Search Results - "TAFESSE, Laykea" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

N-(4-Tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a Novel, Orally Effective Vanilloid Receptor 1 Antagonist with Analgesic Properties: I. In Vitro Characterization and Pharmacokinetic Properties

N-(4-Tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a Novel, Orally Effective Vanilloid Receptor 1 Antagonist with Analgesic Properties: I. In Vitro Characterization and Pharmacokinetic Properties

by Valenzano, Kenneth J, Grant, Elfrida R, Wu, Gang, Hachicha, Mohamed, Schmid, Lori, Tafesse, Laykea, Sun, Qun, Rotshteyn, Yakov, Francis, Joseph, Limberis, James, Malik, Shiazah, Whittemore, Edward R, Hodges, Dianne
Published in The Journal of pharmacology and experimental therapeutics (01.07.2003)

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Journal Article

CARBOXAMIDE DERIVATIVES AND USE THEREOF

CARBOXAMIDE DERIVATIVES AND USE THEREOF

by YAO JIANGCHAO, TAFESSE LAYKEA
Year of Publication 09.05.2019

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Patent

CARBOXAMIDE DERIVATIVES AND USE THEREOF

CARBOXAMIDE DERIVATIVES AND USE THEREOF

by YAO JIANGCHAO, TAFESSE LAYKEA
Year of Publication 25.01.2018

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Patent

Parallel synthesis of a biased library of thiazolidinones as novel sodium channel antagonists

Parallel synthesis of a biased library of thiazolidinones as novel sodium channel antagonists

by Sun, Qun, Tafesse, Laykea, Limberis, James T, Islam, Khondekar, Kyle, Donald J
Published in Combinatorial chemistry & high throughput screening (01.08.2003)

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Journal Article

Dibenzazepines and dibenzoxazepines as sodium channel blockers

Dibenzazepines and dibenzoxazepines as sodium channel blockers

by Lynch, Stephen M., Tafesse, Laykea, Carlin, Kevin, Ghatak, Parijat, Kyle, Donald J.
Published in Bioorganic & medicinal chemistry letters (01.01.2015)

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Journal Article

Dissociation Rates as One of the Differentiating Factors for Hyperthermic and Non-Hyperthermic TRPV1 Antagonists

Dissociation Rates as One of the Differentiating Factors for Hyperthermic and Non-Hyperthermic TRPV1 Antagonists

by Tafesse, Laykea, Wu, Gang, Carlin, Kevin, Asaki, Toshiyuki, Kanemasa, Toshiyuki, Ilyin, Victor
Published in Biophysical journal (27.01.2015)

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Journal Article

Structure–Activity Relationship Studies and Discovery of a Potent Transient Receptor Potential Vanilloid (TRPV1) Antagonist 4-[3-Chloro-5-[(1 S )-1,2-dihydroxyethyl]-2-pyridyl]- N -[5-(trifluoromethyl)-2-pyridyl]-3,6-dihydro-2 H -pyridine-1-carboxamide (V116517) as a Clinical Candidate for Pain Management

Structure–Activity Relationship Studies and Discovery of a Potent Transient Receptor Potential Vanilloid (TRPV1) Antagonist 4-[3-Chloro-5-[(1 S )-1,2-dihydroxyethyl]-2-pyridyl]- N -[5-(trifluoromethyl)-2-pyridyl]-3,6-dihydro-2 H -pyridine-1-carboxamide (V116517) as a Clinical Candidate for Pain Management

by Tafesse, Laykea, Kanemasa, Toshiyuki, Kurose, Noriyuki, Yu, Jianming, Asaki, Toshiyuki, Wu, Gang, Iwamoto, Yuka, Yamaguchi, Yoshitaka, Ni, Chiyou, Engel, John, Tsuno, Naoki, Patel, Aniket, Zhou, Xiaoming, Shintani, Takuya, Brown, Kevin, Hasegawa, Tsuyoshi, Shet, Manjunath, Iso, Yasuyoshi, Kato, Akira, Kyle, Donald J.
Published in Journal of medicinal chemistry (14.08.2014)

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Journal Article

BUPRENORPHINE ANALOGS

BUPRENORPHINE ANALOGS

by KYLE DONALD J, TAFESSE LAYKEA
Year of Publication 02.06.2016

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Patent

N-Aryl azacycles as novel sodium channel blockers

N-Aryl azacycles as novel sodium channel blockers

by Lynch, Stephen M., Tafesse, Laykea, Carlin, Kevin, Ghatak, Parijat, Shao, Bin, Abdelhamid, Haissam, Kyle, Donald J.
Published in Bioorganic & medicinal chemistry letters (01.01.2015)

