Oligodendroglial TNFR2 Mediates Membrane TNF-Dependent Repair in Experimental Autoimmune Encephalomyelitis by Promoting Oligodendrocyte Differentiation and Remyelination
Madsen, Pernille M, Motti, Dario, Karmally, Shaffiat, Szymkowski, David E, Lambertsen, Kate Lykke, Bethea, John R, Brambilla, Roberta
Published in The Journal of neuroscience (04.05.2016)
Published in The Journal of neuroscience (04.05.2016)
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Inhibition of soluble tumour necrosis factor is therapeutic in experimental autoimmune encephalomyelitis and promotes axon preservation and remyelination
Brambilla, Roberta, Ashbaugh, Jessica Jopek, Magliozzi, Roberta, Dellarole, Anna, Karmally, Shaffiat, Szymkowski, David E., Bethea, John R.
Published in Brain (London, England : 1878) (01.09.2011)
Published in Brain (London, England : 1878) (01.09.2011)
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Systemically administered anti-TNF therapy ameliorates functional outcomes after focal cerebral ischemia
Clausen, Bettina Hjelm, Degn, Matilda, Martin, Nellie Anne, Couch, Yvonne, Karimi, Leena, Ormhøj, Maria, Mortensen, Maria-Louise Bergholdt, Gredal, Hanne Birgit, Gardiner, Chris, Sargent, Ian I L, Szymkowski, David E, Petit, Géraldine H, Deierborg, Tomas, Finsen, Bente, Anthony, Daniel Clive, Lambertsen, Kate Lykke
Published in Journal of neuroinflammation (12.12.2014)
Published in Journal of neuroinflammation (12.12.2014)
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Transmembrane tumour necrosis factor is neuroprotective and regulates experimental autoimmune encephalomyelitis via neuronal nuclear factor-κB
Taoufik, Era, Tseveleki, Vivian, Chu, Seung Y., Tselios, Theodore, Karin, Michael, Lassmann, Hans, Szymkowski, David E., Probert, Lesley
Published in Brain (London, England : 1878) (01.09.2011)
Published in Brain (London, England : 1878) (01.09.2011)
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Journal Article
A B7-H3-targeted CD28 bispecific antibody enhances the activity of anti-PD1 and CD3 T-cell engager immunotherapies
Moore, Gregory L, Zeng, Veronica G, Diaz, Juan E, Bonzon, Christine, Avery, Kendra N, Rashid, Rumana, Qi, Jing, Nam, Dong Hyun, Jacinto, Jonathan, Dragovich, Matthew A, Kim, Yoon Kyung, Balcazar, Karen P, Bakhit, Charles G, Eivazi, Araz, Nguyen, Hanh, Muchhal, Umesh S, Szymkowski, David E, Desjarlais, John R, Hedvat, Michael
Published in Molecular cancer therapeutics (20.09.2024)
Published in Molecular cancer therapeutics (20.09.2024)
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Topical Administration of a Soluble TNF Inhibitor Reduces Infarct Volume After Focal Cerebral Ischemia in Mice
Yli-Karjanmaa, Minna, Clausen, Bettina Hjelm, Degn, Matilda, Novrup, Hans Gram, Ellman, Ditte Gry, Toft-Jensen, Peter, Szymkowski, David E, Stensballe, Allan, Meyer, Morten, Brambilla, Roberta, Lambertsen, Kate Lykke
Published in Frontiers in neuroscience (07.08.2019)
Published in Frontiers in neuroscience (07.08.2019)
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Inhibition of soluble tumor necrosis factor ameliorates synaptic alterations and Ca2+ dysregulation in aged rats
Sama, Diana M, Mohmmad Abdul, Hafiz, Furman, Jennifer L, Artiushin, Irina A, Szymkowski, David E, Scheff, Stephen W, Norris, Christopher M
Published in PloS one (29.05.2012)
Published in PloS one (29.05.2012)
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The TNF superfamily in 2009: new pathways, new indications, and new drugs
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Conference Proceeding
Neutralization of membrane TNF, but not soluble TNF, is crucial for the treatment of experimental colitis
Perrier, Clémentine, de Hertogh, Gert, Cremer, Jonathan, Vermeire, Severine, Rutgeerts, Paul, Van Assche, Gert, Szymkowski, David E, Ceuppens, Jan L
Published in Inflammatory bowel diseases (01.02.2013)
Published in Inflammatory bowel diseases (01.02.2013)
