Ubiquitin-activating enzyme inhibition induces an unfolded protein response and overcomes drug resistance in myeloma
Zhuang, Junling, Shirazi, Fazal, Singh, Ram Kumar, Kuiatse, Isere, Wang, Hua, Lee, Hans C., Berkova, Zuzana, Berger, Allison, Hyer, Marc, Chattopadhyay, Nibedita, Syed, Sakeena, Shi, Judy Qiuju, Yu, Jie, Shinde, Vaishali, Tirrell, Stephen, Jones, Richard Julian, Wang, Zhiqiang, Davis, R. Eric, Orlowski, Robert Z.
Published in Blood (04.04.2019)
Published in Blood (04.04.2019)
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Journal Article
Abstract P212: Systems biology-guided indication selection to inform the clinical development of a novel TEAD inhibitor
Sanchez-Martin, Marta, Syed, Sakeena, Frosch, Hyejin, Turcotte, Chelsea, Amidon, Benjamin, McGovern, Karen, Ecsedy, Jeffrey, Zhang, Michelle X.
Published in Molecular cancer therapeutics (01.12.2021)
Published in Molecular cancer therapeutics (01.12.2021)
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Journal Article
Abstract P216: IK-930 mediated TEAD inhibition decreases and delays tumor growth and enhances targeted apoptosis in lung and colon cancer xenografts when combined with MEK or EGFR inhibitors
Amidon, Benjamin, Frosch, Hyejin, Syed, Sakeena, Cavanaugh, Jill, Turcotte, Chelsea, O'Callaghan, Katie, Natarajan, Prabitha, Ecsedy, Jeffrey, McGovern, Karen, Castro, Alfredo
Published in Molecular cancer therapeutics (01.12.2021)
Published in Molecular cancer therapeutics (01.12.2021)
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Journal Article
Discovery and characterization of a novel aryl hydrocarbon receptor inhibitor, IK-175, and its inhibitory activity on tumor immune suppression
McGovern, Karen, Castro, Alfredo C, Cavanaugh, Jill, Coma, Silvia, Walsh, Meghan, Tchaicha, Jeremy, Syed, Sakeena, Natarajan, Prabitha, Manfredi, Mark, Zhang, Xiaoyan M, Ecsedy, Jeffrey
Published in Molecular cancer therapeutics (02.08.2022)
Published in Molecular cancer therapeutics (02.08.2022)
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Journal Article
Abstract 2474: Potent small molecule TEAD inhibitors targeting the Hippo pathway exhibit antiproliferation in vitro and anti-tumor effect in vivo
Amidon, Ben, Syed, Sakeena, Cavanaugh, Jill, Frosch, Hyejin, Natarajan, Prabitha, Ecsedy, Jeffrey, McGovern, Karen, Castro, Alfredo C.
