Mechanistic Multilayer Quantitative Model for Nonlinear Pharmacokinetics, Target Occupancy and Pharmacodynamics (PK/TO/PD) Relationship of D-Amino Acid Oxidase Inhibitor, TAK-831 in Mice
Yoneyama, Tomoki, Sato, Sho, Sykes, Andy, Fradley, Rosa, Stafford, Stuart, Bechar, Shyam, Howley, Eimear, Patel, Toshal, Tagawa, Yoshihiko, Moriwaki, Toshiya, Asahi, Satoru
Published in Pharmaceutical research (01.08.2020)
Published in Pharmaceutical research (01.08.2020)
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Assessment of the Target Engagement and d-Serine Biomarker Profiles of the d-Amino Acid Oxidase Inhibitors Sodium Benzoate and PGM030756
Howley, Eimear, Bestwick, Michael, Fradley, Rosa, Harrison, Helen, Leveridge, Mathew, Okada, Kengo, Fieldhouse, Charlotte, Farnaby, Will, Canning, Hannah, Sykes, Andy P., Merchant, Kevin, Hazel, Katherine, Kerr, Catrina, Kinsella, Natasha, Walsh, Louise, Livermore, David G., Hoffman, Isaac, Ellery, Jonathan, Mitchell, Phillip, Patel, Toshal, Carlton, Mark, Barnes, Matt, Miller, David J.
Published in Neurochemical research (01.11.2017)
Published in Neurochemical research (01.11.2017)
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An Exploratory Study of Daprodustat in Erythropoietin-Hyporesponsive Subjects
Cizman, Borut, Sykes, Andy P, Paul, Gitanjali, Zeig, Steven, Cobitz, Alexander R
Published in Kidney international reports (01.07.2018)
Published in Kidney international reports (01.07.2018)
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PERFORMANCE OF AN ACTIVITY MONITOR INTEGRATED INTO A MICROPROCESSOR KNEE
Sykes, Andy, Stech, Nadine, Laszczak, Piotr, McGrath, Michael, Kercher, Alan, Zahedi, Saeed, Moser, David
Published in Canadian prosthetics & orthotics journal (15.12.2018)
Published in Canadian prosthetics & orthotics journal (15.12.2018)
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Machine Learning Models for Human In Vivo Pharmacokinetic Parameters with In-House Validation
Miljković, Filip, Martinsson, Anton, Obrezanova, Olga, Williamson, Beth, Johnson, Martin, Sykes, Andy, Bender, Andreas, Greene, Nigel
Published in Molecular pharmaceutics (06.12.2021)
Published in Molecular pharmaceutics (06.12.2021)
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Abstract OT-09-02: A randomized, open-label, parallel-group, multicenter phase 2 study comparing the efficacy and safety of oral AZD9833 versus fulvestrant in women with advanced ER-positive HER2-negative breast cancer (SERENA-2)
Oliveira, Mafalda, Bennett, Maxine, Khalil, Ali, Mather, Richard, Maudsley, Rhiannon, McGuinness, Sam, Morrow, Christopher J, Sykes, Andy, Zhang, Li, Klinowska, Teresa, Lindemann, Justin PO, Carroll, Danielle
Published in Cancer research (Chicago, Ill.) (15.02.2021)
Published in Cancer research (Chicago, Ill.) (15.02.2021)
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Abstract 1042: Preclinical pharmacokinetic and metabolic characterization of the next generation oral SERD AZD9833
Gangl, Eric T., Markandu, Roshini, Sharma, Pradeep, Sykes, Andy, Pop-Damkov, Petar, Gutierrez, Pablo Morentin, Scott, James S., McGinnity, Dermot F., Fretland, Adrian J., Klinowska, Teresa
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Brain exposure of the ATM inhibitor AZD1390 in humans-a positron emission tomography study
Jucaite, Aurelija, Stenkrona, Per, Cselényi, Zsolt, De Vita, Serena, Buil-Bruna, Nuria, Varnäs, Katarina, Savage, Alicia, Varrone, Andrea, Johnström, Peter, Schou, Magnus, Davison, Chris, Sykes, Andy, Pilla Reddy, Venkatesh, Hoch, Matthias, Vazquez-Romero, Ana, Moein, Mohammad Mahdi, Halldin, Christer, Merchant, Melinda S, Pass, Martin, Farde, Lars
Published in Neuro-oncology (Charlottesville, Va.) (12.04.2021)
Published in Neuro-oncology (Charlottesville, Va.) (12.04.2021)
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Abstract OT-09-05: A randomized, pre-surgical study to investigate the biological effects of AZD9833 doses in women with ER-positive HER2-negative primary breast cancer (SERENA-3)
