Probing Steric and Hydrophobic Effects on Enzyme-Substrate Interactions by Protein Engineering
Estell, D. A., Graycar, T. P., Miller, J. V., Powers, D. B., Burnier, J. P., Ng, P. G., Wells, J. A.
Published in Science (American Association for the Advancement of Science) (08.08.1986)
Published in Science (American Association for the Advancement of Science) (08.08.1986)
Get full text
Journal Article
Importance of Hydrogen-Bond Formation in Stabilizing the Transition State of Subtilisin
J. A. Wells, B. C. Cunningham, T. P. Graycar, D. A. Estell
Published in Philosophical transactions of the Royal Society of London. Series A: Mathematical, physical, and engineering sciences (30.04.1986)
Published in Philosophical transactions of the Royal Society of London. Series A: Mathematical, physical, and engineering sciences (30.04.1986)
Get full text
Journal Article
Altering the specificity of subtilisin B. Lentus by combining site-directed mutagenesis and chemical modification
Berglund, Per, Stabile, Michele R., Gold, Marvin, Jones, J.Bryan, Mitchinson, Colin, Bott, Richard R., Graycar, Thomas P.
Published in Bioorganic & medicinal chemistry letters (05.11.1996)
Published in Bioorganic & medicinal chemistry letters (05.11.1996)
Get full text
Journal Article
Altering the proteolytic activity of subtilisin through protein engineering
Graycar, T P, Bott, R R, Caldwell, R M, Dauberman, J L, Lad, P J, Power, S D, Sagar, I H, Silva, R A, Weiss, G L, Woodhouse, L R
Published in Annals of the New York Academy of Sciences (30.11.1992)
Published in Annals of the New York Academy of Sciences (30.11.1992)
Get more information
Journal Article
Chemical Modification of Cysteine Mutants of Subtilisin Bacillus lentus Can Create Better Catalysts Than the Wild-Type Enzyme
Berglund, Per, DeSantis, Grace, Stabile, Michele R, Shang, Xiao, Gold, Marvin, Bott, Richard R, Graycar, Thomas P, Lau, Tony Hing, Mitchinson, Colin, Jones, J. Bryan
Published in Journal of the American Chemical Society (04.06.1997)
Published in Journal of the American Chemical Society (04.06.1997)
Get full text
Journal Article
The Effects of Organic Solvents on Wild-Type and Mutant Subtilisin-Catalyzed Hydrolyses
Bonneau, P.R., Eyer, M., Graycar, T.P., Estell, D.A., Jones, J.B.
Published in Bioorganic chemistry (01.12.1993)
Published in Bioorganic chemistry (01.12.1993)
Get full text
Journal Article