01.01.2017)
Get more information
Journal Article
Chloroquine and hydroxychloroquine provoke arrhythmias at concentrations higher than those clinically used to treat COVID‐19: A simulation study
Okada, Jun‐ichi, Yoshinaga, Takashi, Washio, Takumi, Sawada, Kohei, Sugiura, Seiryo, Hisada, Toshiaki
Published in Clinical and Translational Science (01.05.2021)
Published in Clinical and Translational Science (01.05.2021)
Get full text
Journal Article
Web Resource
Left atrial intramural hematoma after percutaneous coronary intervention
Takaki, Jun, Yoshinaga, Takashi, Nishigawa, Kosaku, Okamoto, Ken, Fukui, Toshihiro
Published in Clinical case reports (01.08.2021)
Published in Clinical case reports (01.08.2021)
Get full text
Journal Article
Screening system for drug-induced arrhythmogenic risk combining a patch clamp and heart simulator
Okada, Jun-Ichi, Yoshinaga, Takashi, Kurokawa, Junko, Washio, Takumi, Furukawa, Tetsushi, Sawada, Kohei, Sugiura, Seiryo, Hisada, Toshiaki
Published in Science advances (01.05.2015)
Published in Science advances (01.05.2015)
Get full text
Journal Article
A novel method of selecting human embryonic stem cell-derived cardiomyocyte clusters for assessment of potential to influence QT interval
Yamazaki, Kazuto, Hihara, Taro, Taniguchi, Tomohiko, Kohmura, Naohiro, Yoshinaga, Takashi, Ito, Masashi, Sawada, Kohei
Published in Toxicology in vitro (01.03.2012)
Published in Toxicology in vitro (01.03.2012)
Get full text
Journal Article
On the solutions of quadratic Diophantine equations
Yoshinaga, Takashi
Published in Documenta mathematica Journal der Deutschen Mathematiker-Vereinigung. (2010)
Published in Documenta mathematica Journal der Deutschen Mathematiker-Vereinigung. (2010)
Get full text
Journal Article
Design, synthesis, and characterization of BK channel openers based on oximation of abietane diterpene derivatives
Cui, Yong-Mei, Yasutomi, Eriko, Otani, Yuko, Ido, Katsutoshi, Yoshinaga, Takashi, Sawada, Kohei, Ohwada, Tomohiko
Published in Bioorganic & medicinal chemistry (15.12.2010)
Published in Bioorganic & medicinal chemistry (15.12.2010)
Get full text
Journal Article
N-type Calcium Channel in the Pathogenesis of Experimental Autoimmune Encephalomyelitis
Tokuhara, Naoki, Namiki, Kana, Uesugi, Mai, Miyamoto, Chihiro, Ohgoh, Makoto, Ido, Katsutoshi, Yoshinaga, Takashi, Yamauchi, Toshihiko, Kuromitsu, Junro, Kimura, Sadao, Miyamoto, Norimasa, Kasuya, Yoshitoshi
Published in The Journal of biological chemistry (22.10.2010)
Published in The Journal of biological chemistry (22.10.2010)
Get full text
Journal Article
A small-animal pharmacokinetic/pharmacodynamic PET study of central serotonin 1A receptor occupancy by a potential therapeutic agent for overactive bladder
Nakatani, Yosuke, Suzuki, Michiyuki, Tokunaga, Masaki, Maeda, Jun, Sakai, Miyuki, Ishihara, Hiroki, Yoshinaga, Takashi, Takenaka, Osamu, Zhang, Ming-Rong, Suhara, Tetsuya, Higuchi, Makoto
Published in PloS one (23.09.2013)
Published in PloS one (23.09.2013)
Get full text
Journal Article
Functional disorders of the sympathetic nervous system in mice lacking the α1B subunit (Cav 2.2) of N-type calcium channels
Ino, Mitsuhiro, Yoshinaga, Takashi, Wakamori, Minoru, Miyamoto, Norimasa, Takahashi, Eiki, Sonoda, Jiro, Kagaya, Takaki, Oki, Tohru, Nagasu, Takeshi, Nishizawa, Yukio, Tanaka, Isao, Imoto, Keiji, Aizawa, Shinichi, Koch, Sheryl, Schwartz, Arnold, Niidome, Tetsuhiro, Sawada, Kohei, Mori, Yasuo
Published in Proceedings of the National Academy of Sciences - PNAS (24.04.2001)
Published in Proceedings of the National Academy of Sciences - PNAS (24.04.2001)
Get full text
Journal Article