601 Development of improved small molecule STING agonists suitable for systemic administration
Rogacki, Maciej, Chmielewski, Stefan, Zawadzka, Magdalena, Mazurek, Jolanta, Wnuk-Lipińska, Katarzyna, Kuś, Kamil, Gluza, Karolina, Wójcik-Jaszczyńska, Katarzyna, Poczkaj, Aleksandra, Dudek, Lukasz, Schonemann, Wojciech, Głowniak-Kwitek, Urszula, Leś, Marcin, Wronowski, Marek, Mahajan, Tushar, Kulesza, Urszula, Zastawna, Magdalena, Synak, David, Zuchowicz, Karol, Banaszak, Katarzyna, Wiatrowska, Karolina, Strojny, Izabela, Gładysz, Mirosława, Jabłońska, Justyna, Gabor-Worwa, Ewelina, Tangirala, Raghuram, Stasi, Luigi, Littlewood, Peter, Brzózka, Krzysztof, Dobrzańska, Monika
Published in Journal for immunotherapy of cancer (01.11.2020)
Published in Journal for immunotherapy of cancer (01.11.2020)
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Journal Article
Abstract 1280: New generation of STING agonists: Development and characterization of a novel series of systemic immunomodulators with improved potency
Rogacki, Maciej Krzysztof, Chmielewski, Stefan, Mazurek, Jolanta, Zawadzka, Magdalena, Wnuk-Lipińska, Katarzyna, Kuś, Kamil, Wójcik-Jaszczyńska, Katarzyna, Poczkaj, Aleksandra, Dudek, Łukasz, Schonemann, Wojciech, Głowniak-Kwitek, Urszula, Leś, Marcin, Wronowski, Marek, Mahajan, Tushar, Kulesza, Urszula, Zastawna, Magdalena, Synak, David, Zuchowicz, Karol, Gluza, Karolina, Banaszak, Katarzyna, Wiatrowska, Karolina, Strojny, Izabela, Gładysz, Mirosława, Jabłońska, Justyna, Gabor-Worwa, Ewelina, Dobrzańska, Monika, Tangirala, Raghuram, Littlewood, Peter, Brzózka, Krzysztof
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Novel multi-target directed ligands based on annelated xanthine scaffold with aromatic substituents acting on adenosine receptor and monoamine oxidase B. Synthesis, in vitro and in silico studies
Załuski, Michał, Schabikowski, Jakub, Schlenk, Miriam, Olejarz-Maciej, Agnieszka, Kubas, Bartłomiej, Karcz, Tadeusz, Kuder, Kamil, Latacz, Gniewomir, Zygmunt, Małgorzata, Synak, David, Hinz, Sonja, Müller, Christa E., Kieć-Kononowicz, Katarzyna
Published in Bioorganic & medicinal chemistry (01.04.2019)
Published in Bioorganic & medicinal chemistry (01.04.2019)
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Abstract 1281: Development and characterization of small molecule HPK1 inhibitors
Kujawa, Maciej, Zimoląg, Eliza, Gałęzowski, Michał, Guzik, Paweł, Dudek, Agata, Gondela, Andrzej, Nowogródzki, Marcin, Girardi, Marianna, Krolenko, Kostiantyn, Bugaj, Marta, Sudoł, Sylwia, Gibas, Agnieszka, Szeremeta-Spisak, Joanna, Bobowska, Aneta, Zastawna, Magdalena, Wyrębek, Przemysław, Boutard, Nicolas, Więckowska, Aleksandra, Jasnosz, Wojciech, Schonemann, Wojciech, Zuchowicz, Karol, Synak, David, Kulesza, Urszula, Leventes, Oleksandr, Świrski, Mateusz, Sasmal, Sujit, Gluza, Karolina, Kret, Patryk, Ogórek, Mateusz, Michalik, Kinga, Banaszak, Katarzyna, Podkowa, Adrian, Wnuk-Lipińska, Katarzyna, Dobrzańska, Monika, Littlewood, Peter, Brzózka, Krzysztof, Bartosik, Anna, Chmielewski, Stefan
