MYC and MCL1 Cooperatively Promote Chemotherapy-Resistant Breast Cancer Stem Cells via Regulation of Mitochondrial Oxidative Phosphorylation
Lee, Kyung-min, Giltnane, Jennifer M., Balko, Justin M., Schwarz, Luis J., Guerrero-Zotano, Angel L., Hutchinson, Katherine E., Nixon, Mellissa J., Estrada, Mónica V., Sánchez, Violeta, Sanders, Melinda E., Lee, Taekyu, Gómez, Henry, Lluch, Ana, Pérez-Fidalgo, J. Alejandro, Wolf, Melissa Magdalene, Andrejeva, Gabriela, Rathmell, Jeffrey C., Fesik, Stephen W., Arteaga, Carlos L.
Published in Cell metabolism (03.10.2017)
Published in Cell metabolism (03.10.2017)
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Journal Article
Discovery of Potent Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods and Structure-Based Design
Friberg, Anders, Vigil, Dominico, Zhao, Bin, Daniels, R. Nathan, Burke, Jason P, Garcia-Barrantes, Pedro M, Camper, DeMarco, Chauder, Brian A, Lee, Taekyu, Olejniczak, Edward T, Fesik, Stephen W
Published in Journal of medicinal chemistry (10.01.2013)
Published in Journal of medicinal chemistry (10.01.2013)
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Journal Article
Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange
Burns, Michael C., Qi Sun, Daniels, R. Nathan, Camper, DeMarco, Kennedy, J. Phillip, Phan, Jason, Olejniczak, Edward T., Lee, Taekyu, Waterson, Alex G., Rossanese, Olivia W., Fesik, Stephen W.
Published in Proceedings of the National Academy of Sciences - PNAS (04.03.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (04.03.2014)
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Journal Article
Discovery of a Tetracyclic Quinoxaline Derivative as a Potent and Orally Active Multifunctional Drug Candidate for the Treatment of Neuropsychiatric and Neurological Disorders
Li, Peng, Zhang, Qiang, Robichaud, Albert J, Lee, Taekyu, Tomesch, John, Yao, Wei, Beard, J. David, Snyder, Gretchen L, Zhu, Hongwen, Peng, Youyi, Hendrick, Joseph P, Vanover, Kimberly E, Davis, Robert E, Mates, Sharon, Wennogle, Lawrence P
Published in Journal of medicinal chemistry (27.03.2014)
Published in Journal of medicinal chemistry (27.03.2014)
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Journal Article
Ribosome subunit attrition and activation of the p53-MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition
Howard, Gregory Caleb, Wang, Jing, Rose, Kristie L, Jones, Camden, Patel, Purvi, Tsui, Tina, Florian, Andrea C, Vlach, Logan, Lorey, Shelly L, Grieb, Brian C, Smith, Brianna N, Slota, Macey J, Reynolds, Elizabeth M, Goswami, Soumita, Savona, Michael R, Mason, Frank M, Lee, Taekyu, Fesik, Stephen, Liu, Qi, Tansey, William P
Published in eLife (29.04.2024)
Published in eLife (29.04.2024)
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Journal Article
418 The antiplatelet effects of EPA, an omega-3 fatty acid, are mediated by its 12-lipoxygenase metabolite, 12-HEPE
Goerger, Krista, Lee, Taekyu, Gilmore, Devin, Tran, Michelle, Holman, Theodore R., Holinstat, Michael
Published in Journal of clinical and translational science (01.04.2024)
Published in Journal of clinical and translational science (01.04.2024)
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Journal Article
Suppression of the ERK–SRF axis facilitates somatic cell reprogramming
Huh, Sejong, Song, Hwa-Ryung, Jeong, Geuk-Rae, Jang, Hyejin, Seo, Nan-Hee, Lee, Ju-Hyun, Yi, Ji-Yeun, Lee, Byongsun, Choi, Hyun Woo, Do, Jeong Tae, Kim, Jin-Su, Lee, Soo-Hong, Jung, Jae-Won, Lee, Taekyu, Shim, Jaekyung, Han, Myung-Kwan, Lee, Tae-Hee
Published in Experimental & molecular medicine (23.02.2018)
Published in Experimental & molecular medicine (23.02.2018)
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Journal Article
Music for Sleep and Wake-up: An Empirical Study
Lee, Taekyu, Moon, Seong-Eun, Baek, Jongsoo, Lee, Jong-Seok, Kim, Songkuk
Published in IEEE access (01.01.2019)
