Rational design of a new antibiotic class for drug-resistant infections
Durand-Reville, Thomas F, Miller, Alita A, O'Donnell, John P, Wu, Xiaoyun, Sylvester, Mark A, Guler, Satenig, Iyer, Ramkumar, Shapiro, Adam B, Carter, Nicole M, Velez-Vega, Camilo, Moussa, Samir H, McLeod, Sarah M, Chen, April, Tanudra, Angela M, Zhang, Jing, Comita-Prevoir, Janelle, Romero, Jan A, Huynh, Hoan, Ferguson, Andrew D, Horanyi, Peter S, Mayclin, Stephen J, Heine, Henry S, Drusano, George L, Cummings, Jason E, Slayden, Richard A, Tommasi, Ruben A
Published in Nature (London) (30.09.2021)
Published in Nature (London) (30.09.2021)
Get full text
Journal Article
Modulating the strength of hydrogen bond acceptors to achieve low Caco2 efflux for oral bioavailability of PARP inhibitors blocking centrosome clustering
Gu, Chungang, Lamb, Michelle L., Johannes, Jeffrey W., Sylvester, Mark A., Eisman, Mark S., Harrison, Rane A., Hu, Haiqing, Kazmirski, Steven, Mikule, Keith, Peng, Bo, Su, Nancy, Wang, Wenxian, Ye, Qing, Zheng, Xiaolan, Lyne, Paul D., Scott, David A.
Published in Bioorganic & medicinal chemistry letters (01.10.2016)
Published in Bioorganic & medicinal chemistry letters (01.10.2016)
Get full text
Journal Article
N-Hydroxyformamide LpxC inhibitors, their in vivo efficacy in a mouse Escherichia coli infection model, and their safety in a rat hemodynamic assay
Furuya, Takeru, Shapiro, Adam B., Comita-Prevoir, Janelle, Kuenstner, Eric J., Zhang, Jing, Ribe, Seth D., Chen, April, Hines, Daniel, Moussa, Samir H., Carter, Nicole M., Sylvester, Mark A., Romero, Jan A.C., Vega, Camilo V., Sacco, Michael D., Chen, Yu, O'Donnell, John P., Durand-Reville, Thomas F., Miller, Alita A., Tommasi, Ruben A.
Published in Bioorganic & medicinal chemistry (15.12.2020)
Published in Bioorganic & medicinal chemistry (15.12.2020)
Get full text
Journal Article
Whole-Cell-Based Assay To Evaluate Structure Permeation Relationships for Carbapenem Passage through the Pseudomonas aeruginosa Porin OprD
Iyer, Ramkumar, Sylvester, Mark A, Velez-Vega, Camilo, Tommasi, Ruben, Durand-Reville, Thomas F, Miller, Alita A
Published in ACS infectious diseases (14.04.2017)
Published in ACS infectious diseases (14.04.2017)
Get full text
Journal Article
Synthesis and enzymatic evaluation of a P1 arginine aminocoumarin substrate library for trypsin-like serine proteases
EDWARDS, Philip D, MAUGER, Russell C, COTTRELL, Kevin M, MORRIS, Frank X, PINE, Kara K, SYLVESTER, Mark A, SCOTT, Clay W, FURLONG, Stephen T
Published in Bioorganic & medicinal chemistry letters (16.10.2000)
Published in Bioorganic & medicinal chemistry letters (16.10.2000)
Get full text
Journal Article
Linear non-competitive inhibition of solubilized human gamma-secretase by pepstatin A methylester, L685458, sulfonamides, and benzodiazepines
Tian, Gaochao, Sobotka-Briner, Cynthia D, Zysk, John, Liu, Xiaodong, Birr, Cynthia, Sylvester, Mark A, Edwards, Philip D, Scott, Clay D, Greenberg, Barry D
Published in The Journal of biological chemistry (30.08.2002)
Published in The Journal of biological chemistry (30.08.2002)
Get full text
Journal Article
2,6-Disubstituted pyrazines and related analogs as NR2B site antagonists of the NMDA receptor with anti-depressant activity