Robertson, John FR, Moppett, Iain, Rocha, Juan Enrique Bargalló, Dzagnidze, Giorgi, Harding, Joanna, Klinowska, Teresa, Mather, Richard, Mathewson, Alastair, Maudsley, Rhiannon, Morrow, Christopher J, Saunders, Andrew, Sykes, Andy, Zhang, Li, Lindemann, Justin PO
Published in Cancer research (Chicago, Ill.) (15.02.2021)
Published in Cancer research (Chicago, Ill.) (15.02.2021)
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Complete Substrate Inhibition of Cytochrome P450 2C8 by AZD9496, an Oral Selective Estrogen Receptor Degrader
Bapiro, Tashinga E, Sykes, Andy, Martin, Scott, Davies, Michael, Yates, James W T, Hoch, Matthias, Rollison, Helen E, Jones, Barry
Published in Drug metabolism and disposition (01.09.2018)
Published in Drug metabolism and disposition (01.09.2018)
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Abstract 4868: A preclinical PK/PD model based on a mouse glioblastoma survival model for AZD1390, a novel, brain-penetrant ATM kinase inhibitor, to predict the inhibition of DNA damage response induced by radiation and the human efficacious dose
Reddy, Venkatesh Pilla, Sykes, Andy, Colclough, Nicola, Durant, Stephen T., O'Connor, Lenka Oplustil, Hoch, Matthias, Bruna, Nuria Buil, Vita, Serena De, Merchant, Melinda, Pass, Martin
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Identification of Novel, Selective Ataxia-Telangiectasia Mutated Kinase Inhibitors with the Ability to Penetrate the Blood–Brain Barrier: The Discovery of AZD1390
Pike, Kurt G., Hunt, Thomas A., Barlaam, Bernard, Benstead, David, Cadogan, Elaine, Chen, Kan, Cook, Calum R., Colclough, Nicola, Deng, Chao, Durant, Stephen T., Eatherton, Andrew, Goldberg, Kristin, Johnström, Peter, Liu, Libin, Liu, Zhaoqun, Nissink, J. Willem M., Pang, Chengling, Pass, Martin, Robb, Graeme R., Roberts, Caroline, Schou, Magnus, Steward, Oliver, Sykes, Andy, Yan, Yumei, Zhai, Baochang, Zheng, Li
Published in Journal of medicinal chemistry (22.02.2024)
Published in Journal of medicinal chemistry (22.02.2024)
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Abstract 3511: Exploration of pre-clinical relationships between pharmacokinetics, pharmacodynamics and tumor volume for the novel DNA-PK inhibitor AZD7648
Davies, Michael, Jongh, Joost de, Dean, Emma, Fok, Jacquelline H., Goldberg, Frederick W., James, Neil, Karmokar, Ankur, Ramos-Montoya, Antonio, Staniszewska, Anna, Sykes, Andy, Steeg, Tamara van, Cadogan, Elaine
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Identification of a novel GPR81-selective agonist that suppresses lipolysis in mice without cutaneous flushing
Sakurai, Taku, Davenport, Richard, Stafford, Stuart, Grosse, Johannes, Ogawa, Kazumasa, Cameron, Jennifer, Parton, Laura, Sykes, Andy, Mack, Stephen, Bousba, Sarah, Parmar, Alka, Harrison, David, Dickson, Louise, Leveridge, Mathew, Matsui, Junji, Barnes, Matt
Published in European journal of pharmacology (15.03.2014)
Published in European journal of pharmacology (15.03.2014)
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A phase I dose escalation and expansion study of the next generation oral SERD AZD9833 in women with ER-positive, HER2-negative advanced breast cancer
Hamilton, Erika Paige, Oliveira, Mafalda, Banerji, Udai, Hernando, Cristina, Garcia-Corbacho, Javier, Armstrong, Anne, Ciruelos, Eva, Patel, Manish R., Incorvati, Jason, Twelves, Chris, Brier, Tim, Carroll, Danielle, Fox, Steven, Klinowska, Teresa, Lindemann, Justin P O, Mather, Richard, Maudsley, Rhiannon, McGuinness, Sam, Sykes, Andy, Baird, Richard
Published in Journal of clinical oncology (20.05.2020)
Published in Journal of clinical oncology (20.05.2020)
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Abstract PS11-05: Updated data from SERENA-1: A Phase 1 dose escalation and expansion study of the next generation oral SERD AZD9833 as a monotherapy and in combination with palbociclib, in women with ER-positive, HER2-negative advanced breast cancer
