Quantum-based modeling implies that bidentate Arg89-substrate binding enhances serine/threonine protein phosphatase-2A(PPP2R5D/PPP2R1A/PPP2CA)-mediated dephosphorylation
Salter, E. Alan, Wierzbicki, Andrzej, Honkanen, Richard E., Swingle, Mark R.
Published in Frontiers in cell and developmental biology (12.06.2023)
Published in Frontiers in cell and developmental biology (12.06.2023)
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Cardioprotection by mild hypothermia during ischemia involves preservation of ERK activity
Yang, Xiulan, Liu, Yanping, Yang, Xi-Ming, Hu, Fangdi, Cui, Lin, Swingle, Mark R., Honkanen, Richard E., Soltani, Peyman, Tissier, Renaud, Cohen, Michael V., Downey, James M.
Published in Basic research in cardiology (01.05.2011)
Published in Basic research in cardiology (01.05.2011)
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Structure-Activity Relationship Studies of Fostriecin, Cytostatin, and Key Analogs, with PP1, PP2A, PP5, and (β12âβ13)-Chimeras (PP1/PP2A and PP5/PP2A), Provide Further Insight into the Inhibitory Actions of Fostriecin Family Inhibitors
Swingle, Mark R, Amable, Lauren, Lawhorn, Brian G, Buck, Suzanne B, Burke, Christopher P, Ratti, Pukar, Fischer, Kimberly L, Boger, Dale L, Honkanen, Richard E
Published in The Journal of pharmacology and experimental therapeutics (01.10.2009)
Published in The Journal of pharmacology and experimental therapeutics (01.10.2009)
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Structural Basis for the Catalytic Activity of Human Serine/Threonine Protein Phosphatase-5
Swingle, Mark R., Honkanen, Richard E., Ciszak, Ewa M.
Published in The Journal of biological chemistry (06.08.2004)
Published in The Journal of biological chemistry (06.08.2004)
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Phosphatase inhibition by LB-100 enhances BMN-111 stimulation of bone growth
Shuhaibar, Leia C, Kaci, Nabil, Egbert, Jeremy R, Horville, Thibault, Loisay, Léa, Vigone, Giulia, Uliasz, Tracy F, Dambroise, Emilie, Swingle, Mark R, Honkanen, Richard E, Biosse Duplan, Martin, Jaffe, Laurinda A, Legeai-Mallet, Laurence
Published in JCI insight (10.05.2021)
Published in JCI insight (10.05.2021)
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Fundamental Role of the Fostriecin Unsaturated Lactone and Implications for Selective Protein Phosphatase Inhibition
Buck, Suzanne B, Hardouin, Christophe, Ichikawa, Satoshi, Soenen, Danielle R, Gauss, C.-M, Hwang, Inkyu, Swingle, Mark R, Bonness, Kathy M, Honkanen, Richard E, Boger, Dale L
Published in Journal of the American Chemical Society (24.12.2003)
Published in Journal of the American Chemical Society (24.12.2003)
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The Antitumor Drug LB-100 Is a Catalytic Inhibitor of Protein Phosphatase 2A (PPP2CA) and 5 (PPP5C) Coordinating with the Active-Site Catalytic Metals in PPP5C
D'Arcy, Brandon M, Swingle, Mark R, Papke, Cinta M, Abney, Kevin A, Bouska, Erin S, Prakash, Aishwarya, Honkanen, Richard E
Published in Molecular cancer therapeutics (01.03.2019)
Published in Molecular cancer therapeutics (01.03.2019)
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Quantitative proteomics and phosphoproteomics of PP2A-PPP2R5D variants reveal deregulation of RPS6 phosphorylation via converging signaling cascades
Smolen, Kali A., Papke, Cinta M., Swingle, Mark R., Musiyenko, Alla, Li, Chenchen, Salter, E. Alan, Camp, Ashley D., Honkanen, Richard E., Kettenbach, Arminja N.
Published in The Journal of biological chemistry (01.09.2023)
Published in The Journal of biological chemistry (01.09.2023)
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A disorder-related variant (E420K) of a PP2A-regulatory subunit (PPP2R5D) causes constitutively active AKT-mTOR signaling and uncoordinated cell growth
Papke, Cinta M., Smolen, Kali A., Swingle, Mark R., Cressey, Lauren, Heng, Richard A., Toporsian, Mourad, Deng, Liyong, Hagen, Jacob, Shen, Yufeng, Chung, Wendy K., Kettenbach, Arminja N., Honkanen, Richard E.