Published in IEEE access (01.01.2019)
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Journal Article
0854 Observation-based Diurnal Sleepiness Inventory (ODSI) is associated with Objective Sleepiness via Psychomotor Vigilance Task
Pak, Victoria, Russell, Kate, Gooneratne, Nalaka, Cox, John, Servaes, Stijn, Lee, Taekyu, Onen, Hakki, Onen, Fannie
Published in Sleep (New York, N.Y.) (29.05.2023)
Published in Sleep (New York, N.Y.) (29.05.2023)
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Journal Article
A Novel MCL1 Inhibitor Combined with Venetoclax Rescues Venetoclax-Resistant Acute Myelogenous Leukemia
Ramsey, Haley E, Fischer, Melissa A, Lee, Taekyu, Gorska, Agnieszka E, Arrate, Maria Pia, Fuller, Londa, Boyd, Kelli L, Strickland, Stephen A, Sensintaffar, John, Hogdal, Leah J, Ayers, Gregory D, Olejniczak, Edward T, Fesik, Stephen W, Savona, Michael R
Published in Cancer discovery (01.12.2018)
Published in Cancer discovery (01.12.2018)
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Journal Article
Analysis of the S3 and S3′Subsite Specificities of Feline Immunodeficiency Virus (FIV) Protease: Development of a Broad-Based Protease Inhibitor Efficacious against FIV, SIV, and HIV in vitro and ex vivo
Lee, Taekyu, Laco, Gary S., Torbett, Bruce E., Fox, Howard S., Lerner, Danica L., Elder, John H., Wong, Chi-Huey
Published in Proceedings of the National Academy of Sciences - PNAS (03.02.1998)
Published in Proceedings of the National Academy of Sciences - PNAS (03.02.1998)
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Journal Article
Novel, highly potent, selective 5-HT2A/D2 receptor antagonists as potential atypical antipsychotics
TAEKYU LEE, ROBICHAUD, Albert J, BOYLE, Kristopher E, YIMIN LU, ROBERTSON, David W, MILLER, Keith J, FITZGERALD, Larry W, MCELROY, John F, LARGENT, Brian L
Published in Bioorganic & medicinal chemistry letters (24.02.2003)
Published in Bioorganic & medicinal chemistry letters (24.02.2003)
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Journal Article
Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation
Sun, Qi, Burke, Jason P., Phan, Jason, Burns, Michael C., Olejniczak, Edward T., Waterson, Alex G., Lee, Taekyu, Rossanese, Olivia W., Fesik, Stephen W.
Published in Angewandte Chemie International Edition (18.06.2012)
Published in Angewandte Chemie International Edition (18.06.2012)
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Journal Article
Discovery of 2‑Indole-acylsulfonamide Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods
Pelz, Nicholas F, Bian, Zhiguo, Zhao, Bin, Shaw, Subrata, Tarr, James C, Belmar, Johannes, Gregg, Claire, Camper, DeMarco V, Goodwin, Craig M, Arnold, Allison L, Sensintaffar, John L, Friberg, Anders, Rossanese, Olivia W, Lee, Taekyu, Olejniczak, Edward T, Fesik, Stephen W
Published in Journal of medicinal chemistry (10.03.2016)
Published in Journal of medicinal chemistry (10.03.2016)
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Journal Article
Development of a New Type of Protease Inhibitors, Efficacious against FIV and HIV Variants
Lee, Taekyu, Le, Van-Duc, Lim, Dongyeol, Lin, Ying-Chuan, Morris, Garrett M, Wong, Andrew L, Olson, Arthur J, Elder, John H, Wong, Chi-Huey
Published in Journal of the American Chemical Society (17.02.1999)
Published in Journal of the American Chemical Society (17.02.1999)
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Journal Article
Fragment-based screening of programmed death ligand 1 (PD-L1)
Perry, Evan, Mills, Jonathan J., Zhao, Bin, Wang, Feng, Sun, Qi, Christov, Plamen P., Tarr, James C., Rietz, Tyson A., Olejniczak, Edward T., Lee, Taekyu, Fesik, Stephen
Published in Bioorganic & medicinal chemistry letters (15.03.2019)
Published in Bioorganic & medicinal chemistry letters (15.03.2019)
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Journal Article