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Journal Article

AZASPIRO[4.5] DECANE DERIVATIVES AND USE THEREOF

AZASPIRO[4.5] DECANE DERIVATIVES AND USE THEREOF

by PARK JAE HYUN, MARK A YOUNGMAN, TAFESSE LAYKEA
Year of Publication 28.02.2019

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Patent

Structure–Activity Relationship Studies and Discovery of a Potent Transient Receptor Potential Vanilloid (TRPV1) Antagonist 4‑[3-Chloro-5-[(1S)‑1,2-dihydroxyethyl]-2-pyridyl]‑N‑[5-(trifluoromethyl)-2-pyridyl]-3,6-dihydro‑2H‑pyridine-1-carboxamide (V116517) as a Clinical Candidate for Pain Management

Structure–Activity Relationship Studies and Discovery of a Potent Transient Receptor Potential Vanilloid (TRPV1) Antagonist 4‑[3-Chloro-5-[(1S)‑1,2-dihydroxyethyl]-2-pyridyl]‑N‑[5-(trifluoromethyl)-2-pyridyl]-3,6-dihydro‑2H‑pyridine-1-carboxamide (V116517) as a Clinical Candidate for Pain Management

by Tafesse, Laykea, Kanemasa, Toshiyuki, Kurose, Noriyuki, Yu, Jianming, Asaki, Toshiyuki, Wu, Gang, Iwamoto, Yuka, Yamaguchi, Yoshitaka, Ni, Chiyou, Engel, John, Tsuno, Naoki, Patel, Aniket, Zhou, Xiaoming, Shintani, Takuya, Brown, Kevin, Hasegawa, Tsuyoshi, Shet, Manjunath, Iso, Yasuyoshi, Kato, Akira, Kyle, Donald J
Published in Journal of medicinal chemistry (14.08.2014)

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Journal Article

MORPHINAN DERIVATIVES AND USE THEREOF

MORPHINAN DERIVATIVES AND USE THEREOF

by Tafesse, Laykea
Year of Publication 07.09.2023

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Patent

BUPRENORPHINE ANALOGS

BUPRENORPHINE ANALOGS

by KYLE DONALD J, TAFESSE LAYKEA
Year of Publication 11.03.2015

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Patent

TRPV1 ANTAGONISTS AND USES THEREOF

TRPV1 ANTAGONISTS AND USES THEREOF

by KUROSE NORIYUKI, TAFESSE LAYKEA
Year of Publication 10.01.2013

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Patent

PHOSPHORUS SUBSTITUTED-QUINOXALINE-TYPE PIPERIDINE COMPOUND AND USE THEREOF

PHOSPHORUS SUBSTITUTED-QUINOXALINE-TYPE PIPERIDINE COMPOUND AND USE THEREOF

by ZHOU XIAOMING, DAWIT TADESSE, TAFESSE LAYKEA
Year of Publication 02.06.2016

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Patent

Pharmacological and pharmacokinetic characterization of the cannabinoid receptor 2 agonist, GW405833, utilizing rodent models of acute and chronic pain, anxiety, ataxia and catalepsy

Pharmacological and pharmacokinetic characterization of the cannabinoid receptor 2 agonist, GW405833, utilizing rodent models of acute and chronic pain, anxiety, ataxia and catalepsy

by Valenzano, Kenneth J., Tafesse, Laykea, Lee, Gary, Harrison, James E., Boulet, Jamie M., Gottshall, Susan L., Mark, Lilly, Pearson, Michelle S., Miller, Wendy, Shan, Shen, Rabadi, Leyana, Rotshteyn, Yakov, Chaffer, Suzanne M., Turchin, Paul I., Elsemore, David A., Toth, Mathew, Koetzner, Lee, Whiteside, Garth T.
Published in Neuropharmacology (01.04.2005)

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Journal Article

BUPRENORPHINE ANALOGS

BUPRENORPHINE ANALOGS

by KYLE DONALD J, TAFESSE LAYKEA
Year of Publication 02.09.2013

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Patent

TRPV1 ANTAGONISTS INCLUDING DIHYDROXY SUBSTITUENT AND USES THEREOF

TRPV1 ANTAGONISTS INCLUDING DIHYDROXY SUBSTITUENT AND USES THEREOF

by KUROSE NORIYUKI, ANDO SHIGERU, TAFESSE LAYKEA
Year of Publication 20.05.2015

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Patent

BENZOAZOLYLPIPERAZINE DERIVATIVE HAVING mGluR1- AND mGluR5-ANTAGONIST ACTIVITY

BENZOAZOLYLPIPERAZINE DERIVATIVE HAVING mGluR1- AND mGluR5-ANTAGONIST ACTIVITY

by VICTORY SAM, SUN QUN, TAFESSE LAYKEA
Year of Publication 30.04.2015

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Patent

TRPV1 ANTAGONISTS INCLUDING DIHYDROXY SUBSTITUENT AND USES THEREOF

TRPV1 ANTAGONISTS INCLUDING DIHYDROXY SUBSTITUENT AND USES THEREOF

by KUROSE NORIYUKI, ANDO SHIGERU, TAFESSE LAYKEA
Year of Publication 24.02.2014

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Patent

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