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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인터페론 유전자 자극제(STING)의 조절제인 헤테로사이클릭 화합물
WRONOWSKI MAREK, SYNAK DAVID JORG, GIBAS AGNIESZKA JUSTYNA, MAHAJAN TUSHAR RAVINDRA, DUDEK LUKASZ PIOTR, TANGIRALA SUNDARA RAGHURAM, ZUCHOWICZ KAROL, CWIERTNIA GRZEGORZ WOJCIECH, LES MARCIN WOJCIECH, FABRITIUS CHARLES HENRY, RADZIMIERSKI ADAM, STASI LUIGI PIERO, ZAWADZKA MAGDALENA IZABELA, RAJDA ANNA, ROGACKI MACIEJ KRZYSZTOF
Year of Publication 12.08.2022
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Year of Publication 12.08.2022
Patent
인터페론 유전자 자극제(STING)의 조절제로서 기능화된 헤테로사이클릭 화합물
WRONOWSKI MAREK, SYNAK DAVID JORG, GIBAS AGNIESZKA JUSTYNA, MAHAJAN TUSHAR RAVINDRA, DUDEK LUKASZ PIOTR, TANGIRALA SUNDARA RAGHURAM, ZUCHOWICZ KAROL, CWIERTNIA GRZEGORZ WOJCIECH, LES MARCIN WOJCIECH, FABRITIUS CHARLES HENRY, RADZIMIERSKI ADAM, STASI LUIGI PIERO, ZAWADZKA MAGDALENA IZABELA, RAJDA ANNA, ROGACKI MACIEJ KRZYSZTOF
Year of Publication 11.08.2022
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Year of Publication 11.08.2022
Patent
Functionalized heterocyclic compounds as modulators of Stimulator of Interferon Genes (STING)
RAJDA, Anna, FABRITIUS, Charles-Henry, DUDEK, Lukasz Piotr, WRONOWSKI, Marek, STASI, Luigi Piero, SYNAK, David Jörg, CWIERTNIA, Grzegorz Wojciech, RADZIMIERSKI, Adam, MAHAJAN, Tushar Ravindra, LES, Marcin Wojciech, ZUCHOWICZ, Karol, GIBAS, Agnieszka Justyna, ZAWADZKA, Magdalena Izabela, ROGACKI, Maciej Krzysztof, TANGIRALA, Sundara Raghuram
Year of Publication 30.05.2024
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Year of Publication 30.05.2024
Patent
Functionalized heterocyclic compounds as modulators of Stimulator of Interferon Genes (STING)
RAJDA, Anna, FABRITIUS, Charles-Henry, DUDEK, Lukasz Piotr, WRONOWSKI, Marek, STASI, Luigi Piero, SYNAK, David Jörg, CWIERTNIA, Grzegorz Wojciech, RADZIMIERSKI, Adam, MAHAJAN, Tushar Ravindra, LES, Marcin Wojciech, ZUCHOWICZ, Karol, GIBAS, Agnieszka Justyna, ZAWADZKA, Magdalena Izabela, ROGACKI, Maciej Krzysztof, TANGIRALA, Sundara Raghuram
Year of Publication 15.02.2024
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Year of Publication 15.02.2024
Patent
Heterocyclic compounds as modulators of Stimulator of Interferon Genes (STING)
RAJDA, Anna, FABRITIUS, Charles-Henry, DUDEK, Lukasz Piotr, WRONOWSKI, Marek, STASI, Luigi Piero, SYNAK, David Jörg, CWIERTNIA, Grzegorz Wojciech, RADZIMIERSKI, Adam, MAHAJAN, Tushar Ravindra, LES, Marcin Wojciech, ZUCHOWICZ, Karol, GIBAS, Agnieszka Justyna, ZAWADZKA, Magdalena Izabela, ROGACKI, Maciej Krzysztof, TANGIRALA, Sundara Raghuram
Year of Publication 01.02.2024
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Year of Publication 01.02.2024
Patent
Heterocyclic compounds as modulators of Stimulator of Interferon Genes (STING)
RAJDA, Anna, FABRITIUS, Charles-Henry, DUDEK, Lukasz Piotr, WRONOWSKI, Marek, STASI, Luigi Piero, SYNAK, David Jörg, CWIERTNIA, Grzegorz Wojciech, RADZIMIERSKI, Adam, MAHAJAN, Tushar Ravindra, LES, Marcin Wojciech, ZUCHOWICZ, Karol, GIBAS, Agnieszka Justyna, ZAWADZKA, Magdalena Izabela, ROGACKI, Maciej Krzysztof, TANGIRALA, Sundara Raghuram
