sGC stimulator praliciguat suppresses stellate cell fibrotic transformation and inhibits fibrosis and inflammation in models of NASH
Hall, Katherine C., Bernier, Sylvie G., Jacobson, Sarah, Liu, Guang, Zhang, Ping Y., Sarno, Renee, Catanzano, Victoria, Currie, Mark G., Masferrer, Jaime L.
Published in Proceedings of the National Academy of Sciences - PNAS (28.05.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (28.05.2019)
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Discovery of stimulator binding to a conserved pocket in the heme domain of soluble guanylyl cyclase
Wales, Jessica A., Chen, Cheng-Yu, Breci, Linda, Weichsel, Andrzej, Bernier, Sylvie G., Sheppeck, James E., Solinga, Robert, Nakai, Takashi, Renhowe, Paul A., Jung, Joon, Montfort, William R.
Published in The Journal of biological chemistry (02.02.2018)
Published in The Journal of biological chemistry (02.02.2018)
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Rapid discovery and evolution of nanosensors containing fluorogenic amino acids
Kuru, Erkin, Rittichier, Jonathan, de Puig, Helena, Flores, Allison, Rout, Subhrajit, Han, Isaac, Reese, Abigail E., Bartlett, Thomas M., De Moliner, Fabio, Bernier, Sylvie G., Galpin, Jason D., Marchand, Jorge, Bedell, William, Robinson-McCarthy, Lindsey, Ahern, Christopher A., Bernhardt, Thomas G., Rudner, David Z., Collins, James J., Vendrell, Marc, Church, George M.
Published in Nature communications (05.09.2024)
Published in Nature communications (05.09.2024)
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The CNS-penetrant soluble guanylate cyclase stimulator CYR119 attenuates markers of inflammation in the central nervous system
Correia, Susana S, Liu, Guang, Jacobson, Sarah, Bernier, Sylvie G, Tobin, Jenny V, Schwartzkopf, Chad D, Atwater, Emily, Lonie, Elisabeth, Rivers, Sam, Carvalho, Andrew, Germano, Peter, Tang, Kim, Iyengar, Rajesh R, Currie, Mark G, Hadcock, John R, Winrow, Christopher J, Jones, Juli E
Published in Journal of neuroinflammation (18.09.2021)
Published in Journal of neuroinflammation (18.09.2021)
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The CNS-Penetrant Soluble Guanylate Cyclase Stimulator CY6463 Reveals its Therapeutic Potential in Neurodegenerative Diseases
Correia, Susana S., Iyengar, Rajesh R., Germano, Peter, Tang, Kim, Bernier, Sylvie G., Schwartzkopf, Chad D., Tobin, Jenny, Lee, Thomas W.-H., Liu, Guang, Jacobson, Sarah, Carvalho, Andrew, Rennie, Glen R., Jung, Joon, Renhowe, Paul A., Lonie, Elisabeth, Winrow, Christopher J., Hadcock, John R., Jones, Juli E., Currie, Mark G.
Published in Frontiers in pharmacology (24.05.2021)
Published in Frontiers in pharmacology (24.05.2021)
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Olinciguat, an Oral sGC Stimulator, Exhibits Diverse Pharmacology Across Preclinical Models of Cardiovascular, Metabolic, Renal, and Inflammatory Disease
Zimmer, Daniel P, Shea, Courtney M, Tobin, Jenny V, Tchernychev, Boris, Germano, Peter, Sykes, Kristie, Banijamali, Ali R, Jacobson, Sarah, Bernier, Sylvie G, Sarno, Renee, Carvalho, Andrew, Chien, Yueh-Tyng, Graul, Regina, Buys, Emmanuel S, Jones, Juli E, Wakefield, James D, Price, Gavrielle M, Chickering, Jennifer G, Milne, G Todd, Currie, Mark G, Masferrer, Jaime L
Published in Frontiers in pharmacology (08.04.2020)
Published in Frontiers in pharmacology (08.04.2020)
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A Methionine Aminopeptidase-2 Inhibitor, PPI-2458, for the Treatment of Rheumatoid Arthritis
Bernier, Sylvie G., Lazarus, Douglas D., Clark, Edward, Doyle, Beth, Labenski, Matthew T., Thompson, Charles D., Westlin, William F., Hannig, Gerhard, Erikson, R. L.
Published in Proceedings of the National Academy of Sciences - PNAS (20.07.2004)
Published in Proceedings of the National Academy of Sciences - PNAS (20.07.2004)
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Modulation of Pro-inflammatory Gene Expression by Nuclear Lysophosphatidic Acid Receptor Type-1
Gobeil, Fernand, Bernier, Sylvie G., Vazquez-Tello, Alejandro, Brault, Sonia, Beauchamp, Martin H., Quiniou, Christiane, Marrache, Anne Marilise, Checchin, Daniella, Sennlaub, Florian, Hou, Xin, Nader, Mony, Bkaily, Ghassan, Ribeiro-da-Silva, Alfredo, Goetzl, Edward J., Chemtob, Sylvain
Published in The Journal of biological chemistry (03.10.2003)
Published in The Journal of biological chemistry (03.10.2003)
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Olinciguat, a stimulator of soluble guanylyl cyclase, attenuates inflammation, vaso‐occlusion and nephropathy in mouse models of sickle cell disease
Tchernychev, Boris, Li, Huihui, Lee, Sung‐Kyun, Gao, Xin, Ramanarasimhaiah, Raghunath, Liu, Guang, Hall, Katherine C., Bernier, Sylvie G., Jones, Juli E., Feil, Susanne, Feil, Robert, Buys, Emmanuel S., Graul, Regina M., Frenette, Paul S., Masferrer, Jaime L.