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Abstract 3609: Chimeric cytokine receptors increase memory phenotypes and improve expansion and efficacy of CAR-T cell therapies
Newcomb, John R., Ren, Jun, Syed, Sakeena, Caruolo, Zachary, Webb, Lindsay, McKay, Craig, Kwei, Stephanie, Novina, Carl, Mermelstein, Fred
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Corrigendum to “Discovery of 4-aminopyrimidine analogs as highly potent dual P70S6K/Akt inhibitors” [Bioorgan. Med. Chem. Lett. 50 (2021) 128352]
Xiao, Yufang, Huck, Bayard R., Lan, Ruoxi, DeSelm, Lizbeth, Chen, Xiaoling, Qiu, Hui, Neagu, Constantin, Johnson, Theresa, Mochalkin, Igor, Gardberg, Anna, Jiang, Xuliang, Tian, Hui, Dutt, Vikram, Santos, Dusica, Head, Jared, Jackson, Jennifer, Syed, Sakeena, Lin, Jing, Wilker, Erik, Ma, Jianguo, Clark, Anderson, Machl, Andreas, Bankston, Donald, Jones, Christopher C.V., Goutopoulos, Andreas, Sherer, Brian
Published in Bioorganic & medicinal chemistry letters (01.07.2022)
Published in Bioorganic & medicinal chemistry letters (01.07.2022)
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Journal Article
MEK inhibition leads to BRCA2 downregulation and sensitization to DNA damaging agents in pancreas and ovarian cancer models
Vena, Francesca, Jia, Ruochen, Esfandiari, Arman, Garcia-Gomez, Juan J, Rodriguez-Justo, Manuel, Ma, Jianguo, Syed, Sakeena, Crowley, Lindsey, Elenbaas, Brian, Goodstal, Samantha, Hartley, John A, Hochhauser, Daniel
Published in Oncotarget (20.02.2018)
Published in Oncotarget (20.02.2018)
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Journal Article
Discovery of 4-aminopyrimidine analogs as highly potent dual P70S6K/Akt inhibitors
Xiao, Yufang, Huck, Bayard R., Lan, Ruoxi, DeSelm, Lizbeth, Chen, Xiaoling, Qiu, Hui, Neagu, Constantin, Johnson, Theresa, Mochalkin, Igor, Gardberg, Anna, Jiang, Xuliang, Tian, Hui, Dutt, Vikram, Santos, Dusica, Head, Jared, Jackson, Jennifer, Syed, Sakeena, Lin, Jing, Wilker, Erik, Ma, Jianguo, Clark, Anderson, Machl, Andreas, Bankston, Donald, Jones, Christopher C.V., Goutopoulos, Andreas, Sherer, Brian
Published in Bioorganic & medicinal chemistry letters (15.10.2021)
Published in Bioorganic & medicinal chemistry letters (15.10.2021)
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Journal Article
Abstract 2384: TAK-169, an exceptionally potent CD38 targeted engineered toxin body, as a novel direct cell kill approach for the treatment of multiple myeloma
Willert, Erin K., Robinson, Garrett L., Higgins, Jack P., Liu, Jensing, Lee, Janice, Syed, Sakeena, Zhang, Yuhong, Tavares, Dan, Lublinsky, Anya, Chattopadhyay, Nibedita, Wang, Haiqing, Packer, Laura, Shi, Pu, Harbison, Carole, Patel, Sanjay, Newcomb, John
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Abstract 2603: Combination activity of the MEK inhibitor Pimasertib and the hypoxia-activated prodrug TH-302 in pancreatic and biliary tract tumor xenograft models
Ma, Jianguo, Syed, Sakeena, Crowley, Lindsey, Shaw, Jamie, Ogden, Janet, Elenbaas, Brian, Goodstal, Samantha
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Ninlaro (ixazomib) and Brentuximab Vedotin (ADCETRIS) Combination Results in Synergistic Antitumor Activity in Mouse Models of CD30 Positive Anaplastic Large Cell Lymphoma
Chattopadhyay, Nibedita, Syed, Sakeena, Zhang, Yuhong, Yu, Jie, He McDougall, Dan, Yu, Lunyin Yu, Tirrell, Stephen, Berger, Allison, van de Velde, Helgi, Tremblay, Christopher, Huebner, Dirk
Published in Blood (02.12.2016)
Published in Blood (02.12.2016)
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Journal Article
Abstract 2156: IK-930 is a novel TEAD inhibitor for the treatment of cancers harboring mutations in the Hippo signal transduction pathway
Amidon, Benjamin S., Sanchez-Martin, Marta, Bartolini, Wilmin, Syed, Sakeena, McGovern, Karen, Xu, Lan, Ecsedy, Jeffrey, Zhang, X. Michelle, Constan, Alex, Castro, Alfredo C.
