Adenine nucleotide analogues locked in a northern methanocarba conformation: Enhanced stability and potency as P2Y(1) receptor agonists
Ravi, RG, Kim, HS, Servos, J, Zimmermann, H, Lee, K, Maddileti, S, Boyer, JL, Harden, TK, Jacobson, KA
Published in Journal of medicinal chemistry (09.05.2002)
Published in Journal of medicinal chemistry (09.05.2002)
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Journal Article
Molecular Recognition in the P2Y14 Nucleotide Receptor: Probing the Structurally Permissive Terminal Sugar Moiety of Uridine-5′-diphosphoglucose
Ko, Hyojin, Das, Arijit, Carter, Rhonda L., Fricks, Ingrid P., Zhou, Yixing, Ivanov, Andrei A., Melman, Artem, Joshi, Bhalchandra V., Kováč, Pavol, Hajduch, Jan, Kirk, Kenneth L., Harden, T. Kendall, Jacobson, Kenneth A.
Published in Bioorganic & medicinal chemistry (15.05.2009)
Published in Bioorganic & medicinal chemistry (15.05.2009)
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Journal Article
(N)‐methanocarba‐2MeSADP (MRS2365) is a subtype‐specific agonist that induces rapid desensitization of the P2Y1 receptor of human platelets
BOURDON, D. M., MAHANTY, S. K., JACOBSON, K. A., BOYER, J. L., HARDEN, T. K.
Published in Journal of thrombosis and haemostasis (01.04.2006)
Published in Journal of thrombosis and haemostasis (01.04.2006)
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Journal Article
[32P]2-iodo-N6-methy(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate ([32P]MRS2500), a novel radioligand for quantification of native P2Y1 receptors
HOUSTON, Dayle, OHNO, Michihiro, NICHOLAS, Robert A, JACOBSON, Kenneth A, HARDEN, T. Kendall
Published in British journal of pharmacology (2006)
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Published in British journal of pharmacology (2006)
Journal Article
Dominant-negative inhibition of pheromone receptor signaling by a single point mutation in the G protein α subunit. Vol. 279 (2004) 35287-35297
Wu, Yuh-Lin, Hooks, Shelley B., Harden, T. Kendall, Dohlman, Henrik G.
Published in The Journal of biological chemistry (01.08.2005)
Published in The Journal of biological chemistry (01.08.2005)
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Journal Article
βγ-Subunit activation of G-protein-regulated phospholipase C
BOYER, J. L, WALDO, G. L, HARDEN, T. K
Published in The Journal of biological chemistry (15.12.1992)
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Published in The Journal of biological chemistry (15.12.1992)
Journal Article
P2Y 1 Antagonists: Combining Receptor-Based Modeling and QSAR for a Quantitative Prediction of the Biological Activity Based on Consensus Scoring
Costanzi, Stefano, Tikhonova, Irina G., Ohno, Michihiro, Roh, Eun Joo, Joshi, Bhalchandra V., Colson, Anny-Odile, Houston, Dayle, Maddileti, Savitri, Harden, T. Kendall, Jacobson, Kenneth A.
Published in Journal of medicinal chemistry (01.07.2007)
Published in Journal of medicinal chemistry (01.07.2007)
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Journal Article
Molecular recognition in the P2Y 14 receptor: Probing the structurally permissive terminal sugar moiety of uridine-5′-diphosphoglucose
Ko, Hyojin, Das, Arijit, Carter, Rhonda L., Fricks, Ingrid P., Zhou, Yixing, Ivanov, Andrei A., Melman, Artem, Joshi, Bhalchandra V., Kováč, Pavol, Hajduch, Jan, Kirk, Kenneth L., Harden, T. Kendall, Jacobson, Kenneth A.
Published in Bioorganic & medicinal chemistry (2009)
Published in Bioorganic & medicinal chemistry (2009)
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Journal Article
Regulation of PLCbeta isoforms by Rac
Snyder, Jason T, Jezyk, Mark R, Gershburg, Svetlana, Harden, T Kendall, Sondek, John
Published in Methods in enzymology (2006)
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Published in Methods in enzymology (2006)
Journal Article
Quantification of isozyme-specific activation of phospholipase C-beta2 by Rac GTPases and phospholipase C-epsilon by Rho GTPases in an intact cell assay system
Bourdon, David M, Wing, Michele R, Edwards, Earl B, Sondek, John, Harden, T Kendall
Published in Methods in enzymology (2006)
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Published in Methods in enzymology (2006)
Journal Article
Molecular Modeling of the Human P2Y 2 Receptor and Design of a Selective Agonist, 2‘-Amino-2‘-deoxy-2-thiouridine 5‘-Triphosphate
Ivanov, Andrei A., Ko, Hyojin, Cosyn, Liesbet, Maddileti, Savitri, Besada, Pedro, Fricks, Ingrid, Costanzi, Stefano, Harden, T. Kendall, Van Calenbergh, Serge, Jacobson, Kenneth A.
Published in Journal of medicinal chemistry (01.03.2007)
Published in Journal of medicinal chemistry (01.03.2007)
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Journal Article
Molecular Modeling of the Human P2Y2 Receptor and Design of a Selective Agonist, 2′-Amino-2′-deoxy-2-thio-UTP
Ivanov, Andrei A., Ko, Hyojin, Cosyn, Liesbet, Maddileti, Savitri, Besada, Pedro, Fricks, Ingrid, Costanzi, Stefano, Harden, T. Kendall, Van Calenbergh, Serge, Jacobson, Kenneth A.
Published in Journal of medicinal chemistry (16.02.2007)
Published in Journal of medicinal chemistry (16.02.2007)
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Journal Article
Ser352 and Ser354 in the carboxyl terminus of the human P2Y(1) receptor are required for agonist-promoted phosphorylation and internalization in MDCK cells
Qi, Ai-Dong, Houston-Cohen, Dayle, Naruszewicz, Isabella, Harden, T Kendall, Nicholas, Robert A
Published in British journal of pharmacology (01.03.2011)
Published in British journal of pharmacology (01.03.2011)
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Journal Article
HEK293 human embryonic kidney cells endogenously express the P2Y1 and P2Y2 receptors
SCHACHTER, J. B, SROMEK, S. M, NICHOLAS, R. A, HARDEN, T. K
Published in Neuropharmacology (01.09.1997)
Published in Neuropharmacology (01.09.1997)
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Conference Proceeding
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Gβ Association and Effector Interaction Selectivities of the Divergent Gγ Subunit Gγ13
Blake, Bonita L., Wing, Michele R., Zhou, Janice Y., Lei, Qiubo, Hillmann, Jennie R., Behe, Cynthia I., Morris, Rebecca A., Harden, T. Kendall, Bayliss, Douglas A., Miller, Richard J., Siderovski, David P.
Published in The Journal of biological chemistry (28.12.2001)
Published in The Journal of biological chemistry (28.12.2001)
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