Baird, Richard, Oliveira, Mafalda, Gil, Eva Maria Ciruelos, Patel, Manish R, Bermejo de las Heras, Begoña, Ruiz-Borrego, Manuel, García-Corbacho, Javier, Armstrong, Anne, Banerji, Udai, Twelves, Chris, Boni, Valentina, Incorvati, Jason, Kabos, Peter, Cohen, Adam L, de Paula, Bruno, Rodríguez, Marta Capelán, Wang, Judy S, Hernando, Christina, Gonzalez, Alejandro Falcón, Ruiz, Ivan Victoria, Lai-Kwon, Julia, Afghani, Anosheh, Vaklavas, Christos, Brier, Tim, Fox, Steven, Kirova, Bistra, Klinowska, Teresa, Leach, Chris, Lindemann, Justin PO, Mather, Richard, Maudsley, Rhiannon, Morrow, Christopher J, Sathiyayogan, Nitharsan, Sykes, Andy, Zhang, Li, Hamilton, Erika
Published in Cancer research (Chicago, Ill.) (15.02.2021)
Published in Cancer research (Chicago, Ill.) (15.02.2021)
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Abstract PO3-19-09: SERENA-1: Results from a Phase 1 study (Parts I/J) testing the next-generation oral selective estrogen receptor degrader (SERD) camizestrant (AZD9833) in combination with capivasertib in women with ER+, HER2 advanced breast cancer
Vaklavas, Christos, Oliveira, Mafalda, Armstrong, Anne, Moreno, Irene, Twelves, Chris, Ruiz, Ivan Victoria, Bermejo, Begoña, Ajimi, Maxine, Brier, Tim, Ciardullo, Carmela, Gibbons, Lisa, Irurzun-Arana, Itziar, Jack, Tony, Klinowska, Teresa, Lindemann, Justin, Mathewson, Alastair, Morrow, Christopher, Sykes, Andy, Baird, Richard
Published in Cancer research (Chicago, Ill.) (02.05.2024)
Published in Cancer research (Chicago, Ill.) (02.05.2024)
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A European inventory of data elements for patient recruitment
Doods, Justin, Lafitte, Caroline, Ulliac-Sagnes, Nadine, Proeve, Johan, Botteri, Florence, Walls, Robert, Sykes, Andy, Dugas, Martin, Fritz, Fleur
Published in Studies in health technology and informatics (2015)
Published in Studies in health technology and informatics (2015)
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Abstract P3-07-28: SERENA-1: Updated analyses from a Phase 1 study of the next generation oral selective estrogen receptor degrader camizestrant (AZD9833) combined with abemaciclib, in women with ER-positive, HER2-negative advanced breast cancer
Turner, Nicholas, Vaklavas, Christos, Calvo, Emiliano, Garcia-Corbacho, Javier, Incorvati, Jason, Borrego, Manuel Ruiz, Twelves, Chris, Armstrong, Anne, Bermejo, Begoña, Hamilton, Erika, Oliveira, Mafalda, Ciruelos, Eva, Kabos, Peter, Patel, Manish R, Borrell, Maria, Burris, Howard, de Paula, Bruno, Falcon, Alejandro, Hernando, Cristina, Moreno, Irene, O’Brien, Ciara S., Shagisultanova, Elena, Ruiz, Ivan Victoria, Wang, Judy S., Wei, Mei, Brier, Tim, Carroll, Danielle, Ciardullo, Carmela, Gibbons, Lisa, irurzun-Arana, itziar, Jack, Tony, kirova, bistra, Klinowska, Teresa, Lindemann, Justin, Maidment, Julie, Mathewson, Alastair, Maudsley, Rhiannon, McEwen, Robert, Morrow, Christopher, Sykes, Andy, Baird, Richard D.
Published in Cancer research (Chicago, Ill.) (01.03.2023)
Published in Cancer research (Chicago, Ill.) (01.03.2023)
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Abstract P3-07-13: The next generation oral selective estrogen receptor degrader (SERD) camizestrant (AZD9833) is active against wild type and mutant estrogen receptor α
Morrow, Christopher, Carnevalli, Larissa, Baird, Richard D., Brier, Tim, Ciardullo, Carmela, Cureton, Natalie, Lawson, Mandy, McEwen, Robert, Nikolaou, Myria, Armstrong, Anne, Bermejo, Begoña, Calvo, Emiliano, Ciruelos, Eva, Garcia-Corbacho, Javier, Hamilton, Erika, Incorvati, Jason, Kabos, Peter, Oliveira, Mafalda, Patel, Manish R, Ruiz-Borregó, Manuel, Turner, Nicholas, Twelves, Chris, Vaklavas, Christos, Carroll, Danielle, Ching, Steven, Cvetesic, Nevena, DuPont, Michelle, Gibbons, Lisa, Mathewson, Alastair, Maudsley, Rhiannon, Gutierrez, Pablo Morentin, Reddy, Avinash, Rodriguez-Canales, Jaime, Ros, Susana, Sudhan, Dhivya, Sykes, Andy, Whitson, David, Klinowska, Teresa, Lindemann, Justin
Published in Cancer research (Chicago, Ill.) (01.03.2023)
Published in Cancer research (Chicago, Ill.) (01.03.2023)
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