Year of Publication 25.01.2024
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Year of Publication 25.01.2024
Patent
HETEROCYCLIC COMPOUNDS AS MODULATORS OF STIMULATOR OF INTERFERON GENES (STING)
RAJDA, Anna, FABRITIUS, Charles-Henry, DUDEK, Lukasz Piotr, WRONOWSKI, Marek, STASI, Luigi Piero, SYNAK, David Jörg, CWIERTNIA, Grzegorz Wojciech, RADZIMIERSKI, Adam, MAHAJAN, Tushar Ravindra, LES, Marcin Wojciech, ZUCHOWICZ, Karol, GIBAS, Agnieszka Justyna, ZAWADZKA, Magdalena Izabela, ROGACKI, Maciej Krzysztof, TANGIRALA, Sundara Raghuram
Year of Publication 09.03.2023
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Year of Publication 09.03.2023
Patent
FUNCTIONALIZED HETEROCYCLIC COMPOUNDS AS MODULATORS OF STIMULATOR OF INTERFERON GENES (STING)
RAJDA, Anna, FABRITIUS, Charles-Henry, DUDEK, Lukasz Piotr, WRONOWSKI, Marek, STASI, Luigi Piero, SYNAK, David Jörg, CWIERTNIA, Grzegorz Wojciech, RADZIMIERSKI, Adam, MAHAJAN, Tushar Ravindra, LES, Marcin Wojciech, ZUCHOWICZ, Karol, GIBAS, Agnieszka Justyna, ZAWADZKA, Magdalena Izabela, ROGACKI, Maciej Krzysztof, TANGIRALA, Sundara Raghuram
Year of Publication 23.02.2023
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Year of Publication 23.02.2023
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HETEROCYCLIC COMPOUNDS AS MODULATORS OF STIMULATOR OF INTERFERON GENES (STING)
RAJDA, Anna, FABRITIUS, Charles-Henry, DUDEK, Lukasz Piotr, WRONOWSKI, Marek, STASI, Luigi Piero, SYNAK, David Jörg, CWIERTNIA, Grzegorz Wojciech, RADZIMIERSKI, Adam, MAHAJAN, Tushar Ravindra, LES, Marcin Wojciech, ZUCHOWICZ, Karol, GIBAS, Agnieszka Justyna, ZAWADZKA, Magdalena Izabela, ROGACKI, Maciej Krzysztof, TANGIRALA, Sundara Raghuram
Year of Publication 19.10.2022
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Year of Publication 19.10.2022
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FUNCTIONALIZED HETEROCYCLIC COMPOUNDS AS MODULATORS OF STIMULATOR OF INTERFERON GENES (STING)
RAJDA, Anna, FABRITIUS, Charles-Henry, DUDEK, Lukasz Piotr, WRONOWSKI, Marek, STASI, Luigi Piero, SYNAK, David Jörg, CWIERTNIA, Grzegorz Wojciech, RADZIMIERSKI, Adam, MAHAJAN, Tushar Ravindra, LES, Marcin Wojciech, ZUCHOWICZ, Karol, GIBAS, Agnieszka Justyna, ZAWADZKA, Magdalena Izabela, ROGACKI, Maciej Krzysztof, TANGIRALA, Sundara Raghuram
Year of Publication 19.10.2022
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Year of Publication 19.10.2022
Patent
Heterocyclic compounds as modulators of Stimulator of Interferon Genes (STING)
RAJDA, Anna, FABRITIUS, Charles-Henry, DUDEK, Lukasz Piotr, WRONOWSKI, Marek, STASI, Luigi Piero, SYNAK, David Jörg, CWIERTNIA, Grzegorz Wojciech, RADZIMIERSKI, Adam, MAHAJAN, Tushar Ravindra, LES, Marcin Wojciech, ZUCHOWICZ, Karol, GIBAS, Agnieszka Justyna, ZAWADZKA, Magdalena Izabela, ROGACKI, Maciej Krzysztof, TANGIRALA, Sundara Raghuram
Year of Publication 26.05.2022