Brown, Dean G., Maier, Donna L., Sylvester, Mark A., Hoerter, Tiffany N., Menhaji-Klotz, Elnaz, Lasota, Celina C., Hirata, Lee T., Wilkins, Deidre E., Scott, Clay W., Trivedi, Shephali, Chen, Tongming, McCarthy, Dennis J., Maciag, Carla M., Sutton, Evelynjeane J., Cumberledge, Jerry, Mathisen, Don, Roberts, John, Gupta, Anshul, Liu, Frank, Elmore, Charles S., Alhambra, Cristobal, Krumrine, Jennifer R., Wang, Xia, Ciaccio, Paul J., Wood, Michael W., Campbell, James B., Johansson, Magnus J., Xia, Jian, Wen, Xiaotian, Jiang, Ji, Wang, Xiaoping, Peng, Zuozhong, Hu, Tao, Wang, Jian
Published in Bioorganic & medicinal chemistry letters (01.06.2011)
Published in Bioorganic & medicinal chemistry letters (01.06.2011)
Get full text
Journal Article
C3 activation is inhibited by analogs of compstatin but not by serine protease inhibitors or peptidyl α-ketoheterocycles
Furlong, Stephen T, Dutta, Anand S, Coath, Matthew M, Gormley, James J, Hubbs, Stephen J, Lloyd, Darleen, Mauger, Russell C, Strimpler, Anne M, Sylvester, Mark A, Scott, Clay W, Edwards, Philip D
Published in Immunopharmacology (20.07.2000)
Published in Immunopharmacology (20.07.2000)
Get full text
Journal Article
Synthesis and enzymatic evaluation of a P 1 arginine aminocoumarin substrate library for trypsin-like serine proteases
Edwards, Philip D., Mauger, Russell C., Cottrell, Kevin M., Morris, Frank X., Pine, Kara K., Sylvester, Mark A., Scott, Clay W., Furlong, Stephen T.
Published in Bioorganic & medicinal chemistry letters (16.10.2000)
Published in Bioorganic & medicinal chemistry letters (16.10.2000)
Get full text
Journal Article
Linear Non-competitive Inhibition of Solubilized Human γ-Secretase by Pepstatin A Methylester, L685458, Sulfonamides, and Benzodiazepines
Gaochao Tian, Cynthia D. Sobotka-Briner, John Zysk, Xiaodong Liu, Cynthia Birr, Mark A. Sylvester, Philip D. Edwards, Clay D. Scott, Barry D. Greenberg
Published in The Journal of biological chemistry (30.08.2002)
Published in The Journal of biological chemistry (30.08.2002)
Get full text
Journal Article
Non‐Competitive Inhibition of Solubilized Human γ‐Secretase by Pepstatin A Methylester, L‐685458, Sulfonamides and Benzodiazepines
Tian, Gaochao, Sobotka‐Briner, Cynthia D., Zysk, John, Liu, Xiaodong, Birr, Cynthia, Sylvester, Mark A., Edwards, Phil D., Scott, Clay W., Greenberg, Barry D.
Published in CNS drug reviews (01.06.2004)
Published in CNS drug reviews (01.06.2004)
Get full text
Journal Article
Compounds and methods for treating bacterial infections
ZHANG, JING, VELEZ-VEGA, CAMILO, DURAND-REVILLE, THOMAS FRANCOIS, ROMERO, JAN, WU, XIAOYUN, SYLVESTER, MARK, GULER, SATENIG, COMITA-PREVOIR, JANELLE, TOMMASI, RUBEN
Year of Publication 01.02.2023
Get full text
Year of Publication 01.02.2023
Patent
Compounds and methods for treating bacterial infections
VELEZ-VEGA CAMILO, GULER SATENIG, COMITA-PREVOIR JANELLE, TOMMASI RUBEN, DURAND-REVILLE THOMAS, SYLVESTER MARK, ROMERO JAN, WU XIAOYUN, ZHANG JING
Year of Publication 17.01.2020
Get full text
Year of Publication 17.01.2020
Patent
Compounds and methods for treating bacterial infections
ZHANG, JING, VELEZ-VEGA, CAMILO, DURAND-REVILLE, THOMAS FRANCOIS, ROMERO, JAN, WU, XIAOYUN, SYLVESTER, MARK, GULER, SATENIG, COMITA-PREVOIR, JANELLE, TOMMASI, RUBEN
Year of Publication 16.12.2018
Get full text
Year of Publication 16.12.2018
Patent
Spirocyclopropyl piperidine derivatives
CACCIOLA JOSEPH, GROBLEWSKI THIERRY, BROWN DEAN, EDWARDS PHIL, BERNSTEIN PETER, SYLVESTER MARK, FOLMER JAMES, WESOLOWSKI STEVEN
Year of Publication 23.06.2010
Get full text
Year of Publication 23.06.2010
Patent