Effect of substrate concentration on reactive metabolite assessment in drug discovery research
Ozawa, Makoto, Shiozawa, Hideyuki, Shimada, Masaya, Makino, Chie, Takakusa, Hideo, Watanabe, Kengo, Suzuki, Kyosuke
Published in Drug metabolism and pharmacokinetics (01.04.2024)
Published in Drug metabolism and pharmacokinetics (01.04.2024)
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Journal Article
A Zone Classification System for Risk Assessment of Idiosyncratic Drug Toxicity Using Daily Dose and Covalent Binding
NAKAYAMA, Shintaro, ATSUMI, Ryo, TAKAKUSA, Hideo, KOBAYASHI, Yoshimasa, KURIHARA, Atsushi, NAGAI, Yoko, NAKAI, Daisuke, OKAZAKI, Osamu
Published in Drug metabolism and disposition (01.09.2009)
Published in Drug metabolism and disposition (01.09.2009)
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Journal Article
Pharmacokinetics, distribution, and disposition of esaxerenone, a novel, highly potent and selective non-steroidal mineralocorticoid receptor antagonist, in rats and monkeys
Yamada, Makiko, Takei, Makoto, Suzuki, Eiko, Takakusa, Hideo, Kotsuma, Masakatsu, Washio, Takuo, Murayama, Nobuyuki, Inoue, Shin-ichi, Izumi, Takashi
Published in Xenobiotica (02.12.2017)
Published in Xenobiotica (02.12.2017)
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Species differences between rats and primates (humans and monkeys) in complex cleavage pathways of DS-8500a characterized by 14C-ADME studies in humans and monkeys after administration of two radiolabeled compounds and in vitro studies
Makino, Chie, Watanabe, Akiko, Kato, Manabu, Shiozawa, Hideyuki, Takakusa, Hideo, Nakai, Daisuke, Honda, Tomoyo, Watanabe, Nobuaki
Published in Drug metabolism and pharmacokinetics (01.08.2022)
Published in Drug metabolism and pharmacokinetics (01.08.2022)
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Journal Article
Covalent Binding and Tissue Distribution/Retention Assessment of Drugs Associated with Idiosyncratic Drug Toxicity
TAKAKUSA, Hideo, MASUMOTO, Hiroshi, YUKINAGA, Hideo, MAKINO, Chie, NAKAYAMA, Shintaro, OKAZAKI, Osamu, SUDO, Kenichi
Published in Drug metabolism and disposition (01.09.2008)
Published in Drug metabolism and disposition (01.09.2008)
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Journal Article
CS-8958, a Prodrug of the Novel Neuraminidase Inhibitor R-125489, Demonstrates a Favorable Long-Retention Profile in the Mouse Respiratory Tract
KOYAMA, Kumiko, TAKAHASHI, Makoto, OITATE, Masataka, NAKAI, Naoko, TAKAKUSA, Hideo, MIURA, Shin-Ichi, OKAZAKI, Osamu
Published in Antimicrobial Agents and Chemotherapy (01.11.2009)
Published in Antimicrobial Agents and Chemotherapy (01.11.2009)
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Journal Article
Recent advances in the design of small molecule-based FRET sensors for cell biology
Kikuchi, Kazuya, Takakusa, Hideo, Nagano, Tetsuo
Published in TrAC, Trends in analytical chemistry (Regular ed.) (01.06.2004)
Published in TrAC, Trends in analytical chemistry (Regular ed.) (01.06.2004)
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Journal Article
Renadirsen, a Novel 2′OMeRNA/ENA® Chimera Antisense Oligonucleotide, Induces Robust Exon 45 Skipping for Dystrophin In Vivo
Ito, Kentaro, Takakusa, Hideo, Kakuta, Masayo, Kanda, Akira, Takagi, Nana, Nagase, Hiroyuki, Watanabe, Nobuaki, Asano, Daigo, Goda, Ryoya, Masuda, Takeshi, Nakamura, Akifumi, Onishi, Yoshiyuki, Onoda, Toshio, Koizumi, Makoto, Takeshima, Yasuhiro, Matsuo, Masafumi, Takaishi, Kiyosumi
Published in Current issues in molecular biology (25.09.2021)
Published in Current issues in molecular biology (25.09.2021)
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Journal Article
Inhibition of Autotaxin by Lysophosphatidic Acid and Sphingosine 1-Phosphate
van Meeteren, Laurens A., Ruurs, Paula, Christodoulou, Evangelos, Goding, James W., Takakusa, Hideo, Kikuchi, Kazuya, Perrakis, Anastassis, Nagano, Tetsuo, Moolenaar, Wouter H.
Published in The Journal of biological chemistry (03.06.2005)
Published in The Journal of biological chemistry (03.06.2005)
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Journal Article
Combination of GSH Trapping and Time-Dependent Inhibition Assays as a Predictive Method of Drugs Generating Highly Reactive Metabolites
NAKAYAMA, Shintaro, TAKAKUSA, Hideo, OKAZAKI, Osamu, WATANABE, Akiko, MIYAJI, Yoshihiro, SUZUKI, Wataru, SUGIYAMA, Daisuke, SHIOSAKAI, Kazuhito, HONDA, Kokichi, OKUDAIRA, Noriko, IZUMI, Takashi
Published in Drug metabolism and disposition (01.07.2011)
Published in Drug metabolism and disposition (01.07.2011)
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Journal Article
A Novel Design Method of Ratiometric Fluorescent Probes Based on Fluorescence Resonance Energy Transfer Switching by Spectral Overlap Integral
Takakusa, Hideo, Kikuchi, Kazuya, Urano, Yasuteru, Kojima, Hirotatsu, Nagano, Tetsuo
Published in Chemistry : a European journal (04.04.2003)
Published in Chemistry : a European journal (04.04.2003)
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Journal Article
Design and Synthesis of Intramolecular Resonance-Energy Transfer Probes for Use in Ratiometric Measurements in Aqueous Solution
Kawanishi, Yasutomo, Kikuchi, Kazuya, Takakusa, Hideo, Mizukami, Shin, Urano, Yasuteru, Higuchi, Tsunehiko, Nagano, Tetsuo
Published in Angewandte Chemie (International ed.) (02.10.2000)
Published in Angewandte Chemie (International ed.) (02.10.2000)
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Journal Article
Drug Metabolism and Pharmacokinetics of Antisense Oligonucleotide Therapeutics: Typical Profiles, Evaluation Approaches, and Points to Consider Compared with Small Molecule Drugs
Takakusa, Hideo, Iwazaki, Norihiko, Nishikawa, Makiya, Yoshida, Tokuyuki, Obika, Satoshi, Inoue, Takao
Published in Nucleic acid therapeutics (01.04.2023)
Published in Nucleic acid therapeutics (01.04.2023)
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Transition of average drug-to-antibody ratio of trastuzumab deruxtecan in systemic circulation in monkeys using a hybrid affinity capture liquid chromatography-tandem mass spectrometry
Habara, Hiromi, Okamoto, Hiromi, Nagai, Yoko, Oitate, Masataka, Takakusa, Hideo, Watanabe, Nobuaki
Published in Biopharmaceutics & drug disposition (01.10.2023)
Published in Biopharmaceutics & drug disposition (01.10.2023)
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