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Year of Publication 26.05.2022
Patent
Functionalized heterocyclic compounds as modulators of Stimulator of Interferon Genes (STING)
RAJDA, Anna, FABRITIUS, Charles-Henry, DUDEK, Lukasz Piotr, WRONOWSKI, Marek, STASI, Luigi Piero, SYNAK, David Jörg, CWIERTNIA, Grzegorz Wojciech, RADZIMIERSKI, Adam, MAHAJAN, Tushar Ravindra, LES, Marcin Wojciech, ZUCHOWICZ, Karol, GIBAS, Agnieszka Justyna, ZAWADZKA, Magdalena Izabela, ROGACKI, Maciej Krzysztof, TANGIRALA, Sundara Raghuram
Year of Publication 26.05.2022
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Year of Publication 26.05.2022
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FUNCTIONALIZED HETEROCYCLIC COMPOUNDS AS MODULATORS OF STIMULATOR OF INTERFERON GENES (STING)
SYNAK, DAVID JORG, FABRITIUS, CHARLES-HENRY, CWIERTNIA, GRZEGORZ WOJCIECH, MAHAJAN, TUSHAR RAVINDRA, LES, MARCIN WOJCIECH, ZUCHOWICZ, KAROL, TANGIRALA, SUNDARA RAGHURAM, DUDEK, LUKASZ PIOTR, ROGACKI, MACIEJ KRZYSZTOF, WRONOWSKI, MAREK, GIBAS, AGNIESZKA JUSTYNA, RADZIMIERSKI, ADAM, RAJDA, ANNA, ZAWADZKA, MAGDALENA IZABELA, STASI, LUIGI PIERO
Year of Publication 17.06.2021
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Year of Publication 17.06.2021
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FUNCTIONALIZED HETEROCYCLIC COMPOUNDS AS MODULATORS OF STIMULATOR OF INTERFERON GENES (STING)
RAJDA, Anna, FABRITIUS, Charles-Henry, DUDEK, Lukasz Piotr, WRONOWSKI, Marek, STASI, Luigi Piero, SYNAK, David Jörg, CWIERTNIA, Grzegorz Wojciech, RADZIMIERSKI, Adam, MAHAJAN, Tushar Ravindra, LES, Marcin Wojciech, ZUCHOWICZ, Karol, GIBAS, Agnieszka Justyna, ZAWADZKA, Magdalena Izabela, ROGACKI, Maciej Krzysztof, TANGIRALA, Sundara Raghuram
Year of Publication 17.06.2021
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Year of Publication 17.06.2021
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HETEROCYCLIC COMPOUNDS AS MODULATORS OF STIMULATOR OF INTERFERON GENES (STING)
RAJDA, Anna, FABRITIUS, Charles-Henry, DUDEK, Lukasz Piotr, WRONOWSKI, Marek, STASI, Luigi Piero, SYNAK, David Jörg, CWIERTNIA, Grzegorz Wojciech, RADZIMIERSKI, Adam, MAHAJAN, Tushar Ravindra, LES, Marcin Wojciech, ZUCHOWICZ, Karol, GIBAS, Agnieszka Justyna, ZAWADZKA, Magdalena Izabela, ROGACKI, Maciej Krzysztof, TANGIRALA, Sundara Raghuram
Year of Publication 17.06.2021
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Year of Publication 17.06.2021
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HETEROCYCLIC COMPOUNDS AS MODULATORS OF STIMULATOR OF INTERFERON GENES (STING)
SYNAK, DAVID JORG, FABRITIUS, CHARLES-HENRY, CWIERTNIA, GRZEGORZ WOJCIECH, MAHAJAN, TUSHAR RAVINDRA, LES, MARCIN WOJCIECH, ZUCHOWICZ, KAROL, TANGIRALA, SUNDARA RAGHURAM, DUDEK, LUKASZ PIOTR, ROGACKI, MACIEJ KRZYSZTOF, WRONOWSKI, MAREK, GIBAS, AGNIESZKA JUSTYNA, RADZIMIERSKI, ADAM, RAJDA, ANNA, ZAWADZKA, MAGDALENA IZABELA, STASI, LUIGI PIERO
Year of Publication 17.06.2021
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Year of Publication 17.06.2021
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