A Fusion Protein of the Human P2Y1 Receptor and NTPDase1 Exhibits Functional Activities of the Native Receptor and Ectoenzyme and Reduced Signaling Responses to Endogenously Released Nucleotides
Claudia Alvarado-Castillo, Patricia Lozano-Zarain, Jesús Mateo, T. Kendall Harden, José L. Boyer
Published in Molecular pharmacology (01.09.2002)
Published in Molecular pharmacology (01.09.2002)
Get full text
Journal Article
Requirement of Cys399 for Processing of the Human Ecto-ATPase (NTPDase2) and Its Implications for Determination of the Activities of Splice Variants of the Enzyme
Mateo, Jesús, Kreda, Silvia, Henry, Christopher E., Harden, T.Kendall, Boyer, José L.
Published in The Journal of biological chemistry (10.10.2003)
Published in The Journal of biological chemistry (10.10.2003)
Get full text
Journal Article
Fidelity in functional coupling of the rat P2Y1 receptor to phospholipase C
Schachter, Joel B., Boyer, José L., Li, Qing, Nicholas, Robert A., Harden, T. Kendall
Published in British journal of pharmacology (01.11.1997)
Published in British journal of pharmacology (01.11.1997)
Get full text
Journal Article
Antiaggregatory activity in human platelets of potent antagonists of the P2Y1 receptor
CATTANEO, Marco, LECCHI, Anna, OHNO, Michihiro, JOSHI, Bhalchandra V, BESADA, Pedro, TCHILIBON, Susanna, LOMBARDI, Rossana, BISCHOFBERGER, Norbert, HARDEN, T. Kendall, JACOBSON, Kenneth A
Published in Biochemical pharmacology (01.11.2004)
Published in Biochemical pharmacology (01.11.2004)
Get full text
Journal Article
Structure-Based Design of 3-(4-Aryl-1H-1,2,3-triazol-1-yl)-Biphenyl Derivatives as P2Y(14) Receptor Antagonists
Junker, Anna, Balasubramanian, Ramachandran, Ciancetta, Antonella, Uliassi, Elisa, Kiselev, Evgeny, Martiriggiano, Chiara, Trujillo, Kevin, Mtchedlidze, Giorgi, Birdwell, Leah, Brown, Kyle A., Harden, T. Kendall, Jacobson, Kenneth A.
Published in Journal of medicinal chemistry (14.07.2016)
Published in Journal of medicinal chemistry (14.07.2016)
Get full text
Journal Article
A Molecularly Identified P2Y Receptor Simultaneously Activates Phospholipase C and Inhibits Adenylyl Cyclase and Is Nonselectively Activated by All Nucleoside Triphosphates
Boyer, J L, Delaney, S M, Villanueva, D, Harden, T K
Published in Molecular pharmacology (01.04.2000)
Published in Molecular pharmacology (01.04.2000)
Get full text
Journal Article
UDP acts as a growth factor for vascular smooth muscle cells by activation of P2Y6 receptors
MINGYAN HOU, HARDEN, T. Kendall, KUHN, Cynthia M, BALDETORP, Bo, LAZAROWSKI, Eduardo, PENDERGAST, William, MOLLER, Sebastian, EDVINSSON, Lars, ERLINGE, David
Published in American journal of physiology. Heart and circulatory physiology (01.02.2002)
Get full text
Published in American journal of physiology. Heart and circulatory physiology (01.02.2002)
Journal Article
A Guanine Nucleotide-independent Inwardly Rectifying Cation Permeability Is Associated with P2Y1 Receptor Expression in Xenopus Oocytes
O'Grady, Scott M., Elmquist, Eric, Filtz, Theresa M., Nicholas, Robert A., Harden, T. Kendall
Published in The Journal of biological chemistry (15.11.1996)
Published in The Journal of biological chemistry (15.11.1996)
Get full text
Journal Article
Design, synthesis, pharmacological characterization of a fluorescent agonist of the P2Y(14) receptor
Kiselev, Evgeny, Balasubramanian, Ramachandran, Uliassi, Elisa, Brown, Kyle A., Trujillo, Kevin, Katritch, Vsevolod, Hammes, Eva, Stevens, Raymond C., Harden, T. Kendall, Jacobson, Kenneth A.
Published in Bioorganic & medicinal chemistry letters (01.11.2015)
Published in Bioorganic & medicinal chemistry letters (01.11.2015)
Get full text
Journal Article
Structural basis for the activation of PLC-[gamma] isozymes by phosphorylation and cancer-associated mutations
Hajicek, Nicole, Keith, Nicholas C, Siraliev-Perez, Edhriz, Temple, Brenda RS, Huang, Weigang, Zhang, Qisheng, Harden, T Kendall, Sondek, John
Published in eLife (31.12.2019)
Published in eLife (31.12.2019)
Get full text
Journal Article
4-Alkyloxyimino Derivatives of Uridine-5 '-triphosphate: Distal Modification of Potent Agonists as a Strategy for Molecular Probes of P2Y(2), P2Y(4), and P2Y(6) Receptors
Jayasekara, P. Suresh, Barrett, Matthew O., Ball, Christopher B., Brown, Kyle A., Hammes, Eva, Balasubramanian, Ramachandran, Harden, T. Kendall, Jacobson, Kenneth A.
Published in Journal of medicinal chemistry (08.05.2014)
Published in Journal of medicinal chemistry (08.05.2014)
Get full text
Journal Article
Structure-Based Design of 3-(4-Aryl-1 H -1,2,3-triazol-1-yl)-Biphenyl Derivatives as P2Y 14 Receptor Antagonists
Junker, Anna, Balasubramanian, Ramachandran, Ciancetta, Antonella, Uliassi, Elisa, Kiselev, Evgeny, Martiriggiano, Chiara, Trujillo, Kevin, Mtchedlidze, Giorgi, Birdwell, Leah, Brown, Kyle A., Harden, T. Kendall, Jacobson, Kenneth A.
Published in Journal of medicinal chemistry (14.07.2016)
Published in Journal of medicinal chemistry (14.07.2016)
Get full text
Journal Article
Loss of P2Y 1 receptor desensitization does not impact hemostasis or thrombosis despite increased platelet reactivity in vitro
Paul, David S, Blatt, Tasha N, Schug, Wyatt J, Clark, Emily G, Kawano, Tomohiro, Mackman, Nigel, Murcia, Sebastian, Poe, Kathryn O, Mwiza, Jean Marie N, Harden, T Kendall, Bergmeier, Wolfgang, Nicholas, Robert A
Published in Journal of thrombosis and haemostasis (01.07.2023)
Get full text
Published in Journal of thrombosis and haemostasis (01.07.2023)
Journal Article