Published in The Journal of biological chemistry (01.01.2021)
Published in The Journal of biological chemistry (01.01.2021)
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B56δ long-disordered arms form a dynamic PP2A regulation interface coupled with global allostery and Jordan's syndrome mutations
Wu, Cheng-Guo, Balakrishnan, Vijaya K, Merrill, Ronald A, Parihar, Pankaj S, Konovolov, Kirill, Chen, Yu-Chia, Xu, Zhen, Wei, Hui, Sundaresan, Ramya, Cui, Qiang, Wadzinski, Brian E, Swingle, Mark R, Musiyenko, Alla, Chung, Wendy K, Honkanen, Richard E, Suzuki, Aussie, Huang, Xuhui, Strack, Stefan, Xing, Yongna
Published in Proceedings of the National Academy of Sciences - PNAS (02.01.2024)
Published in Proceedings of the National Academy of Sciences - PNAS (02.01.2024)
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Crystal structures and mutagenesis of PPP-family ser/thr protein phosphatases elucidate the selectivity of cantharidin and novel norcantharidin-based inhibitors of PP5C
Chattopadhyay, Debasish, Swingle, Mark R., Salter, Edward A., Wood, Eric, D’Arcy, Brandon, Zivanov, Catherine, Abney, Kevin, Musiyenko, Alla, Rusin, Scott F., Kettenbach, Arminja, Yet, Larry, Schroeder, Chad E., Golden, Jennifer E., Dunham, Wade H., Gingras, Anne-Claude, Banerjee, Surajit, Forbes, David, Wierzbicki, Andrzej, Honkanen, Richard E.
Published in Biochemical pharmacology (01.06.2016)
Published in Biochemical pharmacology (01.06.2016)
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Development of a Synthetic 3-ketosteroid Δ1-dehydrogenase for the Generation of a Novel Catabolic Pathway Enabling Cholesterol Degradation in Human Cells
D’Arcy, Brandon M., Swingle, Mark R., Schambeau, Lindsay, Pannell, Lewis, Prakash, Aishwarya, Honkanen, Richard E.
Published in Scientific reports (12.04.2019)
Published in Scientific reports (12.04.2019)
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Development and validation of a robust and sensitive assay for the discovery of selective inhibitors for serine/threonine protein phosphatases PP1α (PPP1C) and PP5 (PPP5C)
Swingle, Mark R, Honkanen, Richard E
Published in Assay and drug development technologies (01.10.2014)
Published in Assay and drug development technologies (01.10.2014)
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Total Synthesis and Evaluation of Phostriecin and Key Structural Analogues
Burke, Christopher P, Swingle, Mark R, Honkanen, Richard E, Boger, Dale L
Published in Journal of organic chemistry (19.11.2010)
Published in Journal of organic chemistry (19.11.2010)
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Total Synthesis and Evaluation of Cytostatin, Its C10−C11 Diastereomers, and Additional Key Analogues: Impact on PP2A Inhibition
Lawhorn, Brian G, Boga, Sobhana B, Wolkenberg, Scott E, Colby, David A, Gauss, Carla-Maria, Swingle, Mark R, Amable, Lauren, Honkanen, Richard E, Boger, Dale L
Published in Journal of the American Chemical Society (27.12.2006)
Published in Journal of the American Chemical Society (27.12.2006)
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Extended regulation interface coupled to the allosteric network and disease mutations in the PP2A-B56δ holoenzyme
Wu, Cheng-Guo, Balakrishnan, Vijaya K, Parihar, Pankaj S, Konovolov, Kirill, Chen, Yu-Chia, Merrill, Ronald A, Wei, Hui, Carragher, Bridget, Sundaresan, Ramya, Cui, Qiang, Wadzinski, Brian E, Swingle, Mark R, Musiyenko, Alla, Honkanen, Richard, Chung, Wendy K, Suzuki, Aussie, Strack, Stefan, Huang, Xuhui, Xing, Yongna
Published in bioRxiv (05.04.2023)
Published in bioRxiv (05.04.2023)
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Quantum-based modeling implies that bidentate Arg 89 -substrate binding enhances serine/threonine protein phosphatase-2A(PPP2R5D/PPP2R1A/PPP2CA)-mediated dephosphorylation
Salter, E Alan, Wierzbicki, Andrzej, Honkanen, Richard E, Swingle, Mark R
Published in Frontiers in cell and developmental biology (2023)
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Published in Frontiers in cell and developmental biology (2023)
Journal Article
Development of a Synthetic 3-ketosteroid Δ 1 -dehydrogenase for the Generation of a Novel Catabolic Pathway Enabling Cholesterol Degradation in Human Cells
D'Arcy, Brandon M, Swingle, Mark R, Schambeau, Lindsay, Pannell, Lewis, Prakash, Aishwarya, Honkanen, Richard E
Published in Scientific reports (12.04.2019)
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Published in Scientific reports (12.04.2019)
Journal Article
Crystal structures and mutagenesis of PPP-family ser/thr protein phosphatases elucidate the selectivity of cantharidin and novel norcantharidin-based inhibitors of PP5C
Chattopadhyay, Debasish, Swingle, Mark R., Salter, Edward A., Wood, Eric, D’Arcy, Brandon, Zivanov, Catherine, Abney, Kevin, Musiyenko, Alla, Rusin, Scott F., Kettenbach, Arminja, Yet, Larry, Schroeder, Chad E., Golden, Jennifer E., Dunham, Wade H., Gingras, Anne-Claude, Banerjee, Surajit, Forbes, David, Wierzbicki, Andrzej, Honkanen, Richard E.
Published in Biochemical pharmacology (01.06.2016)
Published in Biochemical pharmacology (01.06.2016)
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