Design and synthesis of a highly selective, orally active and potent anaplastic lymphoma kinase inhibitor (CH5424802)
Kinoshita, Kazutomo, Asoh, Kohsuke, Furuichi, Noriyuki, Ito, Toshiya, Kawada, Hatsuo, Hara, Sousuke, Ohwada, Jun, Miyagi, Takuho, Kobayashi, Takamitsu, Takanashi, Kenji, Tsukaguchi, Toshiyuki, Sakamoto, Hiroshi, Tsukuda, Takuo, Oikawa, Nobuhiro
Published in Bioorganic & medicinal chemistry (01.02.2012)
Published in Bioorganic & medicinal chemistry (01.02.2012)
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Journal Article
Selective TRK Inhibitor CH7057288 against TRK Fusion-Driven Cancer
Tanaka, Hiroshi, Sase, Hitoshi, Tsukaguchi, Toshiyuki, Hasegawa, Masami, Tanimura, Hiromi, Yoshida, Miyuki, Sakata, Kiyoaki, Fujii, Toshihiko, Tachibana, Yukako, Takanashi, Kenji, Higashida, Atsuko, Hasegawa, Kiyoshi, Ono, Yoshiyuki, Oikawa, Nobuhiro, Mio, Toshiyuki
Published in Molecular cancer therapeutics (01.12.2018)
Published in Molecular cancer therapeutics (01.12.2018)
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Journal Article
Prediction of Drug-Drug Interactions based on Time-Dependent Inhibition from High Throughput Screening of Cytochrome P450 3A4 Inhibition
Sekiguchi, Nobuo, Higashida, Atsuko, Kato, Motohiro, Nabuchi, Yoshiaki, Mitsui, Tetsuya, Takanashi, Kenji, Aso, Yoshinori, Ishigai, Masaki
Published in DRUG METABOLISM AND PHARMACOKINETICS (01.01.2009)
Published in DRUG METABOLISM AND PHARMACOKINETICS (01.01.2009)
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Journal Article
Metabolites of alectinib in human: their identification and pharmacological activity
Sato-Nakai, Mika, Kawashima, Kosuke, Nakagawa, Toshito, Tachibana, Yukako, Yoshida, Miyuki, Takanashi, Kenji, Morcos, Peter N., Binder, Martin, Moore, David J, Yu, Li
Published in Heliyon (01.07.2017)
Published in Heliyon (01.07.2017)
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Journal Article
Fluorine Scanning by Nonselective Fluorination: Enhancing Raf/MEK Inhibition while Keeping Physicochemical Properties
Hyohdoh, Ikumi, Furuichi, Noriyuki, Aoki, Toshihiro, Itezono, Yoshiko, Shirai, Haruyoshi, Ozawa, Sawako, Watanabe, Fumio, Matsushita, Masayuki, Sakaitani, Masahiro, Ho, Pil-Su, Takanashi, Kenji, Harada, Naoki, Tomii, Yasushi, Yoshinari, Kiyoshi, Ori, Kazutomo, Tabo, Mitsuyasu, Aoki, Yuko, Shimma, Nobuo, Iikura, Hitoshi
Published in ACS medicinal chemistry letters (14.11.2013)
Published in ACS medicinal chemistry letters (14.11.2013)
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Journal Article
In vitro metabolism of alectinib, a novel highly potent alk inhibitor: Contribution of CYP3A enzymes in microsomes and hepatocytes
Nakagawa, Toshito, Takanashi, Kenji, Hoshino-Yoshino, Azusa, Yamauchi, Tsuyoshi, Kawashima, Kosuke, Tachibana, Yukako, Yoshida, Miyuki, Fowler, Stephen, Youdim, Kuresh, Yu, Li, Ishigai, Masaki
Published in Drug metabolism and pharmacokinetics (01.01.2017)
Published in Drug metabolism and pharmacokinetics (01.01.2017)
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Journal Article
Discovery of an Orally-Active Nonsteroidal Androgen Receptor Pure Antagonist and the Structure–Activity Relationships of Its Derivatives
Tachibana, Kazutaka, Imaoka, Ikuhiro, Shiraishi, Takuya, Yoshino, Hitoshi, Nakamura, Mitsuaki, Ohta, Masateru, Kawata, Hiromitsu, Taniguchi, Kenji, Ishikura, Nobuyuki, Tsunenari, Toshiaki, Saito, Hidemi, Nagamuta, Masahiro, Nakagawa, Toshito, Takanashi, Kenji, Onuma, Etsuro, Sato, Haruhiko
Published in Chemical & Pharmaceutical Bulletin (01.11.2008)
Published in Chemical & Pharmaceutical Bulletin (01.11.2008)
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Journal Article
Optimizing the Physicochemical Properties of Raf/MEK Inhibitors by Nitrogen Scanning
Aoki, Toshihiro, Hyohdoh, Ikumi, Furuichi, Noriyuki, Ozawa, Sawako, Watanabe, Fumio, Matsushita, Masayuki, Sakaitani, Masahiro, Morikami, Kenji, Takanashi, Kenji, Harada, Naoki, Tomii, Yasushi, Shiraki, Koji, Furumoto, Kentaro, Tabo, Mitsuyasu, Yoshinari, Kiyoshi, Ori, Kazutomo, Aoki, Yuko, Shimma, Nobuo, Iikura, Hitoshi
Published in ACS medicinal chemistry letters (10.04.2014)
Published in ACS medicinal chemistry letters (10.04.2014)