Published in British journal of pharmacology (01.09.2021)
Published in British journal of pharmacology (01.09.2021)
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Pharmacological Characterization of IW-1973, a Novel Soluble Guanylate Cyclase Stimulator with Extensive Tissue Distribution, Antihypertensive, Anti-Inflammatory, and Antifibrotic Effects in Preclinical Models of Disease
Tobin, Jenny V, Zimmer, Daniel P, Shea, Courtney, Germano, Peter, Bernier, Sylvie G, Liu, Guang, Long, Kim, Miyashiro, Joy, Ranganath, Sheila, Jacobson, Sarah, Tang, Kim, Im, G-Yoon Jamie, Sheppeck, 2nd, James, Moore, Joel D, Sykes, Kristine, Wakefield, James, Sarno, Renee, Banijamali, Ali R, Profy, Albert T, Milne, G Todd, Currie, Mark G, Masferrer, Jaime L
Published in The Journal of pharmacology and experimental therapeutics (01.06.2018)
Published in The Journal of pharmacology and experimental therapeutics (01.06.2018)
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The Soluble Guanylate Cyclase Stimulator IWP-953 Increases Conventional Outflow Facility in Mouse Eyes
Ge, Pei, Navarro, Iris D, Kessler, Marco M, Bernier, Sylvie G, Perl, Nicholas R, Sarno, Renee, Masferrer, Jaime, Hannig, Gerhard, Stamer, W Daniel
Published in Investigative ophthalmology & visual science (01.03.2016)
Published in Investigative ophthalmology & visual science (01.03.2016)
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Discovery of CYR715: A novel carboxylic acid-containing soluble guanylate cyclase stimulator
Rennie, Glen R., Barden, Timothy C., Bernier, Sylvie G., Carvalho, Andrew, Deming, Renee, Germano, Peter, Hudson, Colleen, Im, G-Yoon J., Iyengar, Rajesh R., Jia, Lei, Jung, Joon, Kim, Elise, Lee, Thomas W.-H., Mermerian, Ara, Moore, Joel, Nakai, Takashi, Perl, Nicholas R., Tobin, Jenny, Zimmer, Daniel P., Renhowe, Paul A.
Published in Bioorganic & medicinal chemistry letters (15.05.2021)
Published in Bioorganic & medicinal chemistry letters (15.05.2021)
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Permeability of endothelial monolayers to albumin is increased by bradykinin and inhibited by prostaglandins
Farmer, Pierre J, Bernier, Sylvie G, Lepage, Andree, Guillemette, Gaetan, Regoli, Domenico, Sirois, Pierre
Published in American journal of physiology. Lung cellular and molecular physiology (01.04.2001)
Published in American journal of physiology. Lung cellular and molecular physiology (01.04.2001)
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Discovery of Clinical Candidate GSK1842799 As a Selective S1P1 Receptor Agonist (Prodrug) for Multiple Sclerosis
Deng, Hongfeng, Bernier, Sylvie G, Doyle, Elisabeth, Lorusso, Jeanine, Morgan, Barry A, Westlin, William F, Evindar, Ghotas
Published in ACS medicinal chemistry letters (10.10.2013)
Published in ACS medicinal chemistry letters (10.10.2013)
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Exploring amino acids derivatives as potent, selective, and direct agonists of sphingosine-1-phosphate receptor subtype-1
Evindar, Ghotas, Deng, Hongfeng, Bernier, Sylvie G, Doyle, Elisabeth, Lorusso, Jeanine, Morgan, Barry A, Westlin, William F
Published in Bioorganic & medicinal chemistry letters (15.01.2013)
Published in Bioorganic & medicinal chemistry letters (15.01.2013)
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Gastrointestinal pain: Unraveling a novel endogenous pathway through uroguanylin/guanylate cyclase-C/cGMP activation
Silos-Santiago, Inmaculada, Hannig, Gerhard, Eutamene, Helene, Ustinova, Elena E., Bernier, Sylvie G., Ge, Pei, Graul, Christopher, Jacobson, Sarah, Jin, Hong, Liong, Elaine, Kessler, Marco M., Reza, Tammi, Rivers, Samuel, Shea, Courtney, Tchernychev, Boris, Bryant, Alexander P., Kurtz, Caroline B., Bueno, Lionel, Pezzone, Michael A., Currie, Mark G.
Published in Pain (Amsterdam) (01.09.2013)
Published in Pain (Amsterdam) (01.09.2013)
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N- and C-terminal structure-activity study of angiotensin II on the angiotensin AT2 receptor
BOULEY, R, PERODIN, J, PLANTE, H, RIHAKOVA, L, BERNIER, S. G, MALETINSKA, L, GUILLEMETTE, G, ESCHER, E
Published in European journal of pharmacology (19.02.1998)
Published in European journal of pharmacology (19.02.1998)
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Regulation of eNOS Expression in Brain Endothelial Cells by Perinuclear EP3 Receptors
Gobeil, Fernand, Dumont, Isabelle, Marrache, Anne Marilise, Vazquez-Tello, Alejandro, Bernier, Sylvie G, Abran, Daniel, Hou, Xin, Beauchamp, Martin H, Quiniou, Christiane, Bouayad, Asmaa, Choufani, Sanaa, Bhattacharya, Mousumi, Molotchnikoff, Stephane, Ribeiro-da-Silva, Alfredo, Varma, Daya R, Bkaily, Ghassan, Chemtob, Sylvain
Published in Circulation research (05.04.2002)
Published in Circulation research (05.04.2002)
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