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Blocking Soluble Tumor Necrosis Factor Signaling with Dominant-Negative Tumor Necrosis Factor Inhibitor Attenuates Loss of Dopaminergic Neurons in Models of Parkinson's Disease
McCoy, Melissa K, Martinez, Terina N, Ruhn, Kelly A, Szymkowski, David E, Smith, Christine G, Botterman, Barry R, Tansey, Keith E, Tansey, Malu G
Published in The Journal of neuroscience (13.09.2006)
Published in The Journal of neuroscience (13.09.2006)
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Reduction of total IgE by targeted coengagement of IgE B-cell receptor and FcγRIIb with Fc-engineered antibody
Chu, Seung Y., PhD, Horton, Holly M., PhD, Pong, Erik, MS, Leung, Irene W.L., PhD, Chen, Hsing, MS, Nguyen, Duc-Hanh, BS, Bautista, Cristina, BS, Muchhal, Umesh S., PhD, Bernett, Matthew J., PhD, Moore, Gregory L., PhD, Szymkowski, David E., PhD, Desjarlais, John R., PhD
Published in Journal of allergy and clinical immunology (01.04.2012)
Published in Journal of allergy and clinical immunology (01.04.2012)
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Accelerated Clearance and Degradation of Cell-Free HIV by Neutralizing Antibodies Occurs via FcγRIIb on Liver Sinusoidal Endothelial Cells by Endocytosis
Turman, James M, Cheplowitz, Alana M, Tiwari, Charu, Thomas, Thushara, Joshi, Dhruvi, Bhat, Menakshi, Wu, Qian, Pong, Erik, Chu, Seung Y, Szymkowski, David E, Sharma, Amit, Seveau, Stephanie, Robinson, John M, Kwiek, Jesse J, Burton, Dennis, Rajaram, Murugesan V S, Kim, Jonghan, Hangartner, Lars, Ganesan, Latha P
Published in The Journal of immunology (1950) (15.03.2021)
Published in The Journal of immunology (1950) (15.03.2021)
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Antibody-mediated coengagement of FcγRIIb and B cell receptor complex suppresses humoral immunity in systemic lupus erythematosus
Horton, Holly M, Chu, Seung Y, Ortiz, Elizabeth C, Pong, Erik, Cemerski, Saso, Leung, Irene W L, Jacob, Noam, Zalevsky, Jonathan, Desjarlais, John R, Stohl, William, Szymkowski, David E
Published in The Journal of immunology (1950) (01.04.2011)
Published in The Journal of immunology (1950) (01.04.2011)
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Inhibition of TNF reduces mechanical orofacial hyperalgesia induced by Complete Freund’s Adjuvant by a TRPV1-dependent mechanism in mice
Lis, Krzysztof, Grygorowicz, Tomasz, Cudna, Agnieszka, Szymkowski, David E., Bałkowiec-Iskra, Ewa
Published in Pharmacological reports (01.12.2017)
Published in Pharmacological reports (01.12.2017)
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Therapeutic inhibition of soluble brain TNF promotes remyelination by increasing myelin phagocytosis by microglia
Karamita, Maria, Barnum, Christopher, Möbius, Wiebke, Tansey, Malú G, Szymkowski, David E, Lassmann, Hans, Probert, Lesley
Published in JCI insight (20.04.2017)
Published in JCI insight (20.04.2017)
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Transmembrane TNF‐α is sufficient for articular inflammation and hypernociception in a mouse model of gout
Amaral, Flávio A., Bastos, Leandro F. S., Oliveira, Thiago H. C., Dias, Ana C. F., Oliveira, Vívian L. S., Tavares, Lívia D., Costa, Vivian V., Galvão, Izabela, Soriani, Frederico M., Szymkowski, David E., Ryffel, Bernhard, Souza, Danielle G., Teixeira, Mauro M.
Published in European journal of immunology (01.01.2016)
Published in European journal of immunology (01.01.2016)
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Suppression of Rheumatoid Arthritis B Cells by XmAb5871, an Anti‐CD19 Antibody That Coengages B Cell Antigen Receptor Complex and Fcγ Receptor IIb Inhibitory Receptor
Chu, Seung Y., Yeter, Karen, Kotha, Roshan, Pong, Erik, Miranda, Yvonne, Phung, Sheryl, Chen, Hsing, Lee, Sung‐Hyung, Leung, Irene, Bonzon, Christine, Desjarlais, John R., Stohl, William, Szymkowski, David E.
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.05.2014)
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.05.2014)
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