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Errata: Discovery of an Orally-Active Nonsteroidal Androgen Receptor Pure Antagonist and the Structure–Activity Relationships of Its Derivatives [Chem. Pharm. Bull. 56(11): 1555-1561 (2008)]
Tachibana, Kazutaka, Imaoka, Ikuhiro, Shiraishi, Takuya, Yoshino, Hitoshi, Nakamura, Mitsuaki, Ohta, Masateru, Kawata, Hiromitsu, Taniguchi, Kenji, Ishikura, Nobuyuki, Tsunenari, Toshiaki, Saito, Hidemi, Nagamuta, Masahiro, Nakagawa, Toshito, Takanashi, Kenji, Onuma, Etsuro, Sato, Haruhiko
Published in Chemical & pharmaceutical bulletin (2009)
Published in Chemical & pharmaceutical bulletin (2009)
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Journal Article
Discovery of CH7057288 as an Orally Bioavailable, Selective, and Potent pan-TRK Inhibitor
Ito, Toshiya, Kinoshita, Kazutomo, Tomizawa, Masaki, Shinohara, Shojiro, Nishii, Hiroki, Matsushita, Masayuki, Hattori, Kazuo, Kohchi, Yasunori, Kohchi, Masami, Hayase, Tadakatsu, Watanabe, Fumio, Hasegawa, Kiyoshi, Tanaka, Hiroshi, Kuramoto, Shino, Takanashi, Kenji, Oikawa, Nobuhiro
Published in Journal of medicinal chemistry (22.09.2022)
Published in Journal of medicinal chemistry (22.09.2022)
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Journal Article
In vitro metabolism of alectinib, a novel potent ALK inhibitor, in human: contribution of CYP3A enzymes
Nakagawa, Toshito, Fowler, Stephen, Takanashi, Kenji, Youdim, Kuresh, Yamauchi, Tsuyoshi, Kawashima, Kosuke, Sato-Nakai, Mika, Yu, Li, Ishigai, Masaki
Published in Xenobiotica (03.06.2018)
Published in Xenobiotica (03.06.2018)
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Journal Article
Preclinical evaluation of the potential for cytochrome P450 inhibition and induction of the selective ALK inhibitor, alectinib
Sekiguchi, Nobuo, Nagao, Shunsuke, Takanashi, Kenji, Kato, Motohiro, Kaneko, Akihisa, Morita, Keiichi, Shindoh, Hidetoshi, Ishigai, Masaki
Published in Xenobiotica (02.12.2017)
Published in Xenobiotica (02.12.2017)
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Journal Article
9-Substituted 6,6-Dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazoles as Highly Selective and Potent Anaplastic Lymphoma Kinase Inhibitors
Kinoshita, Kazutomo, Kobayashi, Takamitsu, Asoh, Kohsuke, Furuichi, Noriyuki, Ito, Toshiya, Kawada, Hatsuo, Hara, Sousuke, Ohwada, Jun, Hattori, Kazuo, Miyagi, Takuho, Hong, Woo-Sang, Park, Min-Jeong, Takanashi, Kenji, Tsukaguchi, Toshiyuki, Sakamoto, Hiroshi, Tsukuda, Takuo, Oikawa, Nobuhiro
Published in Journal of medicinal chemistry (22.09.2011)
Published in Journal of medicinal chemistry (22.09.2011)
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Abstract 754: Selective ALK inhibitor alectinib (CH5424802/RO5424802) with potent antitumor activity in models of crizotinib resistance, including intracranial metastases
Kodama, Tatsushi, Tsukaguchi, Toshiyuki, Hasegawa, Masami, Yoshida, Miyuki, Takanashi, Kenji, Kondoh, Osamu, Sakamoto, Hiroshi
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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Journal Article
The sulfamide moiety affords higher inhibitory activity and oral bioavailability to a series of coumarin dual selective RAF/MEK inhibitors
Aoki, Toshihiro, Hyohdoh, Ikumi, Furuichi, Noriyuki, Ozawa, Sawako, Watanabe, Fumio, Matsushita, Masayuki, Sakaitani, Masahiro, Ori, Kazutomo, Takanashi, Kenji, Harada, Naoki, Tomii, Yasushi, Tabo, Mitsuyasu, Yoshinari, Kiyoshi, Aoki, Yuko, Shimma, Nobuo, Iikura, Hitoshi
Published in Bioorganic & medicinal chemistry letters (01.12.2013)
Published in Bioorganic & medicinal chemistry letters (01.12.2013)
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Journal Article
Abstract 2789: Discovery of a novel specific MEK and Raf inhibitor, CH5126766 (RO5126766), hit to lead study of a unique scaffold for kinase inhibitor to a clinical compound
Iikura, Hitoshi, Aoki, Toshihiro, Hyoudoh, Ikumi, Furuichi, Noriyuki, Watanabe, Fumio, Ozawa, Sawako, Sakaidani, Masahiro, Matsushita, Masayuki, Shimma, Nobuo, Harada, Naoki, Tomii, Yasushi, Aoki, Yuko, Takanashi, Kenji
Published in Cancer research (Chicago, Ill.) (15.04.2011)
Published in Cancer research (Chicago, Ill.) (15.04.2011)
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