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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TAK-573, an anti-CD38-targeted attenuated interferon alpha (IFNα) fusion protein, showed anti-myeloma tumor responses in combination with standard of care (SOC) agents in multiple myeloma (MM) xenograft tumor models in vivo
Fatholahi, Marjan, Valencia, Miriam, Mark, Armanini, Bi, Mingying, Syed, Sakeena, Zhang, Yuhong, Taura, Tetsuya, Yun, Yong, Wilson, David, Chattopadhyay, Nibedita, Bjorck, Pia, Curley, Michael, Sarah, Pogue
Published in Clinical lymphoma, myeloma and leukemia (01.10.2019)
Published in Clinical lymphoma, myeloma and leukemia (01.10.2019)
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Journal Article
The Anti-Tumor Effect of the Ubiquitin-Activating Enzyme (UAE) Inhibitor TAK-243 on Pre-Clinical Models of Multiple Myeloma
Zhuang, Junling, Lee, Hans, Kuiatse, Isere, Wang, Hua, Shirazi, Fazal, Berger, Allison, Hyer, Marc, Chattopadhyay, Nibedita, Syed, Sakeena, Shi, Judy Qiuju, Yu, Jie, Shinde, Vaishali, Kreshock, Anna, Tirrell, Stephen, Menon, Saurabh, Jones, Richard Julian, Orlowski, Robert Z.
Published in Blood (02.12.2016)
Published in Blood (02.12.2016)
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Journal Article
448 Discovery of clinical candidate IK-175, a selective orally active AHR antagonist
Mcgovern, Karen, Castro, Alfredo, Cavanaugh, Jill, Sanchez-Martin, Marta, Tchaicha, Jeremy, Sakeena Syed, Frosch, Hyejin, Natarajan, Prabitha, Katie O’Callaghan, Amidon, Ben, Zhang, X Michelle, Ecsedy, Jeff
Published in Journal for immunotherapy of cancer (01.11.2020)
Published in Journal for immunotherapy of cancer (01.11.2020)
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Journal Article
Abstract 4516: Evaluation of p70S6K/Akt inhibitor MSC2363318A in patient derived xenograft (PDX) models of breast cancer
Huck, Bayard R., Tian, H, Syed, Sakeena, Lin, Jing, Ma, Jianguo, Clark, Anderson, Kaleta, Remiguisz, Machl, Andreas, Wilker, Erik, Lecomte, Marc
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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Abstract A162: Identification of brain penetrant p70S6K/Akt inhibitor MSC2363318A
Huck, Bayard R., Machl, Andreas, Wilker, Erik, Tian, Hui, Syed, Sakeena, Lin, Jing, Ma, Jianguo, Clark, Anderson, Waterhouse, Roseann, Kaleta, Remiguisz, Micu, Alina, Soughley, Lynne, Li, Long, Groll, Karin, Kroesser, Sonja, Beier, Frank, Hering, Ursula, Lecomte, Marc, Wichert, Katrin, D'Antonio, Mauro, Di Eugenio, Paolo
Published in Molecular cancer therapeutics (01.11.2013)
Published in Molecular cancer therapeutics (01.11.2013)
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Synaptic architecture of leg and wing premotor control networks in Drosophila
Lesser, Ellen, Azevedo, Anthony W., Phelps, Jasper S., Elabbady, Leila, Cook, Andrew, Syed, Durafshan Sakeena, Mark, Brandon, Kuroda, Sumiya, Sustar, Anne, Moussa, Anthony, Dallmann, Chris J., Agrawal, Sweta, Lee, Su-Yee J., Pratt, Brandon, Skutt-Kakaria, Kyobi, Gerhard, Stephan, Lu, Ran, Kemnitz, Nico, Lee, Kisuk, Halageri, Akhilesh, Castro, Manuel, Ih, Dodam, Gager, Jay, Tammam, Marwan, Dorkenwald, Sven, Collman, Forrest, Schneider-Mizell, Casey, Brittain, Derrick, Jordan, Chris S., Macrina, Thomas, Dickinson, Michael, Lee, Wei-Chung Allen, Tuthill, John C.
Published in Nature (London) (11.07.2024)
Published in Nature (London) (